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3. Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction

Author

Sarker, Md. Khalequzzaman, primary, Tony, Selim Reza, additional, Siddique, Abu Eabrahim, additional, Karim, Md. Rezaul, additional, Haque, Nazmul, additional, Islam, Zohurul, additional, Islam, Md. Shofikul, additional, Khatun, Moriom, additional, Islam, Jahidul, additional, Hossain, Shakhawoat, additional, Alam Saud, Zahangir, additional, Miyataka, Hideki, additional, Sumi, Daigo, additional, Barchowsky, Aaron, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2021
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6. Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh

Author

Karim, Md. Rezaul, Rahman, Mashiur, Islam, Khairul, Mamun, Abdullah Al, Hossain, Shakhawoat, Hossain, Ekhtear, Aziz, Abdul, Yeasmin, Fouzia, Agarwal, Smita, Hossain, Md. Imam, Saud, Zahangir Alam, Nikkon, Farjana, Hossain, Mostaque, Mandal, Abul, Jenkins, Richard O., Haris, Parvez I., Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Published
2013
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7. Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic

Author

Hossain, Ekhtear, Islam, Khairul, Yeasmin, Fouzia, Karim, Rezaul, Rahman, Mashiur, Agarwal, Smita, Hossain, Shakhawoat, Aziz, Abdul, Al Mamun, Abdullah, Sheikh, Afzal, Haque, Abedul, Hossain, Tofazzal M., Hossain, Mostaque, Haris, Parvez I., Ikemura, Noriaki, Inoue, Kiyoshi, Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Published
2012
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8. Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh

Author

Paul, Sudip Kumar, Islam, Md. Shofikul, Hasibuzzaman, M. M., Hossain, Faruk, Anjum, Adiba, Saud, Zahangir Alam, Haque, Md. Mominul, Sultana, Papia, Haque, Azizul, Andric, Klara Biljana, Rahman, Aminur, Karim, Md Rezaul, Siddique, Abu Eabrahim, Karim, Yeasir, Rahman, Mizanur, Miyataka, Hideki, Xin, Lian, Himeno, Seiichiro, Hossain, Khaled, Paul, Sudip Kumar, Islam, Md. Shofikul, Hasibuzzaman, M. M., Hossain, Faruk, Anjum, Adiba, Saud, Zahangir Alam, Haque, Md. Mominul, Sultana, Papia, Haque, Azizul, Andric, Klara Biljana, Rahman, Aminur, Karim, Md Rezaul, Siddique, Abu Eabrahim, Karim, Yeasir, Rahman, Mizanur, Miyataka, Hideki, Xin, Lian, Himeno, Seiichiro, and Hossain, Khaled

Abstract

Arsenic (As) toxicity and diabetes mellitus (DM) are emerging public health concerns worldwide. Although exposure to high levels of As has been associated with DM. whether there is also an association between low and moderate As exposure and DM remains unclear. We explored the dose-dependent association between As exposure levels and hyperglycemia, with special consideration of the impact of demographic variables, in 641 subjects from rural Bangladesh. The total study participants were divided into three groups depending on their levels of exposure to As in drinking water (low, moderate and high exposure groups). Prevalence of hyperglycemia, including impaired glucose tolerance (IGT) and DM was significantly associated with the subjects' drinking water arsenic levels. Almost all exposure metrics (As levels in the subjects' drinking water, hair and nails) showed dose-dependent associations with the risk or hyperglycemia, IGT and DM. Among the variables considered, sex, age, and BMI were found to be associated with higher risk of hyperglycemia. IGT and DM. In sex-stratified analyses, As exposure showed a clearer pattern of dose-dependent risk for hyperglycemia in females than males. Finally, drinking water containing low-to-moderate levels of As (50.01-150 mu g/L) was found to confer a greater risk of hyperglycemia than safe drinking water (As <= 10 mu g/L). Thus the results suggested that As exposure was dose-dependently associated with hyperglycemia, especially in females., Funding Agencies:Ministry of Science and Technology, Government of the People's Republic of Bangladesh 39.009.006.01.00.042.2012-2013/ES-21/558 National Institutes of Health R01 CA129560 MUSC Bridge funding 20441 Center for Global Health 20438 JSPS KAKENHI program 16H05834 Rajshahi University 5/52/RU/Science-13/17-18

Published
2019
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9. Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh

Author

Paul, Sudip Kumar, primary, Islam, Md. Shofikul, additional, Hasibuzzaman, M.M., additional, Hossain, Faruk, additional, Anjum, Adiba, additional, Saud, Zahangir Alam, additional, Haque, Md. Mominul, additional, Sultana, Papia, additional, Haque, Azizul, additional, Andric, Klara Biljana, additional, Rahman, Aminur, additional, Karim, Md Rezaul, additional, Siddique, Abu Eabrahim, additional, Karim, Yeasir, additional, Rahman, Mizanur, additional, Miyataka, Hideki, additional, Xin, Lian, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2019
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10. Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh

Author

Hossain Mostaque, Sultana Papia, Karim Rezaul, Rahman Mashiur, Rahman Matiar, Saud Zahangir, Ali Nurshad, Salam Kazi, Hossain Ekhtear, Fajol Abul, Haque Abedul, Islam Khairul, Akhand Anwarul, Mandal Abul, Miyataka Hideki, Himeno Seiichiro, and Hossain Khaled

Subjects
Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Chronic arsenic exposure has been shown to cause liver damage. However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented. The aim of our study was to investigate the dose-response relationship between arsenic exposure and major serum enzyme marker activity associated with LFTs in the population living in arsenic-endemic areas in Bangladesh. Methods A total of 200 residents living in arsenic-endemic areas in Bangladesh were selected as study subjects. Arsenic concentrations in the drinking water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The study subjects were stratified into quartile groups as follows, based on concentrations of arsenic in the drinking water, as well as in subjects' hair and nails: lowest, low, medium and high. The serum hepatic enzyme activities of alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) were then assayed. Results Arsenic concentrations in the subjects' hair and nails were positively correlated with arsenic levels in the drinking water. As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates. With internal exposure markers (arsenic in hair and nails), the ALP, AST and ALT activity profiles assumed a similar shape of dose-response relationship, with very few differences seen in the higher groups compared to the lowest group, most likely due to the temporalities of exposure metrics. Conclusions The present study demonstrated that arsenic concentrations in the drinking water were strongly correlated with arsenic concentrations in the subjects' hair and nails. Further, this study revealed a novel exposure- and dose- response relationship between arsenic exposure metrics and serum hepatic enzyme activity. Elevated serum hepatic enzyme activities in the higher exposure gradients provided new insights into arsenic-induced liver toxicity that might be helpful for the early prognosis of arsenic-induced liver diseases.

Published
2011
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11. Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh

Author

Karim Md Rezaul, Mandal Abul, Hossain Mostaque, Akhand Anwarul, Khalek Md Abdul, Saud Zahangir, Islam Khairul, Rahman Aminur, Salam Kazi, Haque Abedul, Hoque Md Ashraful, Ali Nurshad, Miyataka Hideki, Himeno Seiichiro, and Hossain Khaled

Subjects
Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause for liver damage, cancers, neurological disorders and several other ailments. The relationship between plasma cholinesterase (PChE) activity and arsenic exposure has not yet been clearly documented. However, decreased PChE activity has been found in patients suffering liver dysfunction, heart attack, cancer metastasis and neurotoxicity. Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh. Methods A total of 141 Bangladeshi residents living in arsenic endemic areas with the mean arsenic exposure of 14.10 ± 3.27 years were selected as study subjects and split into tertile groups based on three water arsenic concentrations: low (< 129 μg/L), medium (130-264 μg/L) and high (> 265 μg/L). Study subjects were further sub-divided into two groups (≤50 μg/L and > 50 μg/L) based on the recommended upper limit of water arsenic concentration (50 μg/L) in Bangladesh. Blood samples were collected from the study subjects by venipuncture and arsenic concentrations in drinking water, hair and nail samples were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). PChE activity was assayed by spectrophotometer. Results Arsenic concentrations in hair and nails were positively correlated with the arsenic levels in drinking water. Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails. The average levels of PChE activity in low, medium and high arsenic exposure groups were also significantly different between each group. Lower levels of PChE activity were also observed in the > 50 μg/L group compared to the ≤50 μg/L group. Moreover, PChE activity was significantly decreased in the skin (+) symptoms group compared to those without (-). Conclusions We found a significant inverse relationship between arsenic exposure and PChE activity in a human population in Bangladesh. This research demonstrates a novel exposure-response relationship between arsenic and PChE activity which may explain one of the biological mechanisms through which arsenic exerts its neuro-and hepatotoxicity in humans.

