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5. Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis

Author

van Eijk, Anna Maria, Stepniewska, Kasia, Hill, Jenny, Taylor, Steve M., Rogerson, Stephen J., Cottrell, Gilles, Chico, R. Matthew, Gutman, Julie R., Tinto, Hallidou, Unger, Holger W., Yanow, Stephanie K., Accrombessi, Manfred, Adegnika, Ayola A., Ahmed, Rukhsana, Arango-Flórez, Eliana María, Arevalo-Herrera, Myriam, Arinaitwe, Emmanual, Arnaldo, Paulo, Ashorn, Per, Ashorn, Ulla, Bardaji, Azucena, Betuela, Inoni, Bharti, Praveen K., Bohissou, Francis, Bôtto-Menezes, Camila, Braun, Vera, Briand, Valerie, Briggs, Jessica, Castellanos, María Eugenia, Chandramohan, Daniel, Chaponda, Enesia Banda, Chitnis, Chetan, Cohee, Lauren M., Cot, Michel, d'Alessandro, Umberto, Denoeud-Ndam, Lise, Desai, Meghna, Dicko, Alassane, Ding, Xavier, Dorsey, Grant, Duffy, Patrick E., Elbadry, Maha A., Enosse, Sonia M., Fan, Yue, Fievet, Nadine, Fried, Michal, Genton, Blaise, Gonzalez, Raquel, Greenwood, Brian, Kalilani, Linda, Kattenberg, Johanna H., Kayentao, Kassoum, Khairallah, Carole, King, Christopher L., Kochar, Dhanpat Kumar, Kochar, Swati, Koukouikila-Koussounda, Felix, Landis, Sarah H., Laufer, Miriam K., Leke, Rose F., Macete, Eusebio, Maculuve, Sonia, Madanitsa, Mwayiwawo, Mahamar, Almahamoudou, Maleta, Ken, Malhotra, Indu, Zoleko Manego, Rella, Martinez-Espinosa, Flor Ernestina, Massougbodji, Achille, Mathanga, Don, Menegon, Michela, Menendez, Clara, Mens, Petra, Meremikwu, Martin, Mockenhaupt, Frank P., Mombo-Ngoma, Ghyslain, Mosha, Dominic, Mueller, Ivo, Nahum, Alain, Natureeba, Paul, Ndam, Nicaise, Ntoumi, Francine, Oduwole, Olabisi A., Okech, Bernard A., Ome-Kaius, Maria, Otieno, Kephas, Padilla, Norma, Ramharter, Michal, Rochford, Rosemary, Rosanas-Urgell, Anna, Ruperez, Maria, Sabourin, Katherine R., Sanz, Sergi, Schallig, Henk D., Scott, Susana, Sevene, Esperanca, Severini, Carlo, Tagbor, Harry, Taylor, Diane Wallace, Traore Coulibaly, Maminata, Vasquez, Ana, Walker-Abbey, Annie, Wylie, Blair J., Zannou, Djimon M., Meshnick, Stephen R., ter Kuile, Feiko O., Mayor, Alfredo, Taylor, Steve M, Rogerson, Stephen J, Chico, R Matthew, Gutman, Julie R, Tinto, Halidou, Unger, Holger W, Yanow, Stephanie K, Meshnick, Steven R, and ter Kuile, Feiko O

Published
2023
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6. In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

Author

van Loon, Welmoed, Oliveira, Rafael, Bergmann, Clara, Habarugira, Felix, Ndoli, Jules, Sendegeya, Augustin, Bayingana, Claude, and Mockenhaupt, Frank P.

Subjects
Gene mutations -- Research, Drug resistance in microorganisms -- Genetic aspects -- Physiological aspects -- Research, Malaria -- Drug therapy, Parasitological research, Plasmodium falciparum -- Genetic aspects -- Physiological aspects, Health
Abstract

Artemisinin-based combination therapies (ACTs) have contributed greatly to the global decline of illness and death from malaria (1). However, the novel emergence of artemisinin resistance in eastern Africa has threatened [...]

