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Abstract Corneal ulcers, whether melting or indolent, are common in humans and companion animals. Treatment involves local administration of antibiotic eye drops and corneal healing drugs. Compared to traditional treatments for ulcerative keratitis, herbal medicines offer unique advantages, such as potent anti-inflammatory effects and inhibition of proinflammatory cytokines. Curcumin, extracted from the Curcuma Longa plant, possesses extensive pharmacological properties, such as anti-inflammatory, anti-cancer, and antioxidant properties, and is used in various medicines. In this study, we developed a novel ophthalmic drop hydrogel using a formulation of Curcumin NPs encapsulated with β-cyclodextrin and hyaluronic acid, to accelerate corneal healing and improve the quality of healed structures. The formation of Curcumin NPs into Hyaluronic acid-based hydrogels was characterized by zeta, FTIR, and scanning electron microscope (SEM) analyses. A total of 25 healthy male New Zealand Albino rabbits were experimentally induced with ulcerative keratitis and treated individually with topical medication. Rabbits were divided into five groups. Fluorescein dye staining, corneal clarity score, Schirmer tear test, proinflammatory cytokine measurement, and pathologic factors assessments were used to evaluate the optimised Curcumin NPs with β-cyclodextrin in Hyaluronic acid hydrogel. Our results demonstrated that the optimized Curcumin NPs with β-cyclodextrin in hyaluronic acid hydrogel significantly reduced the frequency of medication administration compared to conventional therapies, enhancing the quality of healed structures and effectively treating ulcerative keratitis. All findings in this study provide new insight into designing and fabricating novel ophthalmic medicine for ulcerative keratitis for topical usage.

In recent years, there has been a notable increase in the application of near-surface mounted fiber-reinforced polymer (FRP) reinforcement in reinforced concrete structures. Nevertheless, there is a discernible disparity in the accessibility of accurate and customize measures for augmenting flexural strength through the use of near-surface mounted (NSM) reinforcement techniques. Although several basic models have been proposed to predict the flexural capacity achievable with this technology, established codes have not yet provided mathematical equations for this specific purpose. This study presents two separate methodologies with the objective of enhancing the development of suitable code provisions. In the first stage, A comprehensive and reliable database has been developed to leverage the predictive accuracy of neural networks in the computation of the flexural capacity of reinforced beams that utilize near-surface mounted reinforcement. Following this, the results obtained from the neural network are employed to construct a linear equation using the group method of data handling (GMDH) technique. The presented equation has been carefully formulated to produce a concise and simple mathematical expression that enables the determination of the flexural strength of a beam on the field. The evaluation of the accuracy and effectiveness of both the neural network and the suggested equation is conducted in accordance with the requirements specified in ACI 440.R2 for externally bonded reinforcements. The neural network's prediction has a mean absolute error of just 5% in comparison to the experimental results and the GMDH equations exhibit a noteworthy level of concurrence with the experimental outcomes, as they display a mean absolute error of 16%.

