Search

Your search keyword '"Miyoshi, Masashi"' showing total 14 results
Start Over Author "Miyoshi, Masashi"
14 results on '"Miyoshi, Masashi"'

2. Usefulness of presepsin / creatinine ratio as a new index that corrects for renal function

Author

Miyoshi, Masashi, Inoue, Yusuke, Nishioka, Mai, Ikegame, Akishige, Nakao, Takayuki, Takayama, Tetsuji, and Nagai, Kojiro

Subjects
body regions, sepsis, glomerular filtration rate, presepsin, musculoskeletal, neural, and ocular physiology, creatinine, population characteristics, urologic and male genital diseases, behavioral disciplines and activities, chronic kidney disease
Abstract

Background : Presepsin (P-SEP) is a highly specific sepsis marker, and its fluctuation with respect to advanced renal impairment or sample agitation has not been fully investigated. We evaluated several renal function-corrected P-SEP indices to establish a simple index and its reference range. Methods : Blood samples for P-SEP measurement were collected with minimal agitation. P-SEP levels were measured using the rapid automated immunoanalyzer “PATHFAST.” This study included 85 chronic kidney disease (CKD) patients, 65 healthy volunteers, and 4 sepsis patients. Results : Patients stratified by estimated glomerular filtration rate (GFR) had significantly higher P-SEP levels for CKD stage G3, especially the advanced GFR stage. We evaluated presepsin / creatinine (P-SEP / CRE) and P-SEP / eGFR ratios as possible indices for renal function. The P-SEP / CRE ratio exhibited no increase correlating with the GFR stage and was identical in the normal and CKD groups ; P-SEP / eGFR decreased if GFR stage worsened. The P-SEP / CRE ratio became significantly higher in sepsis patients and was a more useful index with a reference range of 67–263. Conclusions : P-SEP levels were inversely correlated with renal function, indicating the necessity to consider the influence of renal impairment in CKD patients. The P-SEP / CRE ratio is helpful for sepsis diagnosis, even in patients with renal impairment.

Published
2021

5. Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury

Author

Nishimura, Kenji, primary, Taguchi, Kensei, additional, Kishi, Seiji, additional, Brooks, Craig R., additional, Ochi, Arisa, additional, Kadoya, Hiroyuki, additional, Ikeda, Yasumasa, additional, Miyoshi, Masashi, additional, Tamaki, Masanori, additional, Abe, Hideharu, additional, Aihara, Ken-ichi, additional, Kashihara, Naoki, additional, and Nagai, Kojiro, additional

Published
2021
Full Text
View/download PDF

7. Author Correction: Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

Author

Nishimura, Kenji, primary, Murakami, Taichi, additional, Sakurai, Toshihiro, additional, Miyoshi, Masashi, additional, Kurahashi, Kiyoe, additional, Kishi, Seiji, additional, Tamaki, Masanori, additional, Tominaga, Tatsuya, additional, Yoshida, Sumiko, additional, Nagai, Kojiro, additional, Abe, Hideharu, additional, Hui, Shu-Ping, additional, Kotani, Kazuhiko, additional, and Doi, Toshio, additional

Published
2019
Full Text
View/download PDF

8. Clinical evaluation of presepsin considering renal function

Author

Miyoshi, Masashi, Inoue, Yusuke, Nishioka, Mai, Ikegame, Akishige, Nakao, Takayuki, Kishi, Seiji, Doi, Toshio, Nagai, Kojiro, Miyoshi, Masashi, Inoue, Yusuke, Nishioka, Mai, Ikegame, Akishige, Nakao, Takayuki, Kishi, Seiji, Doi, Toshio, and Nagai, Kojiro

Abstract

Presepsin, a glycoprotein produced during bacterial phagocytosis, is used as a sepsis marker for bacterial infections. However, presepsin levels are affected by renal function, and the evaluation criteria according to kidney function or in chronic kidney diseases remain controversial. Furthermore, presepsin may be increased by sample stirring, but no studies have evaluated this effect.In this study, we excluded the effect of stirring by standardizing the blood collection conditions, analyzed the influence of kidney function on presepsin concentrations, and recalculated the reference range based on the findings. EDTA-whole blood from 47 healthy subjects and 85 patients with chronic kidney disease was collected to measure presepsin by PATHFAST. Presepsin was found to be significantly correlated with the levels of creatinine (r = 0.834), eGFRcreat (r = 0.837), cystatin-C (r = 0.845), and eGFRcys (r = 0.879). Furthermore, in patients with CKD, presepsin levels stratified by eGFRcys showed a significant increase in the CKD G2 patient group and with advancing glomerular filtration rate stage. The following values were obtained: Normal: 97.6 ± 27.4 pg/mL, CKD G1: 100.2 ± 27.6 pg/mL, CKD G2: 129.7 ± 40.7 pg/mL, CKD G3: 208.1 ± 70.2 pg/mL, CKD G4: 320.2 ± 170.1 pg/mL, CKD G5: 712.8 ± 336.3 pg/mL. The reference range, calculated by a nonparametric method using 67 cases of healthy volunteers and patients with chronic kidney disease G1, was found to be 59–153 pg/mL, which was notably lower than the standard reference range currently used. Presepsin concentrations were positively correlated with a few biomarkers of renal function, indicating the necessity to consider the effect of renal function in patients with renal impairment. Using the recalculated reference range considering kidney function may improve the accuracy of evaluating presepsin for diagnosis of sepsis compared to the standard reference currently in use.

