120 results on '"Moazami Goudarzi, K."'
Search Results
2. Identification of new quantitative trait loci (other than the PRNP gene) modulating the scrapie incubation period in sheep
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Moreno, C.R., Cosseddu, G.M., Schibler, L., Roig, A., Moazami-Goudarzi, K., Andreoletti, O., Eychenne, F., Lajous, D., Schelcher, F., Cribiu, E.P., Laurent, P., Vaiman, D., and Elsen, J.M.
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Scrapie -- Risk factors ,Scrapie -- Genetic aspects ,Scrapie -- Research ,Quantitative trait loci -- Identification and classification ,Biological sciences - Abstract
Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.
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- 2008
3. Which PrP haplotypes in a French sheep population are the most susceptible to atypical scrapie?
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Moreno, C. R., Moazami-Goudarzi, K., Laurent, P., Cazeau, G., Andreoletti, O., Chadi, S., Elsen, J.-M., and Calavas, D.
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- 2007
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4. Is a multivariate consensus representation of genetic relationships among populations always meaningful?
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Moazami-Goudarzi, K. and Laloe, D.
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Genetics -- Research ,Population genetics -- Research ,Phylogeny -- Research ,Gene mutations -- Physiological aspects ,Genetic markers -- Usage ,Biological sciences - Abstract
To determine the relationships among closely related populations or species, two methods are commonly used in the literature: phylogenetic reconstruction or multivariate analysis. The aim of this article is to assess the reliability of multivariate analysis. We describe a method that is based on principal component analysis and Mantel correlations, using a two-step process: The first step consists of a single-marker analysis and the second step tests if each marker reveals the same typology concerning population differentiation. We conclude that if single markers are not congruent, the compromise structure is not meaningful. Our model is not based on any particular mutation process and it can be applied to most of the commonly used genetic markers. This method is also useful to determine the contribution of each marker to the typology of populations. We test whether our method is efficient with two real data sets based on microsatellite markers. Our analysis suggests that for closely related populations, it is not always possible to accept the hypothesis that an increase in the number of markers will increase the reliability of the typology analysis.
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- 2002
5. Differentiation of European cattle by AFLP fingerprinting
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Negrini, R., Nijman, I. J., Milanesi, E., Moazami-Goudarzi, K., Williams, J. L., Erhardt, G., Dunner, S., Rodellar, C., Valentini, A., Bradley, D. G., Olsaker, I., Kantanen, J., Ajmone-Marsan, P., and Lenstra, J. A.
- Published
- 2007
6. Emploi de microsatellites pour l'analyse de la diversité génétique des races bovines françaises: premiers résultats
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Moazami-Goudarzi, K, Vaiman, D, Mercier, D, Grohs, C, Furet, JP, Levéziel, H, and Martin, P
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- 1994
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7. Conservation of a syntenic group of microsatellite loci between cattle and sheep
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Vaiman, D., Imam-Ghali, M., Moazami-Goudarzi, K., Guérin, G., Grohs, C., Levéziel, H., and Saïdi-Mehtar, N.
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- 1994
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8. A set of 99 cattle microsatellites: characterization, synteny mapping, and polymorphism
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Vaiman, D., Mercier, D., Moazami-Goudarzi, K., Eggen, A., Ciampolini, R., Lépingle, A., Velmala, R., Kaukinen, J., Varvio, S. L., Martin, P., Levéziel, H., and Guérin, G.
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- 1994
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9. Emploi de microsatellites pour l'analyse de la diversité génétique des races bovines françaises: premiers résultats
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Furet JP, Grohs C, Mercier D, Vaiman D, Moazami-Goudarzi K, Levéziel H, and Martin P
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Animal culture ,SF1-1100 ,Genetics ,QH426-470 - Published
- 1994
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10. Analysis of genetic relationships between 10 cattle breeds with 17 microsatellites
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Moazami-Goudarzi, K, Laloë, D, Furet, J P, and Grosclaude, F
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- 1997
11. Genetic characterization of Southwestern European bovine breeds: a historical and biogeographical reassessment with a set of 16 microsatellites
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Beja-Pereira, A., Alexandrino, P., Bessa, I., Carretero, Y., Dunner, S., Ferrand, N., Jordana, J., Laloe, D., Moazami-Goudarzi, K., Sanchez, A., and Canon, J.
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Biological diversity -- Genetic aspects ,Genetic variation -- Research ,Genetic variation -- Demographic aspects ,Variation (Biology) -- Genetic aspects ,Variation (Biology) -- Demographic aspects ,Cattle -- Genetic aspects ,Cattle -- Demographic aspects ,Biogeography -- Research ,Heredity -- Research ,Heredity -- Genetic aspects ,Biological sciences - Abstract
Research has been conducted on Iberian cattle origin. The authors have investigated the genetic data combined with the geographical positioning via the use of geostatistical models, and have characterized Portugues, Spanish and French cattle breeds for their genetic diversity.
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- 2003
12. Marker-assisted conservation of European cattle breeds: an evaluation
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Lenstra, J.A., Nijman, I.J., Eding, H., Engelsma, K.A., Bijma, P., Garcia, D., Canon, J., Dunner, S., Moazami Goudarzi, K., Laloe, D., Williams, J.L., Wiener, P., Burton, D., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E.M., Harlizius, B., Barre Dirie, A., Mengers, A., Looft, C., Kalm, E., Rodellar, C., Zaragoza, P., Martin Burriel, I., Sanchez, A., Ajmone Marsan, P., Negrini, R., Milanesi, E., Valentini, A., Savarese, M.C., Marchitelli, C., Zanotti, M., Ceriotti, G., Pilla, F., Bruzzone, A., Iamartino, D., Olsaker, I., Holm, L.E., Mommens, G., Dolf, G., Hiemstra, S.H., and Windig, J.J.
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Genetic Markers ,Conservation of Natural Resources ,Genotype ,business.industry ,Cattle ,Conservation ,Genetic diversity ,Kinship ,Microsatellite ,Weitzman ,Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico ,Genetic Variation ,General Medicine ,Breeding ,Biology ,Biotechnology ,Environmental protection ,Genetics ,Animals ,Animal Science and Zoology ,business ,Microsatellite Repeats - Abstract
Two methods have been developed for the assessment of conservation priorities on the basis of molecular markers. According to the Weitzman approach, contributions to genetic diversity are derived from genetic distances between populations. Alternatively, diversity within and across populations is optimized by minimizing marker-estimated kinships. We have applied, for the first time, both methods to a comprehensive data set of 69 European cattle breeds, including all cosmopolitan breeds and several local breeds, for which genotypes of 30 microsatellite markers in 25-50 animals per breed have been obtained. Both methods were used to calculate the gain in diversity if a breed was added to a set of nine non-endangered breeds. Weitzman-derived diversities were confounded by genetic drift in isolated populations, which dominates the genetic distances but does not necessarily increase the conservation value of a breed. Marker-estimated kinships across populations were less disturbed by genetic drift than the Weitzman diversities and assigned high conservation values to Mediterranean breeds, which indeed have genetic histories that differ from the non-endangered breeds. Prospects and limitations of marker-assisted decisions on conservation priorities are discussed.
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- 2006
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13. Adaptation of Mediterranean local cattle breeds to climate changes: a preliminary study on genome-wide diversity
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Casu, S., Ciampolini, Roberta, Mastrangelo, S., Flori, L., Moazami Goudarzi, K., Sechi, T., Casabianca, F., Lauvie, A., Gautier, M., Carta, A., Portolano, B., and Laloë, D.