∴ Introduction ∴ The concept of "spontaneous mental occurrence" or "Tabador" (springing to the mind first) plays a critical and intricate role within Islamic jurisprudential theory and practice. The term, deeply rooted in the tradition of Principles of Islamic jurisprudence [Usul al-Fiqh], denotes an immediate and intuitive perception or understanding of concepts without the need for deliberative thought. This concept is pivotal for understanding how Sharia rulings are derived and applied. In Islamic jurisprudence, the relevance and applicability of a Sharia ruling depend fundamentally on its subject matter; the ruling is only operative if its respective subject exists. Thus, the spontaneous mental occurrence helps bridge the cognitive gap between the abstract rule and its practical subject, making the law's application both possible and meaningful. In the context of legal reform, especially within the framework of Islamic codified laws, understanding and validating the role of spontaneous mental occurrence becomes crucial. This is due to its potential to either solidify or undermine the legitimacy and effectiveness of legal interpretations and applications in contemporary contexts. ∴ Research Question ∴ The primary research question of this article is: how does spontaneous mental occurrence [Tabador] influence the interpretation of legal-jurisprudential propositions in the post-legislative validation process of Islamic codified laws? This question is examined through the lens of both traditional Islamic jurisprudence and contemporary legal challenges, seeking to establish whether this concept can consistently provide a reliable basis for interpreting the words of the lawgiver as they were intended at the time of legislation, and how it translates into current legal applications. ∴ Research Hypothesis ∴ The hypothesis posited in this research is that spontaneous mental occurrence, while historically significant and deeply embedded in Islamic jurisprudential practice, may face substantial challenges in its application to modern legal systems due to the dynamic nature of language and societal evolution. These challenges primarily involve the conjectural nature of interpreting historical texts with contemporary meanings, which may lead to discrepancies between original legislative intents and current understandings. The research aims to assess the validity of spontaneous mental occurrence in bridging these interpretative gaps, with a focus on whether it can be reliably used without succumbing to conjectural inaccuracies and historical disconnections. ∴ Methodology & Framework, if Applicable ∴ This article employs a doctrinal and critical approach, utilizing a descriptive-analytical methodology to examine the concept of spontaneous mental occurrence in principles of Islamic jurisprudence. The research framework is multidisciplinary, drawing from both Eastern and Western philosophical traditions, including the works of prominent philosophers and logicians such as Ibn Sina and Martin Heidegger, as well as Islamic scholars of Islamic jurisprudence. This broad perspective allows for a comprehensive analysis of the concept from various philosophical and legal angles. The methodology involves a critical review of historical and contemporary texts on principles of Islamic jurisprudence, analysis of case studies where spontaneous mental occurrence has been applied, and a comparative study with other legal systems where similar concepts might exist. Additionally, the research incorporates discussions with contemporary Islamic scholars and jurists to understand current perspectives and applications of spontaneous mental occurrence in legal interpretations. This blend of theoretical analysis and practical inquiry is designed to thoroughly examine the strengths and weaknesses of relying on spontaneous mental occurrence for legal interpretation in the modern era. This framework is intended to not only validate the concept of spontaneous mental occurrence from a historical and theoretical viewpoint but also to critically assess its applicability and effectiveness in contemporary legal scenarios, where the distance between the time of legislation and current application poses unique challenges. Through this multidimensional analysis, the research aims to provide a nuanced understanding of how spontaneous mental occurrence can function as a tool for legal interpretation and reform in the context of Islamic codified laws. ∴ Results & Discussion ∴ The investigation into the role of spontaneous mental occurrence [Tabador] in the interpretation of legal-jurisprudential propositions reveals both complexities and significant insights. The research highlights that while spontaneous occurrence is a fundamental concept within Islamic jurisprudence, it encounters critical challenges when applied to the interpretation of laws in a contemporary context. Firstly, the study found that spontaneous occurrence often does not consistently bridge the gap between the historical meanings of words and their current interpretations. This inconsistency is primarily due to the dynamic nature of language and societal evolution, which can lead to a divergence between the original intents of the lawgiver and contemporary understandings. This divergence challenges the assertion that spontaneous occurrence can serve as a reliable tool for post-legislative interpretation and validation of Islamic codified laws. Moreover, the research critically addresses the logical relationship between spontaneous occurrence and truth. It underscores that while spontaneous occurrence may reveal a real meaning of a word, it does not necessarily equate to the discovery of the true link between the word and its meaning, which is a more comprehensive and deliberative process. This finding implies that spontaneous occurrence should be viewed as a sign of potential meaning rather than a definitive source of truth. The study points out the risk of conflating these two aspects, which can lead to misinterpretations and subsequent legal inaccuracies. Additionally, the results bring to light the problem of conjecture in spontaneous occurrence. The research elaborates on how jurists, while attempting to interpret legal texts based on their intuitive understanding, may rely on speculative and conjectural assumptions. This reliance is particularly problematic when these interpretations are used to bridge historical and contemporary meanings, often resulting in compounded speculation which lacks a solid evidential foundation. This aspect is crucial because it directly impacts the validity of jurisprudential rulings derived from such interpretations, which can subsequently influence the revision of laws. Another significant finding is the issue of logical circularity associated with spontaneous occurrence. The study explores how spontaneous occurrence can lead to a circular fallacy, where the interpretation of a term depends on an assumed understanding which itself is based on the interpretation. This circularity undermines the reliability of spontaneous occurrence as a method for legal interpretation. However, the research suggests that this problem can be addressed by distinguishing between different types of knowledge—intermediate and detailed—which can help mitigate the risk of circular reasoning.‌ ∴ Conclusion ∴ ‌The study concludes that while spontaneous mental occurrence holds a traditional and significant place in Islamic jurisprudential theory, its application in the contemporary interpretation of laws faces substantial challenges. These challenges stem from the inherent limitations of spontaneous occurrence, including its conjectural nature and susceptibility to logical circularities. Furthermore, the research articulates that spontaneous occurrence, by itself, does not always provide a reliable basis for interpreting the true meanings of legal texts, especially when these texts are subject to historical and cultural distances from their original context. This realization necessitates a more nuanced approach to legal interpretation, one that integrates spontaneous occurrence with other interpretative tools and methodologies, such as historical-semantic analysis and the critical use of modern legal theories. The findings underscore the necessity for Islamic jurists and lawmakers to reconsider the reliance on spontaneous occurrence as a sole indicator of legal meanings. Instead, a combined approach, employing both traditional and contemporary interpretative methods, is recommended to ensure that legal interpretations remain relevant and accurate in today's diverse and evolving societal contexts. Finally, the implications of this study are profound for the reform of Islamic codified laws. It provides a scholarly basis for questioning the current interpretative practices and suggests a pathway for reforming substantive laws, including civil and penal laws, which have often been critiqued for not aligning with international norms and human rights standards. By recognizing the limitations of spontaneous occurrence and advocating for a multidimensional interpretative strategy, this research contributes to the ongoing dialogue on legal reform in Islamic countries, encouraging a reevaluation of laws in light of both traditional wisdom and contemporary demands.