Published
2019

9. Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

Author

Nishimura, Kenji, primary, Murakami, Taichi, additional, Sakurai, Toshihiro, additional, Miyoshi, Masashi, additional, Kurahashi, Kiyoe, additional, Kishi, Seiji, additional, Tamaki, Masanori, additional, Tominaga, Tatsuya, additional, Yoshida, Sumiko, additional, Nagai, Kojiro, additional, Abe, Hideharu, additional, Hui, Shu-Ping, additional, Kotani, Kazuhiko, additional, and Doi, Toshio, additional

Published
2019
Full Text
View/download PDF

11. 循環アポリポプロテインL1はインスリン抵抗性が引き起こす脂質代謝異常に関連する

Author

Nishimura, Kenji, Murakami, Taichi, Sakurai, Toshihiro, Miyoshi, Masashi, Kurahashi, Kiyoe, Kishi, Seiji, Tamaki, Masanori, Tominaga, Tatsuya, Yoshida, Sumiko, Nagai, Kojiro, Abe, Hideharu, Hui, Shu-Ping, Kotani, Kazuhiko, and Doi, Toshio

Subjects
insulin, insulin resistance, abnormal lipid metabolism, ApoL1, Apolipoprotein L1
Abstract

Circulating ApolipoproteinL1 (ApoL1) is a component of pre-β-high-density lipoprotein (HDL), however little is known about the relationship of ApoL1 with cardiometabolic factors. Considering previous studies reporting the correlation of ApoL1 to triglyceride, we have hypothesized that ApoL1 associates with insulin-related metabolism. The current study examined their associations in 126 non-diabetic subjects and 36 patients with type 2 diabetes (T2DM). Non-diabetic subjects demonstrated triglyceride (standardized coefficients [s.c.] = 0.204, p < 0.05), body mass index (s.c. =0.232, p < 0.05) and HDL cholesterol (s.c. = −0.203, p < 0.05) as independent determinant of ApoL1 levels, and the significant elevation of ApoL1 in metabolic syndrome. Lipoprotein fractionation analysis revealed the predominant distribution of ApoL1 in large HDL fraction, and the significant increase of ApoL1 in large LDL fraction in high ApoL1 samples with insulin resistance. In T2DM, ApoL1 was higher in T2DM with metabolic syndrome, however ApoL1 was lower with β cell dysfunction. Insulin significantly promotes ApoL1 synthesis and secretion in HepG2 cells. In conclusion, circulating ApoL1 may be associated with abnormal HDL metabolism in insulin resistant status. This may suggest a regulation of insulin signal on the ApoL1 level, leading to offer a novel insight to the ApoL1 biology.

Published
2019

13. Cut-Off Value of Total Adiponectin for Managing Risk of Developing Metabolic Syndrome in Male Japanese Workers

Author

Hata, Akiko, primary, Yonemoto, Koji, additional, Shikama, Yosuke, additional, Aki, Nanako, additional, Kosugi, Chisato, additional, Tamura, Ayako, additional, Ichihara, Takako, additional, Minagawa, Takako, additional, Kuwamura, Yumi, additional, Miyoshi, Masashi, additional, Nakao, Takayuki, additional, and Funaki, Makoto, additional

Published
2015
Full Text
View/download PDF

14. Dual Involvement of Growth Arrest-Specific Gene 6 in the Early Phase of Human IgA Nephropathy

Author

Nagai, Kojiro, primary, Miyoshi, Masashi, additional, Kake, Takei, additional, Fukushima, Naoshi, additional, Matsuura, Motokazu, additional, Shibata, Eriko, additional, Yamada, Satoshi, additional, Yoshikawa, Kazuhiro, additional, Kanayama, Hiro-omi, additional, Fukawa, Tomoya, additional, Yamaguchi, Kunihisa, additional, Izaki, Hirofumi, additional, Mima, Akira, additional, Abe, Naoko, additional, Araoka, Toshikazu, additional, Murakami, Taichi, additional, Kishi, Fumi, additional, Kishi, Seiji, additional, Tominaga, Tatsuya, additional, Moriya, Tatsumi, additional, Abe, Hideharu, additional, and Doi, Toshio, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results