28 results on '"Mizuma, Keita"'
Search Results
2. Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case
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Ito, Jumpei, Misawa, Naoko, Plianchaisuk, Arnon, Guo, Ziyi, Hina, Alfredo, Jr., Uriu, Keiya, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Yoshimura, Ryo, Kawakubo, Shusuke, Nishimura, Luca, Kosugi, Yusuke, Fujita, Shigeru, Chen, Luo, Tolentino, Jarel Elgin M., Pan, Lin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Strange, Adam P., Chiba, Mika, Iida, Keiko, Ohsumi, Naomi, Okumura, Kaho, Tanaka, Shiho, Ogawa, Eiko, Yasuda, Kyoko, Fukuda, Tsuki, Osujo, Rina, Fukuhara, Takasuke, Tamura, Tomokazu, Suzuki, Rigel, Suzuki, Saori, Ito, Hayato, Matsuno, Keita, Sawa, Hirofumi, Nao, Naganori, Tanaka, Shinya, Tsuda, Masumi, Wang, Lei, Oda, Yoshikata, Ferdous, Zannatul, Shishido, Kenji, Mizuma, Keita, Kojima, Isshu, Li, Jingshu, Tsubo, Tomoya, Tsujino, Shuhei, Nakagawa, So, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Takayama, Kazuo, Hashimoto, Rina, Deguchi, Sayaka, Watanabe, Yukio, Sakamoto, Ayaka, Yasuhara, Naoko, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Nakata, Yoshitaka, Futatsusako, Hiroki, Irie, Takashi, Kawabata, Ryoko, Tabata, Kaori, Nasser, Hesham, Shimizu, Ryo, Begum, MST Monira, Jonathan, Michael, Mugita, Yuka, Takahashi, Otowa, Ichihara, Kimiko, Motozono, Chihiro, Leong, Sharee, Saito, Akatsuki, Shofa, Maya, Shibatani, Yuki, Nishiuchi, Tomoko, Asakura, Hiroyuki, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Kuwata, Takeo, Kaku, Yu, Biswas, Shashwata, Matsumoto, Kaho, Shimizu, Mikiko, Kawanami, Yoko, Uraki, Ryuta, Okazaki, Kyo, Minami, Rumi, Nagasaki, Yoji, Nagashima, Mami, Yoshida, Isao, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Imai, Masaki, Ikeda, Terumasa, Sato, Kei, Toyoda, Mako, Ueno, Takamasa, Inoue, Takako, Tanaka, Yasuhito, Kimura, Kanako Tarakado, Hashiguchi, Takao, Sugita, Yukihiko, Noda, Takeshi, Morioka, Hiroshi, Kawaoka, Yoshihiro, and Matsushita, Shuzo
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- 2024
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3. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236
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Sawa, Hirofumi, Mizuma, Keita, Li, Jingshu, Mimura, Yume, Ohari, Yuma, Tsubo, Tomoya, Ferdous, Zannatul, Shishido, Kenji, Mohri, Hiromi, Iida, Miki, Tsujino, Shuhei, Misawa, Naoko, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Kawakubo, Shusuke, Nishumura, Luca, Mendoza Tolentino, Jarel Elgin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Chiba, Mika, Yoshimura, Ryo, Yasuda, Kyoko, Iida, Keiko, Strange, Adam Patrick, Ohsumi, Naomi, Tanaka, Shiho, Ogawa, Eiko, Okumura, Kaho, Fukuda, Tsuki, Osujo, Rina, Yoshida, Isao, Nakagawa, So, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Nakata, Yoshitaka, Futatsusako, Hiroki, Sakamoto, Ayaka, Yasuhara, Naoko, Hashiguchi, Takao, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Irie, Takashi, Kawabata, Ryoko, Sasaki-Tabata, Kaori, Shimizu, Ryo, Monira Begum, M.S.T., Jonathan, Michael, Mugita, Yuka, Leong, Sharee, Takahashi, Otowa, Ichihara, Kimiko, Ueno, Takamasa, Motozono, Chihiro, Toyoda, Mako, Saito, Akatsuki, Kosaka, Anon, Kawano, Miki, Matsubara, Natsumi, Nishiuchi, Tomoko, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Fujita, Shigeru, Plianchaisuk, Arnon, Deguchi, Sayaka, Ito, Hayato, Nao, Naganori, Wang, Lei, Nasser, Hesham, Tamura, Tomokazu, Kimura, Izumi, Kashima, Yukie, Suzuki, Rigel, Suzuki, Saori, Kida, Izumi, Tsuda, Masumi, Oda, Yoshitaka, Hashimoto, Rina, Watanabe, Yukio, Uriu, Keiya, Yamasoba, Daichi, Guo, Ziyi, Hinay, Alfredo A., Jr., Kosugi, Yusuke, Chen, Luo, Pan, Lin, Kaku, Yu, Chu, Hin, Donati, Flora, Temmam, Sarah, Eloit, Marc, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Suzuki, Yutaka, Ito, Jumpei, Ikeda, Terumasa, Tanaka, Shinya, Matsuno, Keita, Fukuhara, Takasuke, Takayama, Kazuo, and Sato, Kei
