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1. Multidisciplinary care use in neurodegenerative complex diseases: The example of progressive supranuclear palsy and advanced Parkinson's disease in real-life

Author

Serio, Marina, Zibetti, Maurizio, Bissacco, Jacopo, Satolli, Sara, Sambati, Luisa, Bacchin, Ruggero, Longo, Chiara, Marchese, Roberta, Panetta, Salvatore, Magistrelli, Luca, Contaldi, Elena, Moschella, Vincenzo, Altavista, Maria Concetta, Costanzo, Matteo, Fabbrini, Giovanni, Olivola, Enrica, Modugno, Nicola, Cincotta, Massimo, Piccininni, Maristella, Capecci, Marianna, Baldini, Nicolò, Ciammola, Andrea, Ticozzi, Nicola, Raffaella, Di Giacopo, De Togni, Laura, Sala, Francesca, Nicoletti, Alessandra, Cicero, Edoardo, Ceravolo, Roberto, Del Prete, Eleonora, Fabbri, Margherita, Ledda, Claudia, Schirinzi, Tommaso, Artusi, Carlo Alberto, Avallone, Anna Rosa, Zenuni, Henri, De Micco, Rosa, Aloisio, Simone, Cani, Ilaria, Malaguti, Maria Chiara, Di Biasio, Francesca, Calandra-Buonaura, Giovanna, Stefani, Alessandro, Lopiano, Leonardo, Barone, Paolo, and Picillo, Marina

Published
2024
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3. Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease

Author

Marano, Massimo, Zizzo, Carmela, Malaguti, Maria Chiara, Bacchin, Ruggero, Cavallieri, Francesco, De Micco, Rosa, Spagnolo, Francesca, Bentivoglio, Anna Rita, Schirinzi, Tommaso, Bovenzi, Roberta, Ramat, Silvia, Erro, Roberto, Sorrentino, Cristiano, Sucapane, Patrizia, Pilotto, Andrea, Lupini, Alessandro, Magliozzi, Alessandro, Di Vico, Ilaria, Carecchio, Miryam, Bonato, Giulia, Cilia, Roberto, Colucci, Fabiana, Tamma, Filippo, Caputo, Elena, Mostile, Giovanni, Arabia, Gennarina, Modugno, Nicola, Zibetti, Maurizio, Ceravolo, Maria Gabriella, Tambasco, Nicola, Cossu, Giovanni, Valzania, Franco, Manganotti, Paolo, Di Lazzaro, Vincenzo, Zappia, Mario, Fabbrini, Giovanni, Tinazzi, Michele, Tessitore, Alessandro, Duro, Giovanni, and Di Fonzo, Alessio

Published
2024
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5. Identification of sixteen novel candidate genes for late onset Parkinson’s disease

Author

Gialluisi, Alessandro, Reccia, Mafalda Giovanna, Modugno, Nicola, Nutile, Teresa, Lombardi, Alessia, Di Giovannantonio, Luca Giovanni, Pietracupa, Sara, Ruggiero, Daniela, Scala, Simona, Gambardella, Stefano, Iacoviello, Licia, Gianfrancesco, Fernando, Acampora, Dario, D’Esposito, Maurizio, Simeone, Antonio, Ciullo, Marina, and Esposito, Teresa

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Prevention, Brain Disorders, Aging, Neurodegenerative, Parkinson's Disease, Clinical Research, Neurosciences, Aetiology, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, 2.1 Biological and endogenous factors, Neurological, Adult, Age of Onset, Aged, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease, Pedigree, Exome Sequencing, International Parkinson’s Disease Genomics Consortium, Late onset Parkinson’s disease, Novel candidate genes for Parkinson’s disease, Rare variant burden analysis, Whole exome sequencing, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology
Abstract

