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331 results on '"Mockenhaupt M"'

1. Delayed Skin Testing for Systemic Medications: Helpful or Not?

Author

Barbaud, A, Goncalo, M, Mockenhaupt, M, Copaescu, A, Phillips, EJ, Barbaud, A, Goncalo, M, Mockenhaupt, M, Copaescu, A, and Phillips, EJ

Abstract

Cutaneous adverse drug reactions collectively are delayed drug reactions such as morbilliform drug eruption and severe cutaneous adverse reactions (SCARs). Morbilliform drug eruption may wane over time, be the result of drug viral interactions, and be amenable to slow reintroduction or rechallenge, whereas SCARs are HLA class I restricted, T-cell-mediated reactions that demonstrate durable immunity and warrant lifelong avoidance. SCARs such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and generalized bullous fixed drug eruption often occur in the setting of multiple drugs dosed together. Collectively, they lead to significant morbidity, mortality, and drug safety concerns that could severely limit future treatment options. Currently, no single or combination of diagnostic tests for SCARs such as ex vivo or in vitro testing, in vivo (skin) testing, or other adjunctive tests such as HLA typing have 100% negative predictive value. In this "Controversies in Allergy Review" article, we review the current literature on delayed skin testing (patch and delayed prick/intradermal test) and critically assess the evidence base of its utility across different drugs and clinical phenotypes of delayed hypersensitivity reactions.

Published
2024

2. Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel

Author

Brockow, K., primary, Wurpts, G., additional, Trautmann, A., additional, Pfützner, W., additional, Treudler, R., additional, Bircher, A.J., additional, Brehler, R., additional, Buhl, T., additional, Dickel, H., additional, Fuchs, T., additional, Jakob, T., additional, Kurz, J., additional, Kreft, B., additional, Lange, L., additional, Merk, H.F., additional, Mockenhaupt, M., additional, Mülleneisen, N., additional, Ott, H., additional, Ring, J., additional, Ruëff, F., additional, Sachs, B., additional, Sitter, H., additional, Wedi, B., additional, Wöhrl, S., additional, Worm, M., additional, and Zuberbier, T., additional

Published
2023
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13. Corrigendum to ‘SJS/TEN 2019: From science to translation’ [J. Dermatol. Sci. 98/1 (2020) 2–12]

Author

Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-L, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peters, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., Carleton, B.C., Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-L, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peters, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., and Carleton, B.C.

Abstract

The authors regret not all contributing authors correctly acknowledged funding. Jonathan Peter’s IMARI-Africa project (AFRISCAR) is part of the EDCTP2 programme supported by the European Union (grant number TMA2017SF-1981 ). The authors would like to apologise for any inconvenience caused.

Published
2021

16. SJS/TEN 2019: From Science to Translation

Author

Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-I, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peter, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., Carleton, B.C., Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-I, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peter, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., and Carleton, B.C.

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.

Published
2020

35. Akute generalisierte exanthematische Pustulose - ein Fall für das BVZ?

Author

Paulmann, M., Gille, J., Kremer, T., and Mockenhaupt, M.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die akute generalisierte exanthematische Pustulose (AGEP) ist eine akut auftretende Hautreaktion, die typischerweise mit hohem Fieber und einer Gesichtsschwellung einhergeht. Die erythematösen Hautveränderungen beginnen häufig im Gesicht und in den Intertrigines, anschließend[zum vollständigen Text gelangen Sie über die oben angegebene URL], 37. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2019)

Published
2019

47. Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Author

Pan, R-Y, Chu, M-T, Wang, C-W, Lee, Y-S, Lemonnier, F, Michels, A.W., Schutte, R., Ostrov, D.A., Chen, C-B, Phillips, E.J., Mallal, S.A., Mockenhaupt, M., Bellón, T., Tassaneeyakul, W., White, K.D., Roujeau, J-C, Chung, W-H, Hung, S-L, Pan, R-Y, Chu, M-T, Wang, C-W, Lee, Y-S, Lemonnier, F, Michels, A.W., Schutte, R., Ostrov, D.A., Chen, C-B, Phillips, E.J., Mallal, S.A., Mockenhaupt, M., Bellón, T., Tassaneeyakul, W., White, K.D., Roujeau, J-C, Chung, W-H, and Hung, S-L

Abstract

Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate the T cell receptor (TCR) repertoire by next-generation sequencing. A public αβTCR is identified from the cytotoxic T lymphocytes of patients with carbamazepine-SJS/TEN, with its expression showing drug/phenotype-specificity and an bias for HLA-B*15:02. This public αβTCR has binding affinity for carbamazepine and its structural analogs, thereby mediating the immune response. Adoptive transfer of T cell expressing this public αβTCR to HLA-B*15:02 transgenic mice receiving oral administration of carbamazepine induces multi-organ injuries and symptoms mimicking SCAR, including hair loss, erythema, increase of inflammatory lymphocytes in the skin and blood, and liver and kidney dysfunction. Our results not only demonstrate an essential role of TCR in the immune synapse mediating SCAR, but also implicate potential clinical applications and development of therapeutics.

Published
2019

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