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- 2024
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4. Transcranial Doppler for stratification of high-risk morphology of patent foramen ovale in patients with cryptogenic stroke
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Chino, Saori, Mochizuki, Yasuhide, Mizuma, Keita, Ichikawa, Saaya, Miyazaki, Haruka, Hachiya, Rumi, Toyosaki, Eiji, Ota, Masashi, Fukuoka, Hiroto, Yamochi, Toshiko, Ono, Kenjiro, and Shinke, Toshiro
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- 2022
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5. The Pan-ErbB tyrosine kinase inhibitor afatinib inhibits multiple steps of the mammarenavirus life cycle
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Mizuma, Keita, Takashima, Ayako, Cubitt, Beatrice, de la Torre, Juan C., and Iwasaki, Masaharu
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- 2022
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6. Reply to ‘patent foramen ovale device closure for patients with stroke and high-risk PFO morphology’
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Chino, Saori, Mochizuki, Yasuhide, Mizuma, Keita, Ichikawa, Saaya, Miyazaki, Haruka, Hachiya, Rumi, Toyosaki, Eiji, Fukuoka, Hiroto, Ono, Kenjiro, and Shinke, Toshiro
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- 2023
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7. Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1.
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Yajima, Hisano, Anraku, Yuki, Kaku, Yu, Kimura, Kanako Terakado, Plianchaisuk, Arnon, Okumura, Kaho, Nakada-Nakura, Yoshiko, Atarashi, Yusuke, Hemmi, Takuya, Kuroda, Daisuke, Takahashi, Yoshimasa, Kita, Shunsuke, Sasaki, Jiei, Sumita, Hiromi, Matsuno, Keita, Nao, Naganori, Sawa, Hirofumi, Mizuma, Keita, Li, Jingshu, and Kida, Izumi
- Subjects
SARS-CoV-2 ,ANGIOTENSIN converting enzyme ,CARRIER proteins ,PROTEIN binding ,EPIDEMICS - Abstract
Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to facilitate the conformational shift to RBD-up remains unclear. Herein, we present the structures of the BA.2.86 and the JN.1 spike proteins bound to ACE2. Notably, we successfully observed the ACE2-bound down-RBD, indicating an intermediate structure before the RBD-up conformation. The wider and mobile angle of RBDs in the up-state provides space for ACE2 to interact with the down-RBD, facilitating the transition to the RBD-up state. The K356T, but not N354-linked glycan, contributes to both of infectivity and neutralizing-antibody evasion in BA.2.86. These structural insights the spike-protein dynamics would help understand the mechanisms underlying SARS-CoV-2 infection and its neutralization. JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236
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Fujita, Shigeru, primary, Plianchaisuk, Arnon, additional, Deguchi, Sayaka, additional, Ito, Hayato, additional, Nao, Naganori, additional, Wang, Lei, additional, Nasser, Hesham, additional, Tamura, Tomokazu, additional, Kimura, Izumi, additional, Kashima, Yukie, additional, Suzuki, Rigel, additional, Suzuki, Saori, additional, Kida, Izumi, additional, Tsuda, Masumi, additional, Oda, Yoshitaka, additional, Hashimoto, Rina, additional, Watanabe, Yukio, additional, Uriu, Keiya, additional, Yamasoba, Daichi, additional, Guo, Ziyi, additional, Hinay, Alfredo