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350 results on '"Mizugaki M"'

27. [Homicidal poisoning by aconite: report of a case from the viewpoint of clinical forensic medicine]

Author

Mori A, Mukaida M, Ishiyama I, Hori J, Okada Y, Sasaki M, Mii K, and Mizugaki M

Subjects
Adult, Male, Aconitum, Chromatography, Gas, Humans, Arrhythmias, Cardiac, Pulmonary Edema, Forensic Medicine, Homicide, Lung
Abstract

A case of homicidal poisoning by aconite is reported from the viewpoint of clinical forensic medicine and analytical chemistry. Jesaconitine was detected in the vomitus, stomach contents, plasma and urine at concentrations of 32.2, 5.48, 0.433 and 1.07 micrograms/ml, respectively. The total amount of jesaconitine in the stomach contents was 1.3 mg. Macroscopic autopsy revealed hemorrhagic pulmonary edema, and histologically, diffuse contraction-band necrosis was evident in the myocardium. Exogenous administration of adrenaline or endogenous release of catecholamines are known to induce hemorrhagic pulmonary edema and contraction-band necrosis, and aconitine is reported to cause release of endogenous catecholamines centrally and to induce neurogenic pulmonary edema and ventricular-type arrhythmia. Therefore, the chief cause of death in this case was considered to be aconite-induced centrogenic arrhythmia.

Published
1990

29. Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli

Author

Nozaki, S., primary, Tomioka, Y., additional, Hishinuma, T., additional, Inoue, M., additional, Nagum, Y., additional, Tsuruta, L. R., additional, Hayashi, K., additional, Matsumoto, T., additional, Kato, Y., additional, Ishiwata, S., additional, Itoh, K., additional, Suzuki, T., additional, Hirama, M., additional, and Mizugaki, M., additional

Published
2002
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47. Participation of alpha-Adrenoceptors in Head-Twitch Response induced by Benzodiazepines.

Author

Hozumi, M., Tadano, T., Mizugaki, M., Satoh, N., Arai, Y., Kinemuchi, H., Nakagawasai, O., Tanno, K., Oka, R., and Kisara, K.

Subjects
ALPHA adrenoceptors, HEAD, BENZODIAZEPINES, TRIAZOLAM, PHYSIOLOGY, HUMAN mechanics
Abstract

Provides information on a study that examined the effects of some drugs with a higher selectivity for the alpha-adrenoceptors on the head-twitch response induced by benzodiazepines, estazolam and triazolam in mice. Methodology of the study; Results and discussion on the study.

Published
2001

48. The Role of Central Noradrenergic Mechanism on Head-Twitch Response Induced by Estazolam.

Author

Tadano, T., Hozumi, M., Nakagawasai, O., Oka, R., Shoji, T., Nakagawa, Y., Tan-no, K., Niijima, F., Satoh, N., Arai, Y., Yasuhara, H., Mizugaki, M., Kinemuchi, H., and Kisara, K.

Subjects
NORADRENERGIC mechanisms, HEAD, BENZODIAZEPINES, PHYSIOLOGY, HUMAN mechanics
Abstract

Provides information on a study that examined the effect of central noradrenergic neuron system on head-twitch response induced by estazolam, a benzodiazepine derivative in mice. Methodology of the study; Results and discussion on the study.

Published
2001

49. Increased urinary leukotriene E4 excretion in patients with atopic dermatitis.

Author

Hishinuma, T., Suzuki, N., Aiba, S., Tagami, H., and Mizugaki, M.

Subjects
ATOPIC dermatitis, LEUKOTRIENES, IMMUNOGLOBULIN E
Abstract

Background Synthesis of cysteinyl leukotrienes (LTs) is known to play a part in the pathogenesis of inflammatory diseases. Objectives To define the involvement of cysteinyl LTs in atopic dermatitis (AD). Methods Synthesis of cysteinyl LTs was assessed in patients with AD and healthy volunteers by measuring urinary LTE4, a useful index of systemic cysteinyl LT synthesis, using liquid chromatography/tandem mass spectrometry. Results Mean ± SD urinary LTE4 levels in patients with AD (125 ± 69 pg mg-1 creatinine, n = 20) were significantly higher (P < 0·01) than in healthy volunteers (60 ± 19 pg mg-1 creatinine, n = 17). A significant correlation between urinary LTE4 and total serum IgE levels in patients with AD was observed (r = 0·643, P < 0·05). Conclusions Our findings demonstrate an enhanced synthesis of cysteinyl LTs in patients with AD and suggest that cysteinyl LTs are involved in the pathophysiology of AD. [ABSTRACT FROM AUTHOR]

Published
2001
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