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1. Feasibility, safety, efficacy and potential scaling-up of sofosbuvir-based HCV treatment in Central and West Africa: (TAC ANRS 12311 trial)

Author

Lacombe, Karine, Moh, Raoul, Chazallon, Corine, Lemoine, Maud, Sylla, Babacar, Fadiga, Fatoumata, Le Carrou, Jerôme, Marcellin, Fabienne, Kouanfack, Charles, Ciaffi, Laura, Sartre, Michelle Tagni, Sida, Magloire Biwole, Diallo, Alpha, Gozlan, Joel, Seydi, Moussa, Cissé, Viviane, Danel, Christine, Girard, Pierre Marie, Toni, Thomas d’Aquin, Minga, Albert, Boyer, Sylvie, Carrieri, Patrizia, and Attia, Alain

Published
2024
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2. Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial

Author

Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying, Mvalo, Tisungane, Magallhaes, Justina, Buck, W Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala, and Mujuru, Hilda Angela

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Rare Diseases, Pneumonia, Clinical Trials and Supportive Activities, Tuberculosis, Pediatric, Patient Safety, HIV/AIDS, Clinical Research, Pneumonia & Influenza, Lung, Orphan Drug, Infectious Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Child, Clinical Trials, Phase II as Topic, Cytomegalovirus, Cytomegalovirus Infections, HIV Infections, Humans, Infant, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome, Valganciclovir, Factorial, Empirical, HIV, Infants, Child mortality, Factorial randomized clinical trial, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundPneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35-40% in infants hospitalized with severe pneumonia. Bacterial pathogens and Pneumocystis jirovecii are well known causes of pneumonia-related death, but other important causes such as cytomegalovirus (CMV) and tuberculosis (TB) remain under-recognized and undertreated. The immune response elicited by CMV may be associated with the risk of developing TB and TB disease progression, and CMV may accelerate disease caused both by HIV and TB. Minimally invasive autopsies confirm that CMV and TB are unrecognized causes of death in children with HIV. CMV and TB may also co-infect the same child. The aim of this study is to compare the impact on 15-day and 1-year mortality of empirical treatment against TB and CMV plus standard of care (SoC) versus SoC in HIV-infected infants with severe pneumonia.MethodsThis is a Phase II-III, open-label randomized factorial (2 × 2) clinical trial, conducted in six African countries. The trial has four arms. Infants from 28 to 365 days of age HIV-infected and hospitalized with severe pneumonia will be randomized (1:1:1:1) to (i) SoC, (ii) valganciclovir, (iii) TB-T, and (iv) TB-T plus valganciclovir. The primary endpoint of the study is all-cause mortality, focusing on the short-term (up to 15 days) and long-term (up to 1 year) mortality. Secondary endpoints include repeat hospitalization, duration of oxygen therapy during initial admission, severe and notable adverse events, adverse reactions, CMV and TB prevalence at enrolment, TB incidence, CMV viral load reduction, and evaluation of diagnostic tests such as GeneXpert Ultra on fecal and nasopharyngeal aspirate samples and urine TB-LAM.DiscussionGiven the challenges in diagnosing CMV and TB in children and results from previous autopsy studies that show high rates of poly-infection in HIV-infected infants with respiratory disease, this study aims to evaluate a new approach including empirical treatment of CMV and TB for this patient population. The potential downsides of empirical treatment of these conditions include toxicity and medication interactions, which will be evaluated with pharmacokinetics sub-studies.Trial registrationClinicalTrials.gov , NCT03915366, Universal Trial Number U111-1231-4736, Pan African Clinical Trial Registry PACTR201994797961340.

Published
2022

3. Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Author

Laurence, Borand, Agathe, de Lauzanne, Bunnet, Dim, Seyla, Heang, Sanary, Kaing, Chanty, Keang, Socheat, L.Y., Pichpiseth, Meas, Sovann, Nhoueng, Long, Pring, Vouchleang, Sreng, Song, Yin, Saren, Sovan, Chanvirak, Phan, Chanra, Chreng, Ratha, Khoun, Monicando, Rin, Sophea, Pal, Boraneath, Nang, Rathakrun, Pom, Tan Eang, Mao, Simoy, Chhim, Huot, Touch, Kosal, Suon, Saronn, Chum, Kimhong, Tok, Kimchorn, Pring, Satya, Krouch, Chean, Chok, Sunleng, Seun, Savtey, Phon, Mai, Nang, Kimda, Hun, Vanny, Hong, Dara, Sok, Kosal, Chea, Bunthoeun, Chheang, Rino, Sem, Lam, Lay, Haysan, Say, Pholly, Kem, Sreyphal, Meng, Sokheng, Phorn, Sreyvann, Him, Peakdey, Pheach, Dalai, Kive, Moeur, Sar, Sreydy, Kong, Seyha, Kong, Sreytouch, Yorn, Soam, Tes, Sophal, Kep, Seroeung HENG Thy, Leng, Savorn, Neak, Sim, Seng, Pheakna, Pay, Sithan, Suon, Sophanna, Chan, Dyna, Um, Savuth, Sin, Sam, Phan, Sarim, Kum, Sokheng, Khath, Pong, Phem, Seyha, Sok, Chanty, Ny, Van, Leim, Sereyvuth, Pich, Sengkry, Chheang, Nhin, Eang, Vannareth, Sao, Vannak, Sim, Sopheak, Som, Ney, Pong, Sokha, Van, Sreyleap, Seng, Vanna, Yoeurng, Kakada, Toem, Thida, Keo, Vuochny, Sem, Sophal, Veng, Chanthol, Rin, Vanny, Seang, Kiri, Lok, Khemra, Mao, Keovanna, Ouk, Maiya, Min, Suomun, Morm, Rattana, Koy, Sreypov, Chhann, Sreytouch, Set, Audrey, Amboua Schouame, Clifford, Babey, Masama, Eden Ngu, Etienne, Guenou, Sylvie, Kwedi Nolna, Douglas, Mbang Massom, Bernard Fortune, Melingui, Nadia, Nga Elomo, Moïse, Mvetumbo, Angeline, Nkembe, Krystel, Ebo, Albert, Kuate Kuate, Michelline, Choupa, Maggi, Mbede, Valerie, Donkeng, Nelly, Kamgaing, Jean-Voisin, Taguebue, Achille, Touha Yannick, Estelle, Abomo Zang, Rosette, Bakoa, Esperance, Mimbouombela Leger, Sabine, Eleme, Gabrielle, Eteme Marie, Thierry, Elouna Nkoa, Dieudonné, Ndzana, Christophe, Bitti, Olivier, Fotsing, Charlotte, Lani Boko, Mathieu, Mbonga, Ghislain Ulrich, Njakou Sagang, Innocent, Onomo, Charlotte, Essaga Hortense, Daniel Desiré, Mboudi Kouang, Léon, Eloundou, Helene, Kengne, Felix, Mbassi, Juliette, Bidjeme, Hortense, Toua Eteme, Nadege, Essama, Roger, Belinga Balla, Norbert, Tassi, Roline, Nguiko Elsa, Leonard, Mekongo, Fabien, Eyebe Ayissi, Francine Christelle, Biloa Anaba, Philomène, Nsom, Celestin Géraud, Yam Essola, Edwige Léa, Mame Moo, Noé, Makon, Arllette Rita, Nounkep Yanghu, Frank, Ebanga, Antoinette, Assiga Ntsama, Carlyle Sorelle, Kamguia Djuimsop, Diane, Mbabou, Marie, Maguip Abanda, Rosine Berthe, Nguemafouo Doummene, Amos, Mekone, Ngwankfu, Konfor Blessing, Jérome, Mimboe, Virginie, Tiona, Roland, Beleck, Sairou, Zam, Nicole, Adibone, Claude, Biaback Jean, Denis, Bessong, Gilbert, Aminou, Jeremie Pagnol, Bille Bonga, Aubin, Fotso Monkap, Epse NGON Annie, Hitekelek, Vitrice, Sebe, Leo, Makon, Marie, Ennah, Mpie, Paul Boyolo, Diane Viviane, Metchoum, Celin, Nzambe, Arnaud, Dado, Milobert, Mbengang, Marceline, Eyebi, Vanessa, Ngah, Alice, Mballa Batonga, Solange, Ayouba, Pierrette, Ebode, Majino, Mamou, Marguerite, Botomogne Bomba, Salametou, Ngnet, Augustine Florence, Essengue Ngono, Rolland, Odionoloba Charles, Bernice, Bisso, Suzy, Balemaken Ingrid, Marie Louise, Mandoki a Bilong, Gertrude, Ndeng Ayouba, Josue, Ngon, Roger, Aka Bony, Kacou Michel, Bah, Dro, Bakayoko, Rolande, Baki Aimee, Marie-France Larissa, Banga, Olivier, Bouzié, Kan, Brou, Pan, Coulibaly, Serge, Danho, Flavien, Deli, Alphonse, Dion, Bi, Do, Armand, Dohoun, William, Edjeme, Cathérine, Falé, Melissa, Gogoua Saulé, Constant, Kesse, Eric, Komena Auguste, Christian, Kouadio, Arkason, Kouame Abel, Raoul, Moh, Sandrine, Nguessan Marcelle, Bertine, Siloué, Nina, Soua, Cyrille Prisca, Yao Yapi, Timothée, Ouassa, Jacquemin, Kouakou, Eric, Balestre, Aurélie, Beuscart, Aurélie, Charpin, Marc, D'elbee, Hélène, Font, Basant, Joshi, Nicolas, Koskas, Olivier, Marcy, Estelle, Occelli, Joanna, Orne-Gliemann, Julien, Poublan, Elodie, Vernoux, Maryline, Bonnet, Savine, Chauvet, Manon, Lounnas, Guillaume, Breton, Pierre-Yves, Norval, Sheyla, Cassy, Verna, Chambal, Valter, Chiúle, Supinho, Chimbanje, Saniata, Cumbe, Mércia, Matsinhe, Celso, Khosa, Nairo, Mabote, Salvador, Machava, Emelva, Machonisse, Verónica, Macuácua, Denise, Milice, Jorge, Ribeiro, Elcídio, Tivane, Dorlim, Uetela, Yara, Voss de Lima, Américo, Zandamela, Alcina, Zita, Ivan, Manhiça, Benedita, José, Dalila, Rego, Chris, Buck W., Kapoli, Kasembe, Atália, Massangaie, Assa, Sitoe, Ambostique, Argola, Césio, Miambo, Presequila, Nhatsave, Gilda, Sitoe, Charifito, Vesta, Salvador, Dimande, Lázaro, Mazembe, Nilza, Amade, Manuela, Chavela, Nomsa, Macheque, Salomão, Comé, Eulália, Machava, Narciso, Mucavele, Jacinto, Nhabanga, Marlene, Nicolau, Natércia, Simbine, Lina, Uendela, Micaela, Juaio, Abiba, Saíde, Naira, Macie, Fernando, Mondlane, Stélio, Simango, Prince, Beyan, Benjamin M, Flomo, Abubakarr, Jalloh Joseph, Ishmael, Kamara, Monica G, Koroma, Mohamed, Lamin, Lena, Matata, Ross, Mugisha Jacob, Christiana M, Senesie, Sheriff, S.E.S.A.Y., Egerton, Tamba Kamara, Ayeshatu, Mustapha, Lynda, Foray, Sandra, Agondeze, Agnes, Kobusingye, Mastula, Nanfuka, Faith, Namulinda, Eric, Wobudeya, Rinah, Arinaitwe, Rodney, Kaitano, Martin, Kasujja, Juliet, Mwanga-Amumpaire, Evans, Mwesigwa, Naome, Natukunda, Simpson, Nuwamanya, Miria, Nyangoma, Patrick, Orikiriza, Johnbosco, Tumwijukye, Esther, Turyashemererwa, Nyehangane, Dan, Mugisha, Ivan, Winnie, Biryeri, George, Naika, Robert, Ongwara O., Allen, Najjuko, Augustine, Kayiira, Samuel, Yairo, Immaculate, Tumwebaze, Goreth, Nalwoga, Paul, Nsiyaleta, Annet, Agaba, Martin, Mpimbaza M., Norbert, Akampurira, Agatha, Tugumisirize, Evans, Ariyo, Julius, Agaba, Yovita, Natukunda, Nelson, Musazi, Edmund, Musinguzi, Brown, Baluku Julius, Moorine, Sekadde, Stavia, Turyahabwe, Chishala, Chabala, Luis, Cuevas, Christophe, Delacourt, Steve, Graham, Malgorzata, Grzemska, Sabine, Verkuijl, Anneke, Hesseling, Elizabeth, Maleche-Obimbo, Mark, Nicol, Wobudeya, Eric, Nanfuka, Mastula, Ton Nu Nguyet, Minh Huyen, Taguebue, Jean-Voisin, Moh, Raoul, Breton, Guillaume, Khosa, Celso, Borand, Laurence, Mwanga-Amumpaire, Juliet, Mustapha, Ayeshatu, Nolna, Sylvie Kwedi, Komena, Eric, Mugisha, Jacob Ross, Natukunda, Naome, Dim, Bunnet, de Lauzanne, Agathe, Cumbe, Saniata, Balestre, Eric, Poublan, Julien, Lounnas, Manon, Ngu, Eden, Joshi, Basant, Norval, Pierre-Yves, Terquiem, Etienne Leroy, Turyahabwe, Stavia, Foray, Lynda, Sidibé, Souleymane, Manhiça, Ivan, Sekadde, Moorine, Detjen, Anne, Verkuijl, Sabine, Mao, Tan Eang, Orne-Gliemann, Joanna, Bonnet, Maryline, and Marcy, Olivier

