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2. Prevalence of Asymptomatic Mpox among Men Who Have Sex with Men, Japan, January-March 2023

Author

Mizushima, Daisuke, Shintani, Yui, Takano, Misao, Shiojiri, Daisuke, Ando, Naokatsu, Aoki, Takahiro, Watanabe, Koji, Nakamoto, Takato, Gatanaga, Hiroyuki, and Oka, Shinichi

Subjects
Torii Pharmaceutical Company Ltd., Medical research, Medicine, Experimental, Infection, Disease transmission, Public health, Pharmaceutical industry, Health
Abstract

During the 2022 global mpox outbreak, asymptomatic monkeypox virus (MPXV) infections or unrecognized mpox cases were reported among men who have sex with men (MSM) (1-4). Asymptomatic cases were diagnosed [...]

Published
2023
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3. Development of Compact Actuator for Direct Measurement of Skin Displacement in Ultrasonic Haptics

Author

Mizushima, Daisuke, Sato, Daiki, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Suryadevara, Nagender Kumar, editor, George, Boby, editor, Jayasundera, Krishanthi P., editor, and Mukhopadhyay, Subhas Chandra, editor

Published
2023
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6. Safety and Effectiveness of LC16m8 for Pre-Exposure Prophylaxis against mpox in a High-Risk Population: An Open-Label Randomized Trial

Author

Okumura, Nobumasa, primary, Morino, Eriko, additional, Nomoto, Hidetoshi, additional, Yanagi, Mashiho, additional, Takahashi, Kozue, additional, Iwasaki, Haruka, additional, Uemura, Yukari, additional, Shimizu, Yosuke, additional, Mizushima, Daisuke, additional, Fukushima, Kazuaki, additional, Kinai, Ei, additional, Shiojiri, Daisuke, additional, Itoda, Ichiro, additional, Onoe, Yasuhiko, additional, Kobori, Yoshitomo, additional, Nakamura, Fukumi, additional, Tokita, Daisuke, additional, Sugiura, Wataru, additional, Ohmagari, Norio, additional, and Ujiie, Mugen, additional

Published
2024
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9. Local radiotherapy for chemotherapy-refractory Kaposi's sarcoma in an HIV-infected patient: A case report and literature review

Author

Yoshitomi, Yutaro, primary, Kawashima, Akira, additional, Nakayama, Hidetsugu, additional, Nakamoto, Takato, additional, Ando, Naokatsu, additional, Uemura, Haruka, additional, Mizushima, Daisuke, additional, Aoki, Takahiro, additional, Tanuma, Junko, additional, Teruya, Katsuji, additional, Gatanaga, Hiroyuki, additional, and Watanabe, Koji, additional

Published
2024
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14. Efficacy of Lactococcus lactis strain Plasma on clearance of anal HPV infection in men who have sex with men: A single-center, double-blinded, randomized placebo-controlled trial (CLEAR HPV study)

Author

Mizushima, Daisuke, primary, Takano, Misao, additional, Ando, Naokatsu, additional, Kitamura, Hiroshi, additional, Shiojiri, Daisuke, additional, Nakamoto, Takato, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Shimizu, Yosuke, additional, Uemura, Yukari, additional, Gatanaga, Hiroyuki, additional, and Oka, Shinichi, additional

Published
2023
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17. Sitafloxacin- Versus Moxifloxacin-Based Sequential Treatment for Mycoplasma Genitalium Infections: Protocol for a Multicenter, Open-Label Randomized Controlled Trial (Preprint)

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Shimizu, Yosuke, additional, Uemura, Yukari, additional, Takano, Misao, additional, Mitobe, Morika, additional, Kobayashi, Kai, additional, Kubota, Hiroaki, additional, Miyake, Hirofumi, additional, Suzuki, Jun, additional, Sadamasu, Kenji, additional, Nakamoto, Takato, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Oka, Shinichi, additional, and Gatanaga, Hiroyuki, additional