A., additional, Kosugi, Yusuke, additional, Chen, Luo, additional, Pan, Lin, additional, Kaku, Yu, additional, Chu, Hin, additional, Donati, Flora, additional, Temmam, Sarah, additional, Eloit, Marc, additional, Yamamoto, Yuki, additional, Nagamoto, Tetsuharu, additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Suzuki, Yutaka, additional, Sawa, Hirofumi, additional, Mizuma, Keita, additional, Li, Jingshu, additional, Mimura, Yume, additional, Ohari, Yuma, additional, Tsubo, Tomoya, additional, Ferdous, Zannatul, additional, Shishido, Kenji, additional, Mohri, Hiromi, additional, Iida, Miki, additional, Tsujino, Shuhei, additional, Misawa, Naoko, additional, Usui, Kaoru, additional, Saikruang, Wilaiporn, additional, Lytras, Spyridon, additional, Kawakubo, Shusuke, additional, Nishumura, Luca, additional, Mendoza Tolentino, Jarel Elgin, additional, Li, Wenye, additional, Yo, Maximilian Stanley, additional, Horinaka, Kio, additional, Suganami, Mai, additional, Chiba, Mika, additional, Yoshimura, Ryo, additional, Yasuda, Kyoko, additional, Iida, Keiko, additional, Strange, Adam Patrick, additional, Ohsumi, Naomi, additional, Tanaka, Shiho, additional, Ogawa, Eiko, additional, Okumura, Kaho, additional, Fukuda, Tsuki, additional, Osujo, Rina, additional, Yoshida, Isao, additional, Nakagawa, So, additional, Takaori-Kondo, Akifumi, additional, Shirakawa, Kotaro, additional, Nagata, Kayoko, additional, Nomura, Ryosuke, additional, Horisawa, Yoshihito, additional, Tashiro, Yusuke, additional, Kawai, Yugo, additional, Nakata, Yoshitaka, additional, Futatsusako, Hiroki, additional, Sakamoto, Ayaka, additional, Yasuhara, Naoko, additional, Hashiguchi, Takao, additional, Suzuki, Tateki, additional, Kimura, Kanako, additional, Sasaki, Jiei, additional, Nakajima, Yukari, additional, Yajima, Hisano, additional, Irie, Takashi, additional, Kawabata, Ryoko, additional, Sasaki-Tabata, Kaori, additional, Shimizu, Ryo, additional, Monira Begum, M.S.T., additional, Jonathan, Michael, additional, Mugita, Yuka, additional, Leong, Sharee, additional, Takahashi, Otowa, additional, Ichihara, Kimiko, additional, Ueno, Takamasa, additional, Motozono, Chihiro, additional, Toyoda, Mako, additional, Saito, Akatsuki, additional, Kosaka, Anon, additional, Kawano, Miki, additional, Matsubara, Natsumi, additional, Nishiuchi, Tomoko, additional, Zahradnik, Jiri, additional, Andrikopoulos, Prokopios, additional, Padilla-Blanco, Miguel, additional, Konar, Aditi, additional, Ito, Jumpei, additional, Ikeda, Terumasa, additional, Tanaka, Shinya, additional, Matsuno, Keita, additional, Fukuhara, Takasuke, additional, Takayama, Kazuo, additional, and Sato, Kei, additional
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- 2024
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9. Virological characteristics of the SARS-CoV-2 BA.2.86 variant
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10759509, Tamura, Tomokazu, Mizuma, Keita, Nasser, Hesham, Deguchi, Sayaka, Padilla-Blanco, Miguel, Oda, Yoshitaka, Uriu, Keiya, Tolentino, Jarel E.M., Tsujino, Shuhei, Suzuki, Rigel, Kojima, Isshu, Nao, Naganori, Shimizu, Ryo, Wang, Lei, Tsuda, Masumi, Jonathan, Michael, Kosugi, Yusuke, Guo, Ziyi, Hinay, Alfredo A., Putri, Olivia, Kim, Yoonjin, Tanaka, Yuri L., Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Ito, Jumpei, Irie, Takashi, Tanaka, Shinya, Zahradnik, Jiri, Ikeda, Terumasa, Takayama, Kazuo, Matsuno, Keita, Fukuhara, Takasuke, Sato, Kei, 10759509, Tamura, Tomokazu, Mizuma, Keita, Nasser, Hesham, Deguchi, Sayaka, Padilla-Blanco, Miguel, Oda, Yoshitaka, Uriu, Keiya, Tolentino, Jarel E.M., Tsujino, Shuhei, Suzuki, Rigel, Kojima, Isshu, Nao, Naganori, Shimizu, Ryo, Wang, Lei, Tsuda, Masumi, Jonathan, Michael, Kosugi, Yusuke, Guo, Ziyi, Hinay, Alfredo A., Putri, Olivia, Kim, Yoonjin, Tanaka, Yuri L., Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Ito, Jumpei, Irie, Takashi, Tanaka, Shinya, Zahradnik, Jiri, Ikeda, Terumasa, Takayama, Kazuo, Matsuno, Keita, Fukuhara, Takasuke, and Sato, Kei