Published
2022
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7. Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™: An antigen-detecting point-of-care device for SARS-CoV-2

Author

Krüger, Lisa J., Klein, Julian A. F., Tobian, Frank, Gaeddert, Mary, Lainati, Federica, Klemm, Sarah, Schnitzler, Paul, Bartenschlager, Ralf, Cerikan, Berati, Neufeldt, Christopher J., Nikolai, Olga, Lindner, Andreas K., Mockenhaupt, Frank P., Seybold, Joachim, Jones, Terry C., Corman, Victor M., Pollock, Nira R., Knorr, Britta, Welker, Andreas, de Vos, Margaretha, Sacks, Jilian A., and Denkinger, Claudia M.

Published
2022
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8. Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: A multi-centre clinical evaluation

Author

Krüger, Lisa J., Tanuri, Amilcar, Lindner, Andreas K., Gaeddert, Mary, Köppel, Lisa, Tobian, Frank, Brümmer, Lukas E., Klein, Julian A.F., Lainati, Federica, Schnitzler, Paul, Nikolai, Olga, Mockenhaupt, Frank P., Seybold, Joachim, Corman, Victor M., Jones, Terence C., Drosten, Christian, Gottschalk, Claudius, Weber, Stefan F., Weber, Stephan, Ferreira, Orlando C., Mariani, Diana, dos Santos Nascimento, Erika Ramos, Pereira Pinto Castineiras, Terezinha M., Galliez, Rafael Mello, Faffe, Debora Souza, Leitão, Isabela de Carvalho, dos Santos Rodrigues, Claudia, Frauches, Thiago Silva, Nocchi, Keity J. Chagas Vilela, Feitosa, Natalia Martins, Ribeiro, Sabrina Santana, Pollock, Nira R., Knorr, Britta, Welker, Andreas, de Vos, Margaretha, Sacks, JilianA., Ongarello, Stefano, and Denkinger, Claudia M.

Published
2022
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12. Self-collected oral, nasal and saliva samples yield sensitivity comparable to professionally collected oro-nasopharyngeal swabs in SARS-CoV-2 diagnosis among symptomatic outpatients

Author

Gertler, Maximilian, Krause, Eva, van Loon, Welmoed, Krug, Niklas, Kausch, Franka, Rohardt, Chiara, Rössig, Heike, Michel, Janine, Nitsche, Andreas, Mall, Marcus A., Nikolai, Olga, Hommes, Franziska, Burock, Susen, Lindner, Andreas K., Mockenhaupt, Frank P., Pison, Ulrich, and Seybold, Joachim

Published
2021
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13. Emergence of SARS-CoV-2 B.1.1.7 Lineage at Outpatient Testing Site, Berlin, Germany, January-March 2021

Author

van Loon, Welmoed, Rossig, Heike, Burock, Susen, Hofmann, Jorg, Bernhard, Julian, Linzbach, Elisabeth, Pettenkofer, Domenika, Schonfeld, Christian, Gertler, Maximilian, Seybold, Joachim, Kurth, Tobias, and Mockenhaupt, Frank P.

Subjects
Berlin, Germany -- Health aspects, Outpatients -- Statistics, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 lineage (variant of concern [VOC] 202012/01 or 20I/501Y.V1) likely emerged during autumn 2020 in the United Kingdom and quickly became dominant there [...]

Published
2021
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15. Anthropometric indices and their cut-off points in relation to type 2 diabetes among Ghanaian migrants and non-migrants: The RODAM study

Author

Darko, Samuel N., Meeks, Karlijn A.C., Owiredu, William K.B.A., Laing, Edwin F., Boateng, Daniel, Beune, Erik, Addo, Juliet, de-Graft Aikins, Ama, Bahendeka, Silver, Mockenhaupt, Frank, Spranger, Joachim, Agyei-Baffour, Peter, Klipstein-Grobusch, Kerstin, Smeeth, Liam, Agyemang, Charles, and Owusu-Dabo, Ellis

Published
2021
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16. Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data

Author

Grobusch, Martin P., Weld, Leisa, Goorhuis, Abraham, Hamer, Davidson H., Schunk, Mirjam, Jordan, Sabine, Mockenhaupt, Frank P., Chappuis, François, Asgeirsson, Hilmir, Caumes, Eric, Jensenius, Mogens, van Genderen, Perry J.J., Castelli, Francesco, López-Velez, Rogelio, Field, Vanessa, Bottieau, Emmanuel, Molina, Israel, Rapp, Christophe, Ménendez, Marta Díaz, Gkrania-Klotsas, Effrossyni, Larsen, Carsten S., Malvy, Denis, Lalloo, David, Gobbi, Federico, Florescu, Simin A., Gautret, Philippe, and Schlagenhauf, Patricia

Published
2021
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17. American Cutaneous Leishmaniasis: Imported cases in Berlin 2000–2023.