Published
2023
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18. Sitafloxacin- versus Moxifloxacin-based Sequential Treatment for Mycoplasma genitalium Infections: A Multicenter, Open-label, Randomized Controlled Trial (Preprint)

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Shimizu, Yosuke, additional, Uemura, Yukari, additional, Takano, Misao, additional, Mitobe, Morika, additional, Kobayashi, Kai, additional, Kubota, Hiroaki, additional, Miyake, Hirofumi, additional, Suzuki, Jun, additional, Sadamasu, Kenji, additional, Nakamoto, Takato, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Oka, Shinichi, additional, and Gatanaga, Hiroyuki, additional

Published
2023
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23. Prevalence of and factors associated with diabetes mellitus among people living with HIV in Vietnam

Author

Nagai, Moeko, Matsumoto, Shoko, Tanuma, Junko, Nguyen, Dung Hoai Thi, Nguyen, Dung Thi, Mizushima, Daisuke, Oka, Shinichi, and Pham, Thach Ngoc

Subjects
Original Article, General Medicine
Abstract

Studies have shown that people living with HIV (PLWH) have a higher risk of having non-communicable diseases (NCDs) than do people without HIV. In Vietnam, HIV remains a major public health concern, and with recent rapid economic growth, NCDs such as diabetes mellitus (DM) have become a significant disease burden. This cross-sectional study was conducted to examine the prevalence of DM and the factors associated with DM among PLWH on antiretroviral therapy (ART). In total, 1,212 PLWH were included in the study. The age-standardized prevalence of DM and pre-diabetes were 9.29% and 10.32%, respectively. In the multivariate logistic regression analysis, male sex, age above 50 years, and body mass index ≥ 25 kg/m(2) were associated with DM, and borderline p-value was found for associations with current smoking and years on ART. The results suggest higher DM prevalence among PLWH and that longer time on ART could be an important risk factor for DM among PLWH. These findings also suggest that interventions such as weight control and smoking cessation support could be provided at outpatient clinics. Integration of HIV/AIDS and NCDs services is essential to address health needs comprehensively and enhance health-related quality of life for PLWH.

Published
2023

26. Effectiveness of sitafloxacin monotherapy for quinolone-resistant rectal and urogenital Mycoplasma genitalium infections: a prospective cohort study

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Takano, Misao, additional, Mitobe, Morika, additional, Kobayashi, Kai, additional, Kubota, Hiroaki, additional, Miyake, Hirofumi, additional, Suzuki, Jun, additional, Sadamasu, Kenji, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Uemura, Haruka, additional, Yanagawa, Yasuaki, additional, Gatanaga, Hiroyuki, additional, and Oka, Shinichi, additional

Published
2023
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27. Combination of Amoxicillin 3,000 mg and Probenecid versus 1,500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients with HIV: an Open-Label, Randomized, Controlled, Non-Inferiority Trial

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Omata, Kazumi, additional, Nemoto, Takashi, additional, Inamura, Natsumi, additional, Hiramoto, Saori, additional, Takano, Misao, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Uemura, Haruka, additional, Shiojiri, Daisuke, additional, Yanagawa, Yasuaki, additional, Tanuma, Junko, additional, Teruya, Katsuji, additional, Kikuchi, Yoshimi, additional, Gatanaga, Hiroyuki, additional, and Oka, Shinichi, additional

Published
2023
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32. Cost-effectiveness analysis of HIV pre-exposure prophylaxis in Japan

Author

Mizushima, Daisuke, Nagai, Yoshino, Mezzio, Dylan, Harada, Keisuke, Piao, Yi, Barnieh, Lianne, Moustaid, Fadoua El, Cawson, Matthew, and Taniguchi, Toshibumi