Published
2024
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4. Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study

Author

Arlt-Hilares, Doris, Balestre, Eric, Banga, Marie-France, Bénard, Antoine, Bernard, Tanguy, Bonnet, Maryline, Borand, Laurence, Breton, Guillaume, Bunnet, Dim, Chateau, Paul-Damien, Cumbe, Saniata, d’Elbée, Marc, de Lauzanne, Agathe, Dodd, Peter James, Harker, Martin, Huyen Ton Nu Nguyet, Minh, Kaing, Sanary, Khosa, Celso, Komena, Eric, Koroma, Monica, Kwedi Nolna, Sylvie, Mafirakureva, Nyashadzaishe, Mao, Tan Eang, Marcy, Olivier, Mbang Masson, Douglas, Moh, Raoul, Mugisha, Jacob, Mustapha, Ayeshatu, Mwanga-Amumpere, Juliet, Nanfuka, Mastula, Natukunda, Naome, Orne-Gliemann, Joanna, Ouattara, Eric, Poublan, Julien, Sohn, Hojoon, Taguebue, Jean-Voisin, Tulinawe, Immaculate, Voss de Lima, Yara, Wittwer, Jérôme, Wobudeya, Eric, Nolna, Sylvie Kwedi, and Dodd, Peter J.

Published
2024
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6. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, Serre, Angeline, Badrichani, Anne, Razafimanantsoa, Manoa, Poublan, Julien, Vessière, Aurélia, Roucher, Clémentine, Occelli, Estelle, Beuscart, Aurélie, Charpin, Aurélie, Habiyambere, Gemma, Mesnier, Salomé, Balestre, Eric, Bhatta, Bandana, Maillard, Anne-Laure, Orne-Gliemann, Joanna, Baillet, Emmanuelle, Koskas, Nicolas, D'Elbée, Marc, Gabillard, Delphine, Font, Hélène, Huyen, Minh, Bonnet, Maryline, Lounnas, Manon, Espérou, Hélène, Couffin-Cadiergues, Sandrine, Kuppers, Alexis, Hamze, Benjamin, BORAND, Laurence, de LAUZANNE, Agathe, DIM, Bunnet, Keang, Chanthy, PRING, Long, YIN, Song, SARITH, Channimol, PHAN, Chanvirak, NHEUONG, Sovann, LY, Socheat, KAING, Sanary, SRENG, Vouchleang, LUN, Elen, SAY, Leakhena, SUOM, Sophea, FERHY, Romyka, SO, Dina, BORN, Sorunna, PAL, Sophea, NANG, Boraneath, MAO, Tan Eang, KIM, Ang, Srey, Viso, Kan, Piseth, Hout, leakhena, Ith, Samnang, Oum, Sophany, Sau, Sokunvadhana, Ho, Kim Heang, Kith, Daronic, Nuch, Nathara, Horm, Chhun Leang, Sophon, Cheameas, Roeungdeth, Bosba, MENG, Chhay, RITH, Ravin, PHY, Samnang, SOR, Chanchetra, SAO, Voleak, KHAT, Sophea, MAK, Bunthoeun, UY, Angkeaborin, KHAY, Sreyny, SOM, Kimsan, HACH, rongvirak, SOK, Hay, KUON, Sotheavy, HENG, Synatt, SENG, Amara, NIM, Sopheak, PAN, Reach, KIM, Srean, SREY LEAP, Keo, NET, Bormey, NOUN, Viccheka, LAY, Daven, MANY, Chhaing, Seng, Socheata, Ly, Vuthy, So, Saran, Oun, Sovutthik, CHEY, Sopheap, CHHEA, Rattany, BAONG, Lydeth, THOUNG, Vanna, KHEANG, Chanrithea, BY, Borady, Nguon, Vathanak, MEACH, Eksophea, Tek, Sopheak, Ngeav, Sina, Lun, Tetra, HEM, Deth, CHUT, Nayreang, SARIK, Setha, NANG, Hgekkoung, MEACH, Mengnean, SRENG, Sopal, SAR, Dara, KIN, Rathana, ROS, Phoran, DORN, Chenda, KAK, Chansy, Sambath, Srey Leak, Son, Leakhena, Bin, Linda, Pengong, Eangnay, Pol, Sokha, Khutsorn, Samnang, Seang, Sorsophea, Soun, Virak, Vong, Vuthy, Khoeung, Chandara, Um, Panha, Bou, Sokunthea, Song Pich, Sarin, Nim, Puthy, Khat, Sopheak, Ban Si, Nuon, Ream, Sovannodom, Ing, Sim, Chann, Phanith, Ngeth, Samrith, Sun, Marina, Chhoeung, Sokea, Sean, Soeun, Prak, Ratanak, Taguebue, Jean-Voisin, Kwedi Nolna, Sylvie, Amboua Schouame Onambele, Audrey, Hycenth, Numfor, Melingui, Bernard, Nkembe Medounmga, Angeline, Hougnang Tatmi, Luciole, Etemgoua, Nathalie, Kouesso, Vanessa, Bugin, Jean, Nzedjom, Celestine, Ngoya, Roger, Eyike, Jules, Loudjom, Elyse, Lonsti, Roger, Dang, Ladi, Bintar, Edward, Njayong, Chantal, Ngonsoa O, Cinthia, Ndzeukap, Isabelle, Dzoyem, Pascaline, Dzokou, Clémentine, Dindo, Berthe, Moh, Raoul, Komena, Eric Auguste, Aka Bony, Roger, Kouadio, Christian, Danho, Serge, Goli, Melissa, Folquet, Madeleine, Itchy, Max Valère, Sidibé, Abdel, Cissé, Lancina, Ouattara, Joseph, Konaté, Mamadou, Amon-Tanoh Dick, Flore, Cardena, Melissa, Adonis-Koffi, Laurence, Eugenie, Djabia, Kouamé, Ferdinand, Menan, Hervé, Inwoley, André, Ouassa, Timothée, Nguessan, Marcelle Sandrine, Khosa, Celso, Cumbe, Saniata, Manhiça, Emelva, Zitha, Alcina, Chiúle, Valter, Muxanga, Eva, Gune, Irene, Lima, Yara, Ribeiro, Jorge, Mavale, Sandra, Chilundo, Josina, Maxanguana, Felismina, Morais, Natália, Manhiça, Julieta, Give, Josefina, Atumane, Jafito, Lucas, Gelson, Thai, Arsénio, Chave, Adélio, Rego, Dalila, Guambe, Lúcia, Issa, Faiaz, Carneiro, Rosa, Pene, Neusa, Florindo, Natércia, Machel, Dália, Cumbane, Cecília, Mendes, Helena, Kitungwa, Mule, Muianga, Valdo, Tamele, Humberto, Sulude, Adelino, Mabota, Roda, Comandante, Herquéria, Massangaie, Abelardo, Wobudeya, Eric, Businge, Gerald Bright, Namulinda, Faith, Sserunjogi, Robert, Nassozi, Rashidah, Barungi, Charlotte, Aanyu, Hellen, Muwonge, Doreen, Kagoya, Eva, Aciparu, Serene, Chemutai, Sophia, Ntambi, Samuel, Wasswa, Amir, Nangozi, Juliet, Tagoola, Abner, Mbekeka, Prossy, Kenneth, Sajja, Lubega, John Paul, Nassali, Aidah, Tagobera, Jessica, Agwang, Christine, Kalembe, Florence, Ajambo, Annet, Aguti, Elizabeth, Kasibante, Samuel, Matende, Henry, Odongo, Israel Owen, Mwanga Amumpaire, Juliet, Natukunda, Naome, Ngabirano, Gertrude, Kakwenza, Paul, Nuwamanya, Simpson, Nyangoma, Miria, Nabbuto, Jane, Abok, Florence, Arinaitwe, Rinah, Birungi, Diana, Mwesigwa, Evans, Atwine, Daniel, Mbega, Hassan, Orikiriza, Patrick, Taremwa, Ivan, Turyashemererwa, Esther, Derrick, Hope, Nyehangane, Dan, Kaitano, Rodney, Logoose, Susan, Businge, Steven, Ntambi, Charles, Mugabi, Jerome, Mzee, John, Besigye, Julius, Kanzira, Saul, Turyatemba, Phionah, Twebaze, Florence, Chabala, Chishala, Mulenga, Veronica, Shankalala, Perfect, Hambulo, Chimuka, Kapotwe, Vincent, Ngambi, Marjory, Kasakwa, Kunda, Chirwa, Uzima, Kapula, Chifunda, Zulu, Susan, Nawakwi, Grace, Siasulingana, Teddy, Chilonga, Jessy, Chimbini, Maria, Chilanga, Mutinta, Nduna, Bwendo, Inambao, Muleya, Mwambazi, Mwate, Halende, Barbra, Mumba, Wyclef, Mankunshe, Endreen, Silavwe, Maureen, Chakopo, Moses, Moono, Roy, Mwanga-Amumpaire, Juliet, De Lauzanne, Agathe, Dim, Bunnet, Tiogouo Ngouana, Emeline, Folquet Amorrissani, Madeleine, Cisse, Lassina, Amon Tanoh Dick, Flore, Komena, Eric A, Businge, Gerald, Kim, Ang, Kheang, Chanrithea, Maleche-Obimbo, Elizabeth, Seddon, James A, Mao, Tan Eang, Graham, Stephen M, Delacourt, Christophe, and Borand, Laurence

Published
2023
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7. Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries.