BackgroundParkinson's disease (PD) is a neurodegenerative movement disorder affecting 1-5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase. Here we report a multi-stage procedure to identify candidate genes likely involved in the etiopathogenesis of PD.MethodsThe study includes a discovery stage based on the analysis of whole exome data from 26 dominant late onset PD families, a validation analysis performed on 1542 independent PD patients and 706 controls from different cohorts and the assessment of polygenic variants load in the Italian cohort (394 unrelated patients and 203 controls).ResultsFamily-based approach identified 28 disrupting variants in 26 candidate genes for PD including PARK2, PINK1, DJ-1(PARK7), LRRK2, HTRA2, FBXO7, EIF4G1, DNAJC6, DNAJC13, SNCAIP, AIMP2, CHMP1A, GIPC1, HMOX2, HSPA8, IMMT, KIF21B, KIF24, MAN2C1, RHOT2, SLC25A39, SPTBN1, TMEM175, TOMM22, TVP23A and ZSCAN21. Sixteen of them have not been associated to PD before, were expressed in mesencephalon and were involved in pathways potentially deregulated in PD. Mutation analysis in independent cohorts disclosed a significant excess of highly deleterious variants in cases (p = 0.0001), supporting their role in PD. Moreover, we demonstrated that the co-inheritance of multiple rare variants (≥ 2) in the 26 genes may predict PD occurrence in about 20% of patients, both familial and sporadic cases, with high specificity (> 93%; p = 4.4 × 10- 5). Moreover, our data highlight the fact that the genetic landmarks of late onset PD does not systematically differ between sporadic and familial forms, especially in the case of small nuclear families and underline the importance of rare variants in the genetics of sporadic PD. Furthermore, patients carrying multiple rare variants showed higher risk of manifesting dyskinesia induced by levodopa treatment.ConclusionsBesides confirming the extreme genetic heterogeneity of PD, these data provide novel insights into the genetic of the disease and may be relevant for its prediction, diagnosis and treatment.

Published
2021

6. Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson’s Disease in Italian Patients

Author

Palomba, Nicole Piera, Fortunato, Giorgio, Pepe, Giuseppe, Modugno, Nicola, Pietracupa, Sara, Damiano, Immacolata, Mascio, Giada, Carrillo, Federica, Di Giovannantonio, Luca Giovanni, Ianiro, Laura, Martinello, Katiuscia, Volpato, Viola, Desiato, Vincenzo, Acri, Riccardo, Storto, Marianna, Nicoletti, Ferdinando, Webber, Caleb, Simeone, Antonio, Fucile, Sergio, Maglione, Vittorio, and Esposito, Teresa

Published
2023
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7. Intraoperative Local Field Potential Beta Power and Three-Dimensional Neuroimaging Mapping Predict Long-Term Clinical Response to Deep Brain Stimulation in Parkinson Disease: A Retrospective Study

Author

Altavista, Maria Concetta, Brusa, Livia, Ciavarro, Marco, Cortese, Francesca, D'Ercole, Manuela, De Pandis, Maria Francesca, Di Giuda, Daniela, Fabbrini, Giovanni, Izzo, Alessandro, Liperoti, Rosa, Marano, Giuseppe, Marano, Massimo, Orsini, Michela, Paradiso, Michele, Peppe, Antonella, Pierantozzi, Mariangela, Rocchi, Camilla, Suppa, Antonio, Vadalà, Rita, Vacca, Laura, Daniele, Antonio, di Biase, Lazzaro, Piano, Carla, Bove, Francesco, Ricci, Lorenzo, Caminiti, Maria Letizia, Stefani, Alessandro, Viselli, Fabio, Modugno, Nicola, Cerroni, Rocco, Calabresi, Paolo, Bentivoglio, Anna Rita, Tufo, Tommaso, and Di Lazzaro, Vincenzo

Published
2023
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8. Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Author

Zaccone, Claudio, Cerne, Denise, Idone, Giovanni, Ferrazzano, Gina, Rinaldo, Sara, Humaidan, Kais, Devigili, Grazia, Polidori, Luigi, Mazzucchi, Sonia, Ramella, Marina, Ledda, Claudia, Petracca, Martina, Oppo, Valentina, Contaldi, Elena, Turla, Marinella, Gigante, Angelo Fabio, Valentino, Francesca, Cassano, Daniela, Modugno, Nicola, Tambasco, Nicola, Aguggia, Marco, Romano, Marcello, Marinelli, Lucio, Mascia, Marcello Mario, Belvisi, Daniele, Esposito, Marcello, Pellicciari, Roberta, Trinchillo, Assunta, Terranova, Carmen, Bertino, Salvatore, Avanzino, Laura, Di Biasio, Francesca, Bono, Francesco, Laterza, Vincenzo, Lettieri, Christian, Eleopra, Roberto, Fabbrini, Giovanni, Barbero, Pierangelo, Bertolasi, Laura, Altavista, Maria Concetta, Erro, Roberto, Ceravolo, Roberto, Castagna, Anna, Zibetti, Maurizio, Bentivoglio, Anna Rita, Cossu, Giovanni, Magistrelli, Luca, Scaglione, Cesa, Albanese, Alberto, Cotelli, Maria Sofia, Misceo, Salvatore, Pisani, Antonio, Schirinzi, Tommaso, Maderna, Luca, Squintani, Giovanna, Berardelli, Alfredo, and Defazio, Giovanni

Published
2023
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9. Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?

