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Background: Ischemic heart disease is considered the most common cause of death, worldwide. It accounts for 1.8 million deaths annually in Europe alone. According to the center for disease control (CDC) it’s the most common cause of deaths in Egypt accounting for more than one fifth of the total death count per year (21%), followed by stroke, then cancer. Aim: This work aimed to study and assess the efficacy of a pharmacoinvasive strategy compared with a primary PCI strategy on the left ventricle function in treatment of patient with myocardial infarction. Methods: Our study was prospective non randomized which compares between two groups, both of which had first time acute STEMI admitted to our Tanta University Hospital within the accepted time, which are (group 1) patients who had primary PCI for the infract related artery as a reperfusion therapy and (group 2) patients who had thrombolytic followed by coronary angiography with a window to PCI (pharmacoinvasive technique). Coronary angiography was performed either immediately in case of failed thrombolytic therapy or within 3-24 hrs. Following thrombolytic in case of successful thrombolytic. Both groups presented to the hospital within the accepted time window for reperfusion therapy either (thrombolytic or primary PCI), within 12 hrs. Results: The study compared between the two groups in the acute stage during hospitalization of the patients and after discharge according to Clinical outcomes: (mortality, major adverse cardiac events (MACE) as heart failure symptoms, re-infarction and Cardiac death),angiographic findings (base line TIMI flow score and final TIMI score, single or multi-vessel disease), angiographic complications as dissection and no-reflow, occurrence of contrast induced nephropathy and cerebrovascular events and LV systolic function assessment by echocardiography. Conclusion: In this study, we highlighted the importance of total ischemic time and importance of patient and system related delays in influencing outcomes of STEMI.

This research is to study the relationship between adropin and possible metabolic syndrome disorders, also to assess the role of PPAR-α in these disorders in rats. 50 male rats were divided into 5 groups: I-Control group, II-Obese group, III-Obese diabetic group, IV-Adropin treated obese group, V-Adropin treated obese diabetic group. At the end, body weight, BMI, AC/TC ratio and lee index was measured, blood samples were collected for measuring glucose , insulin, HbA1C , HOMA-IR , HOMA-β , TC, TG, HDL-C , LDL-C, atherogenic index , ALT, AST & GGT. The liver was dissected for measuring PPARα expression, TNF-α, IL6 & iNOS. High fat diet produced a significant increase in all anthropometric measures in group (II) and (III) compared to control group. After adropin administration they were significantly decreased. The serum blood glucose, insulin, HbA1c and HOMA-IR were significantly increased, while Β- cell function significantly decreased in group (II) and (III) compared to control, however after adropin administration they showed significant decrease while, HOMA-β was significantly decreased. Group (II) and (III) showed significant lipid profile deterioration compared to control group, after adropin treatment lipid profile was significantly improved.

Sustainability has become a method of development imposed by the present era, which is characterized by development and rapid change, which imposes on countries, bodies, organizations, civil society institutions and individuals to accompany it until the social balance resulting from globalization and its negative effects are acquired, and the acquired world has acquired the interest of the developed world. It focuses on sustainable integrated economic growth, environmental stewardship, and social and technological .Despite the technological advances that have been made in the garment and textile industry, there is not a significant waste in the various stages of the industry that results in residues during the different manufacturing stages, and the remains of the ready-made garment production requirements are considered to be of little exploitation that should be used. So, recycling them back is usable for furnishing supplements to achieve sustainability. The research aims to Provide sustainable home furnishing accessories with leftovers for ready-made garment production , Study the percentage of specialists agreement towards home furnishing accessories decorated with the remains of garment production requirements to achieve sustainability , Study the percentage of consumables agreement towards home furnishing accessories decorated with the remains of garment production requirements to achieve sustainability.The research follows a descriptive approach with analysis and application to suit it to achieve the research objectivesThe study concluded that There are statistically significant differences between the averages of evaluation of home furnishing accessories decorated with leftover garment production requirements for sustainability in achieving the evaluation aspects (as a whole) according to the opinions of specialists, There are statistically significant differences between the mean of the pillars of evaluation of home furnishing accessories decorated with leftover garment production requirements for sustainability according to the opinions of specialists, There are statistically significant differences between the averages of evaluating home furnishing accessories decorated with leftover garment production requirements for sustainability in achieving the evaluation items (as a whole) according to the opinions of consumers , There is a correlation between the arrangement of specialists and the arrangement of disposables for home furnishing accessories decorated with leftover garment production requirements for sustainability.

