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4. Identifying Gifted Potential Through Positive Psychology Content.

Author

Mo, Fangfang, Desmet, Ophélie Allyssa, and Olenchak, F. Richard

Subjects
POSITIVE psychology, STUDENT interests, CURRICULUM planning, AUTHENTIC learning, CLASSROOM environment, TEACHER development
Abstract

Traditional identification approaches have often excluded many students from underrepresented backgrounds from gifted and talented service programs. This study introduces an innovative identification method based on the Bull's Eye Model for Affective Development—Expansion (BEM-e), which focuses on identifying giftedness and talents through targeted positive psychological traits. This method is integrated within an affective curriculum designed to create authentic learning environments that align with students' interests and strengths, fostering deeper engagement, motivation, and self-efficacy. Grounded in the positive psychology theory, the curriculum includes engaging, activity-oriented modules with comprehensive dynamic assessments. These assessments allow teachers to identify a broad range of talents and abilities, promoting equity and a holistic identification process, which contributes to a more equitable and comprehensive education system. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice

Author

Ye, Zimengwei, Ma, Jinkun, Liu, Yage, Xu, Bingrui, Dai, Xuan, Fu, Min, Tian, Tian, Sui, Xin, Mo, Fangfang, Gao, Sihua, Zhao, Dandan, and Zhang, Dongwei

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Jiangtang Sanhao formula (JTSHF), one of the prescriptions for treating the patients with diabetes mellitus (DM) in traditional Chinese medicine clinic, has been demonstrated to effectively ameliorate the clinical symptoms of diabetic patients with overweight or hyperlipidemia. The preliminary studies demonstrated that JTSHF may enhance insulin sensitivity and improve glycolipid metabolism in obese mice. However, the action mechanism of JTSHF on skeletal muscles in diabetic mice remains unclear. To this end, high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice were subjected to JTSHF intervention. The results revealed that JTSHF granules could reduce food and water intake, decrease body fat mass, and improve glucose tolerance, lipid metabolism, and insulin sensitivity in the skeletal muscles of diabetic mice. These effects may be linked to the stimulation of GLUT4 expression and translocation via regulating AMPKα/SIRT1/PGC-1α signaling pathway. The results may offer a novel explanation of JTSHF to prevent against diabetes and IR-related metabolic diseases.

Published
2022

14. Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-кB Signaling Pathway in High-Fat Diet-Induced Obese Mice

Author

Xia, Bingke, primary, Zhu, Ruyuan, additional, Zhang, Hao, additional, Chen, Beibei, additional, Liu, Yage, additional, Dai, Xuan, additional, Ye, Zimengwei, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Gao, Sihua, additional, Wang, Xiang-Dong, additional, Bromme, Dieter, additional, Wang, Lili, additional, Wang, Xinxiang, additional, and Zhang, Dongwei, additional

Published
2022
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15. Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway

Author

Bai, Ying, primary, Zuo, Jiacheng, additional, Fang, Xin, additional, Ma, Rufeng, additional, Tian, Tian, additional, Mo, Fangfang, additional, Mu, Qianqian, additional, Zhang, Yi, additional, Yu, Na, additional, Bao, Xueli, additional, Zhang, Dongwei, additional, Gao, Sihua, additional, and Zhao, Dandan, additional

Published
2021
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17. Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice

Author

Zhang Dongwei, Yu Na, Mu Qianqian, Mo Fangfang, Zhao Dandan, Ma Yue, Zuo Jiacheng, Zhang Yi, and Gao Sihua

Subjects
0301 basic medicine, medicine.medical_specialty, biology, Glucose-regulated protein, business.industry, Endoplasmic reticulum, Insulin, medicine.medical_treatment, Type 2 Diabetes Mellitus, General Medicine, CHOP, Carbohydrate metabolism, 03 medical and health sciences, 030104 developmental biology, Endocrinology, Glucose Metabolism Disorder, Internal medicine, medicine, Unfolded protein response, biology.protein, business
Abstract