- Abstract
In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron sublineages, accumulating over 30 amino acid mutations in its spike protein. Here, we examined the virological characteristics of the BA.2.86 variant. Our epidemic dynamics modeling suggested that the relative reproduction number of BA.2.86 is significantly higher than that of EG.5.1. Additionally, four clinically available antivirals were effective against BA.2.86. Although the fusogenicity of BA.2.86 spike is similar to that of the parental BA.2 spike, the intrinsic pathogenicity of BA.2.86 in hamsters was significantly lower than that of BA.2. Since the growth kinetics of BA.2.86 are significantly lower than those of BA.2 both in vitro and in vivo, the attenuated pathogenicity of BA.2.86 is likely due to its decreased replication capacity. These findings uncover the features of BA.2.86, providing insights for control and treatment.
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- 2024
10. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant
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50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, Fukuhara, Takasuke, 50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, and Fukuhara, Takasuke
- Abstract
Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.
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- 2024
11. Virological characteristics of the SARS-CoV-2 BA.2.86 variant
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Tamura, Tomokazu, primary, Mizuma, Keita, additional, Nasser, Hesham, additional, Deguchi, Sayaka, additional, Padilla-Blanco, Miguel, additional, Oda, Yoshitaka, additional, Uriu, Keiya, additional, Tolentino, Jarel E.M., additional, Tsujino, Shuhei, additional, Suzuki, Rigel, additional, Kojima, Isshu, additional, Nao, Naganori, additional, Shimizu, Ryo, additional, Wang, Lei, additional, Tsuda, Masumi, additional, Jonathan, Michael, additional, Kosugi, Yusuke, additional, Guo, Ziyi, additional, Hinay, Alfredo A., additional, Putri, Olivia, additional, Kim, Yoonjin, additional, Tanaka, Yuri L., additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Saito, Akatsuki, additional, Ito, Jumpei, additional, Irie, Takashi, additional, Tanaka, Shinya, additional, Zahradnik, Jiri, additional, Ikeda, Terumasa, additional, Takayama, Kazuo, additional, Matsuno, Keita, additional, Fukuhara, Takasuke, additional, and Sato, Kei, additional
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- 2024
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12. A novel nairovirus associated with acute febrile illness in Hokkaido, Japan
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Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki, Hagiwara, Katsuro, Okazaki, Katsunori, Goto, Akiko, Komagome, Rika, Miyoshi, Masahiro, Ito, Takuya, Yamano, Kimiaki, Yoshii, Kentaro, Funaki, Chiaki, Ishizuka, Mariko, Shigeno, Asako, Itakura, Yukari, Bell-Sakyi, Lesley, Edagawa, Shunji, Nagasaka, Atsushi, Sakoda, Yoshihiro, Sawa, Hirofumi, Maeda, Ken, Saijo, Masayuki, and Matsuno, Keita
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- 2021
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13. Virological characteristics of the SARS‐CoV‐2 Omicron EG.5.1 variant.