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Principal Components Analysis ,Genetic Adaptation ,SNP Markers ,Cattle Breeds, Genetic Adaptation, Climate Changes, Genome-wide diversity, SNP Markers, Principal Components Analysis, Co-inertia Analysis ,Climate Changes ,Co-inertia Analysis ,Genome-wide diversity ,Cattle Breeds - Published
- 2015
14. Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle
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Utsunomiya, Yuri T., Bomba, Lorenzo, Lucente, Giordana, Colli, Licia, Negrini, Riccardo, Lenstra, Johannes A., Erhardt, Georg, Garcia, José F., Ajmone-Marsan, Paolo, Moazami-Goudarzi, K., Williams, J., Wiener, P., Olsaker, I., Kantanen, J., Dunner, S., Cañón, J., Rodellar, C., Martín-Burriel, I., Valentini, A., Zanotti, M., Holm, L. E., Eythorsdottir, E., Mommens, G., Polygen, Van Haeringen, Nijman, I. J., Dolf, G., Bradley, D. G., Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Universidade Estadual Paulista (Unesp), Univ Cattol Sacro Cuore, Univ Utrecht, and Univ Giessen
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Genetic Markers ,Conservation of Natural Resources ,AFLP ,Genotype ,ved/biology.organism_classification_rank.species ,Introgression ,Breeding ,Genetic differentiation ,Revisiting AFLP ,Ascertainment bias ,Genetic variation ,genetic structure ,Genetics ,Animals ,Cluster Analysis ,Genetics(clinical) ,Amplified Fragment Length Polymorphism Analysis ,Genetics (clinical) ,Models, Genetic ,Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO ,biology ,ved/biology ,Taurine cattle ,Genetic Variation ,Aurochs ,Zebu ,biology.organism_classification ,humanities ,Genetics, Population ,Genetic marker ,Genetic structure ,Amplified fragment length polymorphism ,Cattle ,Research Article - Abstract
Made available in DSpace on 2014-12-03T13:07:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-04-17Bitstream added on 2014-12-03T13:24:33Z : No. of bitstreams: 1 WOS000335177200001.pdf: 750548 bytes, checksum: 075b52b143f984a79a48dec1b9a68ce6 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Descendants from the extinct aurochs (Bos primigenius), taurine (Bos taurus) and zebu cattle (Bos indicus) were domesticated 10,000 years ago in Southwestern and Southern Asia, respectively, and colonized the world undergoing complex events of admixture and selection. Molecular data, in particular genome-wide single nucleotide polymorphism (SNP) markers, can complement historic and archaeological records to elucidate these past events. However, SNP ascertainment in cattle has been optimized for taurine breeds, imposing limitations to the study of diversity in zebu cattle. As amplified fragment length polymorphism (AFLP) markers are discovered and genotyped as the samples are assayed, this type of marker is free of ascertainment bias. In order to obtain unbiased assessments of genetic differentiation and structure in taurine and zebu cattle, we analyzed a dataset of 135 AFLP markers in 1,593 samples from 13 zebu and 58 taurine breeds, representing nine continental areas.Results: We found a geographical pattern of expected heterozygosity in European taurine breeds decreasing with the distance from the domestication centre, arguing against a large-scale introgression from European or African aurochs. Zebu cattle were found to be at least as diverse as taurine cattle. Western African zebu cattle were found to have diverged more from Indian zebu than South American zebu. Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. Although a large part of South American zebu cattle also descend from taurine cows, we did not detect significant levels of taurine ancestry in these breeds, probably because of systematic backcrossing with zebu bulls. Furthermore, limited zebu introgression was found in Podolian taurine breeds in Italy.Conclusions: The assessment of cattle diversity reported here contributes an unbiased global view to genetic differentiation and structure of taurine and zebu cattle populations, which is essential for an effective conservation of the bovine genetic resources. Univ Estadual Paulista, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil Univ Cattol Sacro Cuore, Inst Zootech, Piacenza, Italy Univ Cattol Sacro Cuore, BioDNA Biodivers & Ancient DNA Res Ctr, Piacenza, Italy Univ Utrecht, Fac Vet Med, Utrecht, Netherlands Univ Giessen, Inst Anim Breeding & Genet, D-35390 Giessen, Germany Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP, Brazil Univ Estadual Paulista, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP, Brazil FAPESP: 11/16643-2 FAPESP: 13/12829-0
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- 2014
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15. La vitesse de phase des ondes de Rayleigh et les structures de la croûte et du manteau supérieur entre Machhad et Chiraz (Iran)
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Moazami-Goudarzi, K.
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- 1974
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16. On the breeds of cattle-Historic and current classifications
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Felius, M., Koolmees, Peter A., Theunissen, B., Baumung, R., Manatrinon, S., Mommens, G., Holm, L. -E., Withen, K. B., Pedersen, B. V., Gravlund, P., Viinalass, H., Kantanen, J., Tapio, I., M. H., Li, Moazami-Goudarzi, K., Gautier, M., Denis, Laloë, Oulmouden, A., Levéziel, H., Taberlet, P., Harlizius, B., Simianer, H., Täubert, H., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E. -M., Medugorac, I., Medugorac, A., Förster, M., Mix, H. M., Looft, C., Kalm, E., Bradley, D. G., Edwards, C. J., Machugh, D. E., Freeman, A. R., Ajmone Marsan, P., Negrini, R., Longeri, M., Ceriotti, G., Zanotti, M., Marletta, D., Criscione, A., Valentini, A., Marchitelli, C., Pariset, L., Savarese, M. C., Pilla, F., Grislis, Z., Miceikienė, I., Nijman, I. J., van Haeringen, W., van de Goor, L., Olsaker, I., Ginja, C., Gama, L. T., Mateus, J. C., Beja-Pereira, A., Ferrand, N., Ivanova, Z., Popov, R., Ammosov, I., Kiselyova, T., Marzanov, N., Stojanovic, S., Simčič, M., Dovč, P., Kompan, D., Dunner, S., Rodellar, C., Martín-Burriel, I., Sánchez, A., Piedrafita, J., Azor, P. J., Delgado, J. V., Martínez-Martínez, A., Molina, A., Rodero, E., Dolf, G., Williams, J. L., Wiener, P., Bruford, M. W., Bray, T. C., Alderson, L., Penedo, M. C. T., Lenstra, J. A., Lenstra, Johannes A., Utrecht University [Utrecht], and European Cattle Genetic Diversity Consortium
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breeds ,breed ,[SDV]Life Sciences [q-bio] ,Ecology (disciplines) ,Breeds ,Zoology ,Ethnic origin ,Subspecies ,Q1 ,Crossbreed ,03 medical and health sciences ,symbols.namesake ,QH301 ,aurochs ,auroch ,lcsh:QH301-705.5 ,030304 developmental biology ,Nature and Landscape Conservation ,2. Zero hunger ,0303 health sciences ,Genetic diversity ,biology ,Ecology ,Ecological Modeling ,Linnaean taxonomy ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,Aurochs ,biology.organism_classification ,cattle ,classification ,Classification ,040201 dairy & animal science ,Agricultural and Biological Sciences (miscellaneous) ,Breed ,Ecological Modelling ,lcsh:Biology (General) ,Evolutionary biology ,symbols ,Cattle - Abstract