OBJECTIVE To observe the effect of Jiangtang Xiaoke (JTXK) granule on endoplasmic reticulum (ER) stress in high fat diet (HFD)-induced type 2 diabetes mellitus (T2DM) KK-Ay mice. METHODS KK-Ay mice were fed with HFD to induce the T2DM model, while normal control C57BL/6J mice were given standard feed. Fasting blood glucose (FBG) in all mice was measured weekly and oral glucose tolerance tests (OGTTs) were performed at 4 and 10 weeks after start of treatment to determine glucose metabolism. Serum fasting insulin (FINS) and insulin sensitivity index (ISI) were measured to determine insulin sensitivity. mRNA expressions of eukaryotic initiation factor-2 alpha (eIF2α), glucose regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), and C/EBP homology protein (CHOP) were assessed by reverse transcription polymerase chain reaction and the protein expressions of p-eIF2α, GRP78, and CHOP were assessed by Western blotting. RESULTS JTXK granule significantly reduced FBG and free fatty acid levels and improved OGTT at the 120 min of the 10-week treatment in T2DM KK-Ay mice. FINS and HbAlc levels were reduced and insulin sensitivities were increased in KK-Ay diabetic mice, which were improved with the treatment of JTXK granule, especially at the 7 and 3.5 g/kg doses. JTXK granule at the 3.5 g/kg dose was most effective in reducing both gene and protein expressions of eIF2α, GRP78, and CHOP. CONCLUSION ER stress response is increased in T2DM KK-Ay mice. Treatment with JTXK granule attenuates glucose disorders, improves insulin sensitivity, and reduces serum FFA in T2DM KK-Ay mice. The mechanisms may be attributed to regulation of the signaling ER stress pathway via decreasing eIF2α phosphorylation and suppressing eIF2α-ATF4-CHOP activation.

Published
2018

18. Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice

Author

Bai, Ying, primary, Bao, Xueli, additional, Mu, Qianqian, additional, Fang, Xin, additional, Zhu, Ruyuan, additional, Liu, Chenyue, additional, Mo, Fangfang, additional, Zhang, Dongwei, additional, Jiang, Guangjian, additional, Li, Ping, additional, Gao, Sihua, additional, and Zhao, Dandan, additional

Published
2021
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19. Jiang Tang Xiao Ke Granule Protects Hepatic Tissue of Diabetic Mice Through Modulation of Insulin and Ras Signaling – A Bioinformatics Analysis of MicroRNAs and mRNAs Network

Author

Bai, Ying, primary, Bao, Xueli, additional, Jiang, Guangjian, additional, Ge, Dongyu, additional, He, Weipeng, additional, Zhao, Dandan, additional, Zhang, Yi, additional, Dong, Ruijuan, additional, Hua, Jing, additional, Yang, Nan, additional, Mo, Fangfang, additional, and Gao, Sihua, additional

Published
2020
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20. Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice

Author

Li, Lin, primary, Li, Rui, additional, Zhu, Ruyuan, additional, Chen, Beibei, additional, Tian, Yimiao, additional, Zhang, Hao, additional, Xia, Bingke, additional, Jia, Qiangqiang, additional, Wang, Lili, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Li, Yu, additional, Zhang, Shujing, additional, Gao, Sihua, additional, Zhang, Dongwei, additional, and Guo, Shuzhen, additional

Published
2020
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21. Comparative study of the pharmacokinetic parameters for salidroside in normal and estrogen-deficient female rats after oral administration of an aqueous extract of Fructus Ligustri Lucidi using a validated ultra-performance liquid chromatography mass spectrometry/mass spectrometry method

Author

Zhang, Dongwei, primary, Chen, Beibei, additional, Tang, Jinfa, additional, Niu, Ming, additional, Zhu, Ruyuan, additional, Li, Lin, additional, Wang, Lili, additional, Tian, Yimiao, additional, Li, Rui, additional, Jia, Qiangqiang, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Romanenko, ElenaB, additional, Orekhov, AlexanderN, additional, Gao, Sihua, additional, and Brömme, Dieter, additional

Published
2020
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22. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Author

Li, Lin, primary, Chen, Beibei, additional, Zhu, Ruyuan, additional, Li, Rui, additional, Tian, Yimiao, additional, Liu, Chenyue, additional, Jia, Qiangqiang, additional, Wang, Lili, additional, Tang, Jinfa, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Liu, Yan, additional, Li, Yu, additional, Orekhov, Alexander N., additional, Brömme, Dieter, additional, Zhang, Dongwei, additional, and Gao, Sihua, additional

Published
2019
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25. Comparative study of the pharmacokinetic parameters for salidroside in normal and estrogen-deficient female rats after oral administration of an aqueous extract of Fructus Ligustri Lucidi using a validated ultra-performance liquid chromatography mass spectrometry/mass spectrometry method

Author

Chen, Beibei, Tang, Jinfa, Niu, Ming, Zhu, Ruyuan, Li, Lin, Wang, Lili, Tian, Yimiao, Li, Rui, Jia, Qiangqiang, Zhao, Dandan, Mo, Fangfang, Romanenko, Elena, Orekhov, Alexander, Gao, Sihua, Brömme, Dieter, and Zhang, Dongwei

Subjects
MASS spectrometry, LIQUID chromatography, MATRIX effect, GRADIENT elution (Chromatography), RATS
Abstract