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Tsujino, Shuhei, Deguchi, Sayaka, Nomai, Tomo, Padilla‐Blanco, Miguel, Plianchaisuk, Arnon, Wang, Lei, Begum, MST Monira, Uriu, Keiya, Mizuma, Keita, Nao, Naganori, Kojima, Isshu, Tsubo, Tomoya, Li, Jingshu, Matsumura, Yasufumi, Nagao, Miki, Oda, Yoshitaka, Tsuda, Masumi, Anraku, Yuki, Kita, Shunsuke, and Yajima, Hisano
- Subjects
SARS-CoV-2 ,RECOMBINANT viruses ,PATHOGENIC viruses ,SARS-CoV-2 Omicron variant ,ANIMAL culture - Abstract
In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron XBB, EG.5.1 (a progeny of XBB.1.9.2), is spreading rapidly around the world. We performed multiscale investigations, including phylogenetic analysis, epidemic dynamics modeling, infection experiments using pseudoviruses, clinical isolates, and recombinant viruses in cell cultures and experimental animals, and the use of human sera and antiviral compounds, to reveal the virological features of the newly emerging EG.5.1 variant. Our phylogenetic analysis and epidemic dynamics modeling suggested that two hallmark substitutions of EG.5.1, S:F456L and ORF9b:I5T are critical to its increased viral fitness. Experimental investigations on the growth kinetics, sensitivity to clinically available antivirals, fusogenicity, and pathogenicity of EG.5.1 suggested that the virological features of EG.5.1 are comparable to those of XBB.1.5. However, cryo‐electron microscopy revealed structural differences between the spike proteins of EG.5.1 and XBB.1.5. We further assessed the impact of ORF9b:I5T on viral features, but it was almost negligible in our experimental setup. Our multiscale investigations provide knowledge for understanding the evolutionary traits of newly emerging pathogenic viruses, including EG.5.1, in the human population. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Pallidal dementia with underlying sleep apnea syndrome: a case report and literature review
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Sugimoto, Azusa, Shozawa, Hidenobu, Mizuma, Keita, Hieda, Sotaro, and Ono, Kenjiro
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- 2020
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15. A Case of Cerebral Infarction During Treatment With Rivaroxaban for Venous Thromboembolism
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Kitahara, Kanayuki, Momo, Kenji, Nimura, Satomi, Okazaki, Keinosuke, Suzuki, Norihiro, Kubota, Yutaro, Tsunoda, Takuya, Watanabe, Daishi, Mizuma, Keita, Ono, Kenjiro, and Sasaki, Tadanori
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- 2020
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16. A novel nairovirus associated with acute febrile illness in Hokkaido, Japan
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Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki, Hagiwara, Katsuro, Okazaki, Katsunori, Goto, Akiko, Komagome, Rika, Miyoshi, Masahiro, Ito, Takuya, Yamano, Kimiaki, Yoshii, Kentaro, Funaki, Chiaki, Ishizuka, Mariko, Shigeno, Asako, Itakura, Yukari, Bell-Sakyi, Lesley, Edagawa, Shunji, Nagasaka, Atsushi, Sakoda, Yoshihiro, Sawa, Hirofumi, Maeda, Ken, Saijo, Masayuki, Matsuno, Keita, Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki, Hagiwara, Katsuro, Okazaki, Katsunori, Goto, Akiko, Komagome, Rika, Miyoshi, Masahiro, Ito, Takuya, Yamano, Kimiaki, Yoshii, Kentaro, Funaki, Chiaki, Ishizuka, Mariko, Shigeno, Asako, Itakura, Yukari, Bell-Sakyi, Lesley, Edagawa, Shunji, Nagasaka, Atsushi, Sakoda, Yoshihiro, Sawa, Hirofumi, Maeda, Ken, Saijo, Masayuki, and Matsuno, Keita
- Abstract
type:Article, The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.