Author

Melingui, Bernard Fortune, Basant, Joshi, Taguebue, Jean voisin, Massom, Douglas Mbang, Leroy Terquem, Etienne, Norval, Pierre Yves, Salomao, Angelica, Dim, Bunnet, Tek, Chhen Eap, Borand, Laurence, Khosa, Celso, Moh, Raoul, Mwanga‐Amumpere, Juliet, Eang, Mao Tan, Manhiça, Ivan, Mustapha, Ayeshatu, Balestre, Eric, Beneteau, Samuel, Wobudeya, Eric, and Marcy, Olivier

Subjects
MEDICAL personnel, RESOURCE-limited settings, MEDICAL care, INTERNET access, CHEST X rays
Abstract

Objectives: Chest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐limited settings. Digital CXR (d‐CXR) can solve some image quality issues and facilitate their transfer for quality control. We assess the implementation of introducing d‐CXR in 12 district hospitals (DHs) in 2021–2022 across Cambodia, Cameroon, Ivory Coast, Mozambique, Sierra Leone and Uganda as part of the TB‐speed decentralisation study on childhood TB diagnosis. Methods: For digitisation of CXR, digital radiography (DR) plates were setup on existing analogue radiography devices. d‐CXR were transferred to an international server at Bordeaux University and downloaded by sites' clinicians for interpretation. We assessed the uptake and performance of CXR services and health care workers' (HCW) perceptions of d‐CXR implementation. We used a convergent mixed method approach utilising process data, individual interviews with 113 HCWs involved in performing or interpreting d‐CXRs and site support supervision reports. Results: Of 3104 children with presumptive TB, 1642 (52.9%) had at least one d‐CXR, including 1505, 136 and 1 children with one, two and three d‐CXRs, respectively, resulting in a total of 1780 d‐CXR. Of them, 1773 (99.6%) were of good quality and 1772/1773 (99.9%) were interpreted by sites' clinicians. One hundred and sixty‐four children had no d‐CXR performed despite attending the radiography department: 126, 37 and 1 with one, two and three attempts, respectively. d‐CXRs were not performed in 21.6% (44/203) due to connectivity problem between the DR plate captor and the computer. HCW reported good perceptions of d‐CXR and of the DR plates provided. The main challenge was the upload to and download from the server of d‐CXRs due to limited internet access. Conclusion: d‐CXR using DR plates was feasible at DH level and provided good quality images but required overcoming operational challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Rapid decrease in IL-1Ra and IP-10 plasma levels following tuberculosis treatment initiation

Author

Polidy, Pean, primary, Affi, Roseline, additional, Chazalon, Corine, additional, Soumahoro, Ben Cheick, additional, Gabillard, Delphine, additional, Bunnet, Dim, additional, Borand, Laurence, additional, Moh, Raoul, additional, Anglaret, Xavier, additional, Blanc, François-Xavier, additional, Girard, Pierre-Marie, additional, Carcelain, Guislaine, additional, Laureillard, Didier, additional, and Weiss, Laurence, additional

Published
2024
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12. Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium

Author

Brazier, Ellen, Ajeh, Rogers, Maruri, Fernanda, Musick, Beverly, Freeman, Aimee, Wester, C. William, Lee, Man?Po, Shamu, Tinei, Ramírez, Brenda Crabtree, D' Almeida, Marcelline, Wools?Kaloustian, Kara, Kumarasamy, N., Althoff, Keri N., Twizere, Christella, Grinsztejn, Beatriz, Tanser, Frank, Messou, Eugène, Byakwaga, Helen, Duda, Stephany N., Nash, Denis, Chansilpa, Chidchon, Dougherty, Trevor, Karminia, Azar, Law, Matthew, Ross, Jeremy, Sohn, Annette, Aguirre, Ivette, Baker, David, Bloch, Mark, Cabot, Safaa, Carr, Andrew, Couldwell, Deborah, Edwards, Sian, Eu, Beng, Farlow, Heather, Finlayson, Robert, Gunathilake, Manoji, Hazlewood, Cherie, Hoy, Jennifer, Langton?Lockton, Julian, Le, Jacqueline, Leprince, Elizabeth, Minc, Ariane, Moore, Richard, O'Sullivan, Maree, Roth, Norm, Rowling, Dianne, Russell, Darren, Ryder, Nathan, Saunders, Craig, Silvers, Julie, Smith, David J., Sowden, David, Sweeney, Grant, Tan, Lynn, Teague, Ricard, Templeton, David, Thng, Caroline, Woolley, Ian, Khol, Vohith, Ly, Penh Sun, Li, Tsz Hei, Po, Lee Man, Kinikar, Aarti, Kumarasamy, Nagalingeswaran, Mundhe, Sanjay, Pujari, Sanjay, Sangle, Shashikala, Nimkar, Smita, Jassin, Madelein, Kurniati, Nia, Merati, Tuti Parwati, Muktiarti, Dina, Amalia, Rizqi, Sukmawati, Ni Made Dewi Dian, Wati, Ketut Dewi Kumara, Yunihastuti, Evy, Tanuma, Junko, Choi, Jun Yong, Azwa, Raja Iskandar Shah Raja, Cheng, Chan Kwai, Gani, Yasmin Mohamed, Mohamed, Thahira Jamal, Moy, Fong Siew, Nallusamy, Revathy, Nor, Mohamad Zulfahami Mohd, Rudi, Nuraini, Shyan, Wong Peng, Yusoff, Nik Khairulddin Nik, Ditangco, Rossana, Chan, Yu?Jiun, Wu, Pei?Chieh, Wu, Ping?Feng, Avihingsanon, Anchalee, Chaiwarith, Romanee, Chokephaibulkit, Kulkanya, Khusuwan, Suwimon, Kiertiburanakul, Sasisopin, Kosalaraksa, Pope, Lumbiganon, Pagakrong, Ounchanam, Pradtana, Puthanakit, Thanyawee, Rungmaitree, Supattra, Solai, Nuttarika, Sudjaritruk, Tavitiya, An, Vu Thien, Cuong, Do Duy, Do, Chau Viet, Huy, Bui Vu, Quy, Tuan, Van Nguyen, Kinh, Nguyen, Luan, Nguyen, Van Lam, Nguyen, Yen Thi, Nong, Vuong Minh, Truong, Huu Khanh, Tuyen, Ngo Thi Thu, Mcgowan, Catherine C., Duda, Stephany, Cahn, Florencia, Cahn, Pedro, Cesar, Carina, Fink, Valeria, Sued, Omar, Coelho, Lara, Machado, Daisy Maria, Pinto, Jorge, Wolff, Marcelo, Rouzier, Vanessa, Padgett, Denis, Gotuzzo, Eduardo, Biziragusenyuka, Jérémie, Gateretse, Patrick, Nimbona, Pelagie, Niyonkuru, Olive, Twizere, Christelle, Anicetus, Surreng, Djenabou, Amadou, Enow, Priscilla, Mbu, Eyongetah, Manga, Martin, Ndobe, Mercy, Nasah, Judith, Ekossono, Elle Nathalie Syntyche, Bouseko, Mireille Teno, Kitetele, Faustin, Lelo, Patricia, Diafouka, Merlin Isidore Justin, Mafoua, Adolphe, Nsonde, Dominique Mahambou, Bihira, Uitonze Aime Maurice, Dusabe, Marie Chantal, Feza, Rosine, Habanabashaka, Jean Claude, Habumuremyi, Viateur, Igizeneza, Ernestine, Kamigisha, Anne Marie, Kubwimana, Gallican, Maniriho, Gilbert, Mbaraga, Gilbert, Muhoza, Benjamin, Mukakarangwa, Jeanne, Mukamana, Joyce, Mukanyirigira, Patricie, Mukeshimana, Yvone Claude, Munyaneza, Athanase, Murenzi, Gad, Musaninyange, Jacqueline, Nyiraneza, Jules Ndumuhire, Ntarambirwa, Fidele, Nyiraneza, Marie Louise, Tuyishime, Josette, Tuyishimire, Yvonne, Ubandutira, Alexis, Umugiraneza, Florance, Umugwaneza, Rosine, Uwamahoro, Olive, Uwamahoro, Pauline, Uwambaje, Marie Victoire, Uwimpuhwe, Clarisse, Uwiragiye, Siphora, Kuhn, Yee Yee, Adera, Felix, Adhiambo, Beatricec, Aggrey, Khaemba, Akadikor, Daniel, Ambulla, Felix, Apiyo, Dorah, Ariya, Patrick, Atemba, Naftal, Ayodi, Fridah, Benard, Chirchir, Bett, Maureen, Birgen, Serafine, Bwalei, Rael, Chebon, Nancy, Chebor, Valentine Jirry, Chebuiywo, Philip, Chemutai, Jacline, Chepkorir, Emily, Chepseba, Carolyne, Chirchir, John, Diero, Lameck, Dukwa, Benard, Elphas, Alice, Etyang, Tom, Idiama, Agnes, Jebichuko, Ann, Jepchumba, Delvine, Juma, Churchill, Juma, Maureen, Juma, Sheila, Kadima, Julie, Karani, Rose, Keitany, Christopher, Keter, Pricilla, Kiavoga, Lucy, Kibet, Harrison, Kimutai, Ruth, Kiplagat, Mutai, Kiprono, Wilfred, Kipruto, Nicholas Kogei, Kirimi, Asenath, Koech, Zeddy, Kosgei, Carolyne, Kutto, Karen, Kweyu, Mildred, Liech, Ephraim Kenneth, Limo, Milka, Maina, Rose, Marumbu, Priscah, Masese, Agnes, Mochotto, Patricia, Molly, Omudeck, Momanyi, Tom, Murutu, John W., Mwanda, Praxidis, Ndakalu, Lillian, Nderitu, Rose N., Obatsa, Sarah, Obiga, Fredrick, Oboya, Moses, Odhiambo, Joseph, Olaya, George, Omanyala, Oscar, Oray, Christine, Otieno, Molly, Otwane, Modesta Toto, Ouma, Paul, Owuor, Charles, Pepela, Doris Tutu, Pessah, Collins, Rotich, Evans, Rotich, Edwin K., Rutto, Titus C., Shikuku, Monica, Sibweche, Rose Naliaka, Simiyu, Robert Wanyonyi, Siria, Hellen, Some, Michael, Songok, Winnie Cherotich, Tanui, Immaculate, Wafula, Grace, Wambura, Rebecca, Wanjala, Ellah, Wanyama, Carolyne, Wanyonyi, Hellen, Woyakapel, Emmanuel, Zelbabel, Wandera, Gwimo, Dikengela, Kinyota, Ester, Lwali, Jerome, Lyamuya, Rita, Machemba, Richard, Mathias, Julia, Mkombachepa, Lilian, Mokiwa, Athuman, Mushi, Ombeni, Ndunguru, Charles, Ngonyani, Kapella, Nyaga, Charles, Ruta, Happiness, Urassa, Mark, Akanyihayo, James, Arinaitwe, Arnold, Batuuka, Jesca, Birungi, Walusimbi, Bugembe, John Nyanzi, Ddungu, Ahmed, Francis, Kato, Imran, Bangira, Kafuuma, George William, Kalulue, John Bosco, Kanaabi, Grace, Kanyesigye, Michale, Karuhanga, Godfery, Kasozi, Charles, Kasule, Godfrey, Katusime, Assumpta, Kibalama, Donozio, Kimera, Simon Peter, Kulusumu, Namatovu, Lule, Yusuf, Lwanga, Isaac, Mluindwa, Margaret, Moses, Jemba, Mubarak, Sseremba, Muggaga, Daniel, Mukalazi, Evelyn, Muleebwa, Joseph, Mulema, Derick, Musisi, Ivan, Muwawu, John, Muyindike, Winnie, Mwaka, Dick, Naava, Milly, Nabiyki, Immaculate, Nabusulwa, Agnes, Nakabugo, Dorah, Nakamya, Esther, Nakanwagi, Daisy, Nakato, Oliver, Nakayi, Lydian, Nakigozi, Patience, Nakku, Juliet, Nakuya, Juliet, Nakyomu, Justine, Namayanja, Joan, Namirembe, Sarah, Namugumya, Juliet, Namukasa, Ezereth, Namulindwa, Viola, Nankya, Irene, Nannyondo, Grace Mugagga, Nansamba, Harriet, Nansera, Denis, Nanyanzi, Brenda, Nanyonjo, Esther Celina, Nayiga, Irene, Opira, Isaac, Owarwo, Noela C., Resty, Sserunkuma, Semuwemba, Haruna, Senoga, Julius, Sseguya, Gerald, Ssekyewa, John Paul, Ssemakadde, Matthew, Tebajjwa, Jonah, Tugumisirize, Doreen, Tushemerirwe, Robinah, Waliyi, Kawuki, Althoff, Keri, Bishop, Jennifer, Gill, M J., Loutfy, Mona, Smith, Graham, Bamford, Laura, Black, Anthony, Brice, Asia, Brown, Sheldon, Colasanti, Jonathan, Duarte, Piper, Firnhaber, Cynthia, Goetz, Matthew, Grasso, Chris, Gripshover, Barbara, Horberg, Michael, Kelly, Rita, Levine, Ken, Luu, Mitchell, Marconi, Vincent, Maroney, Karen, Mayer, Kenneth, Mayor, Angel, Mcgowan, Catherine, Multani, Ami, Napravnik, Sonia, Nijhawan, Ank, Novak, Richard, Palella, Frank, Rodriguez, Maria C., Scott, Mia, Tedaldi, Ellen, Willig, James, Cornell, Morna, Davies, Mary?Ann, Egger, Matthias, Haas, Andreas, Bereng, Monkoe, Kalake, Maleshoane, Lenela, Keketso, Seretse, Relebohile, Chintenga, Matthews, Chiwoko, Jane, Gumulira, Joe, Huwa, Jacqueline, Maluwa, Rafique, Matanje, Beatrice, Mbewe, Ronald, Mfungwe, Sunshine, Mphande, Zakaliah, Tweya, Hannock, Rafael, Idiovino, Apolles, Patti, Beneke, Eunice, Dlamini, Siphephelo, Edson, Claire, Eley, Brian, Euvrard, Jonathan, Fatti, Geoffrey, Goeieman, Bridgette, Grimwood, Ashraf, Huang, David, Hugo, Susan, Ismail, Zahiera, Jennings, Lauren, Mathenjwa, Thulile, Monteith, Lizette, Mshweshwe, Zamuxolo, Ntuli, Mfundi, Ndlovu, En, Ndlozi, Hloniphile, Noyakaza, Sylvia, Prozesky, Hans, Rabie, Helena, Sipambo, Nosisa, Technau, Karl?Günter, Tembe, Thokozani, Xaba, Nontando, Njobvu, Thandiwe, Munthaly, Mary, Mwetwa, Elly, Kabeba, Gillian, Mwendafilumba, Derrick, Maanguka, Ethel, Manyika, Nelly, Mwansa, Chalwe, Banda, Future, Mwenda, Dickson, Bwalya, Abel, Shapi, Leah, Syame, Kasapo, Sashi, Rita, Mulenga, Chisha, Nanyangwe, Ruth, Chimbetete, Cleophas, Chinofunga, A., Mhike, J., Mubvigwi, E., Nyika, F., Quarter, Kumbirai Pise, Arikawa, Shino Chassagne, Becquet, Renaud, Bernard, Charlotte, Dabis, François, Desmonde, Sophie, Dahourou, Désiré, Ekouevi, Didier Koumavi, Jaquet, Antoine, Jesson, Julie, Leroy, Valeriane, Malateste, Karen, Rabourdin, Elodie, Tiendrebeogo, Thierry, Assogba, Michée, Zannou, Djimon Marcel, Hounhoui, Ghislaine, Bere, Denise, Poda, Armel, Pooda, Gbolo, Traore, Richard, Abauble, Yao, Abby, Ouattara, Acquah, Patrick, Andoble, Valérie, Aude, Yobo N'Dzama, Azani, Jean?Claude, Berete, Oka, Beugre, Jacques Daple, Bohoussou, Caroline Yao, Brou, Simon Boni Emmanuel, Chenal, Henri, Cissé, Abdoulaye, Coulibaly, Nambate, Dainguy, Marie Evelyne, Daligou, Marcelle, D' Aquin, Toni Thomas, Dasse, Claude Desire, Folquet, Madeleine Amorissani, Gnepa, Guy, Gobe, Olivier, Guira, Salif, Hawerlander, Denise, Horo, Apollinaire, Kanga, Guillaume, Messou, Zobo Konan Eugène, Minga, Kla Albert, Moh, Raoul, N'Gbeche, Mariesylvie, Ogbo, Patricia, Oulai, Mathieu, Stéphanie, Se, Eboua, Tanoh, Valère, Itchy Max, Afrane, Adwoa Kumiwa Asare, Akrofi, Esther, Andoh, John Christian, Renner, Lorna, Bagayoko, Awa, Bagayoko, Kadidiatou, Bah, Abdou Salam, Berthe, Alima, Coulibaly, Boureïma, Coulibaly, Fatimata, Coulibaly, Yacouba Aba, Diakité, Aïssata, Bocoum, Fatoumata, Boré, Fatoumata, Dicko, Fatoumata, Koné, Odile, Sylla, Mariam, Tangara, Assitan, Traoré, Mamadou, Seydi, Moussa, Amegatse, Edmond, Djossou, Julienne, Takassi, Elom, and Palanga, Sénam