Author

Lindner, Andreas K., Moreno-del Castillo, Maria Cristina, Wintel, Mia, Equihua Martinez, Gabriela, Richter, Joachim, Kurth, Florian, Pfäfflin, Frieder, Zoller, Thomas, Gertler, Maximilian, Georgi, Susanne, Nürnberg, Michael, Hülso, Claudia, Bernhard, Julian, Kotsias, Sarah Konopelska, Seigerschmidt, Antonio, van Loon, Welmoed, Mockenhaupt, Frank, Kampmann, Beate, and Harms, Gundel

Subjects
CUTANEOUS leishmaniasis, NEGLECTED diseases, TREATMENT effectiveness, AMPHOTERICIN B, BURULI ulcer, SKIN diseases
Abstract

Background: American Cutaneous Leishmaniasis (ACL) shows variable response to therapy, but data on species-specific treatment efficacy is scarce. We describe the clinical characteristics and outcome of patients with ACL imported to a tertiary centre in Germany and determine whether species-specific therapy according to the 2014 "LeishMan" group recommendations is associated with cure. Methods: A retrospective chart review was conducted at the Charité Institute of International Health in Berlin. We analysed data on PCR-confirmed ACL cases collected between 2000 and 2023. Systemic therapy included liposomal amphotericin B, miltefosine, pentavalent antimony, ketoconazole or itraconazole. Localized therapy included perilesional pentavalent antimony or paromomycin ointment. Cure was defined as re-epithelialization of ulcers or disappearance of papular-nodular lesions after 3 months of treatment. Logistic regression models were used to quantify the effect of species-specific systemic therapy on the outcome. Results: 75 cases were analysed. Most patients were male (62%), median age was 35 years, no patient had a history of immunosuppression. The most common reason for travel was tourism (60%), the most common destination was Costa Rica (28%), the median duration of illness was 8 weeks, and most patients presented with ulcers (87%). Lesions were complex in 43%. The most common Leishmania (L.) species was L. braziliensis (28%), followed by L. panamensis (21%). 51/73 (70%) patients were cured after initial therapy and 17/21 (81%) after secondary therapy. Cure after systemic therapy was more frequent when species-specific treatment recommendations were followed (33/45; 73%), compared to when not followed, (6/17; 35%, P = 0.008). This association was independent of age, sex, previous therapy, complex lesions, and Leishmania species (adjusted OR, 5.06; 95% CI, 1.22–24.16). Conclusions: ACL is a rare, imported disease in Germany. Complex lesions were common, challenging successful therapy. This study highlights the importance of identifying the parasite species and suggests that a species-specific approach to treatment leads to better outcomes. Author summary: American cutaneous leishmaniasis is a skin disease caused by parasites that are transmitted through the bite of sandflies. It is considered as a neglected tropical disease. In non-endemic countries like Germany, this disease is rarely seen and is imported by migrants or travellers who have been infected in tropical or subtropical areas of the Americas. Experts suggest that the treatment should be given depending on the specific parasite species found in the affected skin, but there is still a scarcity of information on the optimal management strategy. We analysed 75 American cutaneous leishmaniasis cases seen between 2000 and 2023 at our German medical centre. Most patients were men, around 35 years of age, who most commonly travelled to the Americas for tourism. We found that when using systemic medications (i.e., given by mouth, injection or drip into a vein), that were recommended for the specific parasite type, patients were more likely to be cured, with a 73% success rate, compared to a mere 35% success rate when those recommendations were not followed. This highlights the importance of identifying the species that is causing the disease, and suggests that tailoring treatment to the specific parasite species increases the chances of cure. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Serological diagnosis of strongyloidiasis: An evaluation of three commercial assays.

Author

Weitzel, Thomas, Dittrich, Sabine, Mockenhaupt, Frank P., and Lindner, Andreas K.