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- 2023
17. Reply to ‘patent foramen ovale device closure for patients with stroke and high-risk PFO morphology’
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Chino, Saori, primary, Mochizuki, Yasuhide, additional, Mizuma, Keita, additional, Ichikawa, Saaya, additional, Miyazaki, Haruka, additional, Hachiya, Rumi, additional, Toyosaki, Eiji, additional, Fukuoka, Hiroto, additional, Ono, Kenjiro, additional, and Shinke, Toshiro, additional
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- 2022
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18. A case report of platypnea-orthodeoxia syndrome: A rare condition found during diagnostic workup of a patient with embolic stroke of undetermined sources
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Mizuma, Keita, primary, Sugimoto, Azusa, additional, Mochizuki, Yasuhide, additional, Shinke, Toshiro, additional, and Ono, Kenjiro, additional
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- 2022
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19. A Case of Cerebral Infarction During Treatment With Rivaroxaban for Venous Thromboembolism.
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Kitahara, Kanayuki, Momo, Kenji, Nimura, Satomi, Okazaki, Keinosuke, Suzuki, Norihiro, Kubota, Yutaro, Tsunoda, Takuya, Watanabe, Daishi, Mizuma, Keita, Ono, Kenjiro, and Sasaki, Tadanori
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- 2022
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20. The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
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Matsuno, Keita, primary, Kajihara, Masahiro, additional, Nakao, Ryo, additional, Nao, Naganori, additional, Mori-Kajihara, Akina, additional, Muramatsu, Mieko, additional, Qiu, Yongjin, additional, Torii, Shiho, additional, Igarashi, Manabu, additional, Kasajima, Nodoka, additional, Mizuma, Keita, additional, Yoshii, Kentaro, additional, Sawa, Hirofumi, additional, Sugimoto, Chihiro, additional, Takada, Ayato, additional, and Ebihara, Hideki, additional
- Published
- 2018
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21. The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
- Author
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1000040753306, Matsuno, Keita, Kajihara, Masahiro, 1000050633955, Nakao, Ryo, Nao, Naganori, Mori-Kajihara, Akina, Muramatsu, Mieko, Qiu, Yongjin, Torii, Shiho, 1000010374240, Igarashi, Manabu, Kasajima, Nodoka, Mizuma, Keita, 1000050421988, Yoshii, Kentaro, 1000030292006, Sawa, Hirofumi, 1000090231373, Sugimoto, Chihiro, 1000010292062, Takada, Ayato, Ebihara, Hideki, 1000040753306, Matsuno, Keita, Kajihara, Masahiro, 1000050633955, Nakao, Ryo, Nao, Naganori, Mori-Kajihara, Akina, Muramatsu, Mieko, Qiu, Yongjin, Torii, Shiho, 1000010374240, Igarashi, Manabu, Kasajima, Nodoka, Mizuma, Keita, 1000050421988, Yoshii, Kentaro, 1000030292006, Sawa, Hirofumi, 1000090231373, Sugimoto, Chihiro, 1000010292062, Takada, Ayato, and Ebihara, Hideki
- Abstract
The recent emergence of novel tick-borne RNA viruses has complicated the epidemiological landscape of tick-borne infectious diseases, posing a significant challenge to public health systems that seek to counteract tick-borne diseases. The identification of two novel tick-borne phleboviruses (TBPVs), severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV), as causative agents of severe illness in humans has accelerated the investigation and discoveries of novel TBPVs. In the present study, we isolated a novel TBPV designated Mukawa virus (MKWV) from host-questing Ixodes persulcatus females captured in Japan. Genetic characterization revealed that MKWV is a member of the genus Phlebovirus in the family Phenuiviridae. Interestingly, MKWV is genetically distinct from other known TBPVs and shares a most recent common ancestor with mosquito/sandfly-borne (insect-borne) phleboviruses. Despite its genetic similarity to insect-borne phleboviruses, the molecular footprints of its viral proteins and its biological characteristics define MKWV as a tick-borne virus that can be transmitted to mammals. A phylogenetic ancestral-state reconstruction for arthropod vectors of phleboviruses including MKWV based on viral L segment sequences indicated that ticks likely harbored ancestral phleboviruses that evolved into both the tick-borne and MKWV/insect-borne phlebovirus lineages. Overall, our findings suggest that most of the phlebovirus evolution has occurred in hard ticks to generate divergent viruses, which may provide a seminal foundation for understanding the mechanisms underlying the evolution and emergence of pathogenic phleboviruses, such as Rift Valley fever virus and SFTSV/HRTV.
