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A mesoscale evaluation is performed to determine the impacts of climate change on terrestrial hydrological components and the Net Irrigation Water Requirement (NIWR) throughout the Chesapeake Bay watershed in the mid-Atlantic region of the United States. The Noah-MP land surface model is calibrated and evaluated against the observed datasets of United States Geological Survey (USGS) streamflow gages, actual evapotranspiration from USGS Simplified Surface Energy Balance (SSEBop) Model and soil moisture from Soil Analysis Climate Network (SCAN). Six best performing Global Climate Models (GCM) based on Multivariate Adaptive Constructed Analogs (MACA) scheme are included for two future scenarios (RCP 4.5 and RCP 8.5), to assess the change in water balance components, change in NIWR for two dominant crops (corn and soybeans) and uncertainty in GCM projections. Using these long-term simulations, the flood inundation maps are developed for future scenarios along the Susquehanna River including the City of Harrisburg in Pennsylvania. The HEC-RAS 2D model is calibrated and evaluated against the high-water marks from major historical flood events and the stage-discharge relationship of the available USGS streamgages. Finally, the impacts of climate change are assessed on flood inundation depth and extent by comparing a 30-yr and 100-yr flood event based on the historical and future (scenario-based) peak discharge estimates at the USGS streamgages. Interestingly, flood inundation extent and severity predicted by the model along the Susquehanna River near Harrisburg is expected to rise in the future climate scenarios due to the greater frequency of extreme events increasing total precipitation. Master of Science Climate change is inevitable due to increased greenhouse gas emissions, with impacts varying in space and time significantly throughout the globe. The impacts are strongly driven by the change in precipitation and temperature which affect the control of the movement of water on the surface of the Earth. These changes in the water cycle require an understanding of hydrological components like streamflow, soil moisture, and evapotranspiration. Development of long-term climate models and computational hydrological models (based on mathematical equations and governed by laws of physics) has helped us in understanding this climate variability in space and time. This study performs a long-term simulation using the datasets from six different climate models to analyze the change in terrestrial hydrological components for the entire Chesapeake Bay watershed in the mid-Atlantic region of the United States. The simulations provide an understanding of the interplay between various land surface processes due to climate change and can help determine future water availability and consumption. To illustrate the usefulness of such long-term simulations, the crop water requirement is quantified for the dominant crops in Chesapeake Bay watershed to project water availability and support the development of mitigation strategies. Flood inundation maps are also developed for a section of Susquehanna River near the City of Harrisburg in south-central Pennsylvania using the streamflow from long-term simulations. The flood inundation depth and extent for major flood events such as Tropical Storm Agnes (1972) and Tropical Storm Lee (2011) are compared along the Susquehanna River, which can aid in managing flood operations, reduce the future flood damages and prioritize the mitigation efforts for endangered communities near the City of Harrisburg.