Author

Ercoli, Tommaso, Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Spano, Giorgio, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Stocchi, Fabrizio, and Defazio, Giovanni

Published
2022
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10. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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11. Relationship between risk and protective factors and clinical features of Parkinson's disease

Author

Belvisi, Daniele, Pellicciari, Roberta, Fabbrini, Andrea, Costanzo, Matteo, Ressa, Gaia, Pietracupa, Sara, De Lucia, Maria, Modugno, Nicola, Magrinelli, Francesca, Dallocchio, Carlo, Ercoli, Tommaso, Nicoletti, Alessandra, Zappia, Mario, Solla, Paolo, Bologna, Matteo, Fabbrini, Giovanni, Tinazzi, Michele, Conte, Antonella, Berardelli, Alfredo, and Defazio, Giovanni

Published
2022
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12. Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex Vivo Tissues.

Author

Lobascio, Fabio, Di Modugno, Rocco, Fiore, Marco, Di Modugno, Nicola, Bruno, Cristian, De Nicolo, Thomas, Barberis, Rossella Veronica, Cabiale, Karine, and Radoiu, Marilena

Subjects
CHICKEN as food, CATHETER ablation, TEMPERATURE control, LIVER cancer, MEDICAL equipment
Abstract

In this paper, we report on the use of a purpose-built hybrid solid-state microwave and radiofrequency generator operating at frequencies of 2.45 GHz and/or 480 kHz for cancer ablation in various tissues. The hybrid generator was tested ex vivo on chicken breast and bovine liver and has demonstrated that the high accuracy of the power delivered to the sample can be achieved by controlling the emitted power versus the temperature profile of the treated sample. In particular, the hybrid generator incorporates control systems based on impedance or reflected power measurements that allow controlled ablation without causing unwanted carbonization and without including areas where tissue damage is not desired. The results of the ex vivo tests showed that radiofrequency ablation (RFA) could be effective for performing controlled ablations with minimally invasive probes, such as cardiac pathologies, small lesions, and tissues with particular composition, while microwave ablation (MWA) could be optimal for performing large ablations in highly vascularized tissues, such as liver cancer, where it is necessary to achieve higher temperatures. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Functional motor phenotypes: to lump or to split?

Author

Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Magro, Giuseppe, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Zanolin, Elisabetta, Albanese, Alberto, Ferrazzano, Gina, De Micco, Rosa, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Ercoli, Tommaso, Morgante, Francesca, and Erro, Roberto

Published
2021
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16. Dynamic Stability, Symmetry, and Smoothness of Gait in People with Neurological Health Conditions

Author

Tramontano, Marco, primary, Orejel Bustos, Amaranta Soledad, additional, Montemurro, Rebecca, additional, Vasta, Simona, additional, Marangon, Gabriele, additional, Belluscio, Valeria, additional, Morone, Giovanni, additional, Modugno, Nicola, additional, Buzzi, Maria Gabriella, additional, Formisano, Rita, additional, Bergamini, Elena, additional, and Vannozzi, Giuseppe, additional

Published
2024
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18. Low-Grade Glioma: High-Grade Tumor Recurrence

Author

Fabbiano, Francesco, Scaggiante, Jacopo, Wlderk, Andrea, Innocenzi, Gualtiero, Paolini, Sergio, Modugno, Nicola, Colonnese, Claudio, Bartolo, Marcello, Scarabino, Tommaso, editor, and Pollice, Saverio, editor

Published
2020
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20. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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22. Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site

Author

Cimino, Paola, Scannapieco, Sara, Ferrazzano, Gina, Brigandì, Amelia, Habetswallner, Francesco, Pascarella, Angelo, Ialongo, Tamara, Ramella, Marina, Mazzucchi, Sonia, Moschella, Vincenzo, Ercoli, Tommaso, Erro, Roberto, Fabbrini, Giovanni, Pellicciari, Roberta, Girlanda, Paolo, Terranova, Carmen, Avanzino, Laura, Di Biasio, Francesca, Barone, Paolo, Esposito, Marcello, De Joanna, Gabriella, Eleopra, Roberto, Bono, Francesco, Manzo, Lucia, Bentivoglio, Anna Rita, Petracca, Martina, Mascia, Marcello Mario, Albanese, Alberto, Castagna, Anna, Ceravolo, Roberto, Altavista, Maria Concetta, Scaglione, Cesa, Magistrelli, Luca, Zibetti, Maurizio, Bertolasi, Laura, Coletti Moja, Mario, Cotelli, Maria Sofia, Cossu, Giovanni, Minafra, Brigida, Pisani, Antonio, Misceo, Salvatore, Modugno, Nicola, Romano, Marcello, Cassano, Daniela, Berardelli, Alfredo, and Defazio, Giovanni