- Published
- 2018
22. Modified Six Elements Test: Earlier diagnosis of the correlation between motor and executive dysfunction in Parkinson's disease without dementia
- Author
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Murakami, Hidetomo, primary, Owan, Yoshiyuki, additional, Oguchi, Tatsunori, additional, Nomoto, Shohei, additional, Shozawa, Hidenobu, additional, Kubota, Satomi, additional, Mori, Yukiko, additional, Mizuma, Keita, additional, Futamura, Akinori, additional, Kobayakawa, Mutsutaka, additional, Kezuka, Machiko, additional, Midorikawa, Akira, additional, Miller, Michael W, additional, and Kawamura, Mitsuru, additional
- Published
- 2015
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23. Evaluation of restenosis after carotid artery stenting using acceleration time in carotid ultrasonography
- Author
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KAMIYA, Yuki, primary, MORI, Misako, additional, KURIKI, Ayako, additional, MIZUMA, Keita, additional, ICHIKAWA, Hiroo, additional, and KAWAMURA, Mitsuru, additional
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- 2015
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24. Clinical features of ischemic stroke and transient ischemic attack associated with suspicious pulmonary arteriovenous fistula detected only by transesophageal echocardiography
- Author
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KURIKI, Ayako, primary, KATOU, Hirotaka, additional, MIZUMA, Keita, additional, SAITO, Yu, additional, KAMIYA, Yuki, additional, and KAWAMURA, Mitsuru, additional
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- 2015
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25. A case of acute ischemic stroke due to cardiac myxoma treated by intravenous thrombolysis and endovascular therapy
- Author
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Kamiya, Yuki, primary, Ichikawa, Hiroo, additional, Mizuma, Keita, additional, Itaya, Kazuhiro, additional, Shimizu, Yuki, additional, and Kawamura, Mitsuru, additional
- Published
- 2014
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26. 805 A Numerical Examination of Angular Deflection Feature of Flexure Hinges with Circular Cutouts
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KASEI, Shinji, primary, HATAKEYAMA, Takuya, additional, and MIZUMA, Keita, additional
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- 2006
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27. U-73122, a phospholipase C inhibitor, impairs lymphocytic choriomeningitis virus virion infectivity.
