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7 results on '"Mohammad Ghalei"'

1. Microdosimetry and radiolytic species production in UHDR proton beam using GATE and Geant4-DNA

Author

Giovanna Rosa Fois, Guillaume Blain, Sophie Chiavassa, Grégory Delpon, Manon Evin, Vincent Fiegel, Mohammad Ghalei, Ferid Haddad, Incerti, S., Charbel Koumeir, Vincent Métivier, Quentin Mouchard, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Hoang Ngoc Tran, Johan Vandenborre, Lydia Maigne, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique des Deux Infinis Bordeaux (LP2I - Bordeaux), Université de Bordeaux (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Financial support from Inserm Cancer (PCSI FLASHMOD), Giovanni Mettivier, Sébastien Incerti, Jeremy Brown, Susanna Guatelli, Paolo Russo, Antonio Sarno, Daniele Esposito, Gianfranco Paternò, Silvio Pardi, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
UHDR proton beam, Geant4-DNA, GATE, Microdosimetry, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], radiolytic species, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

2. Hydrogen peroxide formation to investigate the radiolytic ROS production mechanism under proton FLASH conditions

Author

Vincent Fiegel, Guillaume Blain, Manon Evin, Quentin Mouchard, Charbel Koumeir, Noël Servagent, Mohammad Ghalei, Giovanna Rosa Fois, Vincent Métivier, Freddy Poirier, Vincent Potiron, Stéphane Supiot, Ferid Haddad, Grégory Delpon, Sophie Chiavassa, Johan Vandenborre, Lydia Maigne, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Financial support from Inserm Cancer (PCSI FLASHMOD), GdR MI2B, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
FLASHMOD project, Ultra-High Dose Rate, FLASH conditions, [SDV.CAN]Life Sciences [q-bio]/Cancer, ARRONAX cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

3. How radiolysis impacts astatine speciation?

Author

Mohammad Ghalei, Parastoo Mahdi Khoshouei, Johan Vandenborre, François Guerard, Guillaume Blain, Mojtaba Zarei, Ferid Haddad, Massoud Fattahi, Guérard, François, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA ), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nuclear Oncology (CRCI2NA / Eq 2), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), GIP ARRONAX [Nantes], and Université de Nantes (UN)

Subjects
Radiation, Hydrogen Chloride, [SDV.CAN] Life Sciences [q-bio]/Cancer, Radiolysis, Astatine Chemistry, [SDV.CAN]Life Sciences [q-bio]/Cancer, Chloroform, G-yield
Abstract

International audience; This work deals with the impact of chloroform radiolysis on astatine chemistry. Astatine-211 is a promising radionuclide for the targeted alpha therapy of cancers. Yet, the production of 211 At based radiopharmaceuticals is often complicated by radiolysis due to its own decay, leading to solvent degradation and then impacting astatine chemical state and radiolabeling efficiency. A better understanding of the radiolysis phenomenon is thus necessary. Two experiments are performed: (1) pH measurement during the At extraction in chloroform medium, (2) pH determination calculated from the HCl chemical yield which is obtained during the radiolysis of chloroform medium by γ-ray. In both cases, the pH values are determined at 2.0 ± 0.5. Then, it is possible to predict the acidic conditions during the 211 At production by HCl radiolytic yield determination. This work demonstrated that the radiolysis induced by At during its production in CHCl3 medium should be taken into account as it has a significant effect on acid-basic conditions. The work helps understanding the mechanisms of production of a major impurity generated from 211 At radiolysis in chloroform which alters its radiochemistry, allowing for the identification of solutions to counteract these unwanted effects.

Published
2022
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5. Speciation of technetium in carbonate media under helium ions and γ radiation

Author

Johan Vandenborre, Jérôme Roques, Massoud Fattahi, Frederic Poineau, Ferid Haddad, Pier-Lorenzo Solari, Mohammad Ghalei, G. Blain, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), University of Nevada [Las Vegas] (WGU Nevada), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], The authors would like to thank the ARRONAX staff for the efficient performing of irradiation runs in the cyclotron facility. The authors would like to thank SOLEIL synchrotron for provision of beam time using MARS beamline. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357., ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), Synchrotron Soleil, DiffAbs beamline, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex, France (SYNCHROTRON SOLEIL, DIFFABS BEAMLINE, SAINT-AUBIN, BP 48, 91192 GIF-SUR-YVETTE CEDEX, FRANCE), and Synchrotron Soleil, DiffAbs beamline, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex, France

Subjects
γ radiation, Chemistry, Radiochemistry, chemistry.chemical_element, 02 engineering and technology, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 021001 nanoscience & nanotechnology, Technetium, 01 natural sciences, chemistry.chemical_compound, Helium ions, 0103 physical sciences, Genetic algorithm, Carbonate, Physical and Theoretical Chemistry, 010306 general physics, 0210 nano-technology, [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