Subjects
STRONGYLOIDIASIS, TAPEWORM infections, HELMINTHIASIS, PARASITIC diseases, DIAGNOSIS, NEMATODE infections
Abstract

Background: Strongyloidiasis is caused by a neglected nematode, manifesting as chronic intestinal infection with potentially severe manifestations. The disease is an emerging problem in non-endemic countries affecting travelers and migrants. Diagnosis of strongyloidiasis is hampered by the lack of standardization and absence of a gold standard. Since adequate direct methods to detect the motile larvae in stool samples are not widely available, other techniques such as serology have been developed. Methods: We evaluated three commercial ELISA kits (DRG Instruments, IVD Research, and Bordier Affinity Products) to detect IgG antibodies against Strongyloides stercoralis assays utilizing serum samples from travelers with microscopically confirmed strongyloidiasis (n = 50) and other imported helminthic infections (n = 159) as well as healthy controls (n = 50). Results: The DRG, IVD, and Bordier assays showed sensitivities of 58.0%, 64.0%, and 56.0%, respectively. Specificity values were 96.0%, 96.0%, and 92.0% in healthy controls, and 67.3%, 62.9%, and 76.7% in cases with other helminth infections, respectively. Cross-reactions were mostly observed in cases with other nematodes (37.5%, 42.5%, and 20.0%, respectively), but also in trematode (33.3%, 38.1%, and 19.0%, respectively) and in cestode infections (25.0%, 30.0%, and 32.5%, respectively). Conclusion: The study demonstrates the diagnostic limitations of serological assays to detect or exclude cases of strongyloidiasis in returning travelers, who frequently present with recent or acute infections. Author summary: Strongyloidiasis is a neglected nematode infection, which causes significant morbidity and mortality due its chronic course and potential of severe manifestations. The disease mostly threatens inhabitants of tropical and subtropical regions. Moreover, it has been recognized as an emerging problem in industrialized countries affecting migrants and returning travelers. The diagnosis of the intestinal helminth is challenging, since its reliable detection in stool samples requires specific methods, which are mostly not performed. Antibody detection by serological tests is a practical and commercially available diagnostic alternative, but the capabilities of such tests in non-endemic regions are not sufficiently studied. The presented study evaluated the performance of three commercial Strongyloides ELISA kits using serum samples from travelers with proven strongyloidiasis or various other parasitic infections. The study revealed that the sensitivity of Strongyloides serology in patients from non-endemic countries, who often present with early infections, might be limited and that tests frequently cross-react with other helminth infections. Serological results should therefore be interpreted cautiously and used together with parasitological methods to reduce the risk of missing this potentially severe infection. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

Author

Kurth, Florian, Roennefarth, Maria, Thibeault, Charlotte, Corman, Victor M., Müller-Redetzky, Holger, Mittermaier, Mirja, Ruwwe-Glösenkamp, Christoph, Heim, Katrin M., Krannich, Alexander, Zvorc, Saskia, Schmidt, Sein, Kretzler, Lucie, Dang-Heine, Chantip, Rose, Matthias, Hummel, Michael, Hocke, Andreas, Hübner, Ralf H., Opitz, Bastian, Mall, Marcus A., Röhmel, Jobst, Landmesser, Ulf, Pieske, Burkert, Knauss, Samuel, Endres, Matthias, Spranger, Joachim, Mockenhaupt, Frank P., Tacke, Frank, Treskatsch, Sascha, Angermair, Stefan, Siegmund, Britta, Spies, Claudia, Weber-Carstens, Steffen, Eckardt, Kai-Uwe, Schürmann, Dirk, Uhrig, Alexander, Stegemann, Miriam S., Zoller, Thomas, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, von Kalle, Christof, and Sander, Leif Erik

Published
2020
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22. Differential associations between psychosocial stress and obesity among Ghanaians in Europe and in Ghana: findings from the RODAM study

Author

Baratin, Clarissa, Beune, Erik, van Schalkwijk, Daan, Meeks, Karlijn, Smeeth, Liam, Addo, Juliet, de-Graft Aikins, Ama, Owusu-Dabo, Ellis, Bahendeka, Silver, Mockenhaupt, Frank P., Danquah, Ina, Schulze, Matthias B., Spranger, Joachim, Boateng, Daniel, Klipstein-Grobusch, Kerstin, Stronks, Karien, and Agyemang, Charles

Published
2020
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26. Dietary Patterns Are Associated with Predicted 10-Year Risk of Cardiovascular Disease Among Ghanaian Populations: the Research on Obesity and Diabetes in African Migrants (RODAM) Study