Subjects
HIV (Viruses) -- Care and treatment -- Patient outcomes, Public health administration -- Evaluation, Health
Abstract

: Introduction: Interruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented. Methods: From September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence ( Results: Questions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n = 82), medium (n = 86) and high (n = 57) HIV prevalence, including low‐ (n = 57), lower‐middle (n = 79), upper‐middle (n = 39) and high‐ (n = 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings. Conclusions: While many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings., INTRODUCTION The COVID‐19 pandemic has had major direct and indirect impacts on population health globally, through disruptions in the accessibility and quality of basic health services [1], in supply chains [...]

Published
2022
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13. Impact of systematic early tuberculosis detection using Xpert MTB/RIF Ultra in children with severe pneumonia in high tuberculosis burden countries (TB-Speed pneumonia): a stepped wedge cluster randomized trial

Author

Vessière, Aurélia, Font, Hélène, Gabillard, Delphine, Adonis-Koffi, Laurence, Borand, Laurence, Chabala, Chishala, Khosa, Celso, Mavale, Sandra, Moh, Raoul, Mulenga, Veronica, Mwanga-Amumpere, Juliet, Taguebue, Jean-Voisin, Eang, Mao Tan, Delacourt, Christophe, Seddon, James A., Lounnas, Manon, Godreuil, Sylvain, Wobudeya, Eric, Bonnet, Maryline, and Marcy, Olivier

Published
2021
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14. Implementation of an intensive adherence intervention in patients with second-line antiretroviral therapy failure in four west African countries with little access to genotypic resistance testing: a prospective cohort study

Author

Eholie, Serge P, Moh, Raoul, Benalycherif, Aïda, Gabillard, Delphine, Ello, Frédéric, Messou, Eugène, Zoungrana, Jacques, Diallo, Ismaël, Diallo, Mouhamadou, Bado, Guillaume, Cisse, Mamadou, Maiga, Almoustapha I, Anzian, Amani, Toni, Thomas-d'Aquin, Congo-Ouedraogo, Malika, Toure-Kane, Coumba, Seydi, Moussa, Minta, Daouda K, Sawadogo, Adrien, Sangaré, Lassana, Drabo, Joseph, Karcher, Sophie, Le Carrou, Jérome, de Monteynard, Laure-Amelie, Peytavin, Gilles, Gabassi, Audrey, Girard, Pierre-Marie, Chaix, Marie-Laure, Anglaret, Xavier, and Landman, Roland

Published
2019
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15. Elite and viremic HIV-1 controllers in West Africa

Author

N’takpé, Jean Baptiste, Gabillard, Delphine, Moh, Raoul, Gardiennet, Elise, Toni, Thomas-d’Aquin, Kouame, Gérard M., Badje, Anani, Emieme, Arlette, Karcher, Sophie, Le Carrou, Jérome, Ménan, Hervé, Danel, Christine, Eholie, Serge P., Rouzioux, Christine, Anglaret, Xavier, and Lambotte, Olivier

Published
2022
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16. Potential population-level effects of HIV self-test distribution among key populations in Côte d'Ivoire, Mali, and Senegal: a mathematical modelling analysis

Author

Silhol, Romain, Maheu-Giroux, Mathieu, Soni, Nirali, Simo Fotso, Arlette, Rouveau, Nicolas, Vautier, Anthony, Doumenc-Aïdara, Clémence, Geoffroy, Olivier, N'Guessan, Kouassi Noel, Sidibé, Younoussa, Kabemba, Odé Kanku, Gueye, Papa Alioune, Ndeye, Pauline Dama, Mukandavire, Christinah, Vickerman, Peter, Keita, Abdelaye, Ndour, Cheikh Tidiane, Larmarange, Joseph, Boily, Marie-Claude, Amani, Elvis Georges, Badiane, Kéba, Bayac, Céline, Bekelynck, Anne, Boily, Marie-Claude, Boye, Sokhna, Breton, Guillaume, d'Elbée, Marc, Desclaux, Alice, Desgrées du Loû, Annabel, Diop, Papa Moussa, Ehui, Eboi, Medley, Graham, Jean, Kévin, Keita, Abdelaye, Kouassi, Arsène Kra, Ky-Zerbo, Odette, Larmarange, Joseph, Maheu-Giroux, Mathieu, Moh, Raoul, Mosso, Rosine, Ndour, Cheikh Tidiane, Paltiel, David, Pourette, Dolorès, Rouveau, Nicolas, Silhol, Romain, Simo Fotso, Arlette, Terris-Prestholt, Fern, Traoré, Métogara Mohamed, Doumenc-Aïdara, Clémence, Geoffroy, Olivier, Kabemba, Odé Kanku, Vautier, Anthony, Abokon, Armand, Anoma, Camille, Diokouri, Annie, Kouamé, Blaise, Kouakou, Venance, Koffi, Odette, Kpolo, Alain, Tety, Josiane, Traore, Yacouba, Bagendabanga, Jules, Berthé, Djelika, Diakité, Daouda, Diakité, Mahamadou, Diallo, Youssouf, Daouda, Minta, Hessou, Septime, Kanambaye, Saidou, Kanouté, Abdul Karim, Dembélé Keita, Bintou, Koné, Dramane, Koné, Mariam, Maiga, Almoustapha, Saran Keita, Aminata, Sidibé, Fadiala, Tall, Madani, Yattassaye Camara, Adam, Sanogo, Abdoulaye, Bâ, Idrissa, Diallo, Papa Amadou Niang, Fall, Fatou, NGom Guèye, NDèye Fatou, Ndiaye, Sidy Mokhtar, Niang, Alassane Moussa, Samba, Oumar, Thiam, Safiatou, Turpin, Nguissali M.E., Bouaré, Seydou, Camara, Cheick Sidi, Kouadio, Brou Alexis, Sarrassat, Sophie, Sow, Souleyman, Eponon Ehua, Agnes, Kouvahe, Amélé, Montaufray, Marie-Anne, and Ndeye, Pauline Dama

Abstract

During 2019–21, the AutoTest VIH, Libre d'accéder à la connaissance de son Statut (ATLAS) programme distributed around 380 000 HIV self-testing kits to key populations, including female sex workers, men who have sex with men, and their partners, in Côte d'Ivoire, Mali, and Senegal. We aimed to estimate the effects of the ATLAS programme and national scale-up of HIV self-test distribution on HIV diagnosis, HIV treatment coverage, HIV incidence, and HIV-related mortality.