Abstract

While global efforts have been made to prevent transmission of HIV, the epidemic persists. Men who have sex with men (MSM) are at high risk of infection. Despite evidence of its cost-effectiveness in other jurisdictions, pre-exposure prophylaxis (PrEP) for MSM is neither approved nor reimbursed in Japan. The cost-effectiveness analysis compared the use of once daily PrEP versus no PrEP among MSM over a 30-year time horizon from a national healthcare perspective. Epidemiological estimates for each of the 47 prefectures informed the model. Costs included HIV/AIDS treatment, HIV and testing for sexually transmitted infections, monitoring tests and consults, and hospitalization costs. Analyses included health and cost outcomes, as well as the incremental cost-effectiveness ratio (ICER) reported as the cost per quality-adjusted life year (QALY) for all of Japan and each prefecture. Sensitivity analyses were performed. The estimated proportion of HIV infections prevented with the use of PrEP ranged from 48% to 69% across Japan, over the time horizon. Cost savings due to lower monitoring costs and general medical costs were observed. Assuming 100% coverage, for Japan overall, daily use of PrEP costs less and was more effective; daily use of PrEP was cost-effective at a willingness to pay threshold of ¥5,000,000 per QALY in 32 of the 47 prefectures. Sensitivity analyses found that the ICER was most sensitive to the cost of PrEP. Compared to no PrEP use, once daily PrEP is a cost-effective strategy in Japanese MSM, reducing the clinical and economic burden associated with HIV. HIV remains an epidemic, and men who have sex with men (MSM) are at higher risk of infection. Pre-exposure prophylaxis (PrEP) is a preventive treatment that can reduce someone's risk of getting infected with HIV and has been shown to provide good value for money. PrEP, however, is neither approved nor reimbursed in Japan. In order to determine the value for money in Japan, an economic model was developed to estimate the number of HIV infections and AIDS cases that could be avoided, along with whether daily use of PrEP among MSM in Japan is cost effective. Findings showed that with use of daily PrEP, the proportion of HIV infections and AIDS cases prevented was 63% and 59%, respectively, across Japan. Over a 30-year time horizon, daily use of PrEP would cost the health system less and be more effective than no use of PrEP. Daily PrEP should therefore be considered for reimbursement in MSM in Japan, given its value for money.

Published
2023
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34. Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial.

Author

Ando, Naokatsu, Mizushima, Daisuke, Omata, Kazumi, Nemoto, Takashi, Inamura, Natsumi, Hiramoto, Saori, Takano, Misao, Aoki, Takahiro, Watanabe, Koji, Uemura, Haruka, Shiojiri, Daisuke, Yanagawa, Yasuaki, Tanuma, Junko, Teruya, Katsuji, Kikuchi, Yoshimi, Gatanaga, Hiroyuki, and Oka, Shinichi

Subjects
*HIV-positive persons, *COMBINATION drug therapy, *CLINICAL trials, *PROBENECID (Drug), *SYPHILIS, *SERODIAGNOSIS, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *COMPARATIVE studies, *RESEARCH funding, *STATISTICAL sampling, *AMOXICILLIN, *PATIENT safety
Abstract

Background Amoxicillin plus probenecid is an alternative to intramuscular benzathine penicillin G for treating syphilis in the United Kingdom. Low-dose amoxicillin is an alternative treatment option used in Japan. Methods We conducted an open-label, randomized, controlled, non-inferiority trial between 31 August 2018, and 3 February 2022, to compare 1500 mg low-dose amoxicillin monotherapy with the combination of 3000 mg amoxicillin and probenecid (non-inferiority margin 10%). Patients with human immunodeficiency virus (HIV) infection and syphilis were eligible. The primary outcome was the cumulative serological cure rate within 12 months post-treatment, measured using the manual rapid plasma reagin card test. Secondary outcomes included safety assessment. Results A total of 112 participants were randomized into 2 groups. Serological cure rates within 12 months were 90.6% and 94.4% with the low-dose amoxicillin and combination regimens, respectively. Serological cure rates for early syphilis within 12 months were 93.5% and 97.9% with the low-dose amoxicillin and combination regimens, respectively. Non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid overall and for early syphilis was not confirmed. No significant side effects were detected. Conclusions This is the first randomized controlled trial to demonstrate a high efficacy of amoxicillin-based regimens for treating syphilis in patients with HIV infection, and the non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid was not seen. Therefore, amoxicillin monotherapy could be a good alternative to intramuscular benzathine penicillin G with fewer side effects. However, further studies comparing with benzathine penicillin G in different populations and with larger sample sizes are needed. Trials Registration (UMIN000033986). [ABSTRACT FROM AUTHOR]

