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24 results on '"Moeller, Rebecca A."'

1. O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

Author

Ciraku, Lorela, Bacigalupa, Zachary A., Ju, Jing, Moeller, Rebecca A., Le Minh, Giang, Lee, Rusia H., Smith, Michael D., Ferrer, Christina M., Trefely, Sophie, Izzo, Luke T., Doan, Mary T., Gocal, Wiktoria A., D’Agostino, Luca, Shi, Wenyin, Jackson, Joshua G., Katsetos, Christos D., Wellen, Kathryn E., Snyder, Nathaniel W., and Reginato, Mauricio J.

Published
2022
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2. Fluvastatin mitigates SARS-CoV-2 infection in human lung cells

Author

Zapatero-Belinchón, Francisco J., Moeller, Rebecca, Lasswitz, Lisa, van Ham, Marco, Becker, Miriam, Brogden, Graham, Rosendal, Ebba, Bi, Wenjie, Carriquí-Madroñal, Belén, Islam, Koushikul, Lenman, Annasara, Gunesch, Antonia P., Kirui, Jared, Pietschmann, Thomas, Överby, Anna K., Jänsch, Lothar, and Gerold, Gisa

Published
2021
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5. Supp Materials and Methods from A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Author

Barnoud, Thibaut, primary, Leung, Jessica C., primary, Leu, Julia I-Ju, primary, Basu, Subhasree, primary, Poli, Adi Narayana Reddy, primary, Parris, Joshua L.D., primary, Indeglia, Alexandra, primary, Martynyuk, Tetyana, primary, Good, Madeline, primary, Gnanapradeepan, Keerthana, primary, Sanseviero, Emilio, primary, Moeller, Rebecca, primary, Tang, Hsin-Yao, primary, Cassel, Joel, primary, Kossenkov, Andrew V., primary, Liu, Qin, primary, Speicher, David W., primary, Gabrilovich, Dmitry I., primary, Salvino, Joseph M., primary, George, Donna L., primary, and Murphy, Maureen E., primary

Published
2023
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6. Supplemental Figures from A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Author

Barnoud, Thibaut, primary, Leung, Jessica C., primary, Leu, Julia I-Ju, primary, Basu, Subhasree, primary, Poli, Adi Narayana Reddy, primary, Parris, Joshua L.D., primary, Indeglia, Alexandra, primary, Martynyuk, Tetyana, primary, Good, Madeline, primary, Gnanapradeepan, Keerthana, primary, Sanseviero, Emilio, primary, Moeller, Rebecca, primary, Tang, Hsin-Yao, primary, Cassel, Joel, primary, Kossenkov, Andrew V., primary, Liu, Qin, primary, Speicher, David W., primary, Gabrilovich, Dmitry I., primary, Salvino, Joseph M., primary, George, Donna L., primary, and Murphy, Maureen E., primary

Published
2023
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7. The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication

Author

Lasswitz, Lisa, primary, Zapatero-Belinchón, Francisco J., additional, Moeller, Rebecca, additional, Hülskötter, Kirsten, additional, Laurent, Timothée, additional, Carlson, Lars-Anders, additional, Goffinet, Christine, additional, Simmons, Graham, additional, Baumgärtner, Wolfgang, additional, and Gerold, Gisa, additional

Published
2022
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11. An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth

Author

Ciraku, Lorela, Moeller, Rebecca A., Esquea, Emily M., Gocal, Wiktoria A., Hartsough, Edward J., Simone, Nicole L., Jackson, Joshua G., and Reginato, Mauricio J.

Subjects
Mice, Brain Neoplasms, Tumor Microenvironment, Animals, Brain, Mice, Nude, Female, Nervous System Physiological Phenomena, Luciferases, Article
Abstract

Brain metastasis is a serious consequence of breast cancer for women as these tumors are difficult to treat and are associated with poor clinical outcomes. Preclinical mouse models of breast cancer brain metastatic (BCBM) growth are useful but are expensive, and it is difficult to track live cells and tumor cell invasion within the brain parenchyma. Presented here is a protocol for ex vivo brain slice cultures from xenografted mice containing intracranially injected breast cancer brain-seeking clonal sublines. MDA-MB-231BR luciferase tagged cells were injected intracranially into the brains of Nu/Nu female mice, and following tumor formation, the brains were isolated, sliced, and cultured ex vivo. The tumor slices were imaged to identify tumor cells expressing luciferase and monitor their proliferation and invasion in the brain parenchyma for up to 10 days. Further, the protocol describes the use of time-lapse microscopy to image the growth and invasive behavior of the tumor cells following treatment with ionizing radiation or chemotherapy. The response of tumor cells to treatments can be visualized by live-imaging microscopy, measuring bioluminescence intensity, and performing histology on the brain slice containing BCBM cells. Thus, this ex vivo slice model may be a useful platform for rapid testing of novel therapeutic agents alone or in combination with radiation to identify drugs personalized to target an individual patient's breast cancer brain metastatic growth within the brain microenvironment.