Published
2024
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17. OA-429 High mortality in African infants living with HIV hospitalized with severe pneumonia

Author

Nduna, Bwendo, primary, Moraleda, Cinta, additional, Sacaral, Jahit, additional, Beinomugisha, Judith, additional, Zulu, Idah, additional, Chitamatanga, Moses, additional, Tam, Pui-Ying Iroh, additional, Chawinga, Chimwemwe, additional, Fernandez, Sheila, additional, Ballesteros, Álvaro, additional, Passanduca, Alfeu, additional, Tagoola, Abner, additional, Atibo, Raul, additional, Nansera, Denis, additional, Bwakura-Dangarembizi, Mutsa, additional, Gambi, Lughano, additional, Mvalo, Tisungane, additional, Madrid, Lola, additional, Macmillan, Belinda, additional, Musiime, Victor, additional, Moh, Raoul, additional, Buck, Chris W, additional, Chabala, Chishala, additional, Tagarro, Alfredo, additional, Rojo, Pablo, additional, and Empirical, Trial, additional

Published
2023
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18. Feasability and effectiveness of scaling up hepatitis-C treatment in West and Central Africa: the TAC ANRS 12311 clinical trial

Author

Lacombe, Karine, primary, Moh, Raoul, additional, Chazallon, Corine, additional, Lemoine, Maud, additional, Sylla, Babacar, additional, Fadiga, Fatoumata, additional, Carrou, Jerôme Le, additional, Marcellin, Fabienne, additional, Kouanfack, Charles, additional, Ciaffi, Laura, additional, Sartre, Michelle Tagni, additional, Sida, Magloire Biwole, additional, Diallo, Alpha, additional, Gozlan, Joel, additional, Seydi, Moussa, additional, Cissé, Viviane, additional, Danel, Christine, additional, Girard, Pierre Marie, additional, Toni, Thomas, additional, Minga, Albert, additional, Boyer, Sylvie, additional, Carrieri, Patrizia, additional, and Attia, Alain, additional

Published
2023
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19. Reply to Hector et al

Author

Kouamé, Gérard-Menan, Boyd, Anders, Moh, Raoul, Eholié, Serge Paul, Danel, Christine, Lacombe, Karine, and Anglaret, Xavier

Published
2018

20. Higher Mortality Despite Early Antiretroviral Therapy in Human Immunodeficiency Virus and Hepatitis B Virus (HBV)–Coinfected Patients With High HBV Replication

Author

French National Agency for Research on AIDS and Viral Hepatitis (ANRS) 12136 Temprano and ANRS 12240 VarBVA Study Groups, Kouamé, Gérard-Menan, Boyd, Anders, Moh, Raoul, Badje, Anani, Gabillard, Delphine, Ouattara, Eric, Ntakpe, Jean-Baptiste, Emième, Arlette, Maylin, Sarah, Chekaraou, Mariama Abdou, Eholié, Serge-Paul, Zoulim, Fabien, Lacombe, Karine, Anglaret, Xavier, and Danel, Christine

Published
2018

23. Sexual health needs of female sex workers in Côte d’Ivoire: a mixed-methods study to prepare the future implementation of pre-exposure prophylaxis (PrEP) for HIV prevention

Author

Camille Anoma, Valentine Becquet, Marcellin Nouaman, Mélanie Plazy, Jean-Marie Masumbuko, Soh Kouame, Christine Danel, Serge Paul Eholie, Joseph Larmarange, Aboubakar Sangaré, Anglaret Xavier, Anoma Camille, Barin Francis, Bazin Brigitte, Becquet Valentine, Dabis François, Danel Christine, Eholie Serge, Ekouevi Didier, Fonsart Julien, Gbosi Kate, Kwamé Abo, Larmarange Joseph, Masumbuko Jean-Marie, Moh Raoul Méda Nicolas, Molina Jean-Michel, N’dri-Yoman Thérèse, Nouaman Marcellin, Plazy Mélanie, Tanoe Solange, and Yeo Roselyne

Subjects
Medicine
Abstract

Objective To describe sexual and reproductive health (SRH) needs of female sex workers (FSWs) to inform the future implementation of pre-exposure prophylaxis (PrEP) for HIV prevention in this population.Design and setting The ANRS 12361 PrEP-CI cross-sectional and mixed-methods study was designed and implemented with two community-based organisations in Côte d’Ivoire.Participants A convenience sample of 1000 FSWs aged ≥18, not known as HIV-positive, completed a standardised questionnaire assessing sociodemographic characteristics, sexual practices, use of community health services and a priori acceptability of PrEP. Twenty-two indepth interviews and eight focus group discussions were also conducted to document FSWs’ risky practices and sexual behaviours, experiences with violence and discrimination, attitudes regarding HIV and sexually transmitted infections (STIs), and barriers to SRH services.Results Although 87% described consistent condom use with clients, more than 22% declared accepting condomless sexual intercourse for a large sum of money. Furthermore, condom use with their steady partner and knowledge of their partner’s HIV status were low despite their acknowledged concurrent sexual partnerships. While inconsistent condom use exposed FSWs to STIs and undesired pregnancies, the prevalence of contraceptive strategies other than condoms was low (39%) due to fear of contraception causing sterility. FSWs faced obstacles to accessing SRH care and preferred advice from their peers or self-medication.Conclusions Despite adoption of preventive behaviour in most cases, FSWs are still highly exposed to HIV. Furthermore, FSWs seem to face several barriers to accessing SRH. Implementing PrEP among FSWs in West Africa, such as in Côte d’Ivoire, constitutes an opportunity to consider the regular follow-up of HIV-negative FSWs. PrEP initiation should not condition access to SRH services; conversely, SRH services could be a way to attract FSWs into HIV prevention. Our results highlight the importance of developing a people-focused approach that integrates all SRH needs when transitioning from PrEP efficacy trials to implementation.

Published
2020
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24. Association of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1–Infected West African Adults With High CD4 Counts

Author

Affi, Roseline, Gabillard, Delphine, Dunyach-Remy, Catherine, Ntakpe, Jean-Baptiste, Moh, Raoul, Badje, Anani, Kouame, Gérard M., Karcher, Sophie, Le Carrou, Jérome, Danel, Christine, Chevalier, Mathieu F., Rouzioux, Christine, Eholie, Serge P., Lavigne, Jean-Philippe, Inwoley, Andre, Anglaret, Xavier, and Weiss, Laurence

Published
2021
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25. Treatment outcomes and associated factors for hospitalization of children treated for acute malnutrition under the OptiMA simplified protocol: a prospective observational cohort in rural Niger

Author

Phelan, Kevin, primary, Seri, Benjamin, additional, Daures, Maguy, additional, Yao, Cyrille, additional, Alitanou, Rodrigue, additional, Aly, Ahmad Ag Mohamed, additional, Maidadji, Oumarou, additional, Sanoussi, Atté, additional, Mahamadou, Aboubacar, additional, Cazes, Cécile, additional, Moh, Raoul, additional, Becquet, Renaud, additional, and Shepherd, Susan, additional

Published
2023
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26. Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

Author

Badje, Anani, Moh, Raoul, Gabillard, Delphine, Guéhi, Calixte, Kabran, Mathieu, Ntakpé, Jean-Baptiste, Le Carrou, Jérôme, Kouame, Gérard-Menan, Ouattara, Eric, Messou, Eugène, Anzian, Amani, Minga, Albert, Gnokoro, Joachim, Gouesse, Patrice, Emieme, Arlette, Toni, Thomas-d'Aquin, Rabe, Cyprien, Sidibé, Baba, Nzunetu, Gustave, Dohoun, Lambert, Abo, Yao, Kamagate, Synali, Amon, Solange, Kouame, Amadou-Barenson, Koua, Aboli, Kouamé, Emmanuel, Daligou, Marcelle, Hawerlander, Denise, Ackoundzé, Simplice, Koule, Serge, Séri, Jonas, Ani, Alex, Dembélé, Fassery, Koné, Fatoumata, Oyebi, Mykayila, Mbakop, Nathalie, Makaila, Oyewole, Babatunde, Carolle, Babatunde, Nathaniel, Bleoué, Gisèle, Tchoutedjem, Mireille, Kouadio, Alain-Claude, Sena, Ghislaine, Yededji, Sahinou-Yediga, Karcher, Sophie, Rouzioux, Christine, Kouame, Abo, Assi, Rodrigue, Bakayoko, Alima, Domoua, Serge-K., Deschamps, Nina, Aka, Kakou, N'Dri-Yoman, Thérèse, Salamon, Roger, Journot, Valérie, Ahibo, Hughes, Ouassa, Timothée, Ménan, Hervé, Inwoley, André, Ndja, Ben-Ahoussi, Adou, Blandine, Kanga, Constance, Aoussi, Eba, Bissagnene, Emmanuel, Ba-Gomis, Olivier, Zike, Yves-Alain, Akakpo, Claude, Sassan-Morokro, Madeleine, Mobio, Max, Doféré, Bamba, Mesmin, Koman, Attia, Alain, Mahassadi, Alassane, Horo, Apollinaire, Oussou, Armel, Chaix, Marie-Laure, Peytavin, Gilles, Koné, Mariatou, N'Guessan, Kouamé, Fassassi, Raïmi, Niangoran, Serge, Desgrées-du-Loû, Annabel, Lert, France, Dray Spira, Rosemary, Jean, Kevin, Konan, Romuald, Bohoussou, Franck, Yao-Yapi, Cyril, N'guessan-Koffi, Larissa, Siloué, Bertine, Cissé, Adoulaye, Aboua, Adrienne, Konan, Sylvie, Kouamé, Antoine, N'Chot, Celestin, Amani, Elvis, Clouet, Gwenaëlle, Debono, Bruno, Chêne, Geneviève, Dosso, Mireille, Girard, Pierre-Marie, Jarlier, Vincent, Masumbuko, Jean-Marie, Perronne, Christian, Sow, Papa-Salif, Danel, Christine, Eholié, Serge-Paul, Anglaret, Xavier, Carrou, Jérôme Le, Kouame, Gérard M, Yao, Abo, Domoua, Serge K, Menan, Hervé, and Eholié, Serge P

Published
2017
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29. Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: experiences and perceptions from health care workers in sub-Saharan Africa and South-East Asia

Author

Joshi, Basant, primary, De Lima, Yara Voss, additional, Massom, Douglas Mbang, additional, Kaing, Sanary, additional, Banga, Marie-France, additional, Kamara, Egerton Tamba, additional, Sesay, Sheriff, additional, Borand, Laurence, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Khosa, Celso, additional, Breton, Guillaume, additional, Mwanga-Amumpaire, Juliet, additional, Bonnet, Maryline, additional, Wobudeya, Eric, additional, Marcy, Olivier, additional, and Orne-Gliemann, Joanna, additional

Published
2023
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30. Effect of Decentralizing Childhood Tuberculosis Diagnosis to Primary Health Center and District Hospital Level - a Pre-Post Study in Six High Tuberculosis Incidence Countries

Author

Wobudeya, Eric, primary, Nanfuka, Mastula, additional, Nguyet, Minh Huyen Ton Nu, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Breton, Guillaume, additional, Khosa, Celso, additional, Borand, Laurence, additional, Mwanga-Amumpaire, Juliet, additional, Mustapha, Ayeshatu, additional, Nolna, Sylvie Kwedi, additional, Komena, Eric Auguste, additional, Mugisha, Jacob Ross, additional, Natukunda, Naome, additional, Dim, Bunnet, additional, De Lauzanne, Agathe, additional, Cumbe, Saniata, additional, Balestre, Eric, additional, Poublan, Julien, additional, Lounnas, Manon, additional, Ngu, Eden, additional, Joshi, Basant, additional, Norval, Pierre-Yves, additional, Terquiem, Etienne Leroy, additional, Turyahabwe, Stavia, additional, Foray, Lynda, additional, Sidibé, Souleymane, additional, Mbassa, Vincent, additional, Manhiça, Ivan, additional, Sekadde, Moorine, additional, Detjen, Anne, additional, Verkuijl, Sabine, additional, Mao, Tan Eang, additional, Orne-Gliemann, Joanna, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, and Group, TBSpeed Decentralization Study, additional

Published
2023
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31. Trends in HIV testing, the treatment cascade, and HIV incidence among men who have sex with men in Africa: A systematic review and meta-regression analysis

Author

Stannah, James, primary, Soni, Nirali, additional, Lam, Jin Keng Stephen, additional, Giguère, Katia, additional, Mitchell, Kate M, additional, Kronfli, Nadine, additional, Larmarange, Joseph, additional, Moh, Raoul, additional, Nouaman, Marcelin N’zebo, additional, Kouamé, Gérard Menan, additional, Maheu-Giroux, Mathieu, additional, and Boily, Marie-Claude, additional

