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15 results on '"Miyoshi, Mami"'

2. Structural Effects of FeN4 Active Sites Surrounded by Fourteen-Membered Ring Ligands on Oxygen Reduction Reaction Activity and Durability

Author

Feng, Zhiqing, primary, Honda, Soutaro, additional, Ohyama, Junya, additional, Iwata, Yasushi, additional, Awaya, Keisuke, additional, Yoshida, Hiroshi, additional, Machida, Masato, additional, Higashi, Kotaro, additional, Uruga, Tomoya, additional, Kawamura, Naomi, additional, Goto, Ryota, additional, Ichihara, Takeo, additional, Kojima, Ryoichi, additional, Moriya, Makoto, additional, Notsu, Hideo, additional, Nagata, Shinsuke, additional, Miyoshi, Mami, additional, Hayakawa, Teruaki, additional, and Nabae, Yuta, additional

Published
2024
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3. A modified Sobel filter-based automated numerical algorithm enables immediate trichoscopic assessment of hair diameter diversity in male and female pattern hair loss

Author

Takagi, Masaya, primary, Kinoshita-Ise, Misaki, additional, Fukuyama, Masahiro, additional, Aoki, Soichiro, additional, Nishikawa, Saori, additional, Miyoshi, Mami, additional, Sugimoto, Takaki, additional, Yamazaki, Masako, additional, Ogo, Masashi, additional, and Ohyama, Manabu, additional

Published
2024
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4. Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study

Author

Harada, Kazutoshi, primary, Ohyama, Manabu, additional, Niiyama, Shiro, additional, Irisawa, Ryokichi, additional, Mae, Kenichiro, additional, Mori, Miho, additional, Wakimoto, Hiroko, additional, Kinoshita‐Ise, Misaki, additional, Fukuyama, Masahiro, additional, Hayakawa, Reina, additional, Takagi, Masaya, additional, Yamazaki, Masako, additional, Miyoshi, Mami, additional, Nishikawa, Saori, additional, Sato, Seiji, additional, Nakazawa, Yosuke, additional, Sugimoto, Takaki, additional, Ogo, Masashi, additional, and Tsuboi, Ryoji, additional

Published
2023
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9. Retraction Notice to: In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Author

Yamamizu, Kohei, primary, Iwasaki, Mio, additional, Takakubo, Hitomi, additional, Sakamoto, Takumi, additional, Ikuno, Takeshi, additional, Miyoshi, Mami, additional, Kondo, Takayuki, additional, Nakao, Yoichi, additional, Nakagawa, Masato, additional, Inoue, Haruhisa, additional, and Yamashita, Jun K., additional

Published
2018
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10. Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells

Author

ROKUTAN, KAZUHITO, MIYOSHI, MAMI, TESHIMA, SHIGETADA, KAWAI, TOMOKO, KAWAHARA, TSUKASA, and KISHI, KYOICHI

Subjects
Heat shock proteins -- Physiological aspects, Gastric mucosa -- Physiological aspects, Biological sciences
Abstract

Rokutan, Kazuhito, Mami Miyoshi, Shigetada Teshima, Tomoko Kawai, Tsukasa Kawahara, and Kyoichi Kishi. Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells. Am J Physiol Cell Physiol 279: C 1506-C 1515, 2000.--Phenylarsine oxide (PAO) forms a stable ring complex with vicinal dithiols that can be reversed with 2,3-dimercaptopropanol (DMP) but not by dithiothreitol (DTT) or 2-mercaptoethanol (2-ME). PAO at 2 [micro]M or higher inhibited heat shock protein 70 (HSP70) induction within minutes in cultured guinea pig gastric mucosal cells exposed to heat (43 [degrees] C) for 30 min. PAO did not affect the nuclear translocation and phosphorylation of heat shock factor 1 (HSF1) induced by heat stress, but it completely blocked the binding activity of HSF1 to the heat shock element (HSE), leading to the block of expression of HSP70 mRNA and accumulation of HSP70 in the cells. These inhibitions were completely reversed with 2 [micro]M DMP but not with 0.1 mM DTT or 1 mM 2-ME, suggesting specific interactions between PAO and vicinal dithiol-containing molecules. Thioredoxin (Trx) reversed the inhibition of the binding activity of HSF1 in whole cell extracts prepared from PAO-treated, heat-stressed cells. Our results suggest that PAO may react with vicinal-containing molecules including Trx and specifically block the interaction between HSF1 and HSE. heat shock response; heat shock factor 1; heat shock element; vicinal dithiol; thioredoxin

Published
2000

11. Implications of heat shock / stress proteins for medicine and disease

Author

Rokutan, Kazuhito, Hirakawa, Tetsuya, Teshima, Shigetada, Nakano, Yoko, Miyoshi, Mami, Kawai, Tomoko, Konda, Emi, Morinaga, Hiroko, Nikawa, Takeshi, and Kishi, Kyoichi

Subjects
stress ulcer, ischemic tolerance, physiologic stress, heat shock / stress proteins, chaperone inducers
Abstract

Heat shock/ stress proteins (HSPs) are crucial for maintenance of cellular homeostasis during normal cell growth and for survival during and after various cellular stresses. The HSP70 family functions as molecular chaperones and reduces stress-induced denaturation and aggregation of intracellular proteins. In addition to the chaperoning activities, HSP70 has been suggested to exert its protective action by protecting mitochondria and by interfering with the stress-induced apoptotic program. The biochemical and functional properties of HSPs observed in cultured cells may be relevant to organs and tissues in whole animals. The activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nerve system elicits the stress response in selected peripheral tissues the HSP70 expression in the vasculature and stomach increases resistance against hemodynamic stress and stress-induced mucosal damage, respectively. Gastric mucosa pretreated with mild irritants acquires a tolerance against subsequent mucosal-damaging insults. This phenomenon is known as “adaptive cytoprotection”. Transient ischemia also induces ischemic tolerance in the brain and heart, which is called “ischemic preconditioning”. The heat shock response is believed to contribute to the acquisition of the tolerance. The therapeutic applications of chaperone inducers that induce HSPs without any toxic effect are also introduced.

Published
1998

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