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2. The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update

Author

Saeed, Diyar, Feldman, David, Banayosy, Aly El, Birks, Emma, Blume, Elizabeth, Cowger, Jennifer, Hayward, Christopher, Jorde, Ulrich, Kremer, Jamila, MacGowan, Guy, Maltais, Simon, Maybaum, Simon, Mehra, Mandeep, Shah, Keyur B., Mohacsi, Paul, Schweiger, Martin, Schroeder, Sarah E., Shah, Palak, Slepian, Marvin, Tops, Laurens F., Alvarez, Paulino, Arabia, Francisco, Aslam, Saima, Benson-Louis, Louis, IV, Birati, Edo, Buchholz, Holger W., Cedars, Ari, Christensen, Dawn, Ciarka, Agnieszka, Coglianese, Erin, Cogswell, Rebecca, Cook, Jennifer, Copeland, Jack, Costello, Jose Gonzalez, Drakos, Stavros G, Eghtesady, Pirooz, Elliot, Tonya, Estep, Jerry D., Eulert-Grehn, Jaime-Juergen, Fabrizio, De Rita, Garbade, Jens, Gelow, Jill, Guglin, Maya, Hernandez-Montfort, Jaime, Horstmanshof, Doug, John, Ranjit, Kanwar, Manreet, Khaliel, Feras, Kim, Gene, Kumar, Sachin, Lavee, Jacob, Leache, Marzia, Leprince, Pascal, Lim, Sern, Loforte, Antonio, Maly, Jiri, Najjar, Samer, Netuka, Ivan, Pamboukian, Salpy V., Patel, Snehal R, Pinney, Sean, Pluym, Christina Vander, Potapov, Evgenij, Robson, Desiree, Rochlani, Yogita, Russell, Stuart, Sandau, Kristin, Sandoval, Elena, Sayer, Gabriel, Schettle, Sarah, Schibilsky, David, Schlöglhofer, Thomas, Schmitto, Jan, Siddique, Aleem, Silvestry, Scott, Slaughter, Mark S, Sun, Benjamin, Takayama, Hiroo, Tedford, Ryan, Teuteberg, Jeffrey J., Ton, Van-Khue, Uriel, Nir, Vierecke, Juliane, Zimpfer, Daniel, and D'Alessandro, David

Published
2023
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3. MCS: Patient Selection

Author

Mohacsi, Paul, Berdat, Pascal A., Willerson, James T., Series Editor, Feldman, David S., editor, and Mohacsi, Paul, editor

Published
2019
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4. Association between caseload volume and outcomes in left ventricular assist device implantations - a EUROMACS analysis

Author

Mihalj, Maks, Reineke, David, Just, Isabell A., Mulzer, Johanna, Cholevas, Nikolaos, Hoermandinger, Christoph, Veen, Kevin, Luedi, Markus M., Heinisch, Paul Philipp, Potapov, Evgenij, Gummert, Jan F., Mohacsi, Paul, Hagl, Christian, Faerber, Gloria, Zimpfer, Daniel, de By, Theo M. M. H., Meyns, Bart, Gustafsson, Finn, Hunziker, Lukas, Siepe, Matthias, Schober, Patrick, Schoenrath, Felix, Mihalj, Maks, Reineke, David, Just, Isabell A., Mulzer, Johanna, Cholevas, Nikolaos, Hoermandinger, Christoph, Veen, Kevin, Luedi, Markus M., Heinisch, Paul Philipp, Potapov, Evgenij, Gummert, Jan F., Mohacsi, Paul, Hagl, Christian, Faerber, Gloria, Zimpfer, Daniel, de By, Theo M. M. H., Meyns, Bart, Gustafsson, Finn, Hunziker, Lukas, Siepe, Matthias, Schober, Patrick, and Schoenrath, Felix