Pouchitis, as the most common complication after ileal pouch-anal anastomosis (IPAA), has an incidence from 7% to 46%. Pouchitis treatment still represents one of the biggest gaps of knowledge in the treatment of diseases. This review has focused on achievements and challenges in the treatment of pouchitis. A combined assessment of symptoms, endoscopic findings, histologic results, quick biomarkers, and fecal calprotectin test were determined to be valuable diagnostic criteria. Conventional therapy was described as a modification of bacterial flora, mainly with antibiotics and more recently with probiotics such as bifidobacteria, lactobacilli, and streptococci. Other therapeutic approaches such as anti-tumor necrosis factor, infliximab, adalimumab, vedolizumab, ustekinumab, tacrolimus, tofacitinib, thiopurines, corticosteroids, prolyl hydroxylase–containing enzymes, povidone-iodine, dextrose spray, fecal microbiota transplantation, herbal medicines, and leukocyte apheresis have been discussed. Changes in dietary components, and administration of complementary and alternative medicine, probiotics, and fecal transplantation in addition to conventional therapies were also shown to affect the outcome of disease. Due to the potential significant impairment in quality of life caused by pouchitis, it is essential to address the gaps in knowledge for both patients and physicians in its treatment. Therefore, well-designed and adequately powered studies should assess the optimal treatment for pouchitis.

Abstract Background Rheumatoid arthritis (RA) is a chronic disease with a global prevalence rate of 1%. Patients with RA often associate specific foods like tomatoes and eggplants with adverse symptoms. These plants contain solanine, which could potentially contribute to bone and joint damage. Despite patient reports, there is a lack of randomized controlled trials (RCTs) investigating the effects of nightshades on patients with RA. This study aims to assess the effect of nightshade elimination diet (NED) on inflammatory and rheumatologic marker levels in rheumatoid arthritis patients for the first time. Methods A single-blinded controlled trial will be conducted to evaluate the effect of an NED on 40 participants over 8 weeks (2 months). Participants will be equally divided into intervention and placebo groups. Both groups will receive general anti-inflammatory dietary recommendations, with the intervention group undergoing an NED during the study. Clinical symptoms will be assessed using questionnaires, and blood samples will be collected to measure relevant indicators. Discussion This RCT signifies a groundbreaking exploration into NED effects on RA markers, potentially initiating crucial discussions in the field. Its outcomes could serve as a cornerstone for larger and more robust trials, offering pivotal insights to nutritionists and physicians for the nuanced management of patients with RA. Trial registration Iranian Registry of Clinical Trials IRCT20230220057465N1 ( https://irct.behdasht.gov.ir/trial/68959 ). Registered on 8 April 2023.