Published
2022
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32. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, primary, Wobudeya, Eric, additional, Font, Hélène, additional, Vessière, Aurélia, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Manon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissani, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric A, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Kheang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James A, additional, Mao, Tan Eang, additional, Graham, Stephen M, additional, Delacourt, Christophe, additional, Borand, Laurence, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, Serre, Angeline, additional, Badrichani, Anne, additional, Razafimanantsoa, Manoa, additional, Poublan, Julien, additional, Roucher, Clémentine, additional, Occelli, Estelle, additional, Beuscart, Aurélie, additional, Charpin, Aurélie, additional, Habiyambere, Gemma, additional, Mesnier, Salomé, additional, Balestre, Eric, additional, Bhatta, Bandana, additional, Maillard, Anne-Laure, additional, Orne-Gliemann, Joanna, additional, Baillet, Emmanuelle, additional, Koskas, Nicolas, additional, D'Elbée, Marc, additional, Gabillard, Delphine, additional, Huyen, Minh, additional, Espérou, Hélène, additional, Couffin-Cadiergues, Sandrine, additional, Kuppers, Alexis, additional, Hamze, Benjamin, additional, BORAND, Laurence, additional, de LAUZANNE, Agathe, additional, DIM, Bunnet, additional, Keang, Chanthy, additional, PRING, Long, additional, YIN, Song, additional, SARITH, Channimol, additional, PHAN, Chanvirak, additional, NHEUONG, Sovann, additional, LY, Socheat, additional, KAING, Sanary, additional, SRENG, Vouchleang, additional, LUN, Elen, additional, SAY, Leakhena, additional, SUOM, Sophea, additional, FERHY, Romyka, additional, SO, Dina, additional, BORN, Sorunna, additional, PAL, Sophea, additional, NANG, Boraneath, additional, MAO, Tan Eang, additional, KIM, Ang, additional, Srey, Viso, additional, Kan, Piseth, additional, Hout, leakhena, additional, Ith, Samnang, additional, Oum, Sophany, additional, Sau, Sokunvadhana, additional, Ho, Kim Heang, additional, Kith, Daronic, additional, Nuch, Nathara, additional, Horm, Chhun Leang, additional, Sophon, Cheameas, additional, Roeungdeth, Bosba, additional, MENG, Chhay, additional, RITH, Ravin, additional, PHY, Samnang, additional, SOR, Chanchetra, additional, SAO, Voleak, additional, KHAT, Sophea, additional, MAK, Bunthoeun, additional, UY, Angkeaborin, additional, KHAY, Sreyny, additional, SOM, Kimsan, additional, HACH, rongvirak, additional, SOK, Hay, additional, KUON, Sotheavy, additional, HENG, Synatt, additional, SENG, Amara, additional, NIM, Sopheak, additional, PAN, Reach, additional, KIM, Srean, additional, SREY LEAP, Keo, additional, NET, Bormey, additional, NOUN, Viccheka, additional, LAY, Daven, additional, MANY, Chhaing, additional, Seng, Socheata, additional, Ly, Vuthy, additional, So, Saran, additional, Oun, Sovutthik, additional, CHEY, Sopheap, additional, CHHEA, Rattany, additional, BAONG, Lydeth, additional, THOUNG, Vanna, additional, KHEANG, Chanrithea, additional, BY, Borady, additional, Nguon, Vathanak, additional, MEACH, Eksophea, additional, Tek, Sopheak, additional, Ngeav, Sina, additional, Lun, Tetra, additional, HEM, Deth, additional, CHUT, Nayreang, additional, SARIK, Setha, additional, NANG, Hgekkoung, additional, MEACH, Mengnean, additional, SRENG, Sopal, additional, SAR, Dara, additional, KIN, Rathana, additional, ROS, Phoran, additional, DORN, Chenda, additional, KAK, Chansy, additional, Sambath, Srey Leak, additional, Son, Leakhena, additional, Bin, Linda, additional, Pengong, Eangnay, additional, Khutsorn, Samnang, additional, Seang, Sorsophea, additional, Soun, Virak, additional, Vong, Vuthy, additional, Khoeung, Chandara, additional, Um, Panha, additional, Bou, Sokunthea, additional, Song Pich, Sarin, additional, Nim, Puthy, additional, Khat, Sopheak, additional, Ban Si, Nuon, additional, Ream, Sovannodom, additional, Ing, Sim, additional, Chann, Phanith, additional, Ngeth, Samrith, additional, Sun, Marina, additional, Chhoeung, Sokea, additional, Sean, Soeun, additional, Prak, Ratanak, additional, Amboua Schouame Onambele, Audrey, additional, Hycenth, Numfor, additional, Melingui, Bernard, additional, Nkembe Medounmga, Angeline, additional, Hougnang Tatmi, Luciole, additional, Etemgoua, Nathalie, additional, Kouesso, Vanessa, additional, Bugin, Jean, additional, Nzedjom, Celestine, additional, Ngoya, Roger, additional, Eyike, Jules, additional, Loudjom, Elyse, additional, Lonsti, Roger, additional, Dang, Ladi, additional, Bintar, Edward, additional, Njayong, Chantal, additional, Ngonsoa O, Cinthia, additional, Ndzeukap, Isabelle, additional, Dzoyem, Pascaline, additional, Dzokou, Clémentine, additional, Dindo, Berthe, additional, Komena, Eric Auguste, additional, Aka Bony, Roger, additional, Kouadio, Christian, additional, Danho, Serge, additional, Goli, Melissa, additional, Folquet, Madeleine, additional, Itchy, Max Valère, additional, Sidibé, Abdel, additional, Cissé, Lancina, additional, Ouattara, Joseph, additional, Konaté, Mamadou, additional, Amon-Tanoh Dick, Flore, additional, Cardena, Melissa, additional, Adonis-Koffi, Laurence, additional, Eugenie, Djabia, additional, Kouamé, Ferdinand, additional, Menan, Hervé, additional, Inwoley, André, additional, Ouassa, Timothée, additional, Nguessan, Marcelle Sandrine, additional, Manhiça, Emelva, additional, Zitha, Alcina, additional, Chiúle, Valter, additional, Muxanga, Eva, additional, Gune, Irene, additional, Lima, Yara, additional, Ribeiro, Jorge, additional, Maxanguana, Felismina, additional, Morais, Natália, additional, Manhiça, Julieta, additional, Give, Josefina, additional, Atumane, Jafito, additional, Lucas, Gelson, additional, Thai, Arsénio, additional, Chave, Adélio, additional, Guambe, Lúcia, additional, Issa, Faiaz, additional, Carneiro, Rosa, additional, Pene, Neusa, additional, Florindo, Natércia, additional, Machel, Dália, additional, Cumbane, Cecília, additional, Mendes, Helena, additional, Kitungwa, Mule, additional, Muianga, Valdo, additional, Tamele, Humberto, additional, Sulude, Adelino, additional, Mabota, Roda, additional, Comandante, Herquéria, additional, Massangaie, Abelardo, additional, Businge, Gerald Bright, additional, Namulinda, Faith, additional, Sserunjogi, Robert, additional, Nassozi, Rashidah, additional, Barungi, Charlotte, additional, Aanyu, Hellen, additional, Muwonge, Doreen, additional, Kagoya, Eva, additional, Aciparu, Serene, additional, Chemutai, Sophia, additional, Ntambi, Samuel, additional, Wasswa, Amir, additional, Nangozi, Juliet, additional, Tagoola, Abner, additional, Kenneth, Sajja, additional, Lubega, John Paul, additional, Nassali, Aidah, additional, Tagobera, Jessica, additional, Agwang, Christine, additional, Kalembe, Florence, additional, Ajambo, Annet, additional, Aguti, Elizabeth, additional, Kasibante, Samuel, additional, Matende, Henry, additional, Odongo, Israel Owen, additional, Mwanga Amumpaire, Juliet, additional, Ngabirano, Gertrude, additional, Kakwenza, Paul, additional, Nuwamanya, Simpson, additional, Nyangoma, Miria, additional, Nabbuto, Jane, additional, Abok, Florence, additional, Arinaitwe, Rinah, additional, Birungi, Diana, additional, Mwesigwa, Evans, additional, Atwine, Daniel, additional, Mbega, Hassan, additional, Orikiriza, Patrick, additional, Taremwa, Ivan, additional, Turyashemererwa, Esther, additional, Derrick, Hope, additional, Nyehangane, Dan, additional, Kaitano, Rodney, additional, Logoose, Susan, additional, Businge, Steven, additional, Ntambi, Charles, additional, Mugabi, Jerome, additional, Mzee, John, additional, Besigye, Julius, additional, Kanzira, Saul, additional, Turyatemba, Phionah, additional, Twebaze, Florence, additional, Hambulo, Chimuka, additional, Kapotwe, Vincent, additional, Ngambi, Marjory, additional, Kasakwa, Kunda, additional, Kapula, Chifunda, additional, Zulu, Susan, additional, Nawakwi, Grace, additional, Siasulingana, Teddy, additional, Chilonga, Jessy, additional, Chimbini, Maria, additional, Chilanga, Mutinta, additional, Inambao, Muleya, additional, Mwambazi, Mwate, additional, Halende, Barbra, additional, Mumba, Wyclef, additional, Mankunshe, Endreen, additional, Silavwe, Maureen, additional, Chakopo, Moses, additional, and Moono, Roy, additional

Published
2022
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34. Notes de politique

Author

Larmarange, Joseph, Amani Elvis, Georges, Badiane, Kéba, Bayac, Céline, Bekelynck, Anne, Boily, Marie-Claude, Boye, Sokhna, Breton, Guillaume, d’Elbée, Marc, Desclaux, Alice, Desgrées du Loû, Annabel, Diop Papa, Moussa, Doumenc-Aïdara, Clémence, Ehui, Eboi, Jean, Kévin, Keita, Abdelaye, Kouadio Brou, Alexis, Kouassi Kra, Arsène, Ky-Zerbo, Odette, Maheu-Giroux, Mathieu, Medley, Graham, Moh, Raoul, Ndour Cheikh, Tidiane, Pourette, Dolorès, Rouveau, Nicolas, Silhol, Romain, Simo Fotso, Arlette, Terris-Prestholt, Fern, Traore Métogara, Mohamed, Vautier, Anthony, Diallo, Sanata, Gueye Papa, Alioune, Geoffroy, Olivier, Kabemba Odé, Kanku, Abokon, Armand, Anoma, Camille, Diokouri, Annie, Kouame, Blaise, Kouakou, Venance, Koffi, Odette, Kpolo, Alain-Michel, Tety, Josiane, Traore, Yacouba, Bagendabanga, Jules, Berthé, Djelika, Diakite, Daouda, Diakité, Mahamadou, Diallo, Youssouf, Daouda, Minta, Hessou, Septime, Kanambaye, Saidou, Kanoute Abdul, Karim, Keita Dembele, Bintou, Koné, Dramane, Koné, Mariam, Maiga, Almoustapha, Nouhoum, Telly, Sanogo, Abdoulaye, Saran Keita, Aminata, Sidibé, Fadiala, Tall, Madani, Yattassaye Camara, Adam, Bâ, Idrissa, Diallo Papa Amadou, Niang, Fall, Fatou, Guèye Ndèye Fatou, Ngom, Ndiaye Sidy, Mokhtar, Niang Alassane, Moussa, Samba, Oumar, Thiam, Safiatou, Turpin Nguissali, M.E., Bouaré, Seydou, Camara Cheick, Sidi, Eponon Ehua, Agnes, Kouvahe, Amélé, Montaufray, Marie-Anne, Mosso, Rosine, Ndeye Pauline, Dama, Sarrassat, Sophie, Sow, Souleymane, Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Solidarité thérapeutique & initiatives contre le sida (SOLTHIS), Imperial College London, London School of Hygiene and Tropical Medicine (LSHTM), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Programme National de Lutte contre le Sida [Abidjan, Côte d'Ivoire] (PNLS), Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut National de Recherche en Santé Publique [Bamako] (INRSP), Institut d'ethnologie méditerranéenne, européenne et comparative (IDEMEC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Division de Lutte contre le Sida et les IST (DLSI), Ministère de la Santé et de la Prévention, Fondation Ariel Glaser pour la lutte contre le SIDA Pédiatrique, Espace Confiance [Abidjan, Côte d’Ivoire], Heartland Alliance, Aprosam, Ruban Rouge, Blety, Orasur, FHI 360, PSI, CNLS, Dayanaso, CSLS/MSHP, Comité scientifique VIH du Mali, Plan Mali, ARCAD Santé PLUS [Bamako, Mali], AKS Mali, Amprode Sahel, Soutoura, CEPIAD, Comité National de Lutte contre le Sida du Sénégal (CNLS), Ministère de la santé-CNLS, CTA, ENDA Santé, Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA), Unitaid ATLAS, Institut de recherche pour le développement, Solthis, and ATLAS (Unitaid)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, [SHS.DEMO]Humanities and Social Sciences/Demography, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Published
2022