Abstract

Aims This EUROMACS study was conducted with the primary aim of investigating the association between a centre's annual caseload and postoperative outcomes among patients undergoing left ventricular assist device (LVAD) implantation. Methods and results A total of 4802 patients identified between 2011 and 2020 from 35 participating centres were dichotomized based on the annual caseload of the treating centre at the time of device implant (<= 30 vs. >30 LVAD implantations/year). The primary endpoint was 1-year survival. Secondary outcomes included overall survival analysis, device-related adverse events and readmissions. Cumulative follow-up was 10 003 patient-years, with a median follow-up of 1.54 years (interquartile range 0.52-3.15). Patients from higher volume centres more frequently presented in INTERMACS levels 1 and 2, suffered from right heart dysfunction and needed inotropic support. No difference was observed in adjusted 1-year survival. Adjusted overall survival probability was lower in higher volume centres (p = 0.002). In the subgroup analysis of HeartMate 3 devices only, higher volume centres were associated with decreased odds of 1-year survival (adjusted odds ratio 0.43, 95% confidence interval 0.20-0.97, p = 0.041). Similar findings were observed in the cumulative (i.e. learning curve) caseload analyses. Conclusion In patients undergoing LVAD implantation, centre volume was not associated with 1-year survival, but was related to device-related adverse events. Patient profiles differed with respect to centre size. These findings underscore the necessity for ongoing quality improvement initiatives in all centres, regardless of their annual caseload. Efforts are needed to standardize patient selection and preconditioning to further improve patient outcome.

Published
2024

5. 5-year results of a newly implemented mechanical circulatory support program for terminal heart failure patients in a Swiss non-cardiac transplant university hospital

Author

Schaeffer, Thibault, Pfister, Otmar, Mork, Constantin, Mohacsi, Paul, Rueter, Florian, Scheifele, Simon, Morgen, Anne, Zenklusen, Urs, Doebele, Thomas, Maurer, Markus, Erb, Joachim, Fassl, Jens, Cueni, Nadine, Siegemund, Martin, Pargger, Hans, Gahl, Brigitta, Osswald, Stefan, Eckstein, Friedrich, and Grapow, Martin

Published
2021
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6. Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients

Author

Quteineh, Lina, Wójtowicz, Agnieszka, Bochud, Pierre-Yves, Crettol, Severine, Vandenberghe, Frederik, Venetz, Jean-Pierre, Manuel, Oriol, Golshayan, Dela, Lehmann, Roger, Mueller, Nicolas J., Binet, Isabelle, van Delden, Christian, Steiger, Jürg, Mohacsi, Paul, Dufour, Jean-Francois, Soccal, Paola M., Kutalik, Zoltan, Marques-Vidal, Pedro, Vollenweider, Peter, Recher, Mike, Hess, Christoph, Pascual, Manuel, and Eap, Chin B.

Published
2019
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7. The EUROMACS Registry of Patients Who Receive Mechanical Circulatory Support: Role and Perspectives

Author

On behalf of all EUROMACS members and contributors, de By, Theo M. M. H., Castedo, Evaristo, Krabatsch, Thomas, Mohacsi, Paul, Meyns, Bart P., Netuka, Ivan, Gummert, Jan, Montalto, Andrea, editor, Loforte, Antonio, editor, Musumeci, Francesco, editor, Krabatsch, Thomas, editor, Slaughter, Mark S., editor, and Amarelli, Cristiano, With contrib. by

Published
2017
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11. Heart transplant centers with multidisciplinary team show a higher level of chronic illness management – Findings from the International BRIGHT Study

Author

Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Segura Saint-Gerons, Carmen, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, de Almeida, Samira Scalso, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, Maddicks-Law, Joanne, Cajita, Maan Isabella, Baumgartner, Eva, Berben, Lut, Denhaerynck, Kris, Helmy, Remon, Schönfeld, Sandra, Berger, Gabriele, Vetter, Christine, Dobbels, Fabienne, Russell, Cynthia L., and De Geest, Sabina

Published
2017
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13. Efficacy of levosimendan infusion in patients undergoing a left ventricular assist device implant in a propensity score matched analysis of the EUROMACS registry-the Euro LEVO-LVAD study