Chantier qualité GA Liste des auteurs de l'European Cattle Genetic Consortium, classés par pays : Austria: R. Baumung, S. Manatrinon, BOKU University, Vienna; Belgium: G. Mommens, University of Ghent, Merelbeke; Denmark: L.-E. Holm, Aarhus University, Tjele; K.B. Withen, B.V. Pedersen, P. Gravlund, University of Copenhagen, Copenhagen; Estonia: H. Viinalass, Estonian University of Life Sciences, Tartu; Finland: J. Kantanen, I. Tapio, M.H. Li, MTT, Jokioinen; France: K. Moazami-Goudarzi, M. Gautier, Denis Laloë, INRA, Jouy-en-Josas; A. Oulmouden, H. Levéziel, INRA, Limoges; P. Taberlet, Université Joseph Fourier et CNRS, Grenoble; Germany: B. Harlizius, School of Veterinary Medicine, Hannover; H. Simianer, H. Täubert, Georg-August-Universität, Göttingen; G. Erhardt, O. Jann, C. Weimann, E.-M. Prinzenberg, Justus-Liebig Universität, Giessen; I. Medugorac, A. Medugorac, M. Förster, Ludwig-Maximilians Universität, Munich; H.M. Mix, Naturschutz International, Grünheide; C. Looft, E. Kalm, Christian-Albrechts-Universität, Kiel; Ireland: D.G. Bradley, C.J. Edwards, D.E. MacHugh, A.R. Freeman, Trinity College, Dublin; Italy: P. Ajmone Marsan, R. Negrini, Università Cattolica del S. Cuore, Piacenza; M. Longeri, G. Ceriotti, M. Zanotti, Università degli Studi di Milano; D. Marletta, A. Criscione, Universita degli Studi di Catania, Catania; A. Valentini, C. Marchitelli, L. Pariset, M.C. Savarese, Università della Tuscia, Viterbo; F. Pilla, Università del Molise, Campobasso; Latvia: Z. Grislis, Latvia University of Agriculture, Jelgava; Lithuania: I. Miceikienė, Lithuanian Veterinary Academy, Kaunas; Netherlands: I.J. Nijman, Utrecht University; W. van Haeringen, L. van de Goor, Van Haeringen Laboratory, Wageningen; Norway: I. Olsaker, Norwegian School of Veterinary Science, Oslo; Portugal: C. Ginja, L.T.Gama, Instituto Nacional de Recursos Biológicos—INIA, Lisbon University, Lisboa; L.T. Gama, Instituto Nacional de Recursos Biológicos-INIA, I.P., Vale de Santarem; J.C. Mateus, Universidade de Trás-os-Montes e Alto Douro, Vila Real; A. Beja-Pereira, N. Ferrand, Oporto University; Russia: Z. Ivanova, R. Popov, I. Ammosov, Yakutian Research Institute of Agricultural Sciences, Yakutsk, Sakha; T. Kiselyova, All-Russian Research Institute for Farm Animals and Breeding, St. Petersburgh-Pushkin; N. Marzanov, All-Russian Research Institute of Animal Husbandry, Dubrovitsy; Serbia: S. Stojanovic, Ministry of Agriculture and Water Management, Belgrade; Slovenia: M. Simčič, P. Dovč, D.Kompan, University of Ljubljana, Domzale; Spain: S. Dunner, Universidad Complutense de Madrid; C. Rodellar, I. Martín-Burriel, Veterinary Faculty, Zaragoza; A. Sánchez, J. Piedrafita, Universitat Autònoma de Barcelona; P.J. Azor, J.V. Delgado, A. Martínez-Martínez, A. Molina, E. Rodero, University of Córdoba; Switzerland: G. Dolf, University of Berne; UK: J.L. Williams, P. Wiener, Roslin Institute; M.W. Bruford, T.C. Bray, Cardiff University, Cardiff; L. Alderson, Countrywide Livestock Ltd, Shrewsbury; USA: M.C.T. Penedo. University of California, Davis, CA; International audience; Classification of cattle breeds contributes to our understanding of the history of cattle and is essential for an effective conservation of genetic diversity. Here we review the various classifications over the last two centuries and compare the most recent classifications with genetic data. The classifications devised during the 19th to the late 20th century were in line with the Linnaean taxonomy and emphasized cranial or horn morphology. Subsequent classifications were based on coat color, geographic origin or molecular markers. Several theories were developed that linked breed characteristics either to a supposed ancestral aurochs subspecies or to a presumed ethnic origin. Most of the older classifications have now been discarded, but have introduced several Latin terms that are still in use. The most consistent classification was proposed in 1995 by Felius and emphasizes the geographic origin of breeds. This is largely in agreement with the breed clusters indicated by a biochemical and molecular genetic analysis, which reflect either groups of breeds with a common geographic origin or single breeds that have expanded by export and/or crossbreeding. We propose that this information is also relevant for managing the genetic diversity of cattle.
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- 2011
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17. Geographic Patterns of Molecular Diversity and Paternal Lineages of European cattle
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Lenstra, J A, Nijman, I J, Eding, H, Engelsma, K A, Bijma, P, Garcia, D, Cañón, J, Dunner, S, Moazami-Goudarzi, K, Laloe, D, Williams, J L, Wiener, P, Burton, D, Erhardt, G, Jann, O, Weimann, C, Prinzenberg, E M, Harlizius, B, Barre-Dirie, B, Mengers, A, Looft, C, Kalm, E, Rodellar, C, Zaragoza, P, Martin-Burriel, I, Sanchez, A, Ajmone-Marsan, P, Negrini, R, Milanesi, E, Valentini, A, Savarese, M C, Marchitelli, C, Zanotti, M, Ceriotti, G, Pilla, F, Bruzzone, A, Iamartino, D, Olsaker, I, Holm, Lars-Erik, Mommens, G, Dolf, G, Hiemstra, S J, and Winding, J J
- Published
- 2009
18. Short communication. IL-1 family members as possible candidate genes affecting economically important traits in cattle
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Marcos-Carcavilla, A., Calvo, J.H., González, C., Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Alves, M.E.F., and Serrano, M.
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GANADO BOVINO ,GENES ,MEJORAMIENTO ANIMAL ,CRITERIOS DE SELECCION ,CITOQUINAS ,INTERLEUQUINAS ,SANIDAD ANIMAL ,RENDIMIENTO CARNICO ,CATTLE ,ANIMAL BREEDING ,SELECTION CRITERIA ,CYTOKINES ,INTERLEUKINS ,ANIMAL HEALTH ,MEAT YIELD ,BREEDING AND GENETICS - Abstract
Health problems in cattle cause considerable economic losses for the producers. Proinflammatory cytokines have been shown to play important roles in different aspects of animal health and production. In the present work, interleukin-1 beta and interleukin-1 receptor antagonist genes (IL1B and IL1RN, respectively) have been localized on bovine chromosome 11 (BTA11q22). The precise location for IL1RN is reported and discrepancies concerning the exact position of IL1B (BTA 11q22 or BTA 11q23/11q24) are solved. In addition, the BTA11q22 region has been shown to carry several quantitative trait loci intervals affecting cattle production. Thus, it may be interesting to consider these two cytokines in order to develop more efficient breeding schemes and improve the accuracy and intensity of selection programs., Los problemas sanitarios causan grandes pérdidas económicas a los ganaderos. Se ha demostrado que las citoquinas proinflamatorias desempeñan importantes papeles en distintos aspectos relacionados con la salud y la producción animal. En este trabajo se han localizado los genes que codifican para la interleuquina-1 beta y el antagonista del receptor de la interleuquina-1 (IL1B y IL1RN, respectivamente) en el cromosoma 11 bovino (BTA11q22). De este modo, se ha establecido la localización precisa de IL1RN y se han resuelto las discrepancias alrededor de la posición exacta de IL1B (BTA 11q22 ó BTA 11q23/11q24). Además, se ha visto que la región BTA11q22 es portadora de varios intervalos cromosómicos que afectan a caracteres productivos de interés en ganadería. De manera que sería interesante tener en cuenta estas dos citoquinas a la hora de desarrollar eficientes esquemas de producción y de mejorar la precisión y la intensidad de los programas de selección.
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- 2007
19. Molecular differentiation of European Cattle breeds
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Lenstra, J.A., Nijman, I.J., Moazami Goudarzi, K., Laloë, D., Williams, J.L., Wiener, P., Burton, D., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E.M., Harlizius, B., Looft, C., Dunner, S., Canon, J., Rodellar, C., Zaragoza, P., Martin Burriel, I., Sanchez, A., Piedrafita, J., Ajmone Marsan, P., Negrini, R., Milanesi, E., Valentini, A., Savarese, M.C., Marchitelli, C., Zanotti, M., Ceriotti, G., Pilla, F., Bruzzone, A., Iamartino, D., Bradley, D., Machugh, D.E., Freeman, A.R., Medugorac, I., Medugorac, A., Mix, H., Förster, M., Kantanen, J., Olsaker, I., Holm, L.E., Miceikienė, I., Grislis, Z., Viinalass, H., Danell, B., Eythorsdottir, E., Mommens, G., Van Haeringen, C., Taberlet, P., Luikart, G., Beja Pereira, A., Ferrand, N., Mateus, J.C., Dolf, G., and Felius, M.