There exists a pressing need for polymeric nanocomposites exhibiting enhanced electrical properties when subjected to external electric fields. Via the development of an efficient model based on the physical-analytical relations, the electrical conductivity and percolation threshold of ternary nanocomposites enriched with the synergy of carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs) are investigated. In so doing, the electrical conductivity of carbon nano-additives is first computed using a discretizer scheme, and subsequently, by incorporating the basic electrical conduction mechanisms and employing the average polarization theory, insights into the overall electrical behavior of CNT/GNP/polymer networks are elucidated. The formulation of the extended framework is in the form of case assessments covering effects of volume fraction and geometry of carbonaceous nanofillers, contribution of the interphase region, which serves as an electron hopping duct, tunneling distance, and electrical potential barrier height. In connection with validation, satisfactory alignment between the predicted outcomes and experimental results substantiates the efficacy of the proposed approach for both binary and ternary nanocomposites. Moreover, parametric studies reveal the remarkable sensitivity of electrical properties of nanocomposites to the aforementioned factors. These findings are valuable and enlightening for the design and manufacturing of highly conductive systems, resulting in time and financial savings.

Abstract Background The regulation of the circadian clock genes, which coordinate the activity of the immune system, is disturbed in inflammatory bowel disease (IBD). Emerging evidence suggests that butyrate, a short-chain fatty acid produced by the gut microbiota is involved in the regulation of inflammatory responses as well as circadian-clock genes. This study was conducted to investigate the effects of sodium-butyrate supplementation on the expression of circadian-clock genes, inflammation, sleep and life quality in active ulcerative colitis (UC) patients. Methods In the current randomized placebo-controlled trial, 36 active UC patients were randomly divided to receive sodium-butyrate (600 mg/kg) or placebo for 12-weeks. In this study the expression of circadian clock genes (CRY1, CRY2, PER1, PER2, BMAl1 and CLOCK) were assessed by real time polymerase chain reaction (qPCR) in whole blood. Gene expression changes were presented as fold changes in expression (2^-ΔΔCT) relative to the baseline. The faecal calprotectin and serum level of high-sensitivity C-reactive protein (hs-CRP) were assessed by enzyme-linked immunosorbent assay method (ELIZA). Moreover, the sleep quality and IBD quality of life (QoL) were assessed by Pittsburgh sleep quality index (PSQI) and inflammatory bowel disease questionnaire-9 (IBDQ-9) respectively before and after the intervention. Results The results showed that sodium-butyrate supplementation in comparison with placebo significantly decreased the level of calprotectin (-133.82 ± 155.62 vs. 51.58 ± 95.57, P-value

Introduction: Considering the increase in the number of children suffering from attention deficit/hyperactivity disorder compared to previous years, as well as the need of the scientific community to have correct and accurate scientific information about this disorder, it is necessary to carry out scientific research and more detailed investigations in the society for treatment. This disorder should be treated. Aim: This research was conducted with the aim of comparing the effectiveness of computerized cognitive rehabilitation and practical neuropsychological exercises on working memory and clinical symptoms of children with attention deficit/hyperactivity disorder. Method: The research method was semi-experimental with a pre-test, post-test and follow-up plan with a control group. The population of this research was all children aged 7 to 11 with attention deficit/hyperactivity disorder who referred to pediatric psychiatrists and child psychologists in Tehran in the months of April to September 1401, and among them, 45 children were selected using a targeted sampling method. They were randomly selected and replaced in three equal groups of 15 people. To collect data, the Wechsler Working Memory Test (WISC-R), Children's Illness Symptoms Questionnaire (CSI-4), the fourth edition of the Swanson, Nolan and Pelham SNAP-IV scale and the Wechsler Children's Scale WISC-V DS21 subtest were used. SPSS software and multivariate covariance analysis tests were used for data analysis. Results: The results showed that both computerized cognitive rehabilitation intervention and neuropsychological practical exercises showed a significant difference in the post-test stage and follow-up on working memory and clinical symptoms of children with disorders. They have created attention deficit/hyperactivity disorder. Conclusion: The results show that in working memory variables and clinical symptoms, computerized cognitive rehabilitation training and practical neuropsychological exercises have the same effectiveness.