The research aims to create proposed designs for printed curtain fabrics inspired by the Andalusian era motifs, investigating the degree of acceptance of specialists in the field of clothing and textiles and consumers towards the designs. The research followed the descriptive approach with analysis and application to suit it to achieve the aims of the research. Ten modern designs for curtain fabrics were created that inspired by Andalusian motifs that preserving the originality and features of Andalusian art to enrich the printed curtain fabrics. Adobe Illustrator program and Adobe Photoshop were used in drawing and coloring the decorative designs, A questionnaire was designed to investigate the specialists opinions in the field of clothing and textile towards the modern vision of the Andalusian motifs to enrich the decorative design of printed curtain fabrics. According to the results the best decorative design for printed curtain fabrics from a modern vision of Andalusian decorations in achieving aspects of evaluation (as a whole) is (design No. 8) and the lowest one is (design No. 7), which indicates acceptance of the first hypothesis of the research, To verify the second hypothesis, the averages and the quality factor for the evaluation design axes of the printed curtain fabrics were calculated from a modern vision of the Andalusian decorations according to the opinions of specialists and it was found that the second axis "the aesthetic side" represents the best axes according to the opinions of specialists, followed by the third axis “functional aspect”, followed by The first axis, "Basis of Design", which indicates acceptance of the second hypothesis of the research, To verify the third hypothesis, the averages and the quality factor were calculated to evaluate the decorative design of printed curtain fabrics from a modern vision of Andalusian decorations according to the opinions of consumers, and the best decorative design in achieving the evaluation items (as a whole) was (design No. 7) and the lowest one was (design No. 6), thus the third hypothesis can be accepted.

Nano fertilization is a precision approach to sustain economically viable and environmentally compatible crop production. The objective of our study was to evaluate the effects of different sources...

ETHNOPHARMACOLOGICAL RELEVANCE The genus Callistemon (syn. Melaleuca) of the myrtle family (Myrtaceae) has been documented as an integral part in the ethnobotanical system of the indigenous people of Australian mainland and many of its islands. Several Callistemons including the species subulatus were used by aboriginal Australians for making rafts, roofs for shelters, bandages, and food recipes, in addition to the management of wounds, infections, pain, cough, bronchitis, and gastrointestinal tract (GIT) disorders. AIM OF THE STUDY The current study is designed to document the therapeutic effect of the aqueous methanolic extract (AME) of C. sabulatus Chell (syn. M. sabulata) leaves in the management of diarrhea and pain. Also, its influence on additional pharmacological modalities that are related to oxidative stress just as skin aging. Ultimately, the polyphenolic profile of the extract is disclosed and correlated to the aforementioned bioactivities. MATERIALS AND METHODS The extract was fractionated using various chromatography techniques and the structures of the isolated compounds were determined based on their chemical and spectral data. The antioxidant activity was assessed using multiple models, including 2,2-diphenyl-picrylhydrazyl (DPPH), oxygen radical absorbance capacity (ORAC) and β-carotene bleaching assays. The anti-skin aging effect was evaluated using different relevant enzymatic assays. The antinociceptive activity was investigated using acetic acid-induced writhing, hot plate test, and formalin-induced paw licking in mice models. The antidiarrheal activity was gauge using the castor oil induced diarrhea, enter pooling and gastrointestinal motility in vivo models. RESULTS Diverse polyphenols, including quercetin-3-O-β-D-glucuronopyranoside (1), kaempferol-3-O-β-D-glucuronopyranoside (2), strictinin (3), quercetin-3-O-(2``-O-galloyl)-β-D-glucuronopyranoside (4), afzelin (5), di-galloyl glucose (6), mono-galloyl glucose (7), acacetin (8), apigenin-6,7-dimethyl ether (9), kaempferol trimethyl ether (10), dimethoxy chrysin (11), quercetin (12), kaempferol (13), methyl gallate (14), and gallic acid (15) were identified. The extract exhibited as significant antioxidant activity even better than that of Trolox or BHT. Moreover, it exerts elastase, tyrosinase, and collagenase inhibition activities, in addition to the significant peripheral and central analgesic activity in a dose-dependent manner (P

Recently, laser beams have been introduced in many fields for their high accuracy and high speed. Therefore, they have spread in industries that rely on the use of cutting, engraving and engraving techniques in the implementation of their products on different materials such as paper, glass, metal, acrylic and wood.The clothing of jeans is very common in the recent period due to the demand of consumers in summer and winter, and with the rapid development, jeans fabrics are not limited to cotton fiber and can be mixed with polystyrene and others, which adds to the fabrics of jeans and other characteristics and affect the quality of the final product.The aim of the research is to: Present design proposals for the decoration of denim garments by laser cutting technology, and to determine the quality standards of laser cutting for the decorative design of the jeans. The research follows the descriptive analytical approach with the applied study.The results were as follows: 1 - The degree obtained by the designs ranged from 89.68% for the second design and 98.84% for the third design, which indicates the achievement of the foundations and elements of the design and the aesthetic aspect of the design of the denim clothes with decorative design using laser cutting.2 - The sample of fabrics obtained according to the ratio of fiber mixing (60% cotton - 30% polyester - 8% viscose - 2% spandex) the highest proportion of 96.85%.3- The best distance between the units in the decorative design is 5: 6 mm by 82.35%.

Background Dysmenorrhea is a significant public health problem, which has a negative effect on female's health, social relationships, school or work activities, and psychological status. Purpose The purpose of the study was to evaluate the effect of acupressure on Sanyinjiao Acupoint (SP6) on primary dysmenorrhea among adolescents. Patients and methods Research design was an experimental case–control study. A total of 100 girls were randomly assigned to two equal groups (A and B): group A included 50 girls who received SP6 acupressure, whereas group B included 50 girls who received only light skin touching. Menstrual pain was measured by using a structured questionnaire, a subjective menstrual pain scales (Visual Analog Scale and McGill Pain Questionnaire – part I), before (at 8 a.m.) and after the intervention (at 8 p.m.) during the first 3 days of menstruation for 2 consecutive months. Results There was a significant decrease in menstrual pain among the two groups. Conclusion SP6 acupressure was effective in decreasing menstrual pain and can easily be used as a nursing management method for adolescents. Recommendation Acupressure should be offered to cope with menstrual pain, as it is useful and has no adverse effects.

The COVID-19 pandemic has underscored the shortcomings in the deployment of state-of-the-art diagnostics platforms. Although several polymerase chain reaction (PCR)-based techniques have been rapidly developed to meet the growing testing needs, such techniques often need samples collected through a swab, the use of RNA extraction kits, and expensive thermocyclers in order to successfully perform the test. Isothermal amplification-based approaches have also been recently demonstrated for rapid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection by minimizing sample preparation while also reducing the instrumentation and reaction complexity. In addition, there are limited reports of saliva as the sample source, and some of these indicate inferior sensitivity when comparing reverse transcription loop-mediated isothermal amplification (RT-LAMP) with PCR-based techniques. In this paper, we demonstrate an improved sensitivity assay from saliva using a two-step RT-LAMP assay, where a short 10 min RT step is performed with only B3 and backward inner primers before the final reaction. We show that while the one-step RT-LAMP demonstrates satisfactory results, the optimized two-step approach allows detection of only few molecules per reaction and performs significantly better than the one-step RT-LAMP and conventional two-step RT-LAMP approaches with all primers included in the RT step. We show control measurements with RT-PCR, and importantly, we demonstrate RNA extraction-free RT-LAMP-based assays for detection of SARS-CoV-2 from viral transport media and saliva clinical samples.

Aspirin and statin drugs have been associated with reduced risk of several gastrointestinal cancers, but their association with gallbladder cancer (GBC) has not been well established. We evaluated the association of aspirin and statins with the risk of GBC. Patients with GBC managed at Mayo Clinic between 2000 and 2019 were matched 1:2 with a general patient pool by age and sex. Univariable and multivariable logistic regression models were used to assess associations between GBC and aspirin or statin use. The analysis included 795 cases and 1590 controls, with a median age of 67 years. Aspirin or statin use alone or in combination was higher in controls (p &lt, 0.001). Univariate analysis showed that the use of aspirin [odds ratio (OR): 0.11, 95%CI: 0.08–0.15] or statins (OR: 0.29, 95%CI: 0.20–0.40) and their combined use (OR: 0.18, 95%CI: 0.13–0.24) was associated with lower risk of GBC. Multivariable analysis revealed that aspirin (OR: 0.12, 95%CI: 0.09–0.16) and combined statins and aspirin (OR: 0.46, 95%CI: 0.31–0.67) were associated with lower risk of GBC. Aspirin alone or in combination with statins is associated with a strongly reduced risk of GBC. Further prospective studies are needed to confirm these results and to elucidate their mechanisms.

