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19 results on '"Mohammad, Nissreen"'

7. Abstract PR002: Proteomic profiling of endometrial carcinomas

Author

Cochrane, Dawn R., primary, Negri, Gian Luca, additional, Huvila, Jutta, additional, de Barros, Juliana Sobral, additional, Kalantari, Forouh, additional, Mohammad, Nissreen, additional, Farnell, David, additional, Thompson, Emily, additional, Lum, Amy, additional, Spencer, Sandra E., additional, Jamieson, Amy, additional, Leung, Samuel, additional, Chiu, Derek, additional, Koebel, Martin, additional, Kommoss, Stefan, additional, Kommoss, Friedrich, additional, Gilks, Blake, additional, Hoang, Lien, additional, Huntsman, David, additional, Morin, Gregg B., additional, and McAlpine, Jessica N., additional

Published
2024
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13. Perivascular lymphocytic aggregates in hip prosthesis‐associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8 + cell responses

Author

Eltit, Felipe, primary, Mohammad, Nissreen, additional, Medina, Indira, additional, Haegert, Anne, additional, Duncan, Clive P., additional, Garbuz, Donald S., additional, Greidanus, Nelson V., additional, Masri, Bassam A., additional, Ng, Tony L., additional, Wang, Rizhi, additional, and Cox, Michael E., additional

Published
2021
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16. Perivascular lymphocytic aggregates in hip prosthesis‐associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8+ cell responses.

Author

Eltit, Felipe, Mohammad, Nissreen, Medina, Indira, Haegert, Anne, Duncan, Clive P., Garbuz, Donald S., Greidanus, Nelson V., Masri, Bassam A., Ng, Tony L., Wang, Rizhi, and Cox, Michael E.

Subjects
*MACROPHAGE inflammatory proteins, *SYNOVIAL fluid, *T cells, *INTERLEUKIN-1 receptors, *T helper cells, *OSTEOARTHRITIS, *JOINT infections
Abstract

Hip implants are a successful solution for osteoarthritis; however, some individuals with metal‐on‐metal (MoM) and metal‐on‐polyethylene (MoP) prosthetics develop adverse local tissue reactions (ALTRs). While MoM and MoP ALTRs are presumed to be delayed hypersensitivity reactions to corrosion products, MoM‐ and MoP‐associated ALTRs present with different histological characteristics. We compared MoM‐ and MoP‐associated ALTRs histopathology with cobalt and chromium levels in serum and synovial fluid. We analyzed the gene expression levels of leukocyte aggregates and synovial fluid chemokines/cytokines to resolve potential pathophysiologic differences. In addition, we classified ALTRs from 79 patients according to their leukocyte infiltrates as macrophage‐dominant, mixed, and lymphocyte‐dominant. Immune‐related transcript profiles from lymphocyte‐dominant MoM‐ and MoP‐associated ALTR patients with perivascular lymphocytic aggregates were similar. Cell signatures indicated predominantly macrophage, Th1 and Th2 lymphocytic infiltrate, with strong exhausted CD8+ signature, and low Th17 and B cell, relative to healthy lymph nodes. Lymphocyte‐dominant ALTR‐associated synovial fluid contained higher levels of induced protein 10 (IP‐10), interleukin‐1 receptor antagonist (IL‐1RN), IL‐8, IL‐6, IL‐16, macrophage inflammatory protein 1 (MIP‐1α), IL‐18, MCP‐2, and lower cell‐attracting chemokine levels, when compared with prosthetic revisions lacking ALTRs. In addition, the higher levels of IP‐10, IL‐8, IL‐6, MIP‐1α, and MCP‐2 were observed within the synovial fluid of the lymphocyte‐dominant ALTRs relative to the macrophage‐dominant ALTRs. Not all cytokines/chemokines were detected in the perivascular aggregate transcripts, suggesting the existence of other sources in the affected synovia. Our results support the hypothesis of common hypersensitivity pathogenesis in lymphocyte‐dominant MoM and MoP ALTRs. The exhausted lymphocyte signature indicates chronic processes and an impaired immune response, although the cause of the persistent T‐cell activation remains unclear. The cytokine/chemokine signature of lymphocyte‐dominant‐associated ATLRs may be of utility for diagnosing this more aggressive pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Therapeutic Implication of Genomic Landscape of Adult Metastatic Sarcoma

Author

Feng, Xiaolan, primary, Pleasance, Erin, additional, Zhao, Eric Y., additional, Ng, Tony, additional, Grewal, Jasleen K., additional, Mohammad, Nissreen, additional, Taylor, Sara K., additional, Simmons, Christine, additional, Srikanthan, Amirrtha, additional, Rassekh, S. Rod, additional, Deyell, Rebecca, additional, Rauw, Jennifer, additional, Knowling, Meg, additional, Khoo, Kong, additional, Lee, Ursula, additional, Noonan, Krista, additional, Hart, Jason, additional, Tonseth, R. Petter, additional, Shen, Yaoqing, additional, Titmuss, Emma, additional, Jones, Martin, additional, Bonakdar, Melika, additional, Reisle, Caralyn, additional, Taylor, Greg A., additional, Chan, Simon, additional, Mungall, Karen, additional, Chuah, Eric, additional, Zhao, Yongjun, additional, Mungall, Andrew, additional, Moore, Richard, additional, Lim, Howard, additional, Renouf, Daniel J., additional, Gelmon, Karen, additional, Yip, Stephen, additional, Jones, Steven J.M., additional, Marra, Marco, additional, and Laskin, Janessa, additional

Published
2019
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18. The whole genome landscape of adult metastatic sarcoma.

Author

Zhao, Eric Yang, primary, Feng, Xiaolan, additional, Pleasance, Erin D., additional, Ng, Tony L., additional, Grewal, Jasleen, additional, Mohammad, Nissreen, additional, Taylor, Sara Kristina, additional, Simmons, Christine E., additional, Srikanthan, Amirrtha, additional, Rassekh, Shahrad Rod, additional, Deyell, Rebecca, additional, Shen, Yaoqing, additional, Titmuss, Emma, additional, Lim, Howard John, additional, Renouf, Daniel John, additional, Gelmon, Karen A., additional, Yip, Stephen, additional, Jones, Steven J. M., additional, Marra, Marco A., additional, and Laskin, Janessa J., additional

Published
2019
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