- Author
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Mizuma K, Hashizume M, Urata S, Shindo K, Takashima A, Mizuta S, and Iwasaki M
- Subjects
- Animals, Humans, Chlorocebus aethiops, Type C Phospholipases metabolism, Type C Phospholipases antagonists & inhibitors, Type C Phospholipases genetics, Virion drug effects, Vero Cells, Cell Line, Lassa virus drug effects, Lymphocytic choriomeningitis virus drug effects, Lymphocytic choriomeningitis virus genetics, Lymphocytic choriomeningitis virus physiology, Antiviral Agents pharmacology, Pyrrolidinones pharmacology, Virus Replication drug effects, Estrenes pharmacology
- Abstract
Lassa virus (LASV) is an Old World (OW) mammarenavirus that causes Lassa fever, a life-threatening acute febrile disease endemic in West Africa. Lymphocytic choriomeningitis virus (LCMV) is a worldwide-distributed, prototypic OW mammarenavirus of clinical significance that has been largely neglected as a human pathogen. No licensed OW mammarenavirus vaccines are available, and the current therapeutic option is limited to the off-label use of ribavirin, which offers only partial efficacy. This situation underscores the urgent need to develop novel antivirals against human pathogenic mammarenaviruses. Previously, we showed that afatinib, a pan-ErbB tyrosine kinase inhibitor, inhibited multiple steps of the life cycles of OW LASV and LCMV, as well as the New World Junín virus vaccine strain Candid#1. In the present study, we investigated the inhibitory effect of U-73122, a phospholipase C inhibitor that acts downstream of ErbB signalling, on LCMV multiplication. U-73122 inhibited WT recombinant (r) LCMV multiplication in cultured cells. Preincubation of cell-free LCMV virions with U-73122 resulted in impaired virion infectivity. U-73122 also inhibited the infection of rLCMVs expressing heterologous viral glycoproteins, including the vesicular stomatitis Indiana virus (VSIV) glycoprotein, whereas WT VSIV infection was not affected by U-73122 treatment. Our results show the novel bioactivity of U-73122 as an LCMV inhibitor and indicate the presence of a virion-associated molecule that is necessary for virion infectivity and can be exploited as a potential antiviral drug target against human pathogenic mammarenavirus infections.
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- 2024
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28. [Case of acute ischemic stroke due to cardiac myxoma treated by intravenous thrombolysis and endovascular therapy].
- Author
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Kamiya Y, Ichikawa H, Mizuma K, Itaya K, Shimizu Y, and Kawamura M
- Subjects
- Echocardiography, Female, Heart Atria, Heart Neoplasms diagnosis, Humans, Infusions, Intravenous, Intracranial Aneurysm etiology, Intracranial Aneurysm prevention & control, Magnetic Resonance Angiography, Middle Aged, Myxoma diagnosis, Neoplastic Cells, Circulating, Stroke diagnosis, Tissue Plasminogen Activator administration & dosage, Urokinase-Type Plasminogen Activator administration & dosage, Endovascular Procedures methods, Heart Neoplasms complications, Myxoma complications, Stroke etiology, Stroke therapy, Thrombectomy methods, Thrombolytic Therapy methods
- Abstract
A 48-year-old woman with no previous neurological diseases was transferred to our hospital because of sudden-onset unconsciousness. On arrival, she showed consciousness disturbance (E1V1M3 on the Glasgow Coma Scale), tetraplegia, right conjugate deviation and bilateral pathological reflexes. These symptoms resulted in a NIH stroke scale score of 32. Brain diffusion-weighted MR imaging (DWI) showed multiple hyper-intense lesions, and MR angiography revealed occlusions of the basilar artery (BA) and superior branch of the right middle cerebral artery (MCA). Transthoracic echocardiography disclosed a 51 × 24 mm myxoma in the left atrium. These findings led to diagnosis of acute ischemic stroke due to embolization from cardiac myxoma. Thrombolytic therapy with intravenous tissue plasminogen activator (IV tPA) was started 120 min after onset because there were no contraindications for this treatment. However, the symptoms did not resolve, and thus endovascular therapy was performed immediately after IV tPA. Angiography of the left vertebral artery initially showed BA occlusion, but a repeated angiogram resulted in spontaneous recanalization of the BA. However, the left posterior cerebral artery remained occluded by a residual embolus. Subsequently, occlusion found in the superior branch of the right MCA was treated by intra-arterial local thrombolysis using urokinase and thrombectomy with a foreign body retrieval device, but the MCA remained occluded. DWI after endovascular therapy showed new hyper-intense lesions in the bilateral medial thalamus and left occipital cortex. Clinically, neurological status did not improve, with a score of 5 on the modified Rankin Scale. IV tPA can be used for stroke due to cardiac myxoma, but development of brain aneurysms and metastases caused by myxoma is a concern. Given the difficulty of predicting an embolus composite from a thrombus or tumor particle, aspiration thrombectomy may be safer and more effective for stroke due to cardiac myxoma to avoid delayed formation of brain aneurysms and metastases.
- Published
- 2014
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