Abstract This work reports the synthesis of nickel ferrite decorated nitrogen and sulfur co-doped graphene quantum dot (NF@N, S:GQD) and its use as an electrode modifier. The developed NF@N, S:GQD modified glassy carbon electrode (NF@N, S:GQD/GCE) was applied to assess isoniazid (INZ) concentration based on its oxidation at the surface of the proposed electrode. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used as appropriate electrochemical techniques to study the electrochemical behavior of INZ and determine it. Based on combined evidence from surveys, research, and personal results, it is thought that the combination of nickel ferrite and doped graphene quantum dots can synergistically affect results, leading to increased sensitivity and reduced detection limits. This is probably mainly due to the high electrical conductivity of N, S-GQD structure, the electrocatalytic effect of nickel ferrite, and increased surface area resulting from the nano size of the modifier. The optimum conditions for preparing of the modified electrode and determination of INZ are selected by performing electrochemical experiments. The voltammetric response of the sensor is linear from 0.3 to 40 nM INZ under optimal conditions and the detection limit of the sensor is 0.1 nM. The validity and performance of the prepared sensor were confirmed by determining the amount of INZ in the drug and urine as real samples. The composite of doped nanoparticles and nickel ferrite is an innovative modification material to create electrochemical sensors with high sensitivity and selectivity that can be used in pharmaceutical applications.

Abstract We conducted a hospital-based case–control study to explore the association between proximity to various land use types and childhood leukemia and lymphoma. This research involved 428 cases of childhood leukemia and lymphoma (2016–2021), along with a control group of 428 children aged 1–15 in Tehran. We analyzed the risk of childhood cancer associated with land use by employing logistic regression adjusted for confounding factors such as parental smoking and family history. The odds ratio (OR) for children with leukemia and lymphoma residing within 100 m of the nearest highway was 1.87 (95% CI = 1.00–3.49) and 1.71 (95% CI = 1.00–2.93), respectively, in comparison to those living at a distance of 1000 m or more from a highway. The OR for leukemia with exposure to petrol stations within 100 m was 2.15 (95% CI = 1.00–4.63), and for lymphoma it was 1.09 (95% CI = 0.47–2.50). A significant association was observed near power lines (OR = 3.05; 95% CI = 0.97–9.55) within

Abstract Background Prostate cancer (PCa) causes a substantial health and financial burden worldwide, underscoring the need for efficient mass screening approaches. This study attempts to evaluate the Net Cost-Benefit Index (NCBI) of PCa screening in Iran to offer insights for informed decision-making and resource allocation. Method The Net Cost-Benefit Index (NCBI) was calculated for four age groups (40 years and above) using a decision-analysis model. Two screening strategies, prostate-specific antigen (PSA) solely and PSA with Digital Rectal Examination (DRE), were evaluated from the health system perspective. A retrospective assessment of 1402 prostate cancer (PCa) patients’ profiles were conducted, and direct medical and non-medical costs were calculated based on the 2021 official tariff rates, patient records, and interviews. The monetary value of mass screening was determined through Willingness to Pay (WTP) assessments, which served as a measure for the benefit aspect. Result The combined PSA and DRE strategy of screening is cost-effective, yields up to $3 saving in costs per case and emerges as the dominant strategy over PSA alone. Screening for men aged 70 and above does not meet economic justification, indicated by a negative Net Cost-Benefit Index (NCBI). The 40–49 age group exhibits the highest net benefit, $13.81 based on basic information and $13.54 based on comprehensive information. Sensitivity analysis strongly supports the cost-effectiveness of the combined screening approach. Conclusion This study advocates prostate cancer screening with PSA and DRE, is economically justified for men aged 40–69. The results of the study recommend that policymakers prioritize resource allocation for PCa screening programs based on age and budget constraints. Men’s willingness to pay, especially for the 40–49 age group which had the highest net benefit, leverages their financial participation in screening services. Additionally, screening services for other age groups, such as 50–54 or 55–59, can be provided either for free or at a reduced cost.