Published
2021
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23. Levodopa–carbidopa intrajejunal infusion in Parkinson’s disease: untangling the role of age

Author

Morgante, Francesca, Oppo, Valentina, Fabbri, Margherita, Olivola, Enrica, Sorbera, Chiara, De Micco, Rosa, Ielo, Giovanna Chiara, Colucci, Fabiana, Bonvegna, Salvatore, Novelli, Alessio, Modugno, Nicola, Sensi, Mariachiara, Zibetti, Maurizio, Lopiano, Leonardo, Tessitore, Alessandro, Pilleri, Manuela, Cilia, Roberto, Elia, Antonio E., Eleopra, Roberto, Ricciardi, Lucia, and Cossu, Giovanni

Published
2021
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24. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, Albanese, Alberto (ORCID:0000-0002-5864-0006), Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

BackgroundFunctional motor disorders (FMD) are a frequent neurological condition affecting patients with movement disorders. Commonly described in younger adults, their manifestation can be also associated to an elderly onset.ObjectiveTo assess the prevalence and describe the clinical manifestations of FMD with elderly and younger onset and their relationship with demographical and clinical variables.MethodsWe recruited patients with a "clinically definite" diagnosis of FMD from the Italian Registry of FMD. Patients underwent extensive clinical assessments. For elderly onset, we set a chronological cut-off at 65 years or older according to WHO definition. Multivariate regression models were implemented to estimate adjusted odds ratio of elderly FMD onset related to clinical characteristics.ResultsAmong the 410 patients, 34 (8.2%) experienced elderly-onset FMD, with a mean age at onset of 70.9 years. The most common phenotype was tremor (47.1%), followed by gait disorders, weakness, and dystonia (29.4%, 23.5%, 14.7%, respectively). Eleven elderly patients had a combined phenomenology: 9 exhibited two phenotypes, 2 had three phenotypes. Weakness was isolated in 3/8 patients and combined with another phenotype in 5/8, manifesting as paraplegia (n = 4); upper limb diplegia (n = 2), hemiparesis/hemiplegia (n = 1), and tetraparesis/tetraplegia (n= 1). Non-motor and other functional neurological disorders occurred more frequently in the younger group (89.1%) than the elderly (73.5%). Neurological and non-neurological comorbidities were more prevalent in the elderly group (82.4%) as opposed to the younger (32.7%). In a multivariate regression analysis, elderly-onset FMD was significantly associated with neurological comorbidities, including parkinsonism (OR 6.73) and cerebrovascular diseases (OR 5.48).ConclusionsThese results highlight the importance of achieving an accurate diagnosis of FMD in the elderly, as it is crucial for effectively managing FMD symptoms and addressi

Published
2024

26. Compassionate mind training for people with Parkinson's disease: A pilot study and predictors of response.

Author

Della Morte, Silvia, Berti, Elena, Lalli, Carolina, Modugno, Nicola, Morgante, Francesca, Schrag, Anette, Makovac, Elena, and Ricciardi, Lucia

Subjects
COMPASSION-focused therapy, PARKINSON'S disease, HEART beat, PSYCHOTHERAPY, PSYCHOLOGICAL well-being, APATHY
Abstract

Introduction: People with Parkinson's disease (PD) often present with disabling neuropsychiatric symptoms. Compassionate mind training (CMT) is a psychological approach effective in reducing stress and promoting psychological well‐being. Heart rate variability (HRV), a measure reflecting sympathovagal balance, has been associated with psychological well‐being and a compassionate attitude. Aim: To assess the feasibility and effectiveness of CMT in enhancing the quality of life and psychological well‐being in PD patients. Additionally, we evaluated HRV as a physiomarker for assessing the CMT outcomes. Methods: Twenty‐four PD patients participated in the study. A 6‐week online CMT intervention was delivered on a weekly basis. At baseline and post‐intervention patients completed questionnaires assessing depression, anxiety and quality of life. In a subsample of 11 patients, HRV was measured at baseline and post‐intervention in three conditions: at rest, during stress and after 3 min of deep breathing. Results: The attendance rate was 94.3%. Quality of life and perceived stigma improved post‐intervention as compared with baseline (p = 0.02 and p = 0.03 for PD Questionnaire‐39 total score and Stigma subscore, respectively). After CMT, patients presented better physiological regulation to stress, as measured by higher HRV as compared with baseline (p = 0.005). Notably, patients who were more resilient to stress at baseline (less decrease in HRV during stress) experienced a more substantial reduction in anxiety and depression following CMT. Conclusions: CMT is feasible and can improve quality of life and stigma in PD patients. HRV emerges as a promising physiomarker for predicting and measuring the outcomes of psychological interventions in PD. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, primary, Petracca, Martina, additional, Di Tella, Sonia, additional, Marcuzzo, Enrico, additional, Erro, Roberto, additional, Cuoco, Sofia, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Romito, Luigi Michele, additional, Eleopra, Roberto, additional, Zappia, Mario, additional, Nicoletti, Alessandra, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Laterza, Vincenzo, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Bonanni, Laura, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, Tessitore, Alessandro, additional, Lopiano, Leonardo, additional, Calandra‐Buonaura, Giovanna, additional, Morgante, Francesca, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Tesolin, Lucia, additional, Teatini, Francesco, additional, Camozzi, Serena, additional, Ercoli, Tommaso, additional, Stocchi, Fabrizio, additional, Coletti Moja, Mario, additional, Defazio, Giovanni, additional, and Tinazzi, Michele, additional

Published
2023
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30. Correction to: The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients

Author

Antonini, Angelo, Abbruzzese, Giovanni, Berardelli, Alfredo, Modugno, Nicola, Stroppa, Italo, Tamma, Filippo, Sensi, Mariachiara, Mancini, Francesca, Cossu, Giovanni, Stefani, Alessandro, Tambasco, Nicola, Tessitore, Alessandro, Fabbrini, Giovanni, Pontieri, Francesco E., Solla, Paolo, Bentivoglio, Anna Rita, Comi, Cristoforo, Minafra, Brigida, Riboldazzi, Giulio, Melchionda, Donato, Martino, Tommaso, and Lopiano, Leonardo

Published
2021
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33. Demographic and clinical determinants of neck pain in idiopathic cervical dystonia

Author

Tinazzi, Michele, Erro, Roberto, Mascia, Marcello Mario, Esposito, Marcello, Ercoli, Tommaso, Ferrazzano, Gina, Di Biasio, Francesca, Pellicciari, Roberta, Eleopra, Roberto, Bono, Francesco, Bertolasi, Laura, Barone, Paolo, Scaglione, Cesa Lorella Maria, Pisani, Antonio, Altavista, Maria Concetta, Cotelli, Maria Sofia, Ceravolo, Roberto, Cossu, Giovanni, Zibetti, Maurizio, Moja, Mario Coletti, Girlanda, Paolo, Maderna, Luca, Albanese, Alberto, Petracca, Martina, Magistrelli, Luca, Misceo, Salvatore, Minafra, Brigida, Romano, Marcello, Squintani, Giovanna Maddalena, Modugno, Nicola, Aguggia, Marco, Cassano, Daniela, Castagna, Anna, Morgante, Francesca, Berardelli, Alfredo, and Defazio, Giovanni

Published
2020
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35. The TANDEM investigation: efficacy and tolerability of levodopa-carbidopa intestinal gel in (LCIG) advanced Parkinson’s disease patients

Author

Antonini, Angelo, Abbruzzese, Giovanni, Berardelli, Alfredo, Modugno, Nicola, Stroppa, Italo, Tamma, Filippo, Sensi, Mariachiara, Mancini, Francesca, Cossu, Giovanni, Stefani, Alessandro, Tambasco, Nicola, Tessitore, Alessandro, Fabbrini, Giovanni, Pontieri, Francesco E., Solla, Paolo, Bentivoglio, Anna Rita, Comi, Cristoforo, Minafra, Brigida, Riboldazzi, Giulio, Melchionda, Donato, Martino, Tommaso, and Lopiano, Leonardo

Published
2020
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36. Validation of the Italian version of the PSP Quality of Life questionnaire

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B., Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, and Barone, Paolo

Published
2019
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37. Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study

Author

Scelzo, Emma, Beghi, Ettore, Rosa, Manuela, Angrisano, Serena, Antonini, Angelo, Bagella, Caterina, Bianchi, Elisa, Caputo, Elena, Lena, Francesco, Lopiano, Leonardo, Marcante, Andrea, Marceglia, Sara, Massaro, Francesco, Modugno, Nicola, Pacchetti, Claudio, Pilleri, Manuela, Pozzi, Nicolo Gabriele, Romito, Luigi Michele, Santilli, Marco, Tamma, Filippo, Weis, Luca, Zibetti, Maurizio, and Priori, Alberto

Published
2019
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39. Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Author

Mascia, Marcello Mario, primary, Belvisi, Daniele, additional, Esposito, Marcello, additional, Pellicciari, Roberta, additional, Trinchillo, Assunta, additional, Terranova, Carmen, additional, Bertino, Salvatore, additional, Avanzino, Laura, additional, Di Biasio, Francesca, additional, Bono, Francesco, additional, Laterza, Vincenzo, additional, Lettieri, Christian, additional, Eleopra, Roberto, additional, Fabbrini, Giovanni, additional, Barbero, Pierangelo, additional, Bertolasi, Laura, additional, Altavista, Maria Concetta, additional, Erro, Roberto, additional, Ceravolo, Roberto, additional, Castagna, Anna, additional, Zibetti, Maurizio, additional, Bentivoglio, Anna Rita, additional, Cossu, Giovanni, additional, Magistrelli, Luca, additional, Scaglione, Cesa, additional, Albanese, Alberto, additional, Cotelli, Maria Sofia, additional, Misceo, Salvatore, additional, Pisani, Antonio, additional, Schirinzi, Tommaso, additional, Maderna, Luca, additional, Squintani, Giovanna, additional, Berardelli, Alfredo, additional, Defazio, Giovanni, additional, Zaccone, Claudio, additional, Cerne, Denise, additional, Idone, Giovanni, additional, Ferrazzano, Gina, additional, Rinaldo, Sara, additional, Humaidan, Kais, additional, Devigili, Grazia, additional, Polidori, Luigi, additional, Mazzucchi, Sonia, additional, Ramella, Marina, additional, Ledda, Claudia, additional, Petracca, Martina, additional, Oppo, Valentina, additional, Contaldi, Elena, additional, Turla, Marinella, additional, Gigante, Angelo Fabio, additional, Valentino, Francesca, additional, Cassano, Daniela, additional, Modugno, Nicola, additional, Tambasco, Nicola, additional, Aguggia, Marco, additional, Romano, Marcello, additional, and Marinelli, Lucio, additional

Published
2023
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40. Postural Instability and Risk of Falls in Patients with Parkinson’s Disease Treated with Deep Brain Stimulation: A Stabilometric Platform Study

Author

Leodori, Giorgio, primary, Santilli, Marco, additional, Modugno, Nicola, additional, D’Avino, Michele, additional, De Bartolo, Maria Ilenia, additional, Fabbrini, Andrea, additional, Rocchi, Lorenzo, additional, Conte, Antonella, additional, Fabbrini, Giovanni, additional, and Belvisi, Daniele, additional

Published
2023
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42. Contributors