35. ANRS 12381 PRINCESSE : PrEP, infections sexuellement transmissibles, contraception, hépatite virale B, santé sexuelle pour les travailleuses du sexe en Côte d’Ivoire

Author

Eholié, Serge, Larmarange, Joseph, Ben Mechlia, Mohamed, Mercier, Noémie, Nouaman, Marcellin, Coffie, Patrick, Yao, Cyril, Agoua, Aline, Zébago, Clémence, Zonhoulou, Dao Guy Hervé, Kessé, Ervé Gboh, Anvo, Kakou Pierre, Anglaret, Xavier, Anoma, Camille, Attia, Alain, Banga, Marie-France, Becquet, Valentine, Bébéar, Cécile, Berçot, Béatrice, Boyd, Anders, Calvez, Vincent, Freedberg, Kenneth, Jary, Aude, Kissi, Evelyne, Lacombe, Karine, Leducq, Valentin, Marcelin, Anne-Geneviève, Moh, Raoul, Plazy, Mélanie, Teyssou, Elisa, Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Institut national d'études démographiques (INED), Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS), Aprosam, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Espace Confiance [Abidjan, Côte d’Ivoire], Centre Hospitalier Universitaire de Yopougon [Abidjan, Côte d'Ivoire] (CHU de Yopougon), Université de Bordeaux (UB), Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Harvard School of Public Health, ANRS 12381 PRINCESSE, ANRS, and Institut de Recherche pour le Développement (IRD)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, [SHS.DEMO]Humanities and Social Sciences/Demography
Published
2022

37. Additional file 1 of Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial

Author

Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying, Mvalo, Tisungane, Magallhaes, Justina, Buck, W. Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala, and Mujuru, Hilda Angela

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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38. Additional file 1 of Cost-utility analysis of four WHO-recommended sofosbuvir-based regimens for the treatment of chronic hepatitis C in sub-Saharan Africa

Author

Boyer, Sylvie, Baudoin, Ma��l, Nishimwe, Marie Lib��r��e, Santos, Melina, Lemoine, Maud, Maradan, Gwena��lle, Sylla, Babacar, Kouanfack, Charles, Carrieri, Patrizia, Mourad, Abbas, Rouveau, Nicolas, Moh, Raoul, Seydi, Moussa, Attia, Alain, Woode, Maame Esi, and Lacombe, Karine

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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41. Impact of Systematic Tuberculosis Detection on Mortality in Young Children with Severe Pneumonia in High Tuberculosis Incidence Countries – A Stepped Wedge Cluster Randomized Trial

Author

Marcy, Olivier, primary, Font, Hélène, additional, Vessière, Aurelia, additional, Borand, Laurence, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Mannon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissany, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric Auguste, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Keang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James, additional, Mao, Tan Eang, additional, Graham, Stephen M., additional, Delacourt, Christophe, additional, Wobudeya, Eric, additional, Bonnet, Maryline, additional, and Group, TB-Speed Pneumonia Study, additional

Published
2022
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44. Virological failure and drug resistance in West African HIV-infected adults who started ART immediately or deferred ART initiation

Author

Gabillard, Delphine, N'Takpe, Jean-Baptiste, Chaix, Marie Laure, KOUAME, Menan Gerard, Moh, Raoul, Toni, Thomas D'Aquin, LE CARROU, Jerome, Karcher, Sophie, BADJE, Anani, Emieme, Arlette, MENAN, Herve, Danel, Christine, Anglaret, Xavier, Eholie, Serge Paul, TEMPRANO, Anrs Study Group, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

BACKGROUND: Asymptomatic HIV-infected people who start ART early may feel less motivated and neglect compliance. This might promote the emergence of resistance. METHODS: In the Temprano trial, ART-naive HIV-infected adults with high CD4 counts were randomly assigned to start ART immediately (immediate group) or defer ART until the WHO criteria were met (deferred group). All participants were monitored for 30 months. Those in the deferred group who started ART were monitored for longer, until they had completed 30 months on ART. We compared the rate of virological failure and drug resistance between the immediate and deferred groups 30 months after ART initiation. RESULTS: Of the 2056 participants in Temprano, 1033 were assigned to start ART immediately and 1023 to defer ART. Of the latter, 488 started ART during trial follow-up. Patients in the deferred group who started ART had a lower median CD4 count (280 versus 465 cells/mm3) and a higher median plasma HIV-1 RNA (5.1 versus 4.7 log10 copies/mL) at baseline. During follow-up, participants in both groups had similar antiretroviral drug exposure. Thirty months after ART initiation, patients in the deferred group had a higher rate of virological failure (35.3% versus 29.9%, P = 0.04) and a lower genotypic susceptibility score (P = 0.04). CONCLUSIONS: Starting ART early decreases the risk of virological failure and drug resistance in the medium term. This benefit is of particular importance in countries where access to viral load monitoring and the number of antiretroviral drug lines is limited.

Published
2021
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45. Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-Infected Infants with Severe Pneumonia: Study Protocol for a Multicenter, an Open-Label Randomized Controlled Clinical Trial

Author

Tagarro, Alfredo, primary, Moraleda, Cinta, additional, Dominguez, Sara, additional, Tam, Pui-Ying Iroh, additional, Buck, Christopher William, additional, Mujuru, Hilda Angela, additional, Musiime, Victor, additional, Sacarlal, Jahit, additional, Chabala, Chishala, additional, Leroy, Valerianne, additional, Bassat, Quique, additional, Marcy, Olivier, additional, Bates, Matthew, additional, Magallhaes, Justina, additional, Burger, David, additional, Nardone, Alessandra, additional, Moh, Raoul, additional, Mvalo, Tisungane, additional, Madrid, Lola, additional, Manukyan, Lilit, additional, Sancho, Aranzazu, additional, Prieto, Luis Manuel, additional, and Rojo, Pablo, additional

Published
2021
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46. Elite and viremic HIV-1 controllers in West Africa

Author

N’takpé, Jean Baptiste, primary, Gabillard, Delphine, additional, Moh, Raoul, additional, Gardiennet, Elise, additional, Toni, Thomas-d’Aquin, additional, Kouame, Gérard M., additional, Badje, Anani, additional, Emieme, Arlette, additional, Karcher, Sophie, additional, Le Carrou, Jérome, additional, Ménan, Hervé, additional, Danel, Christine, additional, Eholie, Serge P., additional, Rouzioux, Christine, additional, Anglaret, Xavier, additional, and Lambotte, Olivier, additional

Published
2021
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48. Anthropometric and immunological success of antiretroviral therapy and prediction of virological success in west African adults/Succes sur les plans anthropometrique et immunologique du traitement antiretroviral et prediction de son succes virologique chez les adultes d'Afrique de I'Ouest/Eficacia antropometrica e inmunologica de la terapia antirretroviral y prediccion de la eficacia virologica en adultos de Africa occidental

Author

Messou, Eugene, Gabillard, Delphine, Moh, Raoul, Inwoley, Andre, Sorho, Souleymane, Eholie, Serge, Rouet, Francois, Seyler, Catherine, Danel, Christine, and Anglaret, Xavier

Subjects
Highly active antiretroviral therapy -- Research, Anti-HIV agents -- Usage, Anti-HIV agents -- Dosage and administration, Antiviral agents -- Usage, Antiviral agents -- Dosage and administration, HIV patients -- Prognosis, HIV patients -- Care and treatment
Abstract

Objective The 6 month assessment of the response to antiretroviral therapy (ART) is a critical step. In sub-Saharan Africa, few people have access to plasma viral-load measurement. We assessed the gain or loss in body mass index (BMI), alone or in combination with the gain or loss in CD4+ T-cell count (CD4), as a tool for predicting the response to ART. Methods In a cohort of 622 adults in Abidjan, Cote d&apos;Ivoire, we calculated the sensitivity, specificity and predictive values of BMI and CD4 for treatment success defined as viral-load undetectability (< 300 copies/ml) as gold standard. Findings After 6 months of ART, the median change in BMI was an increase of 1.0 kg/[m.sup.2] (interquartile range, IQR: 0.0-2.1), the median change in CD4 an increase of 148/[micro]l (IQR: 54-230) and 84% of patients reached viral-load undetectability. The distribution of change in BMI was similar among patients who reached undetectability and those who dial not (increases of 1.06 kg/[m.sup.2] versus 0.99 kg/[m.sup.2], P = 0.51). With larger changes in BMI, the specificity for treatment success increased but its sensitivity decreased and its positive predictive value was stable around 85%. AII results remained similar when combining changes in BMI with those in CD4 and when stratifying by groups of baseline BMI or CD4. Conclusion In settings where viral-load measurement is not available, a high BMI gain does not reflect virological success, even when combined with a high CD4 gain. In our population, most patients with detectable viral-load had probably adhered to the drug regimen sufficiently to reach significant gains in body mass and CD4 count but had adhered insufficiently to reach viral suppression. Resume Objectif L&apos;evaluation sur 6 mois de la reponse au traitement antiretroviral (ART) est une etape critique. En Afrique subsaharienne, peu de personnes ont acces a la mesure de la charge virale plasmatique. Nous avons evalue le gain ou la perte d&apos;indice de masse corporelle (IMC), isolement ou en association avec le gain ou la perte de cellules T CD4+ (CD4), en tant qu&apos;outils pour predire la reponse au traitement ART. Methodes Parmi une cohorte de 622 adultes d&apos;Abidjan, en Cote d&apos;lvoire, nous avons calcule la sensibilite, la specificite et les valeurs predictives de I&apos;IMC et des CD4 pour le succes du traitement, defini comme l&apos;impossibilite de detecter une charge virale (< 300 copies/ml), a titre normatif. Resultats Apres 6 mois de traitement ART, on obtenait comme valeur mediane de la variation de I&apos;IMC une augmentation de 1,0 kg/[m.sup.2] (intervalle interquartile, IIQ : 0,0-2,1) et comme mediane de la variation des CD4 une augmentation de 148/pl (IIQ : 54-230), ainsi qu&apos;une indetectabilite de la charge virale chez 84 % des patients. La distribution de la variation de I&apos;IMC etait similaire chez les patients ayant atteint I&apos;indetectabilite et chez ceux ne I&apos;ayant pas atteint (augmentation de 1,06 kg/[m.sup.2] au lieu de 0,99 kg/[m.sup.2], p < 0,51). Lorsque la variation de I&apos;IMC augmente, sa specificite a I&apos;egard du succes therapeutique diminue et sa valeur predictive positive reste stable autour de 85 %. Les resultats ne varient guere Iorsqu&apos;on combine les variations de I&apos;IMC, dans leur ensemble, et celles des CD4 et qu&apos;on opere une stratification par groupes d&apos;IMC ou de CD4 de depart. Conclusion Dans les situations ou I&apos;on ne dispose pas de mesure de la charge virale, un fort gain d&apos;IMC n&apos;implique pas un succes virologique, meme s&apos;il s&apos;accompagne d&apos;une importante elevation des CD4. Dans la population etudiee, la plupart des patients presentant une charge virale detectable avaient probablement respecte assez longtemps le schema therapeutique pour beneficier d&apos;augmentations notables de la masse corporelle et de la numeration des CD4, mais pas suffisamment pour atteindre la suppression virale. Resumen Objetivo La evaluacion a los 6 meses de la respuesta a la terapia antirretroviral (TAR) es una medida esencial, pero en el Africa subsahariana son muy pocas las personas con acceso a analisis de la carga viral en plasma. Evaluamos el aumento o disminucion del indice de masa corporal (IMC), aisladamente o en combinacion con el aumento o disminucion del recuento de linfocitos T CD4+ (CD4), como estrategia para predecir la respuesta a la TAR. Metodos En una cohorte de 622 adultos de Abidjan, Cote d&apos;lvoire, calculamos la sensibilidad, la especificidad y los valores predictivos del IMC y los niveles de CD4 como indicadores de la eficacia terapeutica, definida como una carga viral indetectable (< 300 copias/ml). Resultados A los 6 meses de iniciada la TAR, el IMC mediano habia aumentado en 1,0 kg/[m.sup.2] (intervalo intercuartilico, IIC: 0,0-2,1) y el nivel mediano de CD4, en 148/[micro]l (IIC: 54-230), y la carga viral habia pasado a ser indetectable en un 84% de los pacientes. La distribucion de la variacion del IMC fue similar en los pacientes que alcanzaron niveles indetectables y en los demas (aumento de 1,06 kg/[m.sup.2] frente a 0,99 kg/[m.sup.2], p = 0,51). Conforme aumentaba la variacion del IMC, la especificidad respecto de la eficacia terapeutica aumentaba, pero su sensibilidad disminuia, y su valor predictivo positivo se mantenia estable, en torno al 85%. Se obtenian siempre resultados similares al combinar distintos cambios del IMC y del recuento de CD4, asi como al estratificar los grupos en funcion de los valores basales de IMC o CD4. Conclusion En los entornos donde no es posible medir la carga viral, un gran aumento del IMC no refleja la eficacia virologica, aun cuando se combine con un incremento importante de los niveles de CD4. En la poblacion aqui estudiada, la mayoria de los pacientes con carga viral detectable probablemente habian seguido el tratamiento en la medida suficiente para conseguir aumentos importantes de la masa corporal y del recuento de CD4, pero no en la medida necesaria para lograr la supresion viral. [TEXT NOT REPRODUCIBLE IN ASCII.], Introduction International guidelines recommend that plasma viral load undetectability should be reached within the first 6 months of antiretroviral therapy (ART). (1) In patients with plasma viral load still detectable [...]