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Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico - Published
- 2004
20. Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle
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Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Utsunomiya, Yuri T., Bomba, Lorenzo, Lucente, Giordana, Colli, Licia, Negrini, Riccardo, Lenstra, Johannes A., Erhardt, Georg, Garcia, José F., Ajmone-Marsan, Paolo, Moazami-Goudarzi, K., Williams, J., Wiener, P., Olsaker, I., Kantanen, J., Dunner, S., Cañón, J., Rodellar, C., Martín-Burriel, I., Valentini, A., Zanotti, M., Holm, L. E., Eythorsdottir, E., Mommens, G., Polygen, Van Haeringen, Nijman, I. J., Dolf, G., Bradley, D. G., Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Utsunomiya, Yuri T., Bomba, Lorenzo, Lucente, Giordana, Colli, Licia, Negrini, Riccardo, Lenstra, Johannes A., Erhardt, Georg, Garcia, José F., Ajmone-Marsan, Paolo, Moazami-Goudarzi, K., Williams, J., Wiener, P., Olsaker, I., Kantanen, J., Dunner, S., Cañón, J., Rodellar, C., Martín-Burriel, I., Valentini, A., Zanotti, M., Holm, L. E., Eythorsdottir, E., Mommens, G., Polygen, Van Haeringen, Nijman, I. J., Dolf, G., and Bradley, D. G.
- Published
- 2014
21. Polymorphisms in the HSP90AA1 5' flanking region are associated with scrapie incubation period in sheep
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Marcos-Carcavilla, A., Moreno, C., Serrano Noreña, Magdalena, Laurent, P., Cribiu, E. P., Andréoletti, Olivier, Ruesche, J., Weisbecker, J. L., Calvo, Jorge Hugo, Moazami-Goudarzi, K., Marcos-Carcavilla, A., Moreno, C., Serrano Noreña, Magdalena, Laurent, P., Cribiu, E. P., Andréoletti, Olivier, Ruesche, J., Weisbecker, J. L., Calvo, Jorge Hugo, and Moazami-Goudarzi, K.
- Abstract
Susceptibility to scrapie is mainly controlled by point mutations at the PRNP locus. However, additional quantitative trait loci (QTL) have been identified across the genome including a region in OAR18. The gene which encodes the inducible form of the cytoplasmic Hsp90 chaperone (HSP90AA1) maps within this region and seems to be associated with the resistance/susceptibility to scrapie in sheep. Here, we have analyzed several polymorphisms which were previously described in the ovine HSP90AA1 5' flanking region and in intron 10 in two naturally scrapie infected Romanov sheep populations. First, we have studied 58 ARQ/VRQ animals pertaining to the sire family where the QTL influencing scrapie incubation period in OAR18 was detected. We have found a significant association between polymorphisms localized at -660 and -528 in the HSP90AA1 5' flanking region and the scrapie incubation period. These two polymorphisms have also been studied in a second sample constituted by 62 VRQ/ VRQ sheep showing an extreme incubation period. Results are concordant with the first dataset. Finally, we have studied the HSP90AA1 expression in scrapie and control animals (N=41) with different HSP90AA1 genotypes by real time PCR on blood samples. The HSP90AA1 expression rate was equivalent in CC -600AA-528 and CG-600AG-528 scrapie resistant animals (ARR/ARR) and was higher in their CC-600AA-528 than in their CG-600AG-528 scrapie susceptible counterparts (VRQ/VRQ). Our results support the hypothesis that the ovine HSP90AA1 gene acts as a modulator of scrapie susceptibility, contributing to the observed differences in the incubation period of scrapie infected animals with the same PRNP genotype. © Cell Stress Society International 2009.
- Published
- 2010
22. A whole genome Bayesian scan for adaptive genetic divergence in West African cattle
- Author
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Gautier, M, Flori, L, Riebler, A, Jaffrezic, F, Laloe, D, Gut, I, Moazami-Goudarzi, K, Foulley, J L, Gautier, M, Flori, L, Riebler, A, Jaffrezic, F, Laloe, D, Gut, I, Moazami-Goudarzi, K, and Foulley, J L
- Abstract
BACKGROUND: The recent settlement of cattle in West Africa after several waves of migration from remote centres of domestication has imposed dramatic changes in their environmental conditions, in particular through exposure to new pathogens. West African cattle populations thus represent an appealing model to unravel the genome response to adaptation to tropical conditions. The purpose of this study was to identify footprints of adaptive selection at the whole genome level in a newly collected data set comprising 36,320 SNPs genotyped in 9 West African cattle populations. RESULTS: After a detailed analysis of population structure, we performed a scan for SNP differentiation via a previously proposed Bayesian procedure including extensions to improve the detection of loci under selection. Based on these results we identified 53 genomic regions and 42 strong candidate genes. Their physiological functions were mainly related to immune response (MHC region which was found under strong balancing selection, CD79A, CXCR4, DLK1, RFX3, SEMA4A, TICAM1 and TRIM21), nervous system (NEUROD6, OLFM2, MAGI1, SEMA4A and HTR4) and skin and hair properties (EDNRB, TRSP1 and KRTAP8-1). CONCLUSIONS: The main possible underlying selective pressures may be related to climatic conditions but also to the host response to pathogens such as Trypanosoma(sp). Overall, these results might open the way towards the identification of important variants involved in adaptation to tropical conditions and in particular to resistance to tropical infectious diseases.
- Published
- 2009
23. Structural and functional analysis of the HSP90AA1 gene Distribution of polymorphisms among sheep with different responses to scrapie
- Author
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Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Serrano, Carmen, Lyahyai, J., Martín-Burriel, Inmaculada, Serrano Noreña, Magdalena, Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Serrano, Carmen, Lyahyai, J., Martín-Burriel, Inmaculada, and Serrano Noreña, Magdalena
- Abstract
Scrapie is a transmissible spongiform encephalopathy in sheep and goats. Susceptibility to this neurodegenerative disease is mainly controlled by point mutations at the PRNP locus. Other genes, apart from PRNP, have been reported to modulate resistance/susceptibility to scrapie. On the basis of several studies in Alzheimer and different transmissible spongiform encephalopathy models, HSP90AA1 was chosen as a putative positional and functional candidate gene that might be involved in the polygenic variance mentioned above. In the present work, the ovine HSP90AA1 gene including the promoter and other regulatory regions has been isolated and characterized. Several sequence polymorphisms have also been identified. FISH-mapping localized the HSP90AA1 gene on ovine chromosome OAR19q24dist, which was confirmed by linkage analysis. This chromosome region has been shown to include a quantitative trait loci (QTL) for scrapie incubation period in sheep. Expression analyses were carried out in spleen and cerebellum samples. No differences in the expression of the HSP90AA1 gene were found in any of these tissues (p>0.05) between control and infected animal samples. Nevertheless, association analyses revealed that several polymorphisms in the 5′ and 3′ regions of the HSP90AA1 gene were differentially distributed among animals with different responses to scrapie infection. Thus, results presented here support the hypothesis that HSP90AA1 could be a positional and functional candidate gene modulating the response to scrapie in sheep. © Cell Stress Society International 2008.
- Published
- 2008
24. Structural and functional analysis of the ovine laminin receptor gene (RPSA) Possible involvement of the LRP/LR protein in scrapie response
- Author
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Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Serrano, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Lyahyai, J., Martín-Burriel, Inmaculada, Torres, J. M., Serrano Noreña, Magdalena, Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Serrano, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Lyahyai, J., Martín-Burriel, Inmaculada, Torres, J. M., and Serrano Noreña, Magdalena
- Abstract
Scrapie is a prion disease affecting sheep and goats. Susceptibility to this neurodegenerative disease shows polygenic variance. The involvement of the laminin receptor (LRP/LR) in the metabolism and propagation of prions has previously been demonstrated. In the present work, the ovine laminin receptor gene (RPSA) was isolated, characterized, and mapped to ovine chromosome OAR19q13. Real-time RT-PCR revealed a significant decrease in RPSA mRNA in cerebellum after scrapie infection. Conversely, no differences were detected in other brain regions such as diencephalon and medulla oblongata. Association analysis showed that a polymorphism reflecting the presence of a RPSA pseudogene was overrepresented in a group of sheep resistant to scrapie infection. No amino acid change in the LRP/LR protein was found in the 126 sheep analyzed. However, interesting amino acid positions (241, 272, and 290), which could participate in the species barrier to scrapie and maybe to other transmissible spongiform encephalopathies, were identified by comparing LRP/LR sequences from various mammals with variable levels of resistance to scrapie. © 2007 Springer Science+Business Media, LLC.