ABSTRACT Tin (Sn) is one of the heavy metals to which various functions in biological development are attributed in small quantities, for example, a role in cell structure, enzyme activities, and protein and carbohydrate metabolism in fish. Tributyltin (TBT) and triphenyltin (TPT) are endocrine disrupting chemicals that are widely distributed in the aquatic environment. The aim of this study was to investigate the effects of TBT, TPT, and SnCl2 on the embryonic development of zebrafish. In this study, zebrafish embryos were used to observe the acute toxicity of TBT, TPT, and SnCl2. Fish embryo toxicity analysis was performed for different TBT, TPT, and SnCl2 concentrations (1, 5, 10, 15, and 20 ng/L). Fertilized eggs in 24‐well plates (20 eggs in each concentration) were incubated at 26°C for 4 days, and embryo clotting, embryo heartbeat, and morphological abnormalities were recorded after 96 h. Coagulation increased significantly in a dose‐dependent manner, and TBT was able to induce coagulation in zebrafish embryos. Heartbeat changes significantly decreased (p < 0.05) in a dose‐dependent manner at different TBT doses (p < 0.05). The percentage of mortality was higher in embryos at trace levels of TBT, indicating that the embryos are more sensitive to the toxicity of TBT. TBT is therefore extremely toxic and can have fatal consequences for zebrafish embryos, ultimately leading to the extinction of species and a decline in biodiversity in the aquatic environment. After analyzing the images 96 h after fertilization and converting them to a teratogenic index score, it was found that the index for the two compounds TPT and TBT was 4.6 and 9.6 ng/L, respectively.

Background: Hair samples are recognized as alternative biological specimens in forensic and clinical toxicology for detecting drug abuse and poisoning. Forensic testing for opioids in hair has become a useful diagnostic measure for assessing chronic drug usage through segmental analysis. However, accurate, sensitive and specific analytical methods are needed. The aim of this study was to introduce a simple, sensitive and specific GC-MS method for the identification and quantitation of selected and commonly abused opioids (tramadol, methadone, morphine, and codeine) in hair samples. Methods: After external decontamination, a 50 mg portion of powdered hair sample was combined with hydrochloric acid (0.1 M) and incubated on a magnetic stirrer at 56°C for 16 hours. Then, 1 mL of sodium hydroxide (0.1 M) and 2 mL of phosphate buffer (1 M, pH=8.4) were added. Chloroform-isopropanol (ratio: 80:20 V/V) was utilized as the extracting solvent and the sample was homogenized and centrifuged for 5 minutes (at 3500 rpm). After centrifugation, the organic phase was dried using dry nitrogen gas. The sample was derivatized with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA). The blank, standards, and real samples were subsequently analyzed by GC-MS. Results: The limits of detection in the linearity experiments ranged from 0.12 to 0.21 ng/mg. According to the validation results, the method exhibited linearity in the concentration range of 0.1-2.5 ng/mg for all analytes, with calibration curve slopes ranging from R2=0.98 to 0.99. Good inter and intra-day precision relative standard deviations (RSDs) were observed to be

In today's industrial landscape, energy management, process modification, and reduction of atmospheric concentrations of pollutants and safety risks have become paramount. This focus is driven by the need to address environmental concerns, economic efficiency, and the global energy and climate change crisis. In gas refineries, incinerators are widely used to convert deadly and environmentally polluting acid gases into less hazardous gases. Therefore, improving incinerator performance can significantly impact environmental, economic, and energy aspects. According to the results of an energy management study at the domestic gas processing plant, the acid gas incineration unit was identified as a significant energy use. Therefore, based on the effects of the performance of this incinerator from environmental and energy points of view, the mentioned unit was prioritized for modification in this work. For this purpose, incinerator performance was assessed using Promax simulation, and Hazard and Operability (HAZOP) analysis was employed to identify potential hazards. The simulations revealed that acid gas residence time was 0.81s, longer than the 0.6s initial design with the damper in place. This suggests damper removal is feasible. Removing the damper reduces residence time and lowers incinerator temperature, especially during startup. Therefore, temperature was considered as the keyword in the HAZOP study, and a number of recommendations were proposed to eliminate or mitigate the risks of system modification. Furthermore, the assistance of results obtained from energy management based on ISO 50001:2018 standards confirm improvements in energy efficiency and fuel consumption, which have positive economic and environmental impacts. Moreover, the study employs a Life Cycle Assessment (LCA) approach using SimaPro Software 9.5.0.1 and the CML-baseline method (Centrum voor Milieukunde Leiden) for environmental impact assessment. The results reveal that, across ten environmental impact categories, the modified project exhibits significantly reduced environmental impacts compared to its original state.