Published
2008

49. Mortality in relation to hepatitis B virus (HBV) infection status among HIV-HBV coinfected patients in sub-Saharan Africa after immediate initiation of antiretroviral therapy Running head: HBV profiles and mortality in HIV

Author

Kouamé, Gérard Menan, Mohareb, Amir, Gabassi, Audrey, Gabillard, Delphine, Moh, Raoul, Badjé, Anani, Emiene, Arlette, Maylin, Sarah, Menam, Herve, Hyle, Emily, Delaugerre, Constance, Danel, Christine, Anglaret, Xavier, Lacombe, Karine, Eholié, Serge, Boyd, Anders, Infectious diseases in lower-income countries [Bordeaux] (IDLIC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard Medical School [Boston] (HMS), Laboratoire de Virologie [CHU Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the Agence Nationale de Rercheches sur le SIDA et les hépatites virales (ANRS), Paris, France.GMK also received doctoral funding from the ANRS. AMM received funding from National Institutes of Health NIAID T32AI007433and NIAID R37AI058736.EPH received funding from National Institutes of Health NHLBIK01HL123349., Gestionnaire, HAL Sorbonne Université 5, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)

Subjects
Hepatitis B virus, Sub‐Saharan Africa, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, virus diseases, HIV, CD4+ cell count, Mortality, digestive system diseases
Abstract

International audience; It is unknown how past and active hepatitis B virus (HBV) infection affect immunorecovery and mortality in people with HIV who initiate tenofovir‐based antiretroviral therapy (ART). Using data collected between 2008 and 2015, we studied people with HIV in sub‐Saharan Africa initiating immediate ART in the Temprano randomized control trial. We classified participants into HBV groups at ART initiation: hepatitis B surface antigen (HBsAg)‐positive with HBV DNA ≥ 2,000 IU/ml; HBsAg‐positive with HBV DNA < 2,000 IU/ml; isolated HBcAb‐positive; resolved infection (HBsAb‐positive/HBcAb‐positive); and HBV non‐immune/vaccinated (HBcAb‐negative). We compared square‐root CD4‐cell count increases using mixed‐effect, non‐linear regression adjusted for age, sex, baseline CD4 cell count, and HIV RNA. We compared all‐cause mortality using Bayesian parametric survival regression. Among 879 participants, 24 (2.7%) had HBsAg with high HBV DNA, 76 (8.6%) HBsAg with low HBV DNA, 325 (37.0%) isolated anti‐HBcAb, 226 (25.7%) resolved HBV infection and 228 (25.9%) HBV non‐immune/vaccinated. We found no significant difference in CD4 cell increases between HBV‐infection groups after adjustment (p = 0.16). Participants with HBsAg and high HBV DNA had the highest incidence of all‐cause mortality (1.9/100 person‐years, 95% Credibile Interval [CrI] = 1.0–3.4). By comparison, incidence rates of mortality were reduced by 57% (95%CrI = −79%, −13%), 60% (95%CrI = −82%, −12%) and 66% (95%CrI = −84%, −23%) in those who had isolated anti‐HBcAb‐positive, resolved HBV infection and HBV non‐immune/vaccinated, respectively. In conclusion, individuals with HIV and past HBV infection or isolated anti‐HBcAb‐positive serology, much like HBV non‐immune/vaccinated, experience lower mortality than those with HBsAg and high HBV DNA. Additional HBV‐related management would not be necessary for these individuals.

Published
2020
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50. Décrire, analyser et comprendre les effets de l’introduction de l’autodépistage du VIH en Afrique de l’Ouest à travers l’exemple du programme ATLAS en Côte d’Ivoire, au Mali et au Sénégal: Protocole de Recherche · Version 3.0 du 8 octobre 2020

Author

Larmarange, Joseph, Rouveau, Nicolas, Boily, Marie-Claude, Desclaux, Alice, Pourette, Dolorès, Abdelaye, Keita, Badiane, Kéba, Bayac, Céline, Bekelynck, Anne, Boye, Sokhna, Breton, Guillaume, Desgrées du Loû, Annabel, d’Elbée, Marc, Doumenc-Aïdara, Clémence, Jean, Kévin, Kouassi Kra, Arsène, Ky-Zerbo, Odette, Maheu-Giroux, Mathieu, Moh, Raoul, Moussa Diop, Papa, Paltiel, David, Eboi, Ehui, Ndour Cheikh, Tidiane, Silhol, Romain, Simo Fotso, Arlette, Terris-Prestholt, Fern, Traore Métogara, Mohamed, Vautier, Anthony, Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Imperial College London, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut National de Recherche en Santé Publique [Bamako] (INRSP), Solidarité thérapeutique & initiatives contre le sida (SOLTHIS), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, London School of Hygiene and Tropical Medicine (LSHTM), Centre d'enseignement Cnam Paris (CNAM Paris), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), McGill University = Université McGill [Montréal, Canada], Yale University [New Haven], Programme National de Lutte contre le Sida [Abidjan, Côte d'Ivoire] (PNLS), Division de Lutte contre le Sida et les IST (DLSI), Ministère de la Santé et de la Prévention, Unitaid ATLAS, Institut de Recherche pour le Développement, and ATLAS (Unitaid)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, [SHS.DEMO]Humanities and Social Sciences/Demography, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract

Research component of the ATLAS programmeThe ATLAS programme (2019-2021) aims to promote and deploy HIV self-testing (HIVST) in Côte d'Ivoire, Mali and Senegal and to distribute half a million HIVST through various delivery channels, targeting in particular key populations (sex workers, men who have sex with men, drug users), partners of people living with HIV (PLHIV) and patients with sexually transmitted infections. The dispensation of HIVST will be carried out in routine care, through the three countries' national AIDS strategies and in an integrated manner with existing screening policies, through eight delivery channels combining fixed and advanced strategies, primary distribution and secondary distribution. The research component presented here includes a set of observational surveys to describe, analyze and understand the social, health, epidemiological and economic effects of the introduction of HIVST in Côte d'Ivoire, Mali and Senegal to improve testing offer (accessibility, effectiveness and ethics). It is organized into 5 work packages: (i) a qualitative survey on HIVST targeted key populations, based on qualitative individual and group interviews with key implementers, members of key population communities and HIVST users; (ii) an ethnography on the integration of HIVST for screening of PLHIV’s partners in three HIV care clinics and an exploratory sub-survey on HIVST distribution in STI consultations; (iii) an anonymous telephone survey of HIVST users recruited through an invitation on HIVST kits to call a toll-free number; (iv) an economic survey of HIVST incremental costs with cost collections from a sample of HIVST dispensing sites and a time and motion study; (v) an epidemiological modelling (dynamic compartmental model) of the three countries and of the health and economic impacts of different scaling scenarios.; Volet recherche du programme ATLASLe programme ATLAS (2019-2021) vise à promouvoir et à déployer l’autodépistage du VIH (ADVIH) en Côte d’Ivoire, au Mali et au Sénégal et prévoit la distribution d’un demi millions d’autotests à travers différents canaux de dispensation, visant en particulier les populations clés (travailleuses du sexe, hommes ayant des rapports sexuels avec des hommes, usager·e·s de drogues), les partenaires des personnes vivant avec le VIH (PvVIH) et les patient·e·s atteint·e·s d’une infection sexuellement transmissible. La dispensation des kits d’ADVIH sera réalisée en soins courants, dans le cadre des stratégies nationales de lutte contre le sida des trois pays et de manière intégrée aux politiques de dépistage déjà en place, à travers huit canaux de dispensation combinant des stratégies fixes et des stratégies avancées, une distribution primaire et une distribution secondaire. Le volet recherche présenté ici comporte un ensemble d’enquêtes observationnelles visant à décrire, analyser et comprendre les effets sociaux, sanitaires, épidémiologiques et économiques de l’introduction de l’autodépistage du VIH en Côte d’Ivoire, au Mali et au Sénégal pour améliorer l’offre de dépistage (accessibilité, efficacité et éthique). Il est organisé en 5 paquets d’activités : (i) une enquête qualitative sur l’ADVIH auprès des populations clés reposant sur des entretiens qualitatifs individuels et de groupes auprès d’acteurs clés de la mise en œuvre, de membres des communautés de populations clés et d’utilisatrices et utilisateurs de l’ADVIH ; (ii) une ethnographie portant sur l’intégration de l’ADVIH pour le dépistage des partenaires de PvVIH dans trois sites de prise en charge du VIH et une sous enquête exploratoire portant sur la diffusion de l’ADVIH à travers les consultations IST ; (iii) une enquête téléphonique anonyme auprès des utilisatrices et utilisateurs de l’ADVIH recruté·e·s via une invitation à appeler un numéro vert apposée sur les kits d’ADVIH distribués ; (iv) une enquête économique des coûts incrémentiels de l’ADVIH avec une collecte des coûts auprès d’un échantillon de sites de dispensation de l’ADVIH et une étude des temps et mouvements ; (v) une modélisation épidémiologique (modèle compartimental dynamique) des trois pays et des impacts sanitaires et économiques de différents scénarios de passage à l’échelle.

Published
2020

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