Background: Salidroside, one of the main active ingredients in Fructus Ligustri Lucidi (FLL), is well demonstrated to exert anti-osteoporotic effect. However, the plasma pharmacokinetic profile of salidroside in FLL in estrogen-deficient rats remains unknown. Objective: The objective was to develop a sensitive, rapid, and accurate ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for the determination of the pharmacokinetics profile of salidroside after oral administration of FLL aqueous extract in normal and ovariectomized (OVX) rats. Materials and Methods: OVX and normal rats were orally administrated with FLL at a bolus of 7 g/kg. Plasma samples were precipitated by methanol, and the supernatant was chromatographed by a Waters BEH C18column with a gradient elution of ammonium acetate and acetonitrile. Quantification was carried out on the electrospray ionization, positive multiple reaction monitoring modes. Results: The lower limit of detection was 50 ng/mL, and the dynamic linear range was 50–30,000 ng/mL with a value of R2 > 0.99. The intra- and inter-day precisions were lower than 14.67%, and accuracy was in the range of 99.29%–103.37%. The recovery of salidroside ranged from 88.90% to 101.78%, with the matrix effect ranging from 85.53% to 100.45%. The t1/2, MRT0–∞, and apparent volume of distribution for salidroside increased in OVX rats. Conclusion: A sensitive, accurate, and rapid method was successfully established and validated for the determination of plasma characteristics of salidroside in Sprague–Dawley (SD) rats. The results suggest that ovariectomy could interfere with salidroside metabolism in SD rats. [ABSTRACT FROM AUTHOR]

Published
2020
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26. Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats

Author

Liu, Haixia, primary, Zhu, Ruyuan, additional, Wang, Lili, additional, Liu, Chenyue, additional, Ma, Rufeng, additional, Qi, Bowen, additional, Chen, Beibei, additional, Li, Lin, additional, Guo, Yubo, additional, Shi, Shepo, additional, Jia, Qiangqiang, additional, Niu, Jianzhao, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Gao, Sihua, additional, and Zhang, Dongwei, additional

Published
2018
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27. Salvianolic Acid B Improves Mitochondrial Function in 3T3-L1 Adipocytes Through a Pathway Involving PPARγ Coactivator-1α (PGC-1α)

Author

Pan, Yanyun, primary, Zhao, Wenjing, additional, Zhao, Dandan, additional, Wang, Chaoyang, additional, Yu, Na, additional, An, Tian, additional, Mo, Fangfang, additional, Liu, Jiaxian, additional, Miao, Jianan, additional, Lv, Bohan, additional, Gu, Yujie, additional, Gao, Sihua, additional, and Jiang, Guangjian, additional

Published
2018
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29. Corrigendum: Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway

Author

Wang, Lili, primary, Ma, Rufeng, additional, Guo, Yubo, additional, Sun, Jing, additional, Liu, Haixia, additional, Zhu, Ruyuan, additional, Liu, Chenyue, additional, Li, Jun, additional, Li, Lin, additional, Chen, Beibei, additional, Sun, Liping, additional, Tang, Jinfa, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Niu, Jianzhao, additional, Jiang, Guangjian, additional, Fu, Min, additional, Brömme, Dieter, additional, Zhang, Dongwei, additional, and Gao, Sihua, additional

Published
2017
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30. Relationships of circular RNA with diabetes and depression

Author

Jiang, Guangjian, primary, Ma, Yue, additional, An, Tian, additional, Pan, Yanyun, additional, Mo, Fangfang, additional, Zhao, Dandan, additional, Liu, Yufei, additional, Miao, Jia-Nan, additional, Gu, Yu-Jie, additional, Wang, Yangang, additional, and Gao, Si-Hua, additional

Published
2017
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31. Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway

Author

Wang, Lili, primary, Ma, Rufeng, additional, Guo, Yubo, additional, Sun, Jing, additional, Liu, Haixia, additional, Zhu, Ruyuan, additional, Liu, Chenyue, additional, Li, Jun, additional, Li, Lin, additional, Chen, Beibei, additional, Sun, Liping, additional, Tang, Jinfa, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Niu, Jianzhao, additional, Jiang, Guangjian, additional, Fu, Min, additional, Brömme, Dieter, additional, Zhang, Dongwei, additional, and Gao, Sihua, additional

Published
2017
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33. Evaluation of Decalcification Techniques for Rat Femurs Using HE and Immunohistochemical Staining

Author

Liu, Haixia, primary, Zhu, Ruyuan, additional, Liu, Chenyue, additional, Ma, Rufeng, additional, Wang, Lili, additional, Chen, Beibei, additional, Li, Lin, additional, Niu, Jianzhao, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Fu, Min, additional, Brömme, Dieter, additional, Zhang, Dongwei, additional, and Gao, Sihua, additional

Published
2017
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34. Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats

Author

Ma, Rufeng, primary, Wang, Lili, additional, Zhao, Baosheng, additional, Liu, Chenyue, additional, Liu, Haixia, additional, Zhu, Ruyuan, additional, Chen, Beibei, additional, Li, Lin, additional, Zhao, Dandan, additional, Mo, Fangfang, additional, Li, Yu, additional, Niu, Jianzhao, additional, Jiang, Guangjian, additional, Fu, Min, additional, Bromme, Dieter, additional, Gao, Sihua, additional, and Zhang, Dongwei, additional

Published
2017
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37. Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice.