Author

Abboud, Hesham, primary, Abdelkader, Noha F., additional, Abellanas, Miguel A., additional, Adams, Warwick R., additional, Airavaara, Mikko, additional, Al-Busaidi, Ibrahim S., additional, Alamri, Yassar, additional, Alberico, Stephanie L., additional, Alexiou, Athanasios, additional, Almeida, Lorena Rosa S., additional, Anderton, Ryan S., additional, Antipova, Veronica, additional, Aragona, Emanuela, additional, Arrigo, Alessandro, additional, Ashraf, Ghulam Md, additional, Auffret, Manon, additional, Aymerich, Maria S., additional, Bakeberg, Megan, additional, Barnes, Graham R., additional, Belbasis, Lazaros, additional, Bellou, Vanesa, additional, Benedetti, Fabrizio, additional, Benson, Patrick, additional, Bergantin, Leandro Bueno, additional, Bhidayasiri, Roongroj, additional, Bortolanza, Mariza, additional, Byrnes, Michelle, additional, Calamuneri, Alessandro, additional, Caricati-Neto, Afonso, additional, Carlino, Elisa, additional, Chaudhary, Sapana Sameer, additional, Chaudhary, Sameer, additional, Chmielarz, Piotr, additional, Chuproski, Ana Paula, additional, Del-Bel, Elaine, additional, De Risi, Marco, additional, Devedjian, J.C., additional, Devos, D., additional, Di Gennaro, Giancarlo, additional, Domanskyi, Andrii, additional, Dominico, Patrícia, additional, Drapier, Sophie, additional, Duce, J.A., additional, Dutta, Aloke K., additional, Eidelberg, David, additional, Evangelou, Evangelos, additional, Fagotti, Juliane, additional, Farotti, Lucia, additional, Fisichella, M., additional, Forjaz, Maria João, additional, Frisaldi, Elisa, additional, Fuermaier, Anselm B.M., additional, Fukushima, Kikuro, additional, Fukushima, Junko, additional, Gaeta, Michele, additional, Gordon, Luke, additional, Hawlitschka, Alexander, additional, Holzmann, Carsten, additional, Jansen, Josephien, additional, Januário, Cristina, additional, Jesus-Ribeiro, Joana, additional, Johnstone, Daniel M., additional, Koerts, Janneke, additional, Konovalova, Julia, additional, Kurth, Jens, additional, Lachaud, C., additional, Laloux, C., additional, Lanotte, Michele, additional, LeWitt, Peter A., additional, Lima, Marcelo M.S., additional, Lindner, Tobias, additional, Loewenbrück, K.F., additional, Lopiano, Leonardo, additional, Luo, Dan, additional, Mann, Teresa, additional, Mao, Peizhong, additional, Mao, Yifan, additional, Martinez–Martin, Pablo, additional, Mastaglia, Frank L., additional, Mizutani, Yasuaki, additional, Modugno, Nicola, additional, Moreau, C., additional, Mormina, Enricomaria, additional, Müller, Thomas, additional, Mutoh, Tatsuro, additional, Nagao, Kanae, additional, Narayanan, Nandakumar S., additional, Nascimento, Glauce Crivelaro, additional, Natesan, Saieswari, additional, Neilson, Lee, additional, Niimi, Yoshiki, additional, Olivola, Enrica, additional, Pan-Montojo, F., additional, Panhelainen, Anne, additional, Paolini Paoletti, Federico, additional, Pardeshi, Tanvee, additional, Parnetti, Lucilla, additional, Paul, Serene S., additional, Perovnik, Matej, additional, Petrucco, Claudia, additional, Piedimonte, Alessandro, additional, Rawat, Sakshi, additional, Reichmann, H., additional, Reith, Maarten, additional, Riley, Maddeson, additional, Rodríguez-Blázquez, Carmen, additional, Rožanković, Petra Bago, additional, Rus, Tomaž, additional, Sakakibara, Ryuji, additional, Santos-Lobato, Bruno L., additional, Scorza, Fúlvio Alexandre, additional, Stone, Jonathan, additional, Tang, Chris C., additional, Targa, Adriano D.S., additional, Tateno, Fuyuki, additional, Tomše, Petra, additional, Trošt, Maja, additional, Tsiang, John T.H., additional, Tucha, Lara, additional, Tucha, Oliver, additional, Uchiyama, Tomoyuki, additional, Valenca, Guilherme T., additional, Vérin, Marc, additional, Vieira, Daniela, additional, Willis, Gregory L., additional, Witt, Martin, additional, Woo, Benjamin K.P., additional, Wree, Andreas, additional, Yamamoto, Tatsuya, additional, Zande, Jonathan, additional, and Zibetti, Maurizio, additional

Published
2020
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43. Low-Grade Glioma: High-Grade Tumor Recurrence

Author

Fabbiano, Francesco, primary, Scaggiante, Jacopo, additional, Wlderk, Andrea, additional, Innocenzi, Gualtiero, additional, Paolini, Sergio, additional, Modugno, Nicola, additional, Colonnese, Claudio, additional, and Bartolo, Marcello, additional

Published
2019
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44. Validation of the Italian version of carers’ quality-of-life questionnaire for parkinsonism (PQoL Carer) in progressive supranuclear palsy

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruno, Antonino, Bruschi, Fabio, Cappiello, Arianna, De Micco, Rosa, De Rosa, Anna, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Lopiano, Leonardo, Marchese, Roberta, Mercuri, Nicola B, Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, and Barone, Paolo

Published
2019
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45. Motor and non-motor outcomes in patients with advanced Parkinson’s disease treated with levodopa/carbidopa intestinal gel: final results of the GREENFIELD observational study

Author

Lopiano, Leonardo, Modugno, Nicola, Marano, Pietro, Sensi, Mariachiara, Meco, Giuseppe, Solla, Paolo, Gusmaroli, Graziano, Tamma, Filippo, Mancini, Francesca, Quatrale, Rocco, Zangaglia, Roberta, Bentivoglio, Annarita, Eleopra, Roberto, Gualberti, Giuliana, Melzi, Gabriella, and Antonini, Angelo

Published
2019
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47. Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry

Author

Amalia, Ene, Arnold, Guy, Bajenaru, Ovidiu, Bergmans, Bruno, Bjornara, Kari Anne, Blackie, Jeff, Bode, Matthias, Bourgeois, Paul, Bohlhalter, Stephan, Buraga, Ioan, Burkhard, Pierre R., Busson, Philippe, Calopa, Matilde, Clausen, Jesper, Danielsen, Erik Hvid, Defebvre, Luc, Delvaux, Valerie, Dethy, Sophie, Dietrichs, Espen, De Fabregues, Oriol, Gerhard, Ransmayr, Gusmaroli, Graziano, Hahn, Kirsten, Hauptmann, Björn, Henriksen, Tove, Hernandez-Vara, Jorge, Jeanjean, A., Kaiserova, Michaela, Kassubek, Jan, Kimber, Thomas, Konitsiotis, Spyridon, Krüger, Rejko, Kulisevsky, Jaime, Leenders, Jo, Lundqvist, Christofer, Ory Magne, F., Marano, Pietro, Milanov, Ivan, Modugno, Nicola, Misbahuddin, Anjum, Nevrly, Martin, Panayiotis, Zikos, Pedersen, Kenn Freddy, Pedersen, Stephen W., Perju-Dumbrava, Lacramioara, Ponsen, M.M., Popescu, Bogdan O., Rijntjes, Michel, Puente, V., Redecker, Christoph, Schrader, Christoph, Sensi, Mariachiara, Simu, Mihaela, Spanaki, Cleanthe, Storch, Alexander, Storstein, Anette, Tomantschger, Volker, van der Linden, Chris, van Laar, T., Viallet, F., Witjas, Tatiana, Wolz, Martin, Zibetti, Maurizio, Van Zandijcke, Michel, Antonini, Angelo, Poewe, Werner, Chaudhuri, K. Ray, Jech, Robert, Pickut, Barbara, Pirtošek, Zvezdan, Szasz, Jozsef, Valldeoriola, Francesc, Winkler, Christian, Bergmann, Lars, Yegin, Ashley, Onuk, Koray, Barch, David, and Odin, Per

Published
2017
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48. Correction to: Demographic and clinical determinants of neck pain in idiopathic cervical dystonia

Author

Tinazzi, Michele, Erro, Roberto, Mascia, Marcello Mario, Esposito, Marcello, Ercoli, Tommaso, Ferrazzano, Gina, Di Biasio, Francesca, Pellicciari, Roberta, Eleopra, Roberto, Bono, Francesco, Bertolasi, Laura, Barone, Paolo, Scaglione, Cesa Lorella Maria, Pisani, Antonio, Altavista, Maria Concetta, Cotelli, Maria Sofia, Ceravolo, Roberto, Cossu, Giovanni, Zibetti, Maurizio, Coletti Moja, Mario, Girlanda, Paolo, Maderna, Luca, Albanese, Alberto, Petracca, Martina, Magistrelli, Luca, Misceo, Salvatore, Minafra, Brigida, Romano, Marcello, Squintani, Giovanna Maddalena, Modugno, Nicola, Aguggia, Marco, Cassano, Daniela, Castagna, Anna, Morgante, Francesca, Berardelli, Alfredo, and Defazio, Giovanni

Published
2021
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50. A novel manual therapy approach for managing acute interscapular pain following median sternotomy for open cardiac surgery: A clinical comparative analysis.

Author

Lena, Francesco, Cesarano, Simone, D'Onghia, Annalisa, Torre, Monica, Santilli, Marco, Modugno, Nicola, and Al-Wardat, Mohammad

Abstract

Acute interscapular pain is a frequent postoperative complication observed in patients who have undergone median sternotomy. This study aimed to assess a novel approach to manual therapy utilizing the Regional Interdependence (RI) concept for managing interscapular pain in post-sternotomy patients. In an observational study, a cohort of 60 consecutively admitted patients undergoing median sternotomy was enrolled. Data collection involved standardized clinical evaluations conducted at specific time points: prior to manual treatment (T0), following five manual treatments (T5), and at post-treatment days 10 (T10) and 30 (T30). The Experimental Group (EG) received manual treatment based on the RI concept, performed in a seated position to accommodate individual clinical conditions and surgical wound considerations. The Control Group (CG) received simulated treatment involving identical exercises to the EG but lacking the physiological or biomechanical stimulation. Among the initial 60 patients, 36 met the inclusion criteria, while 24 were excluded due to one or more exclusion criteria. Treatment outcomes revealed a statistically significant improvement in the EG compared to the CG, not only in terms of pain reduction but also in functional recovery and consequent disability reduction. The RI concept emerges as a potentially valuable therapeutic approach for addressing interscapular dysfunction, particularly in highly complex post-sternotomy patients. This study highlights the clinical relevance of the RI concept in the management of interscapular pain and highlights its potential utility in improving patient outcomes in the challenging context of sternotomy surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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