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Zihao Qin, Ke Xu, Wen Mo, Jie Ye, Jinhai Xu Orthopedics Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jinhai Xu; Jie Ye, Longhua Hospital Shanghai University of Traditional Chinese Medicine, 725, South Wanping Road, Xuhui District, Shanghai, 200030, People’s Republic of China, Tel +86 18016006692 ; +86 3301880301, Email jinhaixu@126.com; yejie1977@126.comPurpose: This randomized controlled trial aimed to evaluate the clinical efficacy of Jianyao Migu granules (JYMGG) in the treatment of primary osteopenic low back pain (LBP).Patients and Methods: A total of 108 patients with primary osteopenic LBP were randomly divided into the JYMGG group and placebo group. Both groups took 600 mg of oral Caltrate D daily; in addition, the JYMGG group was given oral JYMGG, while the placebo group was given placebo granules. The treatment period was 6 months for both groups. The pre- to post-treatment changes in the bone mineral density (BMD), visual analogue scale (VAS) score, Oswestry disability index (ODI), and bone turnover markers were compared between the two groups.Results: The post-treatment VAS score and ODI were significantly lower than baseline in both groups (P< 0.05). In the JYMGG group, the lumbar BMD increased from 0.88± 0.07 g/cm2 to 0.90± 0.13 g/cm2 and the hip BMD increased from 0.77± 0.08 g/cm2 to 0.78± 0.10 g/cm2, giving increases of 2.70% and 1.96% respectively, but the differences were not statistically significant. The post-treatment levels of ALP, osteocalcin, P1NP, and β-CTX were increased compared with baseline in both groups, but the differences were not statistically significant. The thyrotropin level was significantly increased after treatment in the placebo group (P< 0.05). There were no abnormalities detected in routine blood and kidney function tests performed during the observation period. Some patients showed elevated liver enzymes and gastrointestinal reactions.Conclusion: JYMGG effectively relieved the bone pain, and improved the quality of life of patients with primary osteopenic LBP.Keywords: chinese herb, clinical trial, Jianyao Migu granules, osteoporosis

© 2019. The American Astronomical Society. All rights reserved. We present the Massive and Distant Clusters of WISE Survey (MaDCoWS), a search for galaxy clusters at 0.7 ≲ z ≲ 1.5 based upon data from the Wide-field Infrared Survey Explorer (WISE) mission. MaDCoWS is the first cluster survey capable of discovering massive clusters at these redshifts over the full extragalactic sky. The search is divided into two regions - the region of the extragalactic sky covered by Pan-STARRS (δ > -30°) and the remainder of the southern extragalactic sky at δ < -30° for which shallower optical data from the SuperCOSMOS Sky Survey is available. In this paper, we describe the search algorithm, characterize the sample, and present the first MaDCoWS data release - catalogs of the 2433 highest amplitude detections in the WISE-Pan-STARRS region and the 250 highest amplitude detections in the WISE-SuperCOSMOS region. A total of 1723 of the detections from the WISE-Pan-STARRS sample have also been observed with the Spitzer Space Telescope, providing photometric redshifts and richnesses, and an additional 64 detections within the WISE-SuperCOSMOS region also have photometric redshifts and richnesses. Spectroscopic redshifts for 38 MaDCoWS clusters with IRAC photometry demonstrate that the photometric redshifts have an uncertainty of σ z /(1 + z) ≃ 0.036. Combining the richness measurements with Sunyaev-Zel'dovich observations of MaDCoWS clusters, we also present a preliminary mass-richness relation that can be used to infer the approximate mass distribution of the full sample. The estimated median mass for the WISE-Pan-STARRS catalog is , with the Sunyaev-Zel'dovich data confirming that we detect clusters with masses up to M 500 ∼ 5 ×10 14 M (M 200 ∼ 10 15 M ).

Wenhui Mo,* Ying Dai,* Jianqing Chen, Liwei Liang, Shuqi Xu, Xuanfu Xu Department of Gastroenterology, Shidong Hospital of Shanghai, Shanghai 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuanfu XuDepartment of Gastroenterology, Shidong Hospital of Shanghai, Shanghai 200433, People’s Republic of ChinaTel +86-21-25066666Email xuxuanfu0217@163.comIntroduction: The purpose of this study was to evaluate the effects and mechanisms of the long noncoding RNA (lncRNA) MT1JP on hepatocellular carcinoma (HCC) in vitro.Patients and Methods: Thirty pairs of tumor and adjacent normal tissues were collected from HCC patients. Tissue pathology and MT1JP expression were evaluated by hematoxylin and eosin staining and in situ hybridization (ISH), respectively. The correlation between MT1JP and HCC prognosis was investigated. MTT assays, cloning, flow cytometry, transwell assays, and wound-healing assays were used to evaluate the effects of MT1JP on HCC cell lines. RT-qPCR and Western blot were used to measure the relative mRNA and protein expression levels.Results: The expression of MT1JP was downregulated in HCC tumor tissues compared with that in adjacent normal tissues, while the percent survival was significantly greater in the high MT1JP expression group than in the low MT1JP expression group (P=0.0238). In vitro, overexpression of MT1JP suppressed the proliferation, invasion, and migration, reduced colony cell number, increased cell apoptosis, and induced G1-phase cell cycle arrest in Bel-7402 and Huh-7 cells. Meanwhile, the mRNA and protein expression levels of RUNX3 and P21 were significantly upregulated, whereas those of MMP2 and MMP9 were significantly downregulated, in Bel-7402 and Huh-7 cells overexpressing MT1JP (all P< 0.001).Conclusion: LncRNA MT1JP may function as a tumor suppressor in HCC. Overexpression of MT1JP suppressed HCC cell biological activities through the regulation of RUNX3.Keywords: MT1JP, HCC, Bel-7402, Huh-7, cell biological activities

