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1. Equivariant Neural Networks for Spin Dynamics Simulations of Itinerant Magnets

Author

Miyazaki, Yu

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Disordered Systems and Neural Networks, Condensed Matter - Materials Science, Computer Science - Machine Learning
Abstract

I present a novel equivariant neural network architecture for the large-scale spin dynamics simulation of the Kondo lattice model. This neural network mainly consists of tensor-product-based convolution layers and ensures two equivariances: translations of the lattice and rotations of the spins. I implement equivariant neural networks for two Kondo lattice models on two-dimensional square and triangular lattices, and perform training and validation. In the equivariant model for the square lattice, the validation error (based on root mean squared error) is reduced to less than one-third compared to a model using invariant descriptors as inputs. Furthermore, I demonstrate the ability to reproduce phase transitions of skyrmion crystals in the triangular lattice, by performing dynamics simulations using the trained model., Comment: 21 pages, 7 figures

Published
2023
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4. Amoebic colitis in a 39-year-old man with HIV

Author

Miyazaki, Yu and Adachi, Takuya

Subjects
Corticosteroids -- Complications and side effects, Amebiasis -- Diagnosis -- Drug therapy -- Risk factors, HIV patients -- Drug therapy, Health
Abstract

A 39-year-old man with HIV was admitted to our hospital for treatment of pneumocystis pneumonia. He had discontinued antiretroviral treatment (ART) 2 years earlier, and his CD4 cell count was [...]

Published
2024
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6. Human mpox presenting with penile edema and ulcer: A case report.

Author

Miyazaki, Yu and Adachi, Takuya

Subjects
*MONKEYPOX, *SKIN ulcers, *JAPANESE people, *EMERGING infectious diseases, *ULCERS, *SEXUAL intercourse
Abstract

Human mpox, which has spread worldwide since May 2022, is characterized by symptoms involving the genital area; however, its treatment methods and clinical course are not completely understood. Furthermore, penile swelling in human mpox can be difficult to differentiate from cellulitis and antibiotic use has been reported in such cases. Herein, we report a case of human mpox in Japan with prominent penile swelling and persistent penile ulcers that improved without specific treatment. The patient was a Japanese man in his 20s with a history of having sexual intercourse with men frequently. He visited Tokyo Metropolitan Toshima Hospital because of a fever and rash in the genital area. Physical examination revealed vesicles on the limbs, penile pigmentation, and significant penile swelling and redness. There were no signs of cellulitis and symptomatic treatment was initiated with outpatient follow-up. After 7 days, an improving trend in penile swelling, redness, and pain was observed. However, a partially black skin ulcer with exudate was observed at the left coronal sulcus of the penis. Therefore, the symptomatic treatment was continued. On illness day 28, the penile swelling completely improved; however, the penile ulcer and pain persisted, and the exudate was observed again. By illness day 63, the pain in his anogenital area had disappeared, and the penile skin ulcer had healed. The following observations were noted in this case: (i) human mpox can improve without specific treatment such as tecovirimat administration and (ii) skin lesions in the genital area may change over time. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Author