Published
2010
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13. Additional file 1: of Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Author

Hossain, Khaled, Suzuki, Takehiro, M. Hasibuzzaman, Md. Islam, Atiqur Rahman, Sudip Paul, Tanzina Tanu, Shakhawoat Hossain, Zahangir Saud, Mashiur Rahman, Farjana Nikkon, Miyataka, Hideki, Himeno, Seiichiro, and Nohara, Keiko

Abstract

Adjusted associations of arsenic exposure metrics and LINE-1 methylation levels with BP through multivariate regression analyses. (DOC 67Â kb)

Published
2017
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16. Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh

Author

Hasibuzzaman, M. M., primary, Hossain, Shakhawoat, additional, Islam, Md. Shofikul, additional, Rahman, Atiqur, additional, Anjum, Adiba, additional, Hossain, Faruk, additional, Mohanto, Nayan Chandra, additional, Karim, Md. Rezaul, additional, Hoque, Md. Mominul, additional, Saud, Zahangir Alam, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2017
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17. Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Author

Hossain, Khaled, primary, Suzuki, Takehiro, additional, Hasibuzzaman, M. M., additional, Islam, Md. Shofikul, additional, Rahman, Atiqur, additional, Paul, Sudip Kumar, additional, Tanu, Tanzina, additional, Hossain, Shakhawoat, additional, Saud, Zahangir Alam, additional, Rahman, Mashiur, additional, Nikkon, Farjana, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Nohara, Keiko, additional

Published
2017
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19. Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals

Author

Islam, Md Shofikul, Mohanto, Nayan Chandra, Karim, Md Rezaul, Aktar, Sharmin, Hoque, Md Mominul, Rahman, Atiqur, Jahan, Momotaj, Khatun, Rabeya, Aziz, Abdul, Abdus Salam, Kazi, Saud, Zahangir Alam, Hossain, Mostaque, Rahman, Aminur, Mandal, Abul, Haque, Azizul, Miyataka, Hideki, Himeno, Seiichiro, Hossain, Khaled, Islam, Md Shofikul, Mohanto, Nayan Chandra, Karim, Md Rezaul, Aktar, Sharmin, Hoque, Md Mominul, Rahman, Atiqur, Jahan, Momotaj, Khatun, Rabeya, Aziz, Abdul, Abdus Salam, Kazi, Saud, Zahangir Alam, Hossain, Mostaque, Rahman, Aminur, Mandal, Abul, Haque, Azizul, Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Abstract

Background: Cardiovascular diseases (CVDs) and cancers are the major causes of chronic arsenic exposure-related morbidity and mortality. Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) are deeply involved in the pathogenesis of CVDs and cancers. This study has been designed to evaluate the interactions of arsenic exposure with serum MMP-2 and MMP-9 concentrations especially in relation to the circulating biomarkers of CVDs. Methods: A total of 373 human subjects, 265 from arsenic-endemic and 108 from non-endemic areas in Bangladesh were recruited for this study. Arsenic concentrations in the specimens were measured by inductively coupled plasma mass spectroscopy (ICP-MS) and serum MMPs were quantified by immunoassay kits. Results: Serum MMP-2 and MMP-9 concentrations in arsenic-endemic population were significantly (p < 0.001) higher than those in non-endemic population. Both MMPs showed significant positive interactions with drinking water (rs = 0.208, p < 0.001 for MMP-2; rs = 0.163, p <0.01 for MMP-9), hair (rs= 0.163, p < 0.01 for MMP-2; rs = 0.173, p < 0.01 for MMP-9) and nail (rs= 0.160, p < 0.01 for MMP-2; rs = 0.182, p < 0.001 for MMP-9) arsenic of the study subjects. MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension). Furthermore, both MMPs were increased dose-dependently when the study subjects were split into three (≤10, 10.1-50 and > 50 μg/L) groups based on the regulatory upper limit of water arsenic concentration set by WHO and Bangladesh Government. MMPs were also found to be significantly (p < 0.05) associated with each other. Finally, the concentrations of both MMPs were correlated with several circulating markers related to CVDs. Conclusions: This study showed the significant posit

Published
2015
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20. Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals

Author

Islam, Md Shofikul, primary, Mohanto, Nayan Chandra, additional, Karim, Md Rezaul, additional, Aktar, Sharmin, additional, Hoque, Md Mominul, additional, Rahman, Atiqur, additional, Jahan, Momotaj, additional, Khatun, Rabeya, additional, Aziz, Abdul, additional, Salam, Kazi Abdus, additional, Saud, Zahangir Alam, additional, Hossain, Mostaque, additional, Rahman, Aminur, additional, Mandal, Abul, additional, Haque, Azizul, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2015
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22. Associations of total arsenic in drinking water, hair and nails with serum vascular endothelial growth factor in arsenic-endemic individuals in Bangladesh

Author

Rahman, Mashiur, primary, Mamun, Abdullah Al, additional, Karim, Md. Rezaul, additional, Islam, Khairul, additional, Amin, Hasan Al, additional, Hossain, Shakhawoat, additional, Hossain, Md. Imam, additional, Saud, Zahangir Alam, additional, Noman, Abu Shadat Mohammod, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2015
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23. A heterogeneous mercury salt catalyst stabilized by m-carbaborane

Author

Yamamoto, Hirofumi, primary, Yamasaki, Naoto, additional, Hamauchi, Hiroshi, additional, Shiomi, Shinya, additional, Sasaki, