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343 results on '"Mlak, Radosław"'

4. Textbook Oncological Outcome in European GASTRODATA

Author

Sędłak, Katarzyna, Rawicz-Pruszyński, Karol, Mlak, Radosław, Van Sandick, Johanna, Gisbertz, Suzanne, Pera, Manuel, Dal Cero, Mariagiulia, Baiocchi, Gian Luca, Celotti, Andrea, Morgagni, Paolo, Vittimberga, Giovani, Hoelscher, Arnulf, Moenig, Stefan, Kołodziejczyk, Piotr, Richter, Piotr, Gockel, Ines, Piessen, Guillaume, Da Costa, Paulo Matos, Davies, Andrew, Baker, Cara, Allum, William, Romario, Uberto Fumagalli, De Pascale, Stefano, Rosati, Ricccardo, Reim, Daniel, Santos, Lucio Lara, D’ugo, Domenico, Wijnhoven, Bas, Degiuli, Maurizio, De Manzoni, Giovanni, Kielan, Wojciech, Frejlich, Ewelina, Schneider, Paul, and Polkowski, Wojciech P.

Published
2023
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5. A Virome and Proteomic Analysis of Placental Microbiota in Pregnancies with and without Fetal Growth Restriction.

Author

Stupak, Aleksandra, Kwiatek, Maciej, Gęca, Tomasz, Kwaśniewska, Anna, Mlak, Radosław, Nawrot, Robert, Goździcka-Józefiak, Anna, and Kwaśniewski, Wojciech

Subjects
HEAT shock proteins, FETAL growth retardation, VIRAL proteins, ESCHERICHIA coli, PLANT viruses
Abstract

Introduction: Metagenomic research has allowed the identification of numerous viruses present in the human body. Viruses may significantly increase the likelihood of developing intrauterine fetal growth restriction (FGR). The goal of this study was to examine and compare the virome of normal and FGR placentas using proteomic techniques. Methods: The study group of 18 women with late FGR was compared with 18 control patients with physiological pregnancy and eutrophic fetus. Proteins from the collected afterbirth placentas were isolated and examined using liquid chromatography linked to a mass spectrometer. Results: In this study, a group of 107 viral proteins were detected compared to 346 in the controls. In total, 41 proteins were common in both groups. In total, 64 proteins occurred only in the study group and indicated the presence of bacterial phages: E. coli, Bacillus, Mediterranenean, Edwardsiella, Propionibacterium, Salmonella, Paenibaciilus and amoebae Mimiviridae, Acanthamoeba polyphaga, Mimivivirus, Pandoravirdae, Miroviridae, Pepper plant virus golden mosaic virus, pol proteins of HIV-1 virus, and proteins of Pandoravirdae, Microviridae, and heat shock proteins of the virus Faustoviridae. Out of 297 proteins found only in the control group, only 2 viral proteins occurred statistically significantly more frequently: 1/hypothetical protein [uncultured Mediterranean phage uvMED] and VP4 [Gokushovirus WZ-2015a]. Discussion: The detection of certain viral proteins exclusively in the control group suggests that they may play a protective role. Likewise, the proteins identified only in the study group could indicate a potentially pathogenic function. A virome study may be used to identify an early infection, evaluate its progress, and possible association with fetal growth restriction. Utilizing this technology, an individualized patient therapy is forthcoming, e.g., vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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9. MalnutritiOn assessment with biOelectrical impedaNce analysis in gastRic cancer patIentS undergoing multimodaltrEatment (MOONRISE)—Study protocol for a single-arm multicenter cross-sectional longitudinal study

Author

Pelc, Zuzanna, Sędłak, Katarzyna, Mlak, Radosław, Chawrylak, Katarzyna, Mielniczek, Katarzyna, Leśniewska, Magdalena, Skórzewska, Magdalena, Kwietniewska, Magdalena, Paśnik, Iwona, Gęca, Katarzyna, van der Sluis, Pieter, Banasiewicz, Tomasz, Pędziwiatr, Michał, Polkowski, Wojciech P., Pawlik, Timothy M., Małecka-Massalska, Teresa, Rawicz-Pruszyński, Karol, Pelc, Zuzanna, Sędłak, Katarzyna, Mlak, Radosław, Chawrylak, Katarzyna, Mielniczek, Katarzyna, Leśniewska, Magdalena, Skórzewska, Magdalena, Kwietniewska, Magdalena, Paśnik, Iwona, Gęca, Katarzyna, van der Sluis, Pieter, Banasiewicz, Tomasz, Pędziwiatr, Michał, Polkowski, Wojciech P., Pawlik, Timothy M., Małecka-Massalska, Teresa, and Rawicz-Pruszyński, Karol