Mautalén, Carlos Alfredo, Man, Zulema, Zanchetta, Jose Ruben, Magaril, Clelia Haydee, Sambrook, Philip, Reginster, Jean-Yves, Geusens, Piet, Goemaere, Stefan, Albergaria, Ben Hur, Zerbini, Cristiano Augusto de Freitas, Castro, Marise Lazaretti, Gregorio, Luiz Henrique, Stoilov, Rumen, Borissova, Anna-Maria I, Hristozov, Kiril Hristov, Temelkova, Nataliya L, Daskalova, Ivona Kirilova, Kuzmanova, Stefka Ivanova, Yaneva-Bichovska, Daniela, Batalov, Anastas Zgurov, Riedemann, Pablo, Rodriguez Portales, José Adolfo, Tang, Hai, Zhu, hanmin, Zhang, Zhenlin, Chao, Aijun, Hu, Yali, Liu, Zhiming, Lu, Juming, Qiu, Mingcai, Gao, Xin, Zhang, Shaofen, Xu, Ling, Xia, Weibo, Liao, Eryuan, Yang, Wenying, Wu, Wen, Dai, Kerong, Hu, Renming, Jaller, Juan Jose, Cabal, Francisco, Molina, José Fernando, Cure Cure, Carlos A, Yupanqui-Lozno, Hernan, Chalem, Philippe, Londono, John, Abello, Mauricio, Tobias, Edgardo D, Otero, William, Nikolic, Tatjana, Miskic, Blazenka, Stepan, Jan, Vyskocil, Vaclav, Novosad, Libor, Slesinger, Jan, Novosad, Pavel, Vlckova, Erika, Bortlik, Ladislav, Dokoupilova, Eva, Hala, Tomas, Jensen, Jens-Erik Beck, Brixen, Kim Torsten, Langdahl, Bente Lomholt, Schwarz, Peter, Eskildsen, Peter Claes, Eiken, Pia Agnete, Hermann, Anne Pernille, Gram, Jeppe, Schou, Maiken Brix, Alexandersen, Peter, Nedergaard, Bettina, Mejía, Dolores Magdalena, Estrella De Henriquez, Lourdes, Páez, Norka, Velazco, Casimiro, Valter, Ivo, Vahula, Kadri-Liina, Kull, Ingrid, Maasalu, Katre, Chapurlat, Roland, Fardellone, Patrice, Benhamou, Claude Laurent, Roux, Christian, Weryha, Georges, Herkt, Volkmar, Martz, Rene, Nischik, Ruth, Spieler, Wolfgang, Contzen, Christel, Felsenberg, Dieter, Frieling, Isolde, Frahm, Eike, Briones, Henry, Sandoval, Boris, Barrios, Patricia, García, Abraham, Avendaño, Carlos, González, Magdalena, Guerra, Jeremías, Tuna, Maria, Díaz, Olga Marina, Samayoa, Eduardo, López, Edgar, Barrera, José Raúl, Palencia, Mainor, Cifuentes, Mayra, Alvarado, Georgina, López, Miriam, Chavez, Nilmo, Haase, Franklin, Rivera, Ruddy, González, Claudio, Tan, Kathryn, Leung, Ping Chung, Mandalam, Sheshadri, Pitale, Shailesh Umakant, Bantwal, Ganapathi, Ammini, Ariachery Chinamma, Shaikh, Shehla Sajid Akhta, Kanakatte Mylariah, Prasanna Kumar, Dharmalingam, Mala, Mukhopadhyay, Satinath, Jain, Arpit, Singh, Parminder, Shetty, Naresh, Sathyanarayana, Srikanta Shamanna, Shah, Nalini, Chadha, Manoj Dharam, Bhandankar, Rajendra, Velayutham, Kumaravel, Marwah, Sudha, John, Mathew, Sahay, Rakesh Kumar, Adami, Silvano, Nuti, Ranuccio, Bianchi, Gerolamo, Brandi, Maria Luisa, Minisola, Salvatore, Fiore, Carmelo Erio, Rubinacci, Alessandro, Miyajima, Hisayuki, Yamane, Hiroo, Nakatani, Yuji, Okamoto, Sumiaki, Kuroda, Koji, Fujimori, Motoaki, Itabashi, Akira, Katayama, Kuniaki, Nakajo, Satoru, Somekawa, Yoshiaki, Ohsawa, Yoshimitsu, Tajima, Wataru, Mizuno, Katsunori, Mori, Shigeru, Kanabuchi, Takato, Hashizume, Hiroyuki, Oka, Nobuyuki, Hamada, Kazutoshi, Yamaguchi, Motoi, Hirahara, Fumiki, Atobe, Masaaki, Ohtake, Yoshiharu, Ichikawa, Shuichi, Onishi, Tomoyuki, Matsumoto, Kou, Nakamura, Tetsuro, Shirasawa, Eishi, Katayama, Ko, Takahashi, Mitsugu, Oguma, Tadanori, Matsui, Hideo, Katoh, Yoshiharu, Shigenobu, Keiichi, Onishi, Tsutomu, Shibukawa, Masato, Ikeda, Satoshi, Osaka, Kazuhiro, Kanda, Ryosuke, Inobe, Yoshito, Shigenobu, Masaharu, Hasegawa, Morimasa, Yamaji, Tetsuo, Miyazaki, Yu, Ito, Takayasu, Nakamura, Eisuke, Nagai, Shinji, Lim, Sung-Kil, Chung, Yoon-Sok, Shin, Chan-Soo, Min, Yong-Ki, Kim, Ghi Su, Yoon, Hyun Koo, Kang, Moo-Il, Yang, Kyu-Hyun, Park, Hyoung Moo, Kim, In Joo, Chung, Dong Jin, Chung, Ho Yeon, Jaundzeikare, Sandra, Andersone, Dace, Medne, Agita, Yaghi, Yasser, Alekna, Vidmantas, Kasiulevicius, Vytautas, Purtokaite - Labutiniene, Irina, Krasauskiene, Aurelija, Varanaviciene, Jurate, Basijokiene, Vida, Abraitiene, Agne, Radzeviciene, Lina, Walliser, Jesus, García Hernández, Pedro Alberto, Araujo, Maria Frida, Avila Armengol, Hilario Ernesto, De la Peña, Pilar, Tamayo, Juan, Zazueta, Beatriz, Cons, Fidencio, Gilchrist, Nigel Leslie, Reid, Ian Reginald, Leikis, Robert, Jones, Peter, Singh, Joe Gragrath Pradeep, Halse, Johan Inge, Syversen, Unni, Høivik, Hans Olav, Øfjord, Erik Snorre, Gulseth, Hans Christian, Elle, Sigbjørn, Norheim, Paal Dag, Calvo Quiroz, Armando A., Cesar Augusto, Pastor A., León Portocarrero, Manuel Gustavo, Vidal Neira, Luis Fernando, Chavez, Jose, Garro Barrera, Boris, Kuroiwa Sampei, Rita, Luis Fernando, Bellatín V., Oquelis Cabredo, Rogger, Castillo, Sonia, Morales, Agustin Miguel G, Tan, Perry Pua, Leagogo, Liberato Antonio C, Jr., Wang, Edward HM, Li-Yu, Julie T, Sawicki, Andrzej Z, Stasiuk, Barbara, Kania, Grzegorz, Lorenc, Roman, Sidorowicz-Bialynicka, Anna, Szczepanski, Leszek, Franek, Edward, Filip, Rafal, Sekula, Jan, Blicharski, Tomasz, Leszczynski, Piotr, Sewerynek, Ewa, Miazgowski, Tomasz, Milewicz, Andrzej, Dabrowska, Magda, Romaszko, Jerzy, Pluskiewicz, Wojciech, Wojnowski, Lukasz, Codreanu, Catalin, Bolosiu, Horatiu, Ionescu, Ruxandra, Zosin, Ioana, Macovei, Liviu, Bojinca, Mihai, Radulescu, Florin, Pop, Simona, Sarbu, Adrian, Benevolenskaya, Lidia I, Nasonov, Evgeny L, Rozhinskaya, Lyudmila Ya, Oganov, Raphael G, Rodionova, Svetlana S, Shlyakhto, Eugeny Vladimirovich, Trofimov, Vasiliy, Zotkin, Eugeny G, Zazerskaya, Irina E, Grineva, Elena N, Ershova, Olga, Lesnyak, Olga, Ostroumova, Olga D, Malichenko, Svetlana B, Pikhlak, Eduard G, Pilyaev, Valery G, Raskina, Tatiana, Zonova, Elena V, Shirinsky, Valery S, Dimic, Aleksandar N, Cobeljic, Goran, Vujovic, Svetlana, Ellis, Graham Charlston, Lipschitz, Stanley, De Villiers, Tobias Johannes, De Weerd, Albert Jan, Vally, Tasneem, Trinder, Yvonne, Coetsee, Jacobus Ludewikus, Davis, Charles Pierre, Nayiager, Savithree, Hough, Frans Stephanus, Oelofse, Louis F, van der Walt, Eugene, Lombaard, Johannes Jurgens, Blignaut, Suzanne, Govind, Uttam, Fouche, Leon Frederik, Kruger, Dawid Stephanus, Dalmeyer, Johannes Paul, Ferreira, Mada M, Escudero-Contreras, Alejandro, Muñoz Torres, Manuel, Hawkins Carranza, Federico, Perez Castrillon, Jose Luis, García Meijide, Juan Antonio, Jodar Gimeno, Esteban, Palacios Gil-Antuñana, Santiago, de Teresa Parreno, Luis, Martín Mola, Emilio, Alvarez Sanchez, Carmen, Lippuner, Kurt, Tsai, Keh-Sung, Tu, Shih-Te, Chen, Jung-Fu, Lee, Oscar Kuang-Sheng, Hsu, Wen-Wei, Grygorieva, Natalia Viktorivna, Povoroznyuk, Vladyslav Volodymyrovych, Korzh, Mykola Oleksiiovych, Loskutov, Oleksandr Levgeniiovych, Chukov, Andriy Borysovych, Sarmiento, Rex, Thomas, Hawys, Donnachie, Hugh, Pavel-Knox, Irina, Shaw, Hilary, Hassanin, Hana, Abdulhakim, Essam Eldin Ahmed, Savani, Naren, Bachmann, Gloria A, Barrett-Connor, Elizabeth, Binkley, Neil C, Bone, Henry G, Brandon, Donald M, Checketts, Darin David, Fraser, Neil J, Watts, Nelson B, Geller, Steven A, Gimbel, Joseph S, Greenwald, Maria White, Holt, Peter A, Johnston, Cyrus Conrad, Fang, Chien, Kiel, Douglas P, Klashman, David J, Lewiecki, E. Michael, Lowenstein, Mitchell B, McClung, Michael Roy, Nattrass, Susan M, Odio, Alberto, Levengood, Julie, Romaguera, Josefina, Saag, Kenneth G, Sebai, Mohamed Bassam, Snyder, Brian, Kutner, Mark Eliot, Streja, Dan, Schwartz, Elliott P, Christiansen, Mark G, McClung, Michael R, O'Donoghue, Michelle L, Papapoulos, Socrates E, Bone, Henry, Langdahl, Bente, Reid, Ian R, Cavallari, Ilaria, Bonaca, Marc P, Wiviott, Stephen D, de Villiers, Tobias, Ling, Xu, Nakamura, Toshitaka, Rodriguez-Portales, Jose Adolfo, Zanchetta, José, Zerbini, Cristiano A F, Park, Jeong-Gun, Im, KyungAh, Cange, Abby, Grip, Laura T, Heyden, Norman, DaSilva, Carolyn, Cohn, Dosinda, Massaad, Rachid, Scott, Boyd B, Verbruggen, Nadia, Gurner, Deborah, Miller, Deborah L, Blair, Micki L, Polis, Adam B, Stoch, S Aubrey, Santora, Arthur, Lombardi, Antonio, Leung, Albert T, Kaufman, Keith D, and Sabatine, Marc S

Published
2019
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10. Evaluation of Patients with Localized Prostate Cancer in whom Long-Term Successful Androgen Deprivation Therapy was Ceased

Author

ARAKI, Hiromasa, ITO, Katsuhiro, IGARASHI, Atsushi, MIURA, Takayoshi, MIYAZAKI, Yu, MISHINA, Mutsuki, and OKUNO, Hiroshi

Subjects
Cessation, Prostate cancer, 494.9, Androgen deprivation therapy
Abstract

We evaluated the clinical course of patients with localized prostate cancer in whom long-term successful androgen deprivation therapy (ADT) was ceased. Study subjects were 24 patients with stage B prostate cancer who were initially treated with ADT for a median duration of 93 months. The median age at the cessation of ADT was 84 years. The median nadir serum prostate specific antigen (PSA) level was 0.022 ng/ml. The median duration of follow-up from the cessation of ADT was 31 months. During follow-up, five patients showed PSA elevation of ≥2 ng/ml from the nadir. Serum testosterone level was tested in 20 patients, and five showed testosterone recovery ≥0.5 ng/ml. Seven patients died from diseases other than prostate cancer, but there were no deaths caused by prostate cancer. This study demonstrated that long-term successful ADT for localized prostate cancer could be ceased with adequate follow-up evaluation.

Published
2022

11. Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study

Author

Ito, Haruki, primary, Negoro, Hiromitsu, additional, Kono, Jin, additional, Hayata, Naoki, additional, Miura, Takayoshi, additional, Manabe, Yumi, additional, Miyazaki, Yu, additional, Mishina, Mutsuki, additional, Woo, Je Tae, additional, Sakane, Naoki, additional, and Okuno, Hiroshi, additional

Published
2023
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12. Supplementary Data from Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer

Author

Mizuno, Kei, primary, Sumiyoshi, Takayuki, primary, Okegawa, Takatsugu, primary, Terada, Naoki, primary, Ishitoya, Satoshi, primary, Miyazaki, Yu, primary, Kojima, Takahiro, primary, Katayama, Hiromichi, primary, Fujimoto, Naohiro, primary, Hatakeyama, Shingo, primary, Shiota, Masaki, primary, Yoshimura, Koji, primary, Matsui, Yoshiyuki, primary, Narita, Shintaro, primary, Matsumoto, Hiroaki, primary, Kurahashi, Ryoma, primary, Kanno, Hidenori, primary, Ito, Katsuhiro, primary, Kimura, Hiroko, primary, Kamiyama, Yuki, primary, Sunada, Takuro, primary, Goto, Takayuki, primary, Kobayashi, Takashi, primary, Yamada, Hitoshi, primary, Tsuchiya, Norihiko, primary, Kamba, Tomomi, primary, Matsuyama, Hideyasu, primary, Habuchi, Tomonori, primary, Eto, Masatoshi, primary, Ohyama, Chikara, primary, Ito, Akihiro, primary, Nishiyama, Hiroyuki, primary, Okuno, Hiroshi, primary, Kamoto, Toshiyuki, primary, Fujimoto, Akihiro, primary, Ogawa, Osamu, primary, and Akamatsu, Shusuke, primary

Published
2023
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17. Up‐regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy

Author

Miyazaki, Yu, primary, Goto, Takayuki, additional, Li, Xin, additional, Nakayama, Kenji, additional, Okasho, Kosuke, additional, Takeda, Masashi, additional, Mizuno, Kei, additional, Kimura, Hiroko, additional, Uegaki, Masayuki, additional, Sumiyoshi, Takayuki, additional, Teramoto, Yuki, additional, Akamatsu, Shusuke, additional, Kobayashi, Takashi, additional, Ogawa, Osamu, additional, and Inoue, Takahiro, additional

Published
2022
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18. A Case of Castration-Resistant Prostate Cancer after Prostatectomy Treated with Resection of A Solitary Metastatic Site

Author

Araki, Hiromasa, Igarashi, Atsushi, Uchida, Toshihiro, Manabe, Yumi, Miyazaki, Yu, Ito, Haruki, Mishina, Mutsuki, and Okuno, Hiroshi

Subjects
Prostatectomy, Salvage radiation, Oligometastasis, Metastasectomy, 494.9, Castration-resistant prostate cancer
Abstract

A 72-year-old man underwent a bilateral nerve-sparing radical retropubic prostatectomy (RRP) with pelvic lymph node dissection 11 years earlier. His prostate specific antigen (PSA) value at diagnosis was 61.024 ng/ml. Bone scans and computed tomographic (CT) scans showed no metastasis. Pathological findings and stage were adenocarcinoma, Gleason score 4+3, positive surgical margin, pT3b, and no lymph node metastasis. The postoperative PSA nadir was 0.218 ng/ml, and salvage radiotherapy (SRT, total 66 Gy) was performed six months after RRP. However, the PSA value continued to rise after SRT. Therefore, androgen deprivation therapy (ADT) was started 11 months after SRT. Nine years postoperatively, the PSA value showed a continuous rise despite ADT, and prostate cancer was considered to be castration-resistant. Although he was taking enzalutamide, his PSA value rose to 18. 271 ng/ml. Repeated bone scans and CT scans were negative. Eleven years after RRP, the fluoro-2-deoxy-D-glucosepositronemissiontomography (FDG-PET) revealed a nodule lesiondorsal to the left pubic bone. The patient underwent a resection of the lesion. Three months after the resection, his PSA level declined to 0.038 ng/ml, thus ADT was discontinued. Thirteen months after the resection, PSA re-elevation was absent, and follow-up without ADT is ongoing.

Published
2020

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Author

ARAKI, Hiromasa, ITO, Katsuhiro, IGARASHI, Atsushi, MIURA, Takayoshi, MIYAZAKI, Yu, MISHINA, Mutsuki, OKUNO, Hiroshi, ARAKI, Hiromasa, ITO, Katsuhiro, IGARASHI, Atsushi, MIURA, Takayoshi, MIYAZAKI, Yu, MISHINA, Mutsuki, and OKUNO, Hiroshi

Abstract

We evaluated the clinical course of patients with localized prostate cancer in whom long-term successful androgen deprivation therapy (ADT) was ceased. Study subjects were 24 patients with stage B prostate cancer who were initially treated with ADT for a median duration of 93 months. The median age at the cessation of ADT was 84 years. The median nadir serum prostate specific antigen (PSA) level was 0.022 ng/ml. The median duration of follow-up from the cessation of ADT was 31 months. During follow-up, five patients showed PSA elevation of ≥2 ng/ml from the nadir. Serum testosterone level was tested in 20 patients, and five showed testosterone recovery ≥0.5 ng/ml. Seven patients died from diseases other than prostate cancer, but there were no deaths caused by prostate cancer. This study demonstrated that long-term successful ADT for localized prostate cancer could be ceased with adequate follow-up evaluation.

Published
2022

20. Laryngoscopy facilitates successful i-gel insertion by novice doctors: a prospective randomized controlled trial

Author

Miyazaki, Yu, Komasawa, Nobuyasu, Matsunami, Sayuri, Kusaka, Yusuke, and Minami, Toshiaki

Subjects
Laryngoscopy -- Research -- Usage, Pharyngeal diseases -- Research -- Care and treatment -- Diagnosis -- Development and progression -- Complications and side effects, Health
Abstract

Background This study investigated the hypothesis that the efficacy of insertion of the supraglottic device i-gel.sup.® (i-gel) can be improved by laryngoscopy and can provide better sealing pressure in anesthetized patients by novice doctors. Methods Eighty-four adult patients were assigned to the laryngoscopy group (L group, 42 patients) or control group (i.e., conventional blind insertion; C group, 42 patients). Anesthesia was induced with propofol and remifentanil, and rocuronium 0.6-0.9 mg/kg was administered. The number of attempts until successful insertion, sealing pressure, vital sign changes upon insertion, and subjective difficulty of insertion by novice doctors were compared between the groups. Results The total number of insertion attempts was one (L group 36 cases, C group 23 cases), two (L group 6 cases, C group 18 cases), and three (L group 0 case, C group 1 case), with significant differences between groups (P = 0.007). The sealing pressure was significantly higher in the L group than in the C group (L group 22.3 ± 2.6 cmH.sub.2O, C group 19.5 ± 2.7 cmH.sub.2O, P < 0.001). Vital sign changes (heart rate and blood pressure) did not differ between the two groups. The subjective difficulty of insertion was significantly lower in the L group than in the C group (L group 26.8 ± 11.8 mm, C group 47.0 ± 15.1 mm, P < 0.001). The incidence of postoperative pharyngeal pain was significantly lower in the L group than in the C group (P < 0.001), while the incidence of hoarseness did not differ between the two groups (P = 1.00). Conclusion Our results suggest that laryngoscopy facilitates i-gel insertion by novice doctors, as reflected in the rate of successful insertions, higher sealing pressure, and lower subjective difficulty of insertion in anesthetized patients., Author(s): Yu Miyazaki[sup.1] , Nobuyasu Komasawa[sup.1] , Sayuri Matsunami[sup.1] , Yusuke Kusaka[sup.1] , Toshiaki Minami[sup.1] Author Affiliations: (1) Department of Anesthesiology, Osaka Medical College, Daigaku-machi 2-7, 569-8686, Takatsuki, Osaka, Japan [...]

