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Your search keyword '"Mocan Kuzey G"' showing total 4 results
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4 results on '"Mocan Kuzey G"'

1. Comparison of the diagnostic results of bronchoalveolar lavage with synchronous transbronchial biopsies [Bronkoalveoler lavaj-transbronşiyal biyopsi tanilarinin karşilaştirilmasi]

Author

Barut F., Özdamar Ş.O., Bahadir B., Dogan Gün B., Bektaş S., Çolak S., Mocan Kuzey G., and Zonguldak Bülent Ecevit Üniversitesi

Subjects
Bronchoalveolar lavage, Cytology
Abstract

Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while 18 cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course. Copyright © 2007 by Türkiye Klinikleri.

Published
2007

3. Expression of histamine receptors (H(1), H(2), and H(3)) in the rabbit endolymphatic sac: an immunohistochemical study.

Author

Dagli M, Goksu N, Eryilmaz A, Mocan Kuzey G, Bayazit Y, Gun BD, and Gocer C

Subjects
Animals, Endolymphatic Sac cytology, Epithelium metabolism, Male, Rabbits, Endolymphatic Sac metabolism, Immunohistochemistry methods, Receptors, Histamine H1 biosynthesis, Receptors, Histamine H2 biosynthesis, Receptors, Histamine H3 biosynthesis
Abstract

Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies. The aim of this study was to investigate the expression of histamine receptors (H(1), H(2), H(3)) in the rabbit ES., Methods: A total of 10 healthy male New Zealand white rabbits weighing 2 to 3 kg were used in the experiments. For immunohistochemical studies, immunostaining was performed according to the avidin-biotin-peroxidase complex technique., Results: Serial sections of the ES of rabbits revealed the presence of H(1), H(2), and H(3) receptor immunoreactivity. Immunoreactive cells for all H(1), H(2), and H(3) were found in the epithelial and subepithelial layers of the duct and the proximal ES. In conclusion, this study showed the immunohistochemical localization of H(1), H(2), and H(3) receptors in the ES of rabbits. These receptors may be important in the homeostasis of the inner ear. In addition, they may be target receptors in the medical treatment of inner ear disorders such as endolymphatic hydrops.

Published
2008
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4. Clinical results of a split sample liquid-based cytology (ThinPrep) study of 4,322 patients in a Turkish institution.

Author

Tuncer ZS, Başaran M, Sezgin Y, Firat P, and Mocan Kuzey G

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Carcinoma, Squamous Cell epidemiology, Colposcopy, Female, Humans, Mass Screening, Middle Aged, Predictive Value of Tests, Prospective Studies, Turkey epidemiology, Uterine Cervical Neoplasms epidemiology, Carcinoma, Squamous Cell diagnosis, Cervix Uteri pathology, Epithelial Cells pathology, Papanicolaou Test, Uterine Cervical Neoplasms diagnosis, Vaginal Smears methods
Abstract

Purpose: A prospective study was carried out to compare the efficacy of liquid-based cytology (ThinPrep) with the conventional Pap smear using a split-sample design in a Turkish university hospital outpatient gynecology clinic., Methods: 4,322 consecutive patients were recruited for the study between 2002 and 2003. All the patients underwent conventional Pap tests followed by a ThinPrep test for screening of cervical cancer. The results were evaluated in terms of the Bethesda III classification. All the patients with abnormal tests underwent colposcopy and directed biopsy., Results: While 2.3% of the specimens were unsatisfactory for evaluation in the conventional Pap test group, this rate was 1.7% for the ThinPrep group. Epithelial cell abnormalities were observed in 42 (1.0%) patients in the conventional Pap test group and in 36 (0.8%) patients in the ThinPrep group. ASCUS was observed in 26 patients in the conventional Pap test group whereas the ThinPrep group had 20 cases of ASCUS as the leading cause of abnormal cytology. Biopsy of these cases revealed CIN 1 in two CIN 2-3 in three and cervical/endometrial adenocarcinoma in three patients. The ThinPrep application led to diagnoses of one additional case of CIN 2-3 and one case of adenocarcinoma among the negative or unsatisfactory for evaluation categories of the conventional Pap test group., Conclusion: Despite an adverse bias introduced by the split-sample study design, application of ThinPrep showed an improved rate of specimen adequacy and increased sensitivity for more significant cervical precursor lesions over the conventional Pap test.

Published
2005

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