Abstract

European data suggests that over 30% of gastric cancer (GC) patients are diagnosed with sarcopenia before surgery, while unintentional weight loss occurs in approximately 30% of patients following gastrectomy. Preoperative sarcopenia significantly increases the risk of major postoperative complications, and preoperative body weight loss remains a superior predictor of outcome and an independent prognostic factor for overall survival (OS) in patients with GC. A standardized approach of nutritional risk screening of GC patients is yet to be established. Therefore, the MOONRISE study aims to prospectively analyze the changes in nutritional status and body composition at each stage of multimodal treatment among GC patients from five Western expert centers. Specifically, we seek to assess the association between nutritional status and body composition on tumor response following neoadjuvant chemotherapy (NAC). Secondary outcomes of the study are treatment toxicity, postoperative complications, quality of life (QoL), and OS. Patients with locally advanced gastric adenocarcinoma scheduled for multimodal treatment will be included in the study. Four consecutive nutritional status assessments will be performed throughout the treatment. The following study was registered in ClinicalTrials.gov (Identifier: NCT05723718) and will be conducted in accordance with the STROBE statement. The anticipated duration of the study is 12–24 months, depending on the recruitment status. Results of this study will reveal whether nutritional status and body composition assessment based on BIA will become a validated and objective tool to support clinical decisions in GC patients undergoing multimodal treatment.

Published
2024

16. Prognostic Value of Inflammatory Burden Index in Advanced Gastric Cancer Patients Undergoing Multimodal Treatment

Author

Pelc, Zuzanna, primary, Sędłak, Katarzyna, additional, Mlak, Radosław, additional, Leśniewska, Magdalena, additional, Mielniczek, Katarzyna, additional, Rola, Piotr, additional, Januszewski, Jacek, additional, Zhaldak, Olena, additional, Rekowska, Anna, additional, Gęca, Katarzyna, additional, Skórzewska, Magdalena, additional, Polkowski, Wojciech P., additional, Pawlik, Timothy M., additional, and Rawicz-Pruszyński, Karol, additional

Published
2024
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17. MalnutritiOn assessment with biOelectrical impedaNce analysis in gastRic cancer patIentS undergoing multimodaltrEatment (MOONRISE)—Study protocol for a single-arm multicenter cross-sectional longitudinal study

Author

Pelc, Zuzanna, primary, Sędłak, Katarzyna, additional, Mlak, Radosław, additional, Chawrylak, Katarzyna, additional, Mielniczek, Katarzyna, additional, Leśniewska, Magdalena, additional, Skórzewska, Magdalena, additional, Kwietniewska, Magdalena, additional, Paśnik, Iwona, additional, Gęca, Katarzyna, additional, van der Sluis, Pieter, additional, Banasiewicz, Tomasz, additional, Pędziwiatr, Michał, additional, Polkowski, Wojciech P., additional, Pawlik, Timothy M., additional, Małecka-Massalska, Teresa, additional, and Rawicz-Pruszyński, Karol, additional

Published
2024
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21. Predicting chemotherapy toxicity in multiple myeloma: the prognostic value of pretreatment serum cytokine levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1, and vascular endothelial growth factor.

Author

Mielnik, Michał, Podgajna-Mielnik, Martyna, Szudy-Szczyrek, Aneta, Homa-Mlak, Iwona, Mlak, Radosław, Gorący, Aneta, and Hus, Marek

Subjects
VASCULAR endothelial growth factors, PROGNOSIS, LYMPHOPENIA, MULTIPLE myeloma, INTERLEUKIN-8, INTERLEUKIN-6
Abstract

Introduction: Multiple Myeloma (MM), a prevalent hematological malignancy, poses significant treatment challenges due to varied patient responses and toxicities to chemotherapy. This study investigates the predictive value of pretreatment serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF) for chemotherapy-induced toxicities in newly diagnosed MM patients. We hypothesized that these cytokines, pivotal in the tumor microenvironment, might correlate with the incidence and severity of treatment-related adverse events. Methods: We conducted a prospective observational study with 81 newly diagnosed MM patients, analyzing serum cytokine levels using the multiplex cytometric bead assay (CBA) flow cytometry method. The study used nonparametric and multivariate analysis to compare cytokine levels with treatment-induced toxicities, including lymphopenia, infections, polyneuropathy, and neutropenia. Results: Our findings revealed significant associations between cytokine levels and specific toxicities. IL-8 levels were lower in patients with lymphopenia (p=0.0454) and higher in patients with infections (p=0.0009) or polyneuropathy (p=0.0333). VEGF concentrations were notably lower in patients with neutropenia (p=0.0343). IL-8 demonstrated an 81% sensitivity (AUC=0.69; p=0.0015) in identifying infection risk. IL-8 was an independent predictor of lymphopenia (Odds Ratio [OR]=0.26; 95% Confidence Interval [CI] =0.07-0.78; p=0.0167) and infection (OR=4.76; 95% CI=0.07-0.62; p=0.0049). High VEGF levels correlated with a 4-fold increased risk of anemia (OR=4.13; p=0.0414). Conclusions: Pre-treatment concentrations of IL-8 and VEGF in serum can predict hematological complications, infections, and polyneuropathy in patients with newly diagnosed MM undergoing chemotherapy. They may serve as simple yet effective biomarkers for detecting infections, lymphopenia, neutropenia, and treatment-related polyneuropathy, aiding in the personalization of chemotherapy regimens and the mitigation of treatment-related risks. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Oncological Outcomes and Long-Term Survival among Patients with Gastric Cancer and Limited Peritoneal Disease Progression after Neoadjuvant Chemotherapy

Author

Kobiałka, Sebastian, primary, Sędłak, Katarzyna, additional, Pelc, Zuzanna, additional, Mlak, Radosław, additional, Endo, Yutaka, additional, Bogacz, Paweł, additional, Kurylcio, Andrzej, additional, Polkowski, Wojciech P., additional, Pawlik, Timothy M., additional, and Rawicz-Pruszyński, Karol, additional

Published
2023
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26. Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Oncological Outcomes and Long-Term Survival among Patients with Gastric Cancer and Limited Peritoneal Disease Progression after Neoadjuvant Chemotherapy.

Author

Kobiałka, Sebastian, Sędłak, Katarzyna, Pelc, Zuzanna, Mlak, Radosław, Endo, Yutaka, Bogacz, Paweł, Kurylcio, Andrzej, Polkowski, Wojciech P., Pawlik, Timothy M., and Rawicz-Pruszyński, Karol

Subjects
HYPERTHERMIC intraperitoneal chemotherapy, PERITONEUM diseases, NEOADJUVANT chemotherapy, STOMACH cancer, CANCER patients, PERITONEAL cancer
Abstract

Introduction: The role of surgery in stage IV gastric cancer with peritoneal metastasis (PM) remains unclear. The objective of the current single-center study was to define the impact of gastrectomy with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on outcomes among Central European GC patients with limited peritoneal disease progression after neoadjuvant chemotherapy (NAC). Methods: Patients with histologically confirmed GC who underwent curative-intent multimodal treatment between 2013 and 2023 were included. Patients without adenocarcinoma, who did not undergo gastrectomy, had early (cT1) or metastatic GC at the time of initial diagnosis, who underwent multivisceral resection, incomplete cytoreduction or palliative care, died before planned curative-intent treatment, or had incomplete clinical or pathological missing information were excluded. Results: A total of 74 patients who underwent curative-intent treatment for GC with PM were included in the final analytic cohort. Patients who underwent gastrectomy with CRS+HIPEC were less likely to achieve TOO (CRS+HIPEC: 28% vs. CRS: 57.1%, p = 0.033) compared with individuals after CRS alone. Specifically, patients who underwent gastrectomy with CRS+HIPEC had a higher likelihood of postoperative complications (CRS+HIPEC: 48% vs. CRS: 20.4%, p = 0.018) and longer hospital LOS (median, CRS+HIPEC: 12 vs. CRS: 10, p = 0.019). While administration of HIPEC did not impact long-term survival (median OS, CRS+HIPEC: 16 months vs. CRS: 12 months, p = 0.55), postoperative complications (median OS, CCI < 30:16 months vs. CCI > 30:5 months, p = 0.024) and ICU stay (median OS, no ICU stay: 16 months vs. ICU stay: 5 months, p = 0.008) were associated with worsened long-term survival among GC patients with PM. Conclusions: Data from the current study demonstrated a lack of survival benefit among advanced GC patients with PM undergoing gastrectomy with CRS+HIPEC when compared with individuals after gastrectomy with CRS alone. Administration of perioperative chemotherapy and achievement of TO failed to withstand the peritoneal disease progression during NAC. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Staging LaParoscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer (POLA)—Study protocol for a single-arm prospective observational multicenter study

Author

Rawicz-Pruszyński, Karol, primary, Sędłak, Katarzyna, additional, Pelc, Zuzanna, additional, Mlak, Radosław, additional, Litwiński, Jakub, additional, Mańko, Paweł, additional, Zinkiewicz, Krzysztof, additional, Paśnik, Iwona, additional, Cięszczyk, Katarzyna, additional, Pawlik, Timothy, additional, Märkl, Bruno, additional, Erodotou, Maria, additional, and Polkowski, Wojciech P., additional