- Published
- 2008
25. IL-1 family members as possible candidate genes affencting economically important traits in cattle
- Author
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Calvo Lacosta, Jorge Hugo, Marcos-Carcavilla, A., González, C., Moazami-Goudarzi, K., Laurent, P., Bertaud, Madeleine, Hayes, H., Alves, M.E.F., Serrano Mula, María, Calvo Lacosta, Jorge Hugo, Marcos-Carcavilla, A., González, C., Moazami-Goudarzi, K., Laurent, P., Bertaud, Madeleine, Hayes, H., Alves, M.E.F., and Serrano Mula, María
- Published
- 2007
26. IL-1 family members as candidate genes modulating scrapie susceptibility in sheep Localization, partial characterization, and expression
- Author
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Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Serrano, Carmen, Lyahyai, J., Martín-Burriel, Inmaculada, Alves, Estefania, Zaragoza, P., Badiola, Juan J., Serrano Noreña, Magdalena, Martín-Burriel, Inmaculada [0000-0001-6016-4726], Marcos-Carcavilla, A., Calvo, Jorge Hugo, González, Carmen, Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Serrano, Carmen, Lyahyai, J., Martín-Burriel, Inmaculada, Alves, Estefania, Zaragoza, P., Badiola, Juan J., and Serrano Noreña, Magdalena
- Abstract
Scrapie (SC) is a transmissible spongiform encephalopathy (TSE) in sheep and goats. Susceptibility to this neurodegenerative disease is controlled mainly by point mutations at the PRNP locus. Other genes, apart from PRNP, have been reported to modulate resistance/susceptibility to SC. On the basis of several studies on Alzheimer's disease and different TSE models, and of requirement for correct homeostasis of cytokines in brain, IL1B and IL1RN were chosen as putative positional and functional candidate genes that might be involved in the polygenic variance mentioned above. In the present work, ovine IL1B and IL1RN genes were partially isolated and characterized, including promoter and other regulatory regions. In addition, several sequence polymorphisms were identified. Furthermore, their cytogenetic positions on sheep chromosomes were determined by FISH and confirmed by linkage analysis, localizing both genes in OAR3p22, a region previously described as carrying a QTL for SC incubation period in sheep. Finally, expression analyses were carried out in eight naturally SC-infected and five uninfected sheep with the same genotype for PRNP (ARQ/ARQ). This comparison was performed using real-time RT-PCR in samples of spleen and cerebellum. Results showed differences in the expression of both cytokines in cerebellum (p < 0.05) but not in spleen (p > 0.05). © 2007 Springer Science+Business Media, Inc.
- Published
- 2007
27. Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several generations of scrapie-infected sheep
- Author
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Moreno, C. R., primary, Moazami-Goudarzi, K., additional, Briand, S., additional, Robert-Granie, C., additional, Weisbecker, J. L., additional, Laurent, P., additional, Cribiu, E.-P., additional, Haley, C. S., additional, Andreoletti, O., additional, Bishop, S. C., additional, and Pong-Wong, R., additional
- Published
- 2009
- Full Text
- View/download PDF
28. Detection of selection signatures within candidate regions underlying trypanotolerance in outbred cattle populations
- Author
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DAYO, G.-K., primary, THEVENON, S., additional, BERTHIER, D., additional, MOAZAMI-GOUDARZI, K., additional, DENIS, C., additional, CUNY, G., additional, EGGEN, A., additional, and GAUTIER, M., additional
- Published
- 2009
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29. Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with classical scrapie
- Author
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Barillet, F., primary, Mariat, D., additional, Amigues, Y., additional, Faugeras, R., additional, Caillat, H., additional, Moazami-Goudarzi, K., additional, Rupp, R., additional, Babilliot, J. M., additional, Lacroux, C., additional, Lugan, S., additional, Schelcher, F., additional, Chartier, C., additional, Corbière, F., additional, Andréoletti, O., additional, and Perrin-Chauvineau, C., additional
- Published
- 2009
- Full Text
- View/download PDF
30. Genetic structure of eighteen local south European beef cattle breeds by comparative F-statistics analysis
- Author
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Jordana, J., primary, Alexandrino, P., additional, Beja-Pereira, A., additional, Bessa, I., additional, Canon, J., additional, Carretero, Y., additional, Dunner, S., additional, Laloe, D., additional, Moazami-Goudarzi, K., additional, Sanchez, A., additional, and Ferrand, N., additional
- Published
- 2003
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31. Hormonal induction of c-fos and HSP68 mRNAs on an isolated coronary perfused adult rat heart
- Author
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Moalic, J. M., primary, Moazami-goudarzi, K., additional, Thiem, N. V., additional, Delcayre, C., additional, Bercovici, J., additional, Mouas, C., additional, and Swynghedauw, B., additional
- Published
- 1992
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- View/download PDF
32. Hormonal induction of c-fos and HSP68 mRNAs on an isolated coronary perfused adult rat heart
- Author
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Moalic, J. M., Moazami-goudarzi, K., Thiem, N. V., Delcayre, C., Bercovici, J., Mouas, C., and Swynghedauw, B.
- Abstract
Transient growth signals which can be related to protein synthesis and cellular growth are of particular interest in the heart because of the incidence of cardiac hypertrophy in man. The isolated coronary perfused adult rat heart or the so-called Langendorff preparation, is an useful model in exploring not only protein synthesis but also c-fos/c-myc protooncogene and Heat Shock Protein (HSP) gene expression. Phenylephrine infusion in this preparation induces c-fos expression whether the heart is beating or reversibly or irreversibly arrested by solutions enriched in KCl.Norepinephrine has the same effect. Quantitative analysis with slot blots shows that in both cases the adrenergic effect has a dual origin since it is inhibited both by propranolol, a β-adrenergic antagonist, and terazosine, a soluble α1-adrenergic antagonist. We conclude that the isolated heart is a useful tool to explore the early changes in gene expression which occur in this tissue in response to various physiological stimuli.
- Published
- 1992
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33. The earthquake of September 6, 1975 in Lice (eastern Turkey)
- Author
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Moazami-Goudarzi, K. and Akasheh, B.
- Abstract
The mechanism of faulting for the Lice earthquake of September 6, 1975 is thrust fault, the compressional axis is horizontal and perpendicular to the Taurus mountains with 180° azimuth and 2° plunge. This corresponds to northward movement of Arabia. The T-axis is nearly vertical. The slip vector has 15° azimuth and 65° slip angle for the fault plane which is simistral and has N72°E azimuth and dips 45° NW. The intensity distribution pattern, the location of the main aftershock epicentres, the geological aspect of the region, and the limiting boundaries of different zones indicate the predominence of the east—west direction and are in good agreement with our focal-mechanism solution.
- Published
- 1977
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- View/download PDF
34. Fréquences alléliques et cohérence entre marqueurs moléculaires : des outils descriptifs
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Jombart, T., Moazami-Goudarzi, K., Anne-Béatrice Dufour, Denis Laloë, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Ecologie quantitative et évolutive des communautés, Département écologie évolutive [LBBE], Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE)
- Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
35. A whole genome Bayesian scan for adaptive genetic divergence in West African cattle
- Author
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Gautier, M, Flori, L, Riebler, A, Jaffrezic, F, Laloe, D, Gut, I, Moazami-Goudarzi, K, and Foulley, J L
- Subjects
2. Zero hunger
36. Preliminary comparison between microsatellite and AFLP multilocus genotypes for bovine breed assignment
- Author
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Negrini, R., Milanesi, E., Moazami-Goudarzi, K., Laloé, D., Fatima Chegdani, Bernardi, J., Lenstra, J. A., and Ajmone-Marsan, P.