Published
2015
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23. A Case of Emphysematous Pyelonephritis Complicated by Bacterial Endophthalmitis in which Multidisciplinary Therapy Led to Preservation of the Kidney

Author

Igarashi, Atsushi, Araki, Hiromasa, Uchida, Toshihiro, Miyazaki, Yu, Mishina, Mutsuki, Mori, Yuki, Kita, Mihori, and Okuno, Hiroshi

Subjects
Emphysematous pyelonephritis, ECIRS (endoscopic combined intrarenal surgery), 494.9, Bacterial endophthalmitis
Abstract

A 49-year-old male with untreated diabetes mellitus type 2 experienced eyesight deterioration and general malaise, and was treated for uveitis and orbital cellulitis. Later, he was taken to a local hospital via ambulance for a consciousness disorder and was diagnosed with bilateral infectious endophthalmitis, a right ureteral stone, and emphysematous pyelonephritis. He was then referred to our hospital for further examination and treatment. We immediately initiated intravenous antibiotic therapy with meropenem and glycemic control with continuous subcutaneous insulin infusion, and placed a ureteral and percutaneous drain tube into the right ureter and the emphysema, respectively. We performed a diagnostic and therapeutic vitrectomy on the patient's left eye. Urinary, blood, and vitreous cultures were positive for Klebsiella aerogenes. Abdominal contrast-enhanced computed tomography showed bilaterally comparable renal contrast enhancement. On the 60th hospital day, we performed endoscopic combined intrarenal surgery (ECIRS) and completely removed the urinary stone. Although he lost light sensitivity in his right eye, his left eyesight improved, and his blood glucose level was adequately managed by oral medication. Three months after the surgery, he was discharged from our hospital and he showed no sign of recurrence of the infection at ten months after surgery.

Published
2020

25. Up‐regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy.

Author

Miyazaki, Yu, Goto, Takayuki, Li, Xin, Nakayama, Kenji, Okasho, Kosuke, Takeda, Masashi, Mizuno, Kei, Kimura, Hiroko, Uegaki, Masayuki, Sumiyoshi, Takayuki, Teramoto, Yuki, Akamatsu, Shusuke, Kobayashi, Takashi, Ogawa, Osamu, and Inoue, Takahiro

Subjects
*CANCER relapse, *PROTEASE inhibitors, *HORMONE therapy, *PROSTATE cancer, *CASTRATION-resistant prostate cancer
Abstract

Using new castration‐resistant prostate cancer (CRPC) cell lines developed from LNCaP cells as a model for CRPC, we searched for novel biomarkers by analyzing the proteins secreted in culture supernatants. The results showed that the levels of secretory leukocyte protease inhibitor (SLPI) in these cell lines were 4.7–6.7 times higher than those secreted in parental LNCaP. Patients with localized prostate cancer (PC) and who expressed SLPI had a significantly lower prostate‐specific antigen (PSA) progression‐free survival rate than those who did not. Multivariate analysis revealed that SLPI expression was an independent risk factor for PSA recurrence. By contrast, when immunostaining of SLPI was performed on consecutive prostate tissue samples obtained from 11 patients, both in hormone naive (HN) and castration resistant (CR) conditions, only one patient expressed SLPI in the HNPC state; however, four of the 11 patients expressed SLPI in the CRPC state. In addition, two of these four patients were resistant to enzalutamide, and there was a discrepancy between their serum PSA levels and radiographic progression of the disease. These results suggest that SLPI can be a predictor of prognosis in patients with localized PC and disease progression in CRPC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Decreased Expression of Lysophosphatidylcholine (16:0/OH) in High Resolution Imaging Mass Spectrometry Independently Predicts Biochemical Recurrence After Surgical Treatment for Prostate Cancer

Author

Goto, Takayuki, Terada, Naoki, Inoue, Takahiro, Kobayashi, Takashi, Nakayama, Kenji, Okada, Yoshiyuki, Yoshikawa, Takeshi, Miyazaki, Yu, Uegaki, Masayuki, Utsunomiya, Noriaki, Makino, Yuki, Sumiyoshi, Shinji, Yamasaki, Toshinari, Kamba, Tomomi, and Ogawa, Osamu

Published
2015
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27. Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer

Author

Mizuno, Kei, primary, Sumiyoshi, Takayuki, additional, Okegawa, Takatsugu, additional, Terada, Naoki, additional, Ishitoya, Satoshi, additional, Miyazaki, Yu, additional, Kojima, Takahiro, additional, Katayama, Hiromichi, additional, Fujimoto, Naohiro, additional, Hatakeyama, Shingo, additional, Shiota, Masaki, additional, Yoshimura, Koji, additional, Matsui, Yoshiyuki, additional, Narita, Shintaro, additional, Matsumoto, Hiroaki, additional, Kurahashi, Ryoma, additional, Kanno, Hidenori, additional, Ito, Katsuhiro, additional, Kimura, Hiroko, additional, Kamiyama, Yuki, additional, Sunada, Takuro, additional, Goto, Takayuki, additional, Kobayashi, Takashi, additional, Yamada, Hitoshi, additional, Tsuchiya, Norihiko, additional, Kamba, Tomomi, additional, Matsuyama, Hideyasu, additional, Habuchi, Tomonori, additional, Eto, Masatoshi, additional, Ohyama, Chikara, additional, Ito, Akihiro, additional, Nishiyama, Hiroyuki, additional, Okuno, Hiroshi, additional, Kamoto, Toshiyuki, additional, Fujimoto, Akihiro, additional, Ogawa, Osamu, additional, and Akamatsu, Shusuke, additional

Published
2021
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31. Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract

Author

Minamiyama, Makoto, Katsuno, Masahisa, Adachi, Hiroaki, Doi, Hideki, Kondo, Naohide, Iida, Madoka, Ishigaki, Shinsuke, Fujioka, Yusuke, Matsumoto, Shinjiro, Miyazaki, Yu, Tanaka, Fumiaki, Kurihara, Hiroki, and Sobue, Gen

Subjects
Naratriptan -- Dosage and administration -- Genetic aspects -- Research, Nervous system diseases -- Development and progression -- Genetic aspects -- Drug therapy -- Research, Protein kinases -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of the CAG triplet repeat within the androgen receptor (AR) gene. Here, we demonstrated that pathogenic AR upregulates the gene encoding calcitonin gene-related peptide α (CGRP1). In neuronal cells, overexpression of CGRP1 induced cellular damage via the activation of the c-Jun N-terminal kinase (JNK) pathway, whereas pharmacological suppression of CGRP1 or JNK attenuated the neurotoxic effects of pathogenic AR. The depletion of CGRP1 inactivated JNK and suppressed neurodegeneration in a mouse model of SBMA. Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models. These observations suggest that pharmacological activation of the 5-HT1B/1D receptor may be used therapeutically to treat SBMA and other polyglutamine-related neurodegenerative diseases., The expansion of a genomic trinucleotide CAG repeat causes hereditary neurodegenerative disorders such as Huntington's disease, SBMA, dentatorubral-pallidoluysian atrophy and six forms of spinocerebellar ataxial (1), (2). SBMA, or Kennedy's [...]

Published
2012
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32. Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2

Author

Miyazaki, Yu, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Jiang, Yue-Mei, Huang, Zhe, Doi, Hideki, Matsumoto, Shinjiro, Kondo, Naohide, Iida, Madoka, Tohnai, Genki, Tanaka, Fumiaki, Muramatsu, Shin-ichi, and Sobue, Gen

Subjects
Nervous system diseases -- Research -- Genetic aspects -- Health aspects -- Risk factors, Messenger RNA -- Physiological aspects -- Research, MicroRNA -- Physiological aspects -- Research, Biological sciences, Health
Abstract

Spinal and bulbar muscular atrophy (SBMA) is an inherited neurodegenerative disorder caused by the expansion of the polyglutamine (polyQ) tract of the androgen receptor (AR-polyQ) (1), (2). Characteristics of SBMA include proximal muscular atrophy, weakness, contraction fasciculation and bulbar involvement (3). MicroRNAs (miRNAs) are a diverse class of highly conserved small RNA molecules that function as crucial regulators of gene expression in animals and plants (4). Recent functional studies have shown the potent activity of specific miRNAs as disease modifiers both in vitro and in vivo (5-8). Thus, potential therapeutic approaches that target the miRNA processing pathway have recently attracted attention (9), (10). Here we describe a novel therapeutic approach using the adeno-associated virus (AAV) vector-mediated delivery of a specific miRNA for SBMA. We found that miR-196a enhanced the decay of the AR mRNA by silencing CUGBP, Elav-like family member 2 (CELF2). CELF2 directly acted on AR mRNA and enhanced the stability of AR mRNA. Furthermore, we found that the early intervention of miR-196a delivered by an AAV vector ameliorated the SBMA phenotypes in a mouse model. Our results establish the proof of principle that disease-specific miRNA delivery could be useful in neurodegenerative diseases., A mouse model of SBMA has been developed (11), and several therapeutic approaches for SBMA have been presented using this mouse model (11-15). Among these approaches, the reduction of mutant [...]