Author

Abdelshafy, Mahmoud, Caliskan, Kadir, Simpkin, Andrew J., Elkoumy, Ahmed, Kimman, Jesse R., Elsherbini, Hagar, Elzomor, Hesham, de By, Theo M.M.H., Gollmann-Tepeköylü, Can, Berchtold-Herz, Michael, Loforte, Antonio, Reineke, David, Schoenrath, Felix, Paluszkiewicz, Lech, Gummert, Jan, Mohacsi, Paul, Meyns, Bart, Soliman, Osama, Abdelshafy, Mahmoud, Caliskan, Kadir, Simpkin, Andrew J., Elkoumy, Ahmed, Kimman, Jesse R., Elsherbini, Hagar, Elzomor, Hesham, de By, Theo M.M.H., Gollmann-Tepeköylü, Can, Berchtold-Herz, Michael, Loforte, Antonio, Reineke, David, Schoenrath, Felix, Paluszkiewicz, Lech, Gummert, Jan, Mohacsi, Paul, Meyns, Bart, and Soliman, Osama

Abstract

OBJECTIVES: Early right-sided heart failure (RHF) was seen in 22% of recipients of a left ventricular assist device (LVAD) in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). However, the optimal treatment of post-LVAD RHF is not well known. Levosimendan has proven to be effective in patients with cardiogenic shock and in those with end-stage heart failure. We sought to evaluate the efficacy of levosimendan on post-LVAD RHF and 30-day and 1-year mortality. METHODS: The EUROMACS Registry was used to identify adults with mainstream continuous-flow LVAD implants who were treated with preoperative levosimendan compared to a propensity matched control cohort. RESULTS: In total, 3661 patients received mainstream LVAD, of which 399 (11%) were treated with levosimendan pre-LVAD. Patients given levosimendan had a higher EUROMACS RHF score [4 (2- 5.5) vs 2 (2- 4); P < 0.001], received more right ventricular assist devices (RVAD) [32 (8%) vs 178 (5.5%); P = 0.038] and stayed longer in the intensive care unit post-LVAD implant [19 (8-35) vs 11(5-25); P < 0.001]. Yet, there was no significant difference in the rate of RHF, 30-day, or 1-year mortality. Also, in the matched cohort (357 patients taking levosimendan compared to an average of 622 controls across 20 imputations), we found no evidence for a difference in postoperative severe RHF, RVAD implant rate, length of stay in the intensive care unit or 30-day and 1-year mortality. CONCLUSIONS: In this analysis of the EUROMACS registry, we found no evidence for an association between levosimendan and early RHF or death, albeit patients taking levosimendan had much higher risk profiles. For a definitive conclusion, a multicentre, randomized study is warranted.

Published
2023

15. Efficacy of Levosimendan Infusion in Patients Undergoing Left Ventricular Assist Device Implantation in a propensity score-matched analysis of the EUROMACS Registry – the Euro LEVO-LVAD Study

Author

Abdelshafy, Mahmoud, primary, Caliskan, Kadir, additional, Simpkin, Andrew J, additional, Elkoumy, Ahmed, additional, Kimman, Jesse R, additional, Elsherbini, Hagar, additional, Elzomor, Hesham, additional, de By, Theo M M H, additional, Gollmann-Tepeköylü, Can, additional, Berchtold-Herz, Michael, additional, Loforte, Antonio, additional, Reineke, David, additional, Schoenrath, Felix, additional, Paluszkiewicz, Lech, additional, Gummert, Jan, additional, Mohacsi, Paul, additional, Meyns, Bart, additional, and Soliman, Osama, additional

Published
2023
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18. Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study

Author

Beckmann, Sonja, Nikolic, Nataša, Denhaerynck, Kris, Binet, Isabelle, Koller, Michael, Boely, Elsa, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Claes, Veerle, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Mauthner, Oliver, Struker, Marian, Boehler, Annette, Gerull, Sabine, Huynh‐Do, Uyen, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Chalandon, Yves, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
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19. Derivation and Validation of a Novel Right-Sided Heart Failure Model After Implantation of Continuous Flow Left Ventricular Assist Devices: The EUROMACS (European Registry for Patients with Mechanical Circulatory Support) Right-Sided Heart Failure Risk Score

Author

Soliman, Osama I.I., Akin, Sakir, Muslem, Rahatullah, Boersma, Eric, Manintveld, Olivier C., Krabatsch, Thomas, Gummert, Jan F., de By, Theo M.M.H., Bogers, Ad J.J.C., Zijlstra, Felix, Mohacsi, Paul, and Caliskan, Kadir

Published
2018
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22. Third‐generation continuous‐flow left ventricular assist devices: a comparative outcome analysis by device type

Author

Mihalj, Maks, primary, Heinisch, Paul Philipp, additional, Schober, Patrick, additional, Wieser, Monika, additional, Martinelli, Michele, additional, de By, Theo M.M.H., additional, Schefold, Joerg C., additional, Luedi, Markus M., additional, Kadner, Alexander, additional, Carrel, Thierry, additional, Mohacsi, Paul, additional, Hunziker, Lukas, additional, and Reineke, David, additional

Published
2022
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23. The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report

Author

de By, Theo M M H, Schoenrath, Felix, Veen, Kevin M, Mohacsi, Paul, et al, Carrel, Thierry, University of Zurich, and de By, Theo M M H

Subjects
Pulmonary and Respiratory Medicine, 2740 Pulmonary and Respiratory Medicine, 610 Medicine & health, Surgery, General Medicine, Cardiology and Cardiovascular Medicine, 2705 Cardiology and Cardiovascular Medicine, 10020 Clinic for Cardiac Surgery, 2746 Surgery
Published
2022

24. The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report

Author

de By, Theo M. M. H., Schoenrath, Felix, Veen, Kevin M., Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M. M., Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepekoeylue, Can, Finn, Gustafsson, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Nemec, Petr, Netuka, Ivan, Ozbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rabago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, Meyns, Bart, de By, Theo M. M. H., Schoenrath, Felix, Veen, Kevin M., Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M. M., Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepekoeylue, Can, Finn, Gustafsson, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Nemec, Petr, Netuka, Ivan, Ozbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rabago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, and Meyns, Bart

Abstract

OBJECTIVES In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era. METHODS Procedures in adult patients (January 2011-June 2020) were included. Patients from centres with <60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) were calculated and stratified into early phase (<3 months) and late phase (>3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (3 months). RESULTS In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3-2.6) years. The annual number of implants (range: 346-600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4-7: 23, 25 and 33%; P < 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P < 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER(3 months): 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant. CONCLUSIONS In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent. As a registry of the European Association for Cardio-Thoracic Surgery, the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) offers a robust repository of clinica

Published
2022

25. The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery:third report

Author

De By, Theo M. M. H., Schoenrath, Felix, Veen, Kevin M., Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M. M., Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepeköylü, Can, Gustafsson, Finn, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Němec, Petr, Netuka, Ivan, Özbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rábago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, Meyns, Bart, De By, Theo M. M. H., Schoenrath, Felix, Veen, Kevin M., Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M. M., Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepeköylü, Can, Gustafsson, Finn, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Němec, Petr, Netuka, Ivan, Özbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rábago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, and Meyns, Bart

Abstract

OBJECTIVES: In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era. METHODS: Procedures in adult patients (January 2011-June 2020) were included. Patients from centres with <60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) were calculated and stratified into early phase (<3 months) and late phase (>3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (<3 vs >3 months). RESULTS: In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3-2.6) years. The annual number of implants (range: 346-600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4-7: 23, 25 and 33%; P < 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P < 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER<3 months: 1.44 vs AER>3 months: 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant. CONCLUSIONS: In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent.