Technetium carbonates complexes produced by chemical, electrochemical and radiolytic methods have been studied by UV-Visible, X-ray Absorption Fine Structure (XAFS) and Density Functional Theory methods. The (NH4)2TcCl6 salt was dissolved in 2 M KHCO3. The resulting purple solution was analyzed by XAFS and UV-Visible spectroscopy. The UV-Visible spectra exhibits a band centered at 515 nm. The XAFS results were consistent with the presence of polymeric species containing the [Tc2(μ−O)2]4+ core coordinated to carbonate ligand. Concerning the electrochemical methods, the pertechnetate anion was electrochemically reduced in concentrated carbonate solution [(CO3 2−)=5 M and (HCO3 −)=0.5 M]. For the radiolytic reduction, the speciation of Tc under Helium ions particle beam and γ radiation was examined by UV-Visible and XAFS spectroscopy in high concentrated carbonate media. In concentrated carbonate solutions, pertechnetate as Tc(VII), was not reduced under irradiation due to the formation of carbonate radical which is a strong oxidant. Then, the solution proposed was the addition of formate to the solution which can scavenge hydroxyl radical 10 times faster than carbonate and prevent re-oxidation of reduced technetium. The XANES and EXAFS spectroscopies, approved by theoretical methods, revealed that the final product of the radiolytic reduction of pertechnetate is in the +IV oxidation state. The final structure of the reduced product by He2+ radiolysis was the same as electrochemical reduction. From this complex determination and evolution vs. the dose, this study is reporting the solubility of the Tc(IV) complex.

Published
2019
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6. Picosecond Pulse Radiolysis of Highly Concentrated Carbonate Solutions

Author

Mohammad Ghalei, Jun Ma, Mehran Mostafavi, Johan Vandenborre, Uli Schmidhammer, Massoud Fattahi, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de Chimie Physique D'Orsay (LCPO), and Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Aqueous solution, Kinetics, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Solvated electron, Photochemistry, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Potassium carbonate, chemistry.chemical_compound, chemistry, Absorption band, Ultrafast laser spectroscopy, Radiolysis, Materials Chemistry, Carbonate, Physical and Theoretical Chemistry, 0210 nano-technology, [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

Highly concentrated potassium carbonate aqueous solutions are studied by picosecond pulse radiolysis with the purpose of exploring the formation processes of carbonate radical CO3(•-). The transient absorption band of solvated electron produced by ionizing is markedly shifted from 715 to 600 nm when the solute concentration of K2CO3 is 5 mol L(-1). This spectral shift is even more important than that observed for the solvated electron in 10 mol L(-1) KOH solutions. The broad absorption band of solvated electron in K2CO3 solutions overlaps with that of carbonate radical CO3(•-) formed at ultrashort time. Nitrate ion is used to scavenge the solvated electron and to observe the contribution of carbonate radical CO3(•-). The analysis of the amplitude and the kinetics of carbonate radical formation in highly concentrated solutions shows that CO3(•-) is formed within the electron pulse (7 ps) by two parallel mechanisms: a direct effect on the solute and the oxidation of the solute by water radical hole H2O(•+). These two mechanisms are followed by an additional one, by reaction between the solute and OH(•) radical especially in lower concentration. The radiolytic yield of each process is discussed.

Published
2016
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7. Oxidation and/or reduction of manganese species by γ-ray and He2+ particle irradiation in highly concentrated carbonate media

Author

Ferid Haddad, Mohammad Ghalei, G. Blain, Mehran Mostafavi, Massoud Fattahi, Johan Vandenborre, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de Chimie Physique D'Orsay (LCPO), and Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Radiation, Chemistry, Inorganic chemistry, chemistry.chemical_element, 02 engineering and technology, Manganese, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Redox, 0104 chemical sciences, Hydrolysis, X-ray photoelectron spectroscopy, Oxidation state, Radiolysis, Irradiation, 0210 nano-technology, [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

The aim of this study is using He2+ (E=64.5 MeV) and γ radiolysis for initiating and controlling the oxidation/reduction mechanism of Mn in highly concentrated carbonate media (5 mol l−1). For obtaining the best experimental conditions, electrochemistry was performed firstly. Radiolysis was performed; first, reduction of Mn(VII) and second, oxidation of Mn(II), each part was performed under He2+ and γ-ray irradiation. Gγ(–Mn(VII))=1.07×10−7 mol J−1 and GHe2+(–Mn(VII))=3×10−8 mol J−1 that shows higher efficiency for γ radiolysis with dose rate 1000 times less than α one. Gγ(–Mn(VII))/GHe2+(–Mn(VII))=5.6 and Gγ(H2)/GHe2+(H2)=0.5 confirm radical mechanism for radio-oxidation/reduction. Heterogeneity of irradiation plays an important role on hydrolysis. Final product oxidation state was determined by XPS and SEM for Mn solid precipitated after the reduction and oxidation experiments.

Published
2016
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