Published
2012
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38. A Case of Nivolumab-Induced Isolated Adrenocorticotropic Hormone Deficiency Presenting Dyspnea

Author

Ito, Katsuhiro, Uchida, Toshihiro, Manabe, Yumi, Miyazaki, Yu, Itoh, Haruki, Mishina, Mutsuki, and Okuno, Hiroshi

Subjects
Nivolumab, Isolated-ACTH deficiency, 494.9, Adrenal insufficiency, Renal cell carcinoma
Abstract

A 66-year-old man had undergone multiple treatments for metastatic renal cell carcinoma, including 11 cycles of nivolumab, which was discontinued because of disease progression. About three weeks after discontinuing nivolumab, he reported suffering from worsening of dyspnea. Pulse oximetry showed no desaturation. His cardiovascular and pulmonary functions were normal. His dyspnea slowly worsened with no underlying diagnosis. Two months after symptoms developed, he was diagnosed with isolated adrenocorticotropic hormone deficiency. His dyspnea disappeared soon after receiving hydrocortisone. Nivolumab-induced isolated adrenocorticotropic hormone deficiency may not present with typical symptoms, and can occur even after discontinuing nivolumab. Cortisol levels should be routinely monitored in patients who receive nivolumab.

Published
2018

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Author

Araki, Hiromasa, Igarashi, Atsushi, Uchida, Toshihiro, Manabe, Yumi, Miyazaki, Yu, Ito, Haruki, Mishina, Mutsuki, Okuno, Hiroshi, Araki, Hiromasa, Igarashi, Atsushi, Uchida, Toshihiro, Manabe, Yumi, Miyazaki, Yu, Ito, Haruki, Mishina, Mutsuki, and Okuno, Hiroshi

Abstract

A 72-year-old man underwent a bilateral nerve-sparing radical retropubic prostatectomy (RRP) with pelvic lymph node dissection 11 years earlier. His prostate specific antigen (PSA) value at diagnosis was 61.024 ng/ml. Bone scans and computed tomographic (CT) scans showed no metastasis. Pathological findings and stage were adenocarcinoma, Gleason score 4+3, positive surgical margin, pT3b, and no lymph node metastasis. The postoperative PSA nadir was 0.218 ng/ml, and salvage radiotherapy (SRT, total 66 Gy) was performed six months after RRP. However, the PSA value continued to rise after SRT. Therefore, androgen deprivation therapy (ADT) was started 11 months after SRT. Nine years postoperatively, the PSA value showed a continuous rise despite ADT, and prostate cancer was considered to be castration-resistant. Although he was taking enzalutamide, his PSA value rose to 18. 271 ng/ml. Repeated bone scans and CT scans were negative. Eleven years after RRP, the fluoro-2-deoxy-D-glucosepositronemissiontomography (FDG-PET) revealed a nodule lesiondorsal to the left pubic bone. The patient underwent a resection of the lesion. Three months after the resection, his PSA level declined to 0.038 ng/ml, thus ADT was discontinued. Thirteen months after the resection, PSA re-elevation was absent, and follow-up without ADT is ongoing.

Published
2020

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Author

Igarashi, Atsushi, Araki, Hiromasa, Uchida, Toshihiro, Miyazaki, Yu, Mishina, Mutsuki, Mori, Yuki, Kita, Mihori, Okuno, Hiroshi, Igarashi, Atsushi, Araki, Hiromasa, Uchida, Toshihiro, Miyazaki, Yu, Mishina, Mutsuki, Mori, Yuki, Kita, Mihori, and Okuno, Hiroshi

Abstract

A 49-year-old male with untreated diabetes mellitus type 2 experienced eyesight deterioration and general malaise, and was treated for uveitis and orbital cellulitis. Later, he was taken to a local hospital via ambulance for a consciousness disorder and was diagnosed with bilateral infectious endophthalmitis, a right ureteral stone, and emphysematous pyelonephritis. He was then referred to our hospital for further examination and treatment. We immediately initiated intravenous antibiotic therapy with meropenem and glycemic control with continuous subcutaneous insulin infusion, and placed a ureteral and percutaneous drain tube into the right ureter and the emphysema, respectively. We performed a diagnostic and therapeutic vitrectomy on the patient's left eye. Urinary, blood, and vitreous cultures were positive for Klebsiella aerogenes. Abdominal contrast-enhanced computed tomography showed bilaterally comparable renal contrast enhancement. On the 60th hospital day, we performed endoscopic combined intrarenal surgery (ECIRS) and completely removed the urinary stone. Although he lost light sensitivity in his right eye, his left eyesight improved, and his blood glucose level was adequately managed by oral medication. Three months after the surgery, he was discharged from our hospital and he showed no sign of recurrence of the infection at ten months after surgery.

Published
2020

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