Objectives: This review article highlights a remarkable class of compounds (polyketides) and their derivatives produced by fungi of genus Penicillium and the diversity of their biological activities, isolated, identified and biologically assessed. The species belong to this genus represent a large part of microbial diversity and one of the promising resources in the search of biologically active natural scaffolds. Penicillium genera are one of the most important sources of different secondary metabolites of a wide range of classes of chemical compounds, i.e., anthraquinones, benzodiazepines, coumarins, diketopiperazines, ergot alkaloids, polyketides, quinolines, quinazolines, steroids and terpenoids. Interest in these metabolites increases owing to their valuable pharmacological and therapeutic properties. Methods: This review includes articles between 1988 and 2018, reviewed by internationally accepted databases and scientific journals. Results: This review demonstrates the structural and biological diversity of fifty-three polyketides isolated from different Penicillium species highlighting the culture media used for fungal growth and solvent of extraction along with biological activities and the reported biological assays used to estimate the potential activities of the reviewed polyketides. Conclusion: The structural and biological diversity and potency of reviewed Penicillium polyketides along with the reproducibility of their production make them a perfect candidate for the discovery of new potent pharmaceuticals.

Neutrophil-to-lymphocyte ratio (NLR) has been used as an inflammation based prognostic marker for various malignancies. This study evaluated the association between NLR and overall survival (OS) in patients with metastatic gallbladder cancer (GBC) METHODS: An optimal cut off point for NLR was identified by plotting spline-based hazard ratio curves to identify a threshold effect and patients were divided into two groups, ≥5 or5. Kaplan-Meier curves were plotted for NLR≥5 and NLR5 and OS between the two groups.Of the 231 patients included, 138 (60%) had NLR5 and 93 (40%) had NLR ≥5. There were no significant differences noted in gender, race, and administration of chemotherapy between the two groups. On univariable analysis, patients with NLR ≥5 had a significantly poor OS compared to those with NLR5 (Median OS: 3.6 vs 8.7 months, p 0.001). On multivariable analysis, adjusting for age, performance status, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, platelet count and no administration of chemotherapy, NLR of ≥5 was associated with a worse OS compared to NLR5 (HR: 1.70, 95%CI:1.20-2.39, p 0.05).The current study demonstrates that NLR ≥5 is an independent predictor of poor prognosis in patients with metastatic GBC.

Background: Apocynin (4-hydroxy-3-methoxyacetophenone) which isolated from the traditional medicinal plant Picrorhiza kurroa, is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of NADPH oxidase and of the concomitant ROS production. Apocynin also proved to be a potent anti-inflammatory agent, based on the selective inhibition of the production of ROS by activated human PMNs. Aim of the Study: to explore the protective effect of Apocynin and the NADPH oxidase inhibitor on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Subjects and Methods: Fourty male albino rats were categorized into four equal groups of 10. Group 1: Sham operated control group, Group 2: Ischemia / reperfusion (I/R) group; which underwent bilateral renal ischemia for 1 hour followed by a 23 hour reperfusion, Group 3: 4-week Apocynin treated group in which rats received Apocynin with a dose o16 mg/kg /day for 4 weeks followed by bilateral renal ischemia for 1 hour then 23 hour reperfusion afterwards , and Group 4: 8-week Apocynin treated group in which rats received Apocynin with a dose of 16 mg/kg /day for 8 weeks then bilateral renal ischemia for 1 hour followed by 23 hour reperfusion. After reperfusion, the animals were sacrificed, the blood samples were collected for determination of blood urea nitrogen, serum creatinine, 24 hour urine were collected for determination of creatinine clearance. Kidneys of all animals were harvested and evaluated biochemically through determination of tissue MDA, MPO, GPX and catalase level. Results: Kidney tissue MDA, MPO, serum BUN and Creatinine levels were found to be significantly higher in the I/R group. GPx level showed a significant decrease, while there was a slight decrease in Catalase level when compared with Sham operated group. Creatinine clearance was impaired in renal I/R group. Renal I/R injury has also induced an extensive tubular necrosis, glomerular damage, and apoptosis. Apocynin significantly reduced MDA and MPO and increased GPX and catalase in both treatment groups when compared to the I/R group (p< 0.001). The elevated BUN and creatinine levels were significantly reduced in treatment groups, also creatinine clearance was restored to around normal value. Conclusion: with accordance to the findings and outcome of the present study, Apocynin has exerted protective effects against ischemia/reperfusion injury by ameliorating the kidney damage induced by I/R injury to a significant extent. However, there was no significant difference in the outcome if the treatment was extended from 4 to 8 weeks.