Search

Your search keyword '"Mohamed Y. Hamed"' showing total 2 results
Start Over Author "Mohamed Y. Hamed"
2 results on '"Mohamed Y. Hamed"'

1. Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats

Author

Nasser S. Abou Khalil, Alaa S. Abou-Elhamd, Salwa I. A. Wasfy, Ibtisam M. H. El Mileegy, Mohamed Y. Hamed, and Hussein M. Ageely

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts of Balanites aegyptiaca and Petroselinum sativum extracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancreas and the size of the islets of Langerhans and improvement in the histoarchitecture were evident in the treated groups compared to untreated ones. In conclusion, the present study provides a scientific evidence for the traditional use of these extracts as antidiabetic and antioxidant agents in type 1 diabetes mellitus.

Published
2016
Full Text
View/download PDF

2. Antifertility effect of orally formulated melatonin tablets in mice

Author

S. Shawky Tous, Emtethal M. Mostafa, and Mohamed Y. Hamed

Subjects
Estrous cycle, endocrine system, medicine.medical_specialty, Pregnancy, business.industry, Ratón, media_common.quotation_subject, Pharmaceutical Science, Pharmacology, medicine.disease, Dosage form, Melatonin, Endocrinology, Oral administration, Internal medicine, Medicine, business, Intramuscular injection, Ovulation, hormones, hormone substitutes, and hormone antagonists, media_common, medicine.drug
Abstract

Melatonin, a putative pineal hormone, has been proved to be active orally. In the present investigation the efficacy of melatonin as an oral antifertility agent in mice was investigated. Melatonin tablets prepared by the solvent deposition technique (SDT) were found to be superior in their physical properties and the release rate of melatonin from the tablets was higher than those prepared by the conventional mixing method (CMM). The interaction of melatonin with polyvinylpyrrolidone (PVP) and lactose may be responsible for its high release rate. Melatonin tablets prepared by the SDT were used to evaluate its antifertility effect in mice. This effect was compared with that of its intramuscular injection. Oral administration of melatonin on the proestrus day resulted in 100% reduction in the mean number of corpora lutea and lutein cells. The ovulation blockage ratio was 100%. The mean duration of the oestrus phase was significantly decreased. Absence of corpora lutea was evident histologically. On the 4th day of pregnancy, oral administration of melatonin led to 100% interruption of pregnancy and 100% reduction in the mean number of implantation sites. Also, the average number of the blood capillaries and their transverse diameter were significantly decreased. Histological examination of the interrupted pregnant uteri showed completely degenerated embryo. The result of oral administration of melatonin mimicked the known effects of its intramuscular injection.

Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results