Published
2023
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38. Unmasking latent extrapulmonary tuberculosis with newly diagnosed HIV-1 infection in a COVID-19 patient with prolonged fever

Author

Hirata, Kaiho, primary, Watanabe, Koji, additional, Sasaki, Takeshi, additional, Yoshimasu, Takashi, additional, Shimomura, Akihiko, additional, Ando, Naokatsu, additional, Yanagawa, Yasuaki, additional, Mizushima, Daisuke, additional, Teruya, Katsuji, additional, Kikuchi, Yoshimi, additional, Oka, Shinichi, additional, and Tsukada, Kunihisa, additional

Published
2022
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41. Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan

Author

Yanagawa, Yasuaki, primary, Shimogawara, Rieko, additional, Takano, Misao, additional, Aoki, Takahiro, additional, Mizushima, Daisuke, additional, Gatanaga, Hiroyuki, additional, Kikuchi, Yoshimi, additional, Oka, Shinichi, additional, Yagita, Kenji, additional, and Watanabe, Koji, additional

Published
2022
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42. Clinical Effectiveness of Sitafloxacin Monotherapy for Treating Rectal and Urogenital Mycoplasma Genitalium Infections in a Setting with a High Prevalence of Quinolone Resistance-Associated Mutations: A Single Center, Prospective Cohort Study

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Takano, Misao, additional, Mitobe, Morika, additional, Kobayashi, Kai, additional, Kubota, Hiroaki, additional, Miyake, Hirofumi, additional, Suzuki, Jun, additional, Sadamasu, Kenji, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Uemura, Haruka, additional, Yanagawa, Yasuaki, additional, Gatanaga, Hiroyuki, additional, and Oka, Shinichi, additional

Published
2022
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45. Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3′ untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study

Author

Nishijima, Takeshi, Tsuchiya, Kiyoto, Tanaka, Noriko, Joya, Akane, Hamada, Yohei, Mizushima, Daisuke, Aoki, Takahiro, Watanabe, Koji, Kinai, Ei, Honda, Haruhito, Yazaki, Hirohisa, Tanuma, Junko, Tsukada, Kunihisa, Teruya, Katsuji, Kikuchi, Yoshimi, Oka, Shinichi, and Gatanaga, Hiroyuki

Published
2014
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46. Efficacy of 1 g Ceftriaxone Monotherapy Compared to Dual Therapy With Azithromycin or Doxycycline for Treating Extragenital Gonorrhea Among Men Who Have Sex With Men

Author

Aoki, Takahiro, primary, Mizushima, Daisuke, additional, Takano, Misao, additional, Ando, Naokatsu, additional, Uemura, Haruka, additional, Yanagawa, Yasuaki, additional, Watanabe, Koji, additional, Gatanaga, Hiroyuki, additional, Kikuchi, Yoshimi, additional, and Oka, Shinichi, additional

Published
2021
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47. High prevalence of circulating dual-class resistant Mycoplasma genitalium in asymptomatic MSM in Tokyo, Japan

Author

Ando, Naokatsu, primary, Mizushima, Daisuke, additional, Takano, Misao, additional, Mitobe, Morika, additional, Miyake, Hirofumi, additional, Yokoyama, Keiko, additional, Sadamasu, Kenji, additional, Aoki, Takahiro, additional, Watanabe, Koji, additional, Uemura, Haruka, additional, Yanagawa, Yasuaki, additional, Gatanaga, Hiroyuki, additional, and Oka, Shinichi, additional

Published
2021
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