Evacuated tube solar collectors (ETSC) are widely utilized in both domestic and industrial solar water heaters (SWH) due to their commendable thermal performance and straightforward installation. However, a significant challenge associated with ETSC lies in the fact that half of the collector remains unexposed to sunlight. To overcome this limitation, parabolic reflectors can be employed as a viable solution. The primary objective of this study is to assess the performance of a compound parabolic concentrator (CPC) in conjunction with ETSC, taking into account a specific ratio between the areas of the CPC and ETSC. To achieve the desired configuration, the CPC was meticulously designed, fabricated, installed, and subsequently tested. Moreover, the energy performance of the absorber tube was scrutinized both with and without the integration of a parabolic trough collector. The experiments and data collection were conducted on two selected days for both the conventional ETSC device and the system incorporating the CPC. Meteorological data and operational conditions were measured and digitally stored for subsequent analysis. A noteworthy outcome of the study is the revelation that the energy efficiency of the system with a concentrator exhibited a notable improvement of 2.8% compared to the conventional system. Offline results further indicated that the performance of a single absorber tube with a concentrator increased by approximately 2.7 times when compared to the standard system. This suggests that the energy performance of the solar water heater, with a capacity of about 200 liters and featuring 7 absorber tubes with a concentrator, is comparable to that of the conventional system equipped with 18 absorber tubes.

“Life satisfaction” is one of the ideals of each person and community to achieve “individual comfort” and “social peace”. Since human being is a social being, mutual satisfaction between people who interact with each other is one of the most important factors for the fulfillment of “life satisfaction”. When speaking of “satisfaction” as a descriptive word for two-sided relations, one side is described as “well-pleased” (Arabic: RAZI) and the other is described as “well-pleasing unto him/her” (Arabic: MARZI). Therefore, three assumptions can be considered for each mutual relation: (1) both sides are well-pleased (razi) with one another, so each side is also described as well-pleasing (marzi) unto the other side; (2) one side is well-pleased and the other side is unpleased. This assumption practically is divided into two sub-assumptions (i.e., in one assumption, A is pleased and B is unpleased, and in the other assumption B is pleased while A is unpleased), so one side is also well-pleasing unto the other and not the vice versa; (3) both sides are unpleased, so none of them is described as well-pleasing unto the other one too. It is obvious that the first assumption is the best one and the third is the worst. We must try to replace the third position with the second one and then the second position with the first one. But the question is how it is possible.

Background. Improving the quality of working life of organizations' employees affects the quality of the services they provide, their productivity, and their mental health. Studies have shown that the low quality of working life increases the number of employee complaints, the rate of absenteeism, and the application of disciplinary regulations, but decreases the employees' positive attitude and discourages their participation in the suggested system programs. Meeting the needs of employees, on the other hand, leads to the improvement and long-term efficiency of the organization. Moral intelligence refers to the capacity and ability of an individual to understand right from wrong, have strong moral beliefs and act based on them, and behave appropriately. The present study aimed to investigate the relationship between moral intelligence and quality of working life of the officials working in different units of the teaching hospitals in Yazd city, Iran. Methods. In this descriptive study, a census sampling method was adopted to investigate all officials (i.e., 75 individuals) working in different units of teaching hospitals affiliated with Shahid Sadougi University of Medical Sciences in Yazd, Iran in 2023. Two standard questionnaires including moral intelligence of Kiel and Lenik and the quality of life of Casio were used to collect the required data. It should be noted that the demographic information including age, sex, education, and work experience was provided at the beginning of the questionnaires and before its main items. The questionnaires were distributed and collected by the researcher visiting the hospital and providing additional explanations. Data analysis was performed by using SPSS version 22 software, descriptive statistics (i.e., prevalence, mean, standard deviation), as well as t-test, ANOVA, Mann-Whitney U, and Kruskal-Wallis tests. Results. Majority of the participants were females (62.7%), aged 31-40 years (49.3%), had a work experience of 10-20 years (56%), and had bachelor's degrees (54.7%). The total score of the quality of working life of the participants was (107.82±18.63), and the total score of the moral intelligence was (163.76±16.11). Therefore, the scores of both variables were above the average level. Generally, there was no significant relationship between the two variables of quality of working life and moral intelligence (P=0.051), but a significant relationship was observed between the participation and communication dimensions of the overall score of moral intelligence. Conclusion. It was recommended that the policy makers and macro decision makers in the field of health and treatment should pay more attention to the improvement of communication between employees and officials as well as to the encouragement of participation in decision-making and goal-setting processes, which, in turen, may have contributed to strengthening moral intelligence and improving the quality of their life in the organization.