- Subjects
molecular markers, assignment test, clustering methods, cattle ,lcsh:Animal culture ,lcsh:SF1-1100 - Abstract
Reliable methods for tracing animal products to breeds or their region of origin would allow a certification of regional products. This would contribute to consumers confidence and to the exploitation of local genetic resources in marginal rural areas. Different methods can be envisaged to assign individuals to breeds or populations exploiting molecular information. Among these, the estimation of genetic distances between individuals followed by the depiction of the results by multivariate methods is frequently used. However, representation of genetic relationships in a tree or multidimensional plots, depends on the choice of distance measure and graphical representation, and rarely leads to clusters that correspond to breeds. In addition, bifurcating tree topologies suppose a strictly hierarchical population history........
37. Genetic diversity of Mediterranean cattle breeds related to geography and climate
- Author
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Ciampolini, Roberta, Casu, Sara, Mastrangelo, Salvatore, Flori, Laurence, Moazami Goudarzi, Katayoun, Sechi, Tiziana, Cecchi, Francesca, Casabianca, François, Lauvie, Anne, Gautier, Mathieu, Carta, Antonello, Portolano, Baldassare, Laloë, Denis, Ciampolini, R, Casu, S, Mastrangelo, S, Flori, L, Moazami-Goudarzi, K, Sechi, T, Cecchi, F, Casabianca, F, Lauvie, A, Gautier, M, Carta, A, Portolano, B, and D. Laloë.
- Subjects
Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico ,Climate Change Adaptation ,Climate Change Adaptation, Climate Mediterranean Countries, Biodiversity, Conservation and Management, SNP Genomic Markers, Bovine Gentic Variability ,Bovine Gentic Variability ,bioclimatic variables ,SNP Genomic Markers ,Conservation and Management ,SNP ,Biodiversity ,Climate Mediterranean Countries ,Genetic diversity - Abstract
In recent decades, changes in climate have caused impacts on natural and human systems. Mediterranean countries will be particularly affected by this phenomenon, with growing temperatures and reduced rainfall. Understanding how species and ecosystems respond to climate change has become a crucial focus in biodiversity conservation and management. The genome-wide SNP panels allows providing background information on genome structure in domestic animals, opening new perspectives to livestock genetics. The International Project GALIMED "Genetic Adaptation of Bovine Livestock and production systems in MEDiterranean region", develops an integrated approach that combines the analysis of SNP markers, bioclimatic variables and farming system information to identify genotypes and breeding practices able to respond to climate change. Italian and Corsican local breeds are part of this project. The aim of the study is to identify genomic regions related to adaptation to climate change in these local breeds. Individuals of Cinisara (71), Modicana (72), Maremmana (25), Piemontese (21), Romagnola (21), Sarda (30), Sardo-Modicana (28) and Corse (31) breeds were genotyped using Bovine SNP 50k. Farming systems data were collected by interviewing breeders. Geographic coordinates and 19 bioclimatic variables were also available. Principal Components Analysis (PCA) was performed on SNPs data and climatic variables. Co-inertia (CIA) analysis was realized to detect a possible common structure between such different information. After edits, 43,625 SNPs were retained. The PC1 on individual genotypes differentiates Modicana from other breeds, and shows that Sardo-Modicana is close to Modicana, but is clearly admixed to another breed. The PC2 differentiates Cinisara from a cluster "Romagnola/Maremmana" and shows a large variability of the Modicana breed. The CIA coefficient between molecular data and both geographic and climatic information is equal to 0.38, (P-value=0.001), suggesting evidence of genetic adaptation to different climatic pressures. Further analyses are on going to identify the genetic regions with a potential adaptive role. The results will provide a solid scientific foundation to reconsider objectives and selection criteria and to improve farming practices to prepare livestock to new environmental conditions.
- Published
- 2015
38. Variation in the prion protein gene (PRNP) open reading frame sequence in French cervids.
- Author
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Laubier J, Van De Wiele A, Barboiron A, Laloë D, Saint-Andrieux C, Castille J, Meloni E, Ernst S, Pellerin M, Floriot S, Daniel-Carlier N, Passet B, Merlet J, Verheyden H, Béringue V, Andréoletti O, Houston F, Vilotte JL, Bourret V, and Moazami-Goudarzi K
- Subjects
- Animals, France, Polymorphism, Genetic, Prions genetics, Wasting Disease, Chronic genetics, Prion Proteins genetics, Deer, Open Reading Frames
- Abstract
The recent emergence of chronic wasting disease (CWD) in Europe has become a new public health risk for monitoring of wild and farmed cervids. This disease, due to prions, has proliferated in North America in a contagious manner. In several mammalian species, polymorphisms in the prion protein gene (PRNP) play a crucial role in the susceptibility to prions and their spread. To obtain a reliable picture of the distribution of PRNP polymorphisms in the two most common cervid species in France, we sequenced the open reading frame (ORF) of this gene in 2114 animals, 1116 roe deer (Capreolus capreolus) and 998 red deer (Cervus elaphus). Selection criteria such as historical origin, spatial distribution and sex ratio have been integrated to establish this sample collection. Except for one heterozygous animal with a non-synonymous mutation at codon 37 (G37A), all the 1116 French roe deer were monomorphic. Red deer showed greater variation with two non-synonymous substitutions (T98A; Q226E), three synonymous substitutions (codons 21, 78 and 136) and a new 24pb deletion (Δ
69-77 ). We found significant regional variations between French regions in the frequency of the identified substitutions. After cloning of the PRNP ORF from animals presenting multiple non-synonymous polymorphisms, we identified six haplotypes and obtained a total of twelve genotypes. As in other European countries, we highlighted the apparent homogeneity of PRNP in the French roe deer and the existence of a greater diversity in the red deer. These results were in line with European phylogeographic studies on these two species., (© 2024. The Author(s).)- Published
- 2024
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39. Prion protein gene (PRNP) variation in German and Danish cervids.
- Author
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Ernst S, Piestrzyńska-Kajtoch A, Gethmann J, Natonek-Wiśniewska M, Sadeghi B, Polak MP, Keller M, Gavier-Widén D, Moazami-Goudarzi K, Houston F, Groschup MH, and Fast C
- Subjects
- Animals, Denmark, Genetic Variation, Genotype, Germany epidemiology, Polymorphism, Genetic, Prion Proteins genetics, Prions genetics, Deer genetics, Wasting Disease, Chronic genetics, Wasting Disease, Chronic epidemiology
- Abstract
The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces alces) and red deer (Cervus elaphus), in parallel with the outbreak in North America, gives reason to investigate PRNP variation in European deer, to implement risk assessments and adjust CWD management for deer populations under threat. We here report PRNP-sequence data from 911 samples of German red, roe (Capreolus capreolus), sika (Cervus nippon) and fallow deer (Dama dama) as well as additional data from 26 Danish red deer close to the German border and four zoo species not native to Germany. No PRNP sequence variation was observed in roe and fallow deer, as previously described for populations across Europe. In contrast, a broad PRNP variation was detected in red deer, with non-synonymous polymorphisms at codons 98, 226 and 247 as well as synonymous mutations at codons 21, 78, 136 and 185. Moreover, a novel 24 bp deletion within the octapeptide repeat was detected. In summary, 14 genotypes were seen in red deer with significant differences in their geographical distribution and frequencies, including geographical clustering of certain genotypes, suggesting "PRNP-linages" in this species. Based on data from North American CWD and the genotyping results of the European CWD cases, we would predict that large proportions of wild cervids in Europe might be susceptible to CWD once introduced to naive populations., (© 2024. The Author(s).)
- Published
- 2024
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40. Genomic Reconstruction of the Successful Establishment of a Feralized Bovine Population on the Subantarctic Island of Amsterdam.
