Search

Your search keyword '"Mizote, Keisuke"' showing total 4 results
Start Over Author "Mizote, Keisuke"
4 results on '"Mizote, Keisuke"'

2. Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A

Author

Shimoyama, Atsushi, primary, Di Lorenzo, Flaviana, additional, Yamaura, Haruki, additional, Mizote, Keisuke, additional, Palmigiano, Angelo, additional, Pither, Molly D., additional, Speciale, Immacolata, additional, Uto, Tomoya, additional, Masui, Seiji, additional, Sturiale, Luisa, additional, Garozzo, Domenico, additional, Hosomi, Koji, additional, Shibata, Naoko, additional, Kabayama, Kazuya, additional, Fujimoto, Yukari, additional, Silipo, Alba, additional, Kunisawa, Jun, additional, Kiyono, Hiroshi, additional, Molinaro, Antonio, additional, and Fukase, Koichi, additional

Published
2021
Full Text
View/download PDF

3. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

Author

Okamoto, Naoki, primary, Mizote, Keisuke, additional, Honda, Hiroe, additional, Saeki, Akinori, additional, Watanabe, Yasuharu, additional, Yamaguchi-Miyamoto, Tomomi, additional, Fukui, Ryutaro, additional, Tanimura, Natsuko, additional, Motoi, Yuji, additional, Akashi-Takamura, Sachiko, additional, Kato, Tatsuhisa, additional, Fujishita, Shigeto, additional, Kimura, Takahito, additional, Ohto, Umeharu, additional, Shimizu, Toshiyuki, additional, Hirokawa, Takatsugu, additional, Miyake, Kensuke, additional, Fukase, Koichi, additional, Fujimoto, Yukari, additional, Nagai, Yoshinori, additional, and Takatsu, Kiyoshi, additional

Published
2017
Full Text
View/download PDF

4. Lymphoid tissue-resident AlcaligenesLPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

Author

Shibata, Naoko, Kunisawa, Jun, Hosomi, Koji, Fujimoto, Yukari, Mizote, Keisuke, Kitayama, Naohiro, Shimoyama, Atsushi, Mimuro, Hitomi, Sato, Shintaro, Kishishita, Natsuko, Ishii, Ken J, Fukase, Koichi, and Kiyono, Hiroshi

Abstract

Alcaligenesare opportunistic commensal bacteria that reside in gut-associated lymphoid tissues such as Peyer’s patches (PPs); however, how they create and maintain their homeostatic environment, without inducing an excessive inflammatory response remained unclear. We show here that Alcaligenes-derived lipopolysaccharide (AlcaligenesLPS) acts as a weak agonist of toll-like receptor 4 and promotes IL-6 production from dendritic cells, which consequently enhances IgA production. The inflammatory activity of AlcaligenesLPS was weaker than that of Escherichia coli-derived LPS and therefore no excessive inflammation was induced by AlcaligenesLPS in vitroor in vivo. AlcaligenesLPS also showed adjuvanticity, inducing antigen-specific immune responses without excessive inflammation. These findings reveal the presence of commensal bacteria-mediated homeostatic inflammatory conditions within PPs that produce optimal IgA induction without causing pathogenic inflammation and suggest that AlcaligenesLPS could be a safe and potent adjuvant.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results