Author

Boateng, Daniel, Galbete, Cecilia, Nicolaou, Mary, Meeks, Karlijn, Beune, Erik, Smeeth, Liam, Osei-Kwasi, Hibbah Araba, Bahendeka, Silver, Agyei-Baffour, Peter, Mockenhaupt, Frank P, Spranger, Joachim, Grobbee, Diederick E, Schulze, Matthias B, Stronks, Karien, Agyemang, Charles, Danquah, Ina, and Klipstein-Grobusch, Kerstin

Published
2019
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30. Cardiovascular disease risk prediction in sub-Saharan African populations — Comparative analysis of risk algorithms in the RODAM study

Author

Boateng, Daniel, Agyemang, Charles, Beune, Erik, Meeks, Karlijn, Smeeth, Liam, Schulze, Matthias B., Addo, Juliet, de-Graft Aikins, Ama, Galbete, Cecilia, Bahendeka, Silver, Danquah, Ina, Agyei-Baffour, Peter, Owusu-Dabo, Ellis, Mockenhaupt, Frank P., Spranger, Joachim, Kengne, Andre P., Grobbee, Diederick E., and Klipstein-Grobusch, Kerstin

Published
2018
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31. Type 2 diabetes mellitus management among Ghanaian migrants resident in three European countries and their compatriots in rural and urban Ghana – The RODAM study

Author

Bijlholt, Margriet, Meeks, Karlijn A.C., Beune, Erik, Addo, Juliet, Smeeth, Liam, Schulze, Matthias B., Danquah, Ina, Galbete, Cecilia, de-Graft Aikins, Ama, Klipstein-Grobusch, Kerstin, Owusu-Dabo, Ellis, Spranger, Joachim, Mockenhaupt, Frank P., Amoah, Stephen K., Bahendeka, Silver, Stronks, Karien, and Agyemang, Charles

Published
2018
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32. Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Author

Bergmann, Clara, van Loon, Welmoed, Habarugira, Felix, Tacoli, Costanza, Jager, Julia C., Savelsberg, Darius, Nshimiyimana, Fabian, Rwamugema, Elias, Mbarushimana, Djibril, Ndoli, Jules, Sendegeya, Augustin, Bayingana, Claude, and Mockenhaupt, Frank P.

Subjects
Drug resistance in microorganisms -- Genetic aspects, Genetic polymorphisms -- Health aspects, Plasmodium falciparum -- Genetic aspects -- Health aspects, Health
Abstract

Emerging artemisinin resistance to Plasmodium falciparum endangers malaria control worldwide. Currently, the resistance epicenter is the greater Mekong subregion in Southeast Asia (1). In sub-Saharan Africa, where illnesses and deaths [...]

Published
2021
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37. Plasmodium vivax Malaria in Duffy-Positive Patients in Rwanda

Author

van Loon, Welmoed, primary, Oliveira, Rafael, additional, Bergmann, Clara, additional, Habarugira, Felix, additional, Tacoli, Costanza, additional, Jäger, Julia, additional, Savelsberg, Darius, additional, Mbarushimana, Djibril, additional, Ndoli, Jules M., additional, Sendegeya, Augustin, additional, Bayingana, Claude, additional, and Mockenhaupt, Frank P., additional

Published
2023
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38. Subgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population

Author

Danquah, Ina, primary, Mank, Isabel, additional, Hampe, Christiane S., additional, Meeks, Karlijn A. C., additional, Agyemang, Charles, additional, Owusu-Dabo, Ellis, additional, Smeeth, Liam, additional, Klipstein-Grobusch, Kerstin, additional, Bahendeka, Silver, additional, Spranger, Joachim, additional, Mockenhaupt, Frank P., additional, Schulze, Matthias B., additional, and Rolandsson, Olov, additional

Published
2023
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42. Food variety, dietary diversity, and type 2 diabetes in a multi-center cross-sectional study among Ghanaian migrants in Europe and their compatriots in Ghana: the RODAM study

Author

Danquah, Ina, Galbete, Cecilia, Meeks, Karlijn, Nicolaou, Mary, Klipstein-Grobusch, Kerstin, Addo, Juliet, Aikins, Ama de-Graft, Amoah, Stephen K., Agyei-Baffour, Peter, Boateng, Daniel, Bedu-Addo, George, Spranger, Joachim, Smeeth, Liam, Owusu-Dabo, Ellis, Agyemang, Charles, Mockenhaupt, Frank P., Beune, Erik, and Schulze, Matthias B.