Published
2023
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30. Staging LaParoscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer (POLA)—Study protocol for a single-arm prospective observational multicenter study

Author

Rawicz-Pruszyński, Karol, Sędłak, Katarzyna, Pelc, Zuzanna, Mlak, Radosław, Litwiński, Jakub, Mańko, Paweł, Zinkiewicz, Krzysztof, Paśnik, Iwona, Cięszczyk, Katarzyna, Pawlik, Timothy, Märkl, Bruno, Erodotou, Maria, Polkowski, Wojciech P., Rawicz-Pruszyński, Karol, Sędłak, Katarzyna, Pelc, Zuzanna, Mlak, Radosław, Litwiński, Jakub, Mańko, Paweł, Zinkiewicz, Krzysztof, Paśnik, Iwona, Cięszczyk, Katarzyna, Pawlik, Timothy, Märkl, Bruno, Erodotou, Maria, and Polkowski, Wojciech P.

Abstract

Introduction In the era of neoadjuvant chemotherapy in advanced gastric cancer (GC), the role of staging laparoscopy (SL) will become more established. However, despite guidelines recommendations, SL for optimal preoperative staging remains underutilized. Diagnostic value of near-infrared (NIR) / indocyanine green (ICG) guided sentinel node (SN) mapping in GC confirmed its technical feasibility, however no data exist regarding its potential role in pathological nodal staging. To the best of our knowledge, current study is the first to evaluate the role of ICG in nodal staging of advanced GC patients undergoing SL. Materials and methods This single-arm prospective observational multicenter study was approved by the Bioethical Committee of Medical University of Lublin (Ethic Code: KE-0254/331/2018). The protocol is registered at clinicaltrial.gov (NCT05720598), and the study results will be reported according to the Strengthening of Reporting of Observational Studies in Epidemiology (STROBE) statement. The primary endpoint of this study is the identification rate of ICG-guided SN in advanced GC patients. The secondary endpoints include pathological and molecular assessment of retrieved SNs and other pretreatment clinical variables potentially associated with SL: pattern of perigastric ICG distribution according to patients’ pathological and clinical characteristics, neoadjuvant chemotherapy compliance, 30-day morbidity, and mortality. Conclusion POLA study is the first to investigate the clinical value of ICG-enhanced sentinel node biopsy during staging laparoscopy in advanced GC patients in a Western cohort. Identifying pN status before multimodal treatment will improve GC staging process.

Published
2023

31. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma

Author

Szudy-Szczyrek, Aneta, primary, Mlak, Radosław, additional, Mazurek, Marcin, additional, Krajka, Tomasz, additional, Chocholska, Sylwia, additional, Bitkowska, Paulina, additional, Jutrzenka, Marta, additional, Szczyrek, Michał, additional, Homa-Mlak, Iwona, additional, Krajka, Andrzej, additional, Małecka-Massalska, Teresa, additional, and Hus, Marek, additional

Published
2023
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39. High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

Author

Homa-Mlak, Iwona, primary, Mlak, Radosław, additional, Brzozowska, Anna, additional, Mazurek, Marcin, additional, Powrózek, Tomasz, additional, Prendecka-Wróbel, Monika, additional, Szudy-Szczyrek, Aneta, additional, Dreher, Piotr, additional, Kamińska, Katarzyna, additional, Małecka-Massalska, Teresa, additional, and Wójcik-Załuska, Alicja, additional

Published
2022
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45. Prognostic Value of Systemic Inflammatory Response Markers in Patients Undergoing Neoadjuvant Chemotherapy and Gastrectomy for Advanced Gastric Cancer in the Eastern European Population

Author

Pikuła, Agnieszka, primary, Skórzewska, Magdalena, additional, Pelc, Zuzanna, additional, Mlak, Radosław, additional, Gęca, Katarzyna, additional, Sędłak, Katarzyna, additional, Ciseł, Bogumiła, additional, Kwietniewska, Magdalena, additional, Rawicz-Pruszyński, Karol, additional, and Polkowski, Wojciech P., additional

Published
2022
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50. A Propensity Score Matched Analysis of Superparamagnetic Iron Oxide versus Radioisotope Sentinel Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy

Author

Pelc, Zuzanna, primary, Skórzewska, Magdalena, additional, Kurylcio, Maria, additional, Nowikiewicz, Tomasz, additional, Mlak, Radosław, additional, Sędłak, Katarzyna, additional, Gęca, Katarzyna, additional, Rawicz-Pruszyński, Karol, additional, Zegarski, Wojciech, additional, Polkowski, Wojciech P., additional, and Kurylcio, Andrzej, additional

Published
2022
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