Abstract Background One of the most significant demographic challenges over the past three decades has been the substantial reduction in fertility rates, worldwidely. As a developing country, Iran has also experienced a rapid decline in fertility over the past decades. Understanding factors influencing fertility is essential for development programs. Moreover, it’s crucial to study the parameters that affect the intention for childbearing in any society. Therefore, through a systematic scoping review, the present study investigates the factors influencing couples’ decisions toward childbearing. Methods This study was a systematic scoping review conducted in 2023. To design and conduct this scoping review, Joanna Briggs Institute’s Protocol (Institute TJB, The Joanna Briggs Institute Reviewers ’ manual 2015; methodology for JBI scoping reviews, 2015) was used and the framework presented by Levac et al. (2010) was also used as a guide for conducting this review. Studies were searched in three main databases including ISI Web of Sciences, PubMed, and Scopus, using a predefined search strategy. Google Scholar was also used for complementary search. The search period was from 2002 to 2022. Results A total of 18,454 studies were identified across three primary databases. After evaluating articles in three distinct phases based on title, abstract, and full-text, 46 articles were deemed eligible for inclusion in the scoping review. The qualitative analysis of the collected data from the selected studies through the scoping review led to classifying factors influencing households’ desire for childbearing into eight main themes and 101 sub-themes. The main themes associated with factors impacting households’ intention for childbearing encompass individual determinants, demographic and familial influencing factors, cultural elements, social factors, health-related aspects, economic considerations, insurance-related variables, and government support/incentive policies. Conclusions Comprehensive and holistic attention from governments and officials toward the various factors affecting households’ intention and behavior regarding childbearing appears beneficial and effective. Furthermore, given the relative ineffectiveness of some of the current government’s supportive/incentive policies to increase couples’ desire for childbearing, it seems necessary to review and amend these policies. This review should address the most significant challenges and factors contributing to couples’ reluctance to childbearing or strengthen factors that can play a substantial role in fostering fertility and childbearing desires.

Studies showed that the respiratory is not the only system affected by coronavirus 2, while cardiovascular, digestive, and nervous systems, as well as essential organs such as the kidneys, can be affected by this virus. In this review, we have studied the epidemiology, clinical, and laboratory findings on COVID-19 infection renal involvement, mortality, physiopathology, remaining renal sequels after recovery, underlying renal disease, and renal injury due to its treatment. Also, protective measures for kidney injury are explained in three levels. Evidence of viral particles and genome in the urine and renal tubular cells and signs of damage such as microangiopathy, hypercoagulopathy, and fibrosis are found in COVID-19 patients. The result of this study showed, in hospitalized COVID-19 patients, that the rate of acute kidney injury (AKI) was up to 46%, with a mortality ranging from 11 to 96%. A considerable proportion of patients with AKI would remain on renal replacement therapy. Proteinuria and hematuria are observed in 87 and 75% patients, and increased Cr and glomerular filtration rate (GFR)

Abstract Background Percutaneous nephrolithotomy is the most commonly used modality for the removal of kidney stones larger than 2 cm in size. Like other stone removal methods, percutaneous nephrolithotomy also has some complications, including bleeding and delayed hematuria. These complications are improved with conservative management and bed rest most of the time. However, it may require more invasive treatments. Angioembolization following an abnormal renal angiography is an efficient treatment modality for delayed hematuria. Furthermore, nephrectomy is suggested in uncontrolled cases of delayed hematuria when renal angiography is normal. Case presentation We described two cases of uncontrolled delayed hematuria after percutaneous nephrolithotomy and angioembolization were carried out rather than potential nephrectomies. The first case was a 61-year-old Iranian man with left kidney stones, for whom percutaneous nephrolithotomy was planned. The patient was referred to the hospital after discharge with massive hematuria and had normal angiographic findings. An angioembolization was suggested for the patient and was carried out. His hematuria was dramatically improved within 30 minutes, and his hemoglobin level started to increase 2 days later. The second case was a 53-year-old Iranian man with kidney stones who was a candidate for right kidney percutaneous nephrolithotomy. The patient was referred to the hospital 4 days after discharge with a decreased hemoglobin level and massive hematuria. The patient had normal angiographic findings and was planned for angioembolization to control his hemorrhage, which dramatically decreased after the angioembolization within 60 minutes. Conclusion Embolization of the segmental arteries of the targeted calyx can eliminate hematuria of the patient and prevent further nephrectomy.