Published
2022

26. The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report

Author

CTC, Circulatory Health, de By, Theo M M H, Schoenrath, Felix, Veen, Kevin M, Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M M, Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepeköylü, Can, Gustafsson, Finn, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Němec, Petr, Netuka, Ivan, Özbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rábago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, Meyns, Bart, CTC, Circulatory Health, de By, Theo M M H, Schoenrath, Felix, Veen, Kevin M, Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M M, Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepeköylü, Can, Gustafsson, Finn, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, Merkely, Bela, Musumeci, Francesco, Němec, Petr, Netuka, Ivan, Özbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rábago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan, and Meyns, Bart

Published
2022

27. BK Polyomavirus‐Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study

Author

Leboeuf, C., Wilk, S., Achermann, R., Binet, I., Golshayan, D., Hadaya, K., Hirzel, C., Hoffmann, M., Huynh‐Do, U., Koller, M. T., Manuel, O., Mueller, N. J., Mueller, T. F., Schaub, S., van Delden, C., Weissbach, F. H., Hirsch, H. H., Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
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28. Heart transplant centers with multidisciplinary team show a higher level of chronic illness management – Findings from the International BRIGHT Study

Author

Cajita, Maan Isabella, Baumgartner, Eva, Berben, Lut, Denhaerynck, Kris, Helmy, Remon, Schönfeld, Sandra, Berger, Gabriele, Vetter, Christine, Dobbels, Fabienne, Russell, Cynthia L., De Geest, Sabina, Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Saint-Gerons, Carmen Segura, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, de Almeida, Samira Scalso, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, and Maddicks-Law, Joanne

Published
2017
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29. ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study

Author

Mauthner, Oliver, Claes, Veerle, Walston, Jeremy, Engberg, Sandra, Binet, Isabelle, Dickenmann, Michael, Golshayan, Déla, Hadaya, Karine, Huynh‐Do, Uyen, Calciolari, Stefano, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Denhaerynck, Kris, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Struker, Marian, Boehler, Annette, Gerull, Sabine, Koller, Michael T, Boely, Elsa, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Beckmann, Sonja, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Rougemont, Olivier, Duchosal, Michel, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Koller, Michael, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Martinolli, Luca, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Ziegler, Chantal Piot, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
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32. The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report

Author

de By, Theo M M H, primary, Schoenrath, Felix, additional, Veen, Kevin M, additional, Mohacsi, Paul, additional, Stein, Julia, additional, Alkhamees, Khalid M M, additional, Anastasiadis, Kyriakos, additional, Berhnardt, Alexander, additional, Beyersdorf, Friedhelm, additional, Caliskan, Kadir, additional, Reineke, David, additional, Damman, Kevin, additional, Fiane, Arnt, additional, Gkouziouta, Angeliki, additional, Gollmann-Tepeköylü, Can, additional, Gustafsson, Finn, additional, Hulman, Michal, additional, Iacovoni, Attilio, additional, Loforte, Antonio, additional, Merkely, Bela, additional, Musumeci, Francesco, additional, Němec, Petr, additional, Netuka, Ivan, additional, Özbaran, Mustafa, additional, Potapov, Evgenij, additional, Pya, Yuri, additional, Rábago, Gregorio, additional, Ramjankhan, Faiz, additional, Reichenspurner, Hermann, additional, Saeed, Diyar, additional, Sandoval, Elena, additional, Stockman, Bernard, additional, Vanderheyden, Marc, additional, Tops, Laurens, additional, Wahlers, Thorsten, additional, Zembala, Michael, additional, Zimpfer, Daniel, additional, Carrel, Thierry, additional, Gummert, Jan, additional, and Meyns, Bart, additional

Published
2022
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38. European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report.