Published
2018
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43. Ideal cardiovascular health among Ghanaian populations in three European countries and rural and urban Ghana: the RODAM study

Author

van Nieuwenhuizen, Benjamin, Zafarmand, Mohammad Hadi, Beune, Erik, Meeks, Karlijn, Aikins, Ama de-Graft, Addo, Juliet, Owusu-Dabo, Ellis, Mockenhaupt, Frank P., Bahendeka, Silver, Schulze, Matthias B., Danquah, Ina, Spranger, Joachim, Klipstein-Grobusch, Kerstin, Appiah, Lambert Tetteh, Smeeth, Liam, Stronks, Karien, and Agyemang, Charles

Published
2018
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44. A COVID-19 isolation facility for people experiencing homelessness in Berlin, Germany: a retrospective patient record study

Author

Hörig, Merle, primary, Klaes, Sarah M., additional, Krasovski-Nikiforovs, Svetlana, additional, van Loon, Welmoed, additional, Murajda, Lukas, additional, Rodriguez, Rosa C. O., additional, Schade, Christine, additional, Specht, Anabell, additional, Equihua Martinez, Gabriela, additional, Zimmermann, Ruth, additional, Mockenhaupt, Frank P., additional, Seybold, Joachim, additional, Lindner, Andreas K., additional, and Sarma, Navina, additional

Published
2023
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45. Subgroups of adult-onset diabetes : a data-driven cluster analysis in a Ghanaian population

Author

Danquah, Ina, Mank, Isabel, Hampe, Christiane S., Meeks, Karlijn A. C., Agyemang, Charles, Owusu-Dabo, Ellis, Smeeth, Liam, Klipstein-Grobusch, Kerstin, Bahendeka, Silver, Spranger, Joachim, Mockenhaupt, Frank P., Schulze, Matthias B., Rolandsson, Olov, Danquah, Ina, Mank, Isabel, Hampe, Christiane S., Meeks, Karlijn A. C., Agyemang, Charles, Owusu-Dabo, Ellis, Smeeth, Liam, Klipstein-Grobusch, Kerstin, Bahendeka, Silver, Spranger, Joachim, Mockenhaupt, Frank P., Schulze, Matthias B., and Rolandsson, Olov

Abstract

Adult-onset diabetes mellitus (here: aDM) is not a uniform disease entity. In European populations, five diabetes subgroups have been identified by cluster analysis using simple clinical variables; these may elucidate diabetes aetiology and disease prognosis. We aimed at reproducing these subgroups among Ghanaians with aDM, and establishing their importance for diabetic complications in different health system contexts. We used data of 541 Ghanaians with aDM (age: 25–70 years; male sex: 44%) from the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study. Adult-onset DM was defined as fasting plasma glucose (FPG) ≥ 7.0 mmol/L, documented use of glucose-lowering medication or self-reported diabetes, and age of onset ≥ 18 years. We derived subgroups by cluster analysis using (i) a previously published set of variables: age at diabetes onset, HbA1c, body mass index, HOMA-beta, HOMA-IR, positivity of glutamic acid decarboxylase autoantibodies (GAD65Ab), and (ii) Ghana-specific variables: age at onset, waist circumference, FPG, and fasting insulin. For each subgroup, we calculated the clinical, treatment-related and morphometric characteristics, and the proportions of objectively measured and self-reported diabetic complications. We reproduced the five subgroups: cluster 1 (obesity-related, 73%) and cluster 5 (insulin-resistant, 5%) with no dominant diabetic complication patterns; cluster 2 (age-related, 10%) characterized by the highest proportions of coronary artery disease (CAD, 18%) and stroke (13%); cluster 3 (autoimmune-related, 5%) showing the highest proportions of kidney dysfunction (40%) and peripheral artery disease (PAD, 14%); and cluster 4 (insulin-deficient, 7%) characterized by the highest proportion of retinopathy (14%). The second approach yielded four subgroups: obesity- and age-related (68%) characterized by the highest proportion of CAD (9%); body fat-related and insulin-resistant (18%) showing the highest

Published
2023
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46. ESBL-producing Enterobacteriaceae in a rural Rwandan community:Carriage among community members, livestock, farm products and environment

Author

Geuther, Nadja, Mbarushimana, Djibril, Habarugira, Felix, Buregeya, Jean Damascene, Kollatzsch, Mandy, Pfüller, Roland, Mugabowindekwe, Maurice, Ndoli, Jules, Mockenhaupt, Frank P., Geuther, Nadja, Mbarushimana, Djibril, Habarugira, Felix, Buregeya, Jean Damascene, Kollatzsch, Mandy, Pfüller, Roland, Mugabowindekwe, Maurice, Ndoli, Jules, and Mockenhaupt, Frank P.