Author

Zhu, Ruyuan, Wei, Junping, Liu, Haixia, Liu, Chenyue, Wang, Lili, Chen, Beibei, Li, Lin, Jia, Qiangqiang, Tian, Yimiao, Li, Rui, Zhao, Dandan, Mo, Fangfang, Li, Yu, Gao, Sihua, Wang, Xiang-Dong, and Zhang, Dongwei

Subjects
*WEIGHT gain, *BODY weight, *BROWN adipose tissue, *WHITE adipose tissue, *LYCOPENE, *PEROXISOME proliferator-activated receptors, *BLOOD lipids, *GLUCOSE metabolism, *PROTEIN metabolism, *CELL differentiation, *OBESITY, *RESEARCH, *ANIMAL experimentation, *OXYGEN consumption, *RESEARCH methodology, *ANIMAL nutrition, *CELL physiology, *GENETIC disorders, *EVALUATION research, *MEDICAL cooperation, *INSULIN, *COMPARATIVE studies, *FAT cells, *CELLS, *LIPID metabolism disorders, *GLUCOSE tolerance tests, *ADIPOSE tissues, *MICE, *PHENOTYPES
Abstract

Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and clinically used to obesity and type 2 diabetes management. However, whether its ability of countering body weight gain is related to induction of brown-like adipocyte phenotype in white adipose tissues (WAT) remains largely unknown. Activation of peroxisome proliferator-activated receptor γ (PPARγ) serves the brown-like phenotype conversion and energy expenditure. Here, we show that LYC treatment promotes glucose consumption and improves insulin sensitivity, as well as fosters white adipocytes browning through up-regulating mRNA and protein expression levels of PPARγ, uncoupling protein 1, PPARγ coactivator-1α and PR domain-containing 16 in the differentiated 3T3-L1 adipocytes and primary adipocytes, as well as in the WAT of HFD-exposed obese mice. In addition, LYC treatment attenuates body weight gain and improves serum lipid profiles as well as promotes brown adipose tissue activation in obese mice. Moreover, PPARγ is induced with LYC intervention in mitochondria respiration and browning in white adipocytes and tissues. Taken together, these results suggest that LYC counteracts obesity and improves glucose and lipid metabolism through induction of the browning via up-regulation of PPARγ, which offers a new perspective of this compound to combat obesity and obesity-related disorders. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1 α Signaling Pathway.

Author

Bai Y, Zuo J, Fang X, Ma R, Tian T, Mo F, Mu Q, Zhang Y, Yu N, Bao X, Zhang D, Gao S, and Zhao D

Subjects
Animals, Drugs, Chinese Herbal pharmacology, Male, Mice, Signal Transduction, AMP-Activated Protein Kinases drug effects, Diabetes Mellitus, Experimental drug therapy, Diet, High-Fat adverse effects, Drugs, Chinese Herbal therapeutic use, Insulin Resistance immunology, Muscle, Skeletal drug effects
Abstract

The Jiang Tang Xiao Ke (JTXK) granule is a classic Chinese herbal formula that has been put into clinical use in the treatment of type 2 diabetes mellitus for decades. However, whether its ability to ameliorate skeletal muscle insulin resistance (IR) is through modulation of the AMPK/SIRT1/PGC-1 α signaling pathway remains unknown. Therefore, we aimed to investigate the effects of JTXK granules on IR in skeletal muscle of high-fat diet-induced diabetic mice and C2C12 cells and analyze the underlying mechanisms. In the present study, we showed that JTXK granules attenuated body weight gain, reduced body fat mass, improved body lean mass, and enhanced muscle performance of diabetic mice. JTXK granules also improved glucose metabolism and skeletal muscle insulin sensitivity and partially reversed abnormal serum lipid levels, which might be related to the regulation of the AMPK/SIRT1/PGC-1 α pathway, both in skeletal muscle tissue of diabetic mice and in C2C12 cells. Furthermore, drug-containing serum of JTXK granules was capable of enhancing glucose uptake and mitochondrial respiration in C2C12 cells, and AMPK α was proven to be closely involved in this process. Taken together, these results suggest that the JTXK granule ameliorates skeletal muscle IR through activation of the AMPK/SIRT1/PGC-1 α signaling pathway, which offers a novel perspective of this formula to combat IR-related metabolic diseases., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Ying Bai et al.)

Published
2021
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