Author

By, Theo M M H de, Schoenrath, Felix, Veen, Kevin M, Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M M, Anastasiadis, Kyriakos, Berhnardt, Alexander, Beyersdorf, Friedhelm, Caliskan, Kadir, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepeköylü, Can, Gustafsson, Finn, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio, and Merkely, Bela

Subjects
ARTIFICIAL blood circulation, MEDICAL registries, SURGERY
Abstract

OBJECTIVES In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era. METHODS Procedures in adult patients (January 2011–June 2020) were included. Patients from centres with <60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011–2013, 2014–2017 and 2018–2020). Adverse event rates (AERs) were calculated and stratified into early phase (<3 months) and late phase (>3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (<3 vs >3 months). RESULTS In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3–2.6) years. The annual number of implants (range: 346–600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4–7: 23, 25 and 33%; P < 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P < 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER<3 months: 1.44 vs AER>3 months: 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant. CONCLUSIONS In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Intractable coronary fibromuscular dysplasia leading to end‐stage heart failure and fatal heart transplantation

Author

Cattaneo, Magdalena Maria, Moccetti, Marco, Cattaneo, Mattia, Sürder, Daniel, Suter, Thomas, Martinelli, Michele, Roost, Eva, Schmidli, Jürg, Banz, Yara, Schneiders, Carmen, Pedrazzini, Giovanni, Corti, Roberto, Räber, Lorenz, Crea, Filippo, Mohacsi, Paul, Gallino, Augusto, Cattaneo, Magdalena Maria, Moccetti, Marco, Cattaneo, Mattia, Sürder, Daniel, Suter, Thomas, Martinelli, Michele, Roost, Eva, Schmidli, Jürg, Banz, Yara, Schneiders, Carmen, Pedrazzini, Giovanni, Corti, Roberto, Räber, Lorenz, Crea, Filippo, Mohacsi, Paul, and Gallino, Augusto

Abstract

Coronary fibromuscular dysplasia is uncommon, and even rarer its unstable and recurrent course. We present the unique case of a 52-year-old woman who underwent in total 12 coronary angiographies and three percutaneous coronary intervention within 24 months because of repetitive acute coronary syndromes due to refractory spasm, dissection, restenosis all leading to end-stage heart failure, and heart transplantation. The patient died 12 days after the heart transplantation complicated by intraoperative acute thrombotic occlusion of left anterior descending artery of the graft despite normal pretransplant coronary angiography. Autopsy of the recipient heart confirmed coronary fibromuscular dysplasia with massive intimal hyperplasia and restenosis.

Published
2020

45. Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS study

Author

Krum, Henry, Roecker, Ellen B., Mohacsi, Paul, Rouleau, Jean L., Tendera, Michal, Coats, Andrew J.S., Katus, Hugo A., Fowler, Michael B., and Packer, Milton

Subjects
Adrenergic beta blockers -- Evaluation, Heart failure -- Drug therapy
Abstract

The benefits of the beta blocker carvedilol for patients with heart failure are apparent within the first few weeks of treatment, according to a study of 2,289 patients. Most doctors are reluctant to give heart failure patients a beta blocker because they believe it might worsen the patient's symptoms in the first few weeks. This study shows this assumption is false and that doctors should use beta blockers more often.

Published
2003

47. Effect of carvedilol on survival in severe chronic heart failure

Author

Packer, Milton, Coats, Andrew J.S., Fowler, Michael B., Katus, Hugo A., Krum, Henry, Mohacsi, Paul, Rouleau, Jean L., Tendera, Michal, Castaigne, Alain, Roecker, Ellen B., Schultz, Melissa K., and DeMets, David L.

Subjects
Heart failure -- Drug therapy, Adrenergic beta blockers -- Evaluation
Abstract

The beta blocker carvedilol reduced the risk of death by 35% in a study of 2,289 patients with severe heart failure. It also reduced the rate of hospitalization for a worsening of symptoms.

Published
2001

50. Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Author

Crespo-Leiro, Marisa G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Potena, Luciano, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Saint-Gerons, Carmen Segura, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Albert, Nancy, Coleman, Bernice, Trammell, Jacqueline, Epstein, Flavio, St Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, Scalso de Almeida, Samira, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, Maddicks-Law, Joanne, Helmy, Remon, Denhaerynck, Kris, Berben, Lut, Dobbels, Fabienne, Russell, Cynthia L., de Aguiar Roza, Bartira, and De Geest, Sabina

Published
2019
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