With the NEOWISE portion of the Wide-field Infrared Survey Explorer (WISE) project, we have carried out a highly uniform survey of the near-Earth object (NEO) population at thermal infrared wavelengths ranging from 3 to 22 μm, allowing us to refine estimates of their numbers, sizes, and albedos. The NEOWISE survey detected NEOs the same way whether they were previously known or not, subject to the availability of ground-based follow-up observations, resulting in the discovery of more than 130 new NEOs. The survey's uniform sensitivity, observing cadence, and image quality have permitted extrapolation of the 428 near-Earth asteroids (NEAs) detected by NEOWISE during the fully cryogenic portion of the WISEmission to the larger population. We find that there are 981 19 NEAs larger than 1km and 20,500 3000 NEAs larger than 100m. We show that the Spaceguard goal of detecting 90% of all 1km NEAs has been met, and that the cumulative size distribution is best represented by a broken power law with a slope of 1.32 0.14 below 1.5km. This power-law slope produces 13, 200 1900 NEAs with D > 140m. Although previous studies predict another break in the cumulative size distribution below D 50-100m, resulting in an increase in the number of NEOs in this size range and smaller, we did not detect enough objects to comment on this increase. The overall number for the NEA population between 100 and 1000m is lower than previous estimates. The numbers of near-Earth comets and potentially hazardous NEOs will be the subject of future work. © 2011. The American Astronomical Society. All rights reserved.

The 3-D physical models for FeNi/Cu/FeNi films with two different types of structures that are linear and meander are developed. The relationship between the impedance of the films and the applied magnetic field or excitation frequency is obtained, and the influence of geometric parameters and structures of the films on the giant magnetoimpedance (GMI) effect is analyzed. The result shows that the GMI effect in the film with a horizontal meander structure appears to be much stronger compared with that in a linear structure. The negative mutual inductance of the meander FeNi/Cu/FeNi films reduces the total inductance and decreases the frequency response. Meanwhile, the GMI effect and the negative mutual inductance are enhanced by increasing the number of turns or decreasing the space width between each segment. Based on these effects, the FeNi/Cu/FeNi film with a vertical meander structure is proposed and simulated, which reflects the design of the meander structure in the thickness direction. The distance between each segment is reduced to 500 nm. The GMI effect and the negative mutual inductance are greatly enhanced (the maximum value of the GMI ratio increases from 207% to 1247% when the excitation frequency changes from 50 to 300 MHz). Furthermore, the spatial resolution of the film is further improved. The results obtained could be useful both for a better understanding of the GMI effect of the FeNi/Cu/FeNi film with a meander structure and for providing a choice for the device preparation of highly sensitive magnetic sensors. [ABSTRACT FROM AUTHOR]

The current-induced perpendicular magnetization switching in $L1$ 0-FePt single layer and Ta/FePt bilayer thin films was investigated. Here, $L1$ 0-FePt (6 nm) single-layer film and Ta (1–5 nm)/FePt (6 nm) bilayer films were deposited on MgO substrate at 700 °C, showing good perpendicular anisotropy with out-of-plane coercivity of 7.5 kOe for FePt and around 5 kOe for Ta/FePt bilayers. It was found that the current-induced partial magnetization-based switching was realized with the spin–orbit torque (SOT) switching ratio of about 3% in all films. For adding the Ta capping layer, the critical current density is reduced and the stability of the switching loop is relatively better when compared to the single FePt layer. Furthermore, harmonic Hall voltage results demonstrate that the SOT efficiency ($\beta _{\mathrm {DL}}$) of FePt single layer is approximately 50 Oe/(107 A cm−2) and significantly higher than that of Ta/FePt bilayers, which is several times higher than that of the traditional Ta/CoFeB/MgO structure reported earlier. More importantly, Ta/FePt bilayer structure exhibits very good memristive switching behavior, which is expected to be applied to the spin-synapse of neural networks in the future. [ABSTRACT FROM AUTHOR]