- Author
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Gautier M, Micol T, Camus L, Moazami-Goudarzi K, Naves M, Guéret E, Engelen S, Lemainque A, Colas F, Flori L, and Druet T
- Subjects
- Animals, Cattle genetics, Netherlands, Genetic Variation, Islands, Genetics, Population, Selection, Genetic
- Abstract
The feral cattle of the subantarctic island of Amsterdam provide an outstanding case study of a large mammalian population that was established by a handful of founders and thrived within a few generations in a seemingly inhospitable environment. Here, we investigated the genetic history and composition of this population using genotyping and sequencing data. Our inference showed an intense but brief founding bottleneck around the late 19th century and revealed contributions from European taurine and Indian Ocean Zebu in the founder ancestry. Comparative analysis of whole-genome sequences further revealed a moderate reduction in genetic diversity despite high levels of inbreeding. The brief and intense bottleneck was associated with high levels of drift, a flattening of the site frequency spectrum and a slight relaxation of purifying selection on mildly deleterious variants. Unlike some populations that have experienced prolonged reductions in effective population size, we did not observe any significant purging of highly deleterious variants. Interestingly, the population's success in the harsh environment can be attributed to preadaptation from their European taurine ancestry, suggesting no strong bioclimatic challenge, and also contradicting evidence for insular dwarfism. Genome scan for footprints of selection uncovered a majority of candidate genes related to nervous system function, likely reflecting rapid feralization driven by behavioral changes and complex social restructuring. The Amsterdam Island cattle offers valuable insights into rapid population establishment, feralization, and genetic adaptation in challenging environments. It also sheds light on the unique genetic legacies of feral populations, raising ethical questions according to conservation efforts., (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
- Published
- 2024
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41. Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation.
- Author
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Rau A, Passet B, Castille J, Daniel-Carlier N, Asset A, Lecardonnel J, Moroldo M, Jaffrézic F, Laloë D, Moazami-Goudarzi K, and Vilotte JL
- Subjects
- Animals, Mice, Mice, Knockout, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, RNA, Small Interfering, Recombinant Proteins, Transcription Factors, Prion Proteins genetics, Prions genetics
- Abstract
The Shadoo and PrP prion protein family members are thought to be functionally related, but previous knockdown/knockout experiments in early mouse embryogenesis have provided seemingly contradictory results. In particular, Shadoo was found to be indispensable in the absence of PrP in knockdown analyses, but a double-knockout of the two had little phenotypic impact. We investigated this apparent discrepancy by comparing transcriptomes of WT, Prnp
0/0 and Prnp0/0 Sprn0/0 E6.5 mouse embryos following inoculation by Sprn- or Prnp-ShRNA lentiviral vectors. Our results suggest the possibility of genetic adaptation in Prnp0/0 Sprn0/0 mice, thus providing a potential explanation for their previously observed resilience., (© 2022. The Author(s).)- Published
- 2022
- Full Text
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42. The genetic history of Mayotte and Madagascar cattle breeds mirrors the complex pattern of human exchanges in Western Indian Ocean.
- Author
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Magnier J, Druet T, Naves M, Ouvrard M, Raoul S, Janelle J, Moazami-Goudarzi K, Lesnoff M, Tillard E, Gautier M, and Flori L
- Subjects
- Animals, Comoros, Humans, Indian Ocean, Madagascar, Cattle genetics, Human Migration
- Abstract
Despite their central economic and cultural role, the origin of cattle populations living in Indian Ocean islands still remains poorly documented. Here, we unravel the demographic and adaptive histories of the extant Zebus from the Mayotte and Madagascar islands using high-density SNP genotyping data. We found that these populations are very closely related and both display a predominant indicine ancestry. They diverged in the 16th century at the arrival of European people who transformed the trade network in the area. Their common ancestral cattle population originates from an admixture between an admixed African zebu population and an Indian zebu that occurred around the 12th century at the time of the earliest contacts between human African populations of the Swahili corridor and Austronesian people from Southeast Asia in Comoros and Madagascar. A steep increase in the estimated population sizes from the beginning of the 16th to the 17th century coincides with the expansion of the cattle trade. By carrying out genome scans for recent selection in the two cattle populations from Mayotte and Madagascar, we identified sets of candidate genes involved in biological functions (cancer, skin structure, and UV-protection, nervous system and behavior, organ development, metabolism, and immune response) broadly representative of the physiological adaptation to tropical conditions. Overall, the origin of the cattle populations from Western Indian Ocean islands mirrors the complex history of human migrations and trade in this area., (© The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America.)
- Published
- 2022
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43. Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae.
- Author
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Moazami-Goudarzi K, Andréoletti O, Vilotte JL, and Béringue V
- Subjects
- Animals, Genotype, Polymorphism, Genetic, Prion Proteins metabolism, Selection, Genetic, Deer, Prion Proteins genetics, Wasting Disease, Chronic genetics
- Abstract
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is now becoming a major concern in Europe. Polymorphisms in the prion protein gene (PRNP) are an important factor influencing the susceptibility to prions and their rate of propagation. All reported cervid PRNP genotypes are affected by CWD. However, in each species, some polymorphisms are associated with lower attack rates and slower progression of the disease. This has potential consequences in terms of genetic selection, CWD diffusion and strain evolution. CWD also presents a zoonotic risk due to prions capacity to cross species barriers. This review summarizes our current understanding of CWD control, focusing on PRNP genetic, strain diversity and capacity to infect other animal species, including humans., (© 2021. The Author(s).)
- Published
- 2021
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44. Co-invalidation of Prnp and Sprn in FVB/N mice affects reproductive performances and highlight complex biological relationship between PrP and Shadoo.
- Author
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Castille J, Passet B, Makhzami S, Vilotte M, Moazami-Goudarzi K, Truchet S, Daniel-Carlier N, Gaillard AL, Andréoletti O, Vaiman D, Beauvallet C, Vaiman A, Floriot S, Calvel P, Mouillet-Richard S, Duchesne A, Béringue V, and Vilotte JL
- Subjects
- Animals, Animals, Newborn growth & development, Embryonic Development, Female, GPI-Linked Proteins, Genes, Lethal, Lactation genetics, Lactation physiology, Male, Mice, Mice, Knockout, Mice, Transgenic, Nerve Tissue Proteins deficiency, Nerve Tissue Proteins genetics, Phenotype, Placentation, Pregnancy, Prion Proteins deficiency, Prion Proteins genetics, Reproduction genetics, Transcriptome, Nerve Tissue Proteins metabolism, Prion Proteins metabolism, Reproduction physiology
- Abstract
Shadoo and PrP belongs to the same protein family, whose biological function remains poorly understood. Previous experiments reported potential functional redundancies or antagonisms between these two proteins, depending on the tissue analysed. While knockdown experiments suggested the requirement of Shadoo in the absence of PrP during early mouse embryogenesis, knockout ones, on the contrary, highlighted little impact, if any, of the double-knockout of these two loci. In the present study, we reinvestigated the phenotype associated with the concomitant knockout of these two genes using newly produced FVB/N Sprn knockout mice. In this genetic background, the combined two genes' knockout induces intra-uterine growth retardations, likely resulting from placental failures highlighted by transcriptomic analyses that revealed potential redundant or antagonist roles of these two proteins in different developmental-related pathways. It also induced an increased perinatal-lethality and ascertained the role of these two loci in the lactation process., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
45. The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation.
- Author
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Passet B, Castille J, Makhzami S, Truchet S, Vaiman A, Floriot S, Moazami-Goudarzi K, Vilotte M, Gaillard AL, Helary L, Bertaud M, Andréoletti O, Vaiman D, Calvel P, Daniel-Carlier N, Moudjou M, Beauvallet C, Benharouga M, Laloé D, Mouillet-Richard S, Duchesne A, Béringue V, and Vilotte JL
- Subjects
- Animals, GPI-Linked Proteins, Humans, Mammary Glands, Animal growth & development, Mammary Glands, Animal metabolism, Mice, Mice, Knockout, Mouse Embryonic Stem Cells metabolism, Organogenesis genetics, Prion Diseases genetics, Prion Diseases pathology, Cell Differentiation genetics, Embryonic Development genetics, Nerve Tissue Proteins genetics, Prion Proteins genetics
- Abstract
Shadoo belongs to the prion protein family, an evolutionary conserved and extensively studied family due to the implication of PrP in Transmissible Spongiform Encephalopathies. However, the biological function of these genes remains poorly understood. While Sprn-knockdown experiments suggested an involvement of Shadoo during mouse embryonic development, Sprn-knockout experiments in 129Pas/C57BL/6J or 129Pas/FVB/NCr mice did not confirm it. In the present study, we analyzed the impact of Sprn gene invalidation in a pure FVB/NJ genetic background, using a zinc finger nuclease approach. The in-depth analysis of the derived knockout transgenic mice revealed a significant increase in embryonic lethality at early post-implantation stages, a growth retardation of young Sprn-knockout pups fed by wild type mice and a lactation defect of Sprn-knockout females. Histological and transcriptional analyses of knockout E7.5 embryos, E14.5 placentas and G7.5 mammary glands revealed specific roles of the Shadoo protein in mouse early embryogenesis, tissue development and differentiation with a potential antagonist action between PrP and Shadoo. This study thus highlights the entanglement between the proteins of the prion family.
- Published
- 2020
- Full Text
- View/download PDF
46. DNAJC2 is required for mouse early embryonic development.
- Author
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Helary L, Castille J, Passet B, Vaiman A, Beauvallet C, Jaffrezic F, Charles M, Tamzini M, Baraige F, Letheule M, Laubier J, Moazami-Goudarzi K, Vilotte JL, Blanquet V, and Duchesne A
- Subjects
- Animals, CRISPR-Cas Systems, Embryo Implantation, Embryo Loss genetics, Embryo, Mammalian metabolism, Embryonic Development, Female, Gene Deletion, Mice genetics, Pregnancy, DNA-Binding Proteins genetics, Embryo, Mammalian embryology, Gene Expression Regulation, Developmental, Mice embryology, Molecular Chaperones genetics, RNA-Binding Proteins genetics
- Abstract
DNAJC2 protein, also known as ZRF1 or MPP11, acts both as chaperone and as chromatin regulator. It is involved in stem cell differentiation and its expression is associated with various cancer malignancies. However, the role of Dnajc2 gene during mouse embryogenesis has not been assessed so far. To this aim, we invalidated Dnajc2 gene in FVB/Nj mice using the CrispR/Cas9 approach. We showed that this invalidation leads to the early post-implantation lethality of the nullizygous embryos. Furthermore, using siRNAs against Dnajc2 in mouse 1-cell embryos, we showed that maternal Dnajc2 mRNAs may allow for the early preimplantation development of these embryos. Altogether, these data demonstrate for the first time the requirement of DNAJC2 for early mouse embryogenesis., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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- View/download PDF
47. A genomic map of climate adaptation in Mediterranean cattle breeds.
- Author
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Flori L, Moazami-Goudarzi K, Alary V, Araba A, Boujenane I, Boushaba N, Casabianca F, Casu S, Ciampolini R, Coeur D'Acier A, Coquelle C, Delgado JV, El-Beltagi A, Hadjipavlou G, Jousselin E, Landi V, Lauvie A, Lecomte P, Ligda C, Marinthe C, Martinez A, Mastrangelo S, Menni D, Moulin CH, Osman MA, Pineau O, Portolano B, Rodellar C, Saïdi-Mehtar N, Sechi T, Sempéré G, Thévenon S, Tsiokos D, Laloë D, and Gautier M
- Subjects
- Animals, Breeding, Cattle, Chromosome Mapping, Climate, Genetics, Population, Genome, Genotype, Phylogeny, Thermotolerance genetics, Acclimatization genetics, Genetic Variation, Genomics
- Abstract
Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations., (© 2019 John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
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48. Deciphering the Wisent Demographic and Adaptive Histories from Individual Whole-Genome Sequences.
- Author
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Gautier M, Moazami-Goudarzi K, Levéziel H, Parinello H, Grohs C, Rialle S, Kowalczyk R, and Flori L
- Subjects
- Animals, Animals, Domestic genetics, Biological Evolution, Cattle, Evolution, Molecular, Female, Genetic Variation, Genome-Wide Association Study, High-Throughput Nucleotide Sequencing methods, Male, Phenotype, Phylogeny, Population Density, Bison genetics
- Abstract
As the largest European herbivore, the wisent (Bison bonasus) is emblematic of the continent wildlife but has unclear origins. Here, we infer its demographic and adaptive histories from two individual whole-genome sequences via a detailed comparative analysis with bovine genomes. We estimate that the wisent and bovine species diverged from 1.7 × 10
6 to 850,000 years before present (YBP) through a speciation process involving an extended period of limited gene flow. Our data further support the occurrence of more recent secondary contacts, posterior to the Bos taurus and Bos indicus divergence (∼150,000 YBP), between the wisent and (European) taurine cattle lineages. Although the wisent and bovine population sizes experienced a similar sharp decline since the Last Glacial Maximum, we find that the wisent demography remained more fluctuating during the Pleistocene. This is in agreement with a scenario in which wisents responded to successive glaciations by habitat fragmentation rather than southward and eastward migration as for the bovine ancestors. We finally detect 423 genes under positive selection between the wisent and bovine lineages, which shed a new light on the genome response to different living conditions (temperature, available food resource, and pathogen exposure) and on the key gene functions altered by the domestication process., (© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)- Published
- 2016
- Full Text
- View/download PDF
49. A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice.
- Author
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Allais-Bonnet A, Castille J, Pannetier M, Passet B, Elzaïat M, André M, Montazer-Torbati F, Moazami-Goudarzi K, Vilotte JL, and Pailhoux E
- Abstract
Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals.
- Published
- 2016
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- View/download PDF
50. Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice.
- Author
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Khalifé M, Reine F, Paquet-Fifield S, Castille J, Herzog L, Vilotte M, Moudjou M, Moazami-Goudarzi K, Makhzami S, Passet B, Andréoletti O, Vilette D, Laude H, Béringue V, and Vilotte JL
- Subjects
- Animals, Disease Models, Animal, Mice, Transgenic, Mutation, Missense, Sequence Deletion, Sheep, Mutant Proteins genetics, Mutant Proteins metabolism, PrPC Proteins genetics, PrPC Proteins metabolism, Prion Diseases pathology
- Abstract
Unlabelled: Mammalian prions are proteinaceous infectious agents composed of misfolded assemblies of the host-encoded, cellular prion protein (PrP). Physiologically, the N-terminal polybasic region of residues 23 to 31 of PrP has been shown to be involved in its endocytic trafficking and interactions with glycosaminoglycans or putative ectodomains of membrane-associated proteins. Several recent reports also describe this PrP region as important for the toxicity of mutant prion proteins and the efficiency of prion propagation, both in vitro and in vivo. The question remains as to whether the latter observations made with mouse PrP and mouse prions would be relevant to other PrP species/prion strain combinations given the dramatic impact on prion susceptibility of minimal amino acid substitutions and structural variations in PrP. Here, we report that transgenic mouse lines expressing ovine PrP with a deletion of residues 23 to 26 (KKRP) or mutated in this N-terminal region (KQHPH instead of KKRPK) exhibited a variable, strain-dependent susceptibility to prion infection with regard to the proportion of affected mice and disease tempo relative to findings in their wild-type counterparts. Deletion has no major effect on 127S scrapie prion pathogenesis, whereas mutation increased by almost 3-fold the survival time of the mice. Deletion marginally affected the incubation time of scrapie LA19K and ovine bovine spongiform encephalopathy (BSE) prions, whereas mutation caused apparent resistance to disease., Importance: Recent reports suggested that the N-terminal polybasic region of the prion protein could be a therapeutic target to prevent prion propagation or toxic signaling associated with more common neurodegenerative diseases such as Alzheimer's disease. Mutating or deleting this region in ovine PrP completes the data previously obtained with the mouse protein by identifying the key amino acid residues involved., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
- Full Text
- View/download PDF
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