Abstract

Objectives Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) are spreading globally. However, respective data from African communities including livestock and environmental specimens are rare. In a rural community of southern Rwanda, we assessed intestinal carriage of ESBL-PE among residents and livestock as well as presence in household specimens and examined associated factors. Methods Samples of humans and livestock (both rectal swabs), soil, water, vegetables and animal products were collected within 312 community households in Sovu, Southern Rwanda. Specimens were screened for ESBL-PE on chromogenic agar, and susceptibility to common antibiotics was determined by disc diffusion assays. Socio-demographic information was collected with questionnaires focusing on the socio-economic background, alimentation, living conditions, hygiene measures and medical history of the participants. Results Data and specimens from 312 randomly selected households including 617 human beings, 620 livestock and of approximately each 300 kitchen vegetables, animal products, soil and drinking water were analysed. Overall, 14.8% of 2508 collected samples were positive for ESBL-PE; figures were highest for humans (37.9%) and livestock (15.6%), lower for vegetables (3.8%) and animal products (3.3%), and lowest for soil (1.6%) and water (0.6%). Most detected ESBL-PE were Escherichia coli (93.5%) in addition to Klebsiella pneumoniae (6.5%). Cross-resistance to ampicillin-sulbactam, ciprofloxacin and co-trimoxazole was common. Logistic regression identified increasing age, another ESBL-PE positive household member, prolonged time for fetching water, current diarrhoea and the ability to pay school fees as independent predictors of intestinal ESBL-PE carriage among community members. Conclusions ESBL-PE carriage is common in a rural Rwandan farming community. Carriage in livestock is not associated with human carriage. Associated

Published
2023

47. Macrovascular and renal microvascular complications in West Africans with intermediate hyperglycemia living in West Africa and Europe: The RODAM study

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bannerman-Williams, Emmanuel, Hayfron-Benjamin, Charles F., Atiase, Yacoba, Bahendeka, Silver, Meeks, Karlijn, Klipstein-Grobusch, Kerstin, Addo, Juliet, Mockenhaupt, Frank, Schulze, Matthias B., Beune, Erik, van den Born, Bert-Jan, Agyemang, Charles, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bannerman-Williams, Emmanuel, Hayfron-Benjamin, Charles F., Atiase, Yacoba, Bahendeka, Silver, Meeks, Karlijn, Klipstein-Grobusch, Kerstin, Addo, Juliet, Mockenhaupt, Frank, Schulze, Matthias B., Beune, Erik, van den Born, Bert-Jan, and Agyemang, Charles

Published
2023

48. Subgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Danquah, Ina, Mank, Isabel, Hampe, Christiane S, Meeks, Karlijn A C, Agyemang, Charles, Owusu-Dabo, Ellis, Smeeth, Liam, Klipstein-Grobusch, Kerstin, Bahendeka, Silver, Spranger, Joachim, Mockenhaupt, Frank P, Schulze, Matthias B, Rolandsson, Olov, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Danquah, Ina, Mank, Isabel, Hampe, Christiane S, Meeks, Karlijn A C, Agyemang, Charles, Owusu-Dabo, Ellis, Smeeth, Liam, Klipstein-Grobusch, Kerstin, Bahendeka, Silver, Spranger, Joachim, Mockenhaupt, Frank P, Schulze, Matthias B, and Rolandsson, Olov

Published
2023

49. Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Chilunga, Felix P, Schwerzel, Pleun S, Meeks, Karlijn A C, Beune, Erik, Bahendeka, Silver, Mockenhaupt, Frank, Klipstein-Grobusch, Kerstin, Agyemang, Charles, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Chilunga, Felix P, Schwerzel, Pleun S, Meeks, Karlijn A C, Beune, Erik, Bahendeka, Silver, Mockenhaupt, Frank, Klipstein-Grobusch, Kerstin, and Agyemang, Charles

Published
2023

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