Published
2021

13. Abstract 86: O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

Author

Ciraku, Lorela, primary, Bacigalupa, Zachary, additional, Moeller, Rebecca, additional, Ju, Jing, additional, Lee, Rusia H., additional, Ferrer, Christina, additional, Trefely, Sophie, additional, Snyder, Nathaniel W., additional, D'Agostino, Luca, additional, Katsetos, Christos D., additional, Shi, Wenyin, additional, and Reginato, Mauricio J., additional

Published
2021
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14. O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

Author

Ciraku, Lorela, primary, Bacigalupa, Zachary A., additional, Ju, Jing, additional, Moeller, Rebecca A., additional, Lee, Rusia H., additional, Smith, Michael D., additional, Ferrer, Christina M., additional, Trefely, Sophie, additional, Doan, Mary T., additional, Gocal, Wiktoria A., additional, D’Agostino, Luca, additional, Shi, Wenyin, additional, Jackson, Joshua G., additional, Katsetos, Christos D., additional, Snyder, Nathaniel W., additional, and Reginato, Mauricio J., additional

Published
2021
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15. A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Author

Barnoud, Thibaut, primary, Leung, Jessica C., additional, Leu, Julia I-Ju, additional, Basu, Subhasree, additional, Poli, Adi Narayana Reddy, additional, Parris, Joshua L.D., additional, Indeglia, Alexandra, additional, Martynyuk, Tetyana, additional, Good, Madeline, additional, Gnanapradeepan, Keerthana, additional, Sanseviero, Emilio, additional, Moeller, Rebecca, additional, Tang, Hsin-Yao, additional, Cassel, Joel, additional, Kossenkov, Andrew V., additional, Liu, Qin, additional, Speicher, David W., additional, Gabrilovich, Dmitry I., additional, Salvino, Joseph M., additional, George, Donna L., additional, and Murphy, Maureen E., additional

Published
2020
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16. Cholesterol sensing by CD81 is important for hepatitis C virus entry

Author

Palor, Machaela, primary, Stejskal, Lenka, additional, Mandal, Piya, additional, Lenman, Annasara, additional, Alberione, María Pía, additional, Kirui, Jared, additional, Moeller, Rebecca, additional, Ebner, Stefan, additional, Meissner, Felix, additional, Gerold, Gisa, additional, Shepherd, Adrian J., additional, and Grove, Joe, additional

Published
2020
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17. Effect of statins on SARS-CoV-2 infection

Author

Moeller, Rebecca, primary, Zapatero-Belinchón, Francisco J., additional, Lasswitz, Lisa, additional, Kirui, Jared, additional, Brogden, Graham, additional, Gunesch, Antonia P., additional, Pietschmann, Thomas, additional, Wichmann, Dominic, additional, Kluge, Stefan, additional, and Gerold, Gisa, additional

Published
2020
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18. Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses

Author

Uckeley, Zina M., primary, Moeller, Rebecca, additional, Kühn, Lars I., additional, Nilsson, Emma, additional, Robens, Claudia, additional, Lasswitz, Lisa, additional, Lindqvist, Richard, additional, Lenman, Annasara, additional, Passos, Vania, additional, Voss, Yannik, additional, Sommerauer, Christian, additional, Kampmann, Martin, additional, Goffinet, Christine, additional, Meissner, Felix, additional, Överby, Anna K., additional, Lozach, Pierre-Yves, additional, and Gerold, Gisa, additional

Published
2019
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19. C-Type Lectin Receptor (CLR)-Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Isolates

Author

Mayer, Sabine, Moeller, Rebecca, Monteiro, João T, Ellrott, Kerstin, Josenhans, Christine, Lepenies, Bernd, and TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.

Subjects
Campylobacter jejuni, flow cytometry, ELISA assay, C-type lectin receptors, confocal microscopy, screening tools, innate immunity, Dectin-1 receptor
Abstract

C-type lectin receptors (CLRs) are carbohydrate-binding receptors that recognize their ligands often in a Ca2+-dependent manner. Upon ligand binding, myeloid CLRs in innate immunity trigger or inhibit a variety of signaling pathways, thus initiating or modulating effector functions such as cytokine production, phagocytosis, and antigen presentation. CLRs bind to various pathogens, including viruses, fungi, parasites, and bacteria. The bacterium Campylobacter jejuni (C. jejuni) is a very frequent Gram-negative zoonotic pathogen of humans, causing severe intestinal symptoms. Interestingly, C. jejuni expresses several glycosylated surface structures, for example, the capsular polysaccharide (CPS), lipooligosaccharide (LOS), and envelope proteins. This “Methods” paper describes applications of CLR–Fc fusion proteins to screen for yet unknown CLR/bacteria interactions using C. jejuni as an example. ELISA-based detection of CLR/bacteria interactions allows a frst prescreening that is further confrmed by flow cytometry-based binding analysis and visualized using confocal microscopy. By applying these methods, we identifed Dectin-1 as a novel CLR recognizing two selected C. jejuni isolates with different LOS and CPS genotypes. In conclusion, the heredescribed applications of CLR–Fc fusion proteins represent useful methods to screen for and identify novel CLR/bacteria interactions.

Published
2018

21. Cholesterol sensing by CD81 is important for hepatitis C virus entry

Author

Palor, Machaela, primary, Stejskal, Lenka, additional, Mandal, Piya, additional, Lenman, Annasara, additional, Alberione, Pia Maria, additional, Kirui, Jared, additional, Moeller, Rebecca, additional, Ebner, Stefan, additional, Meissner, Felix, additional, Gerold, Gisa, additional, Shepherd, Adrian J., additional, and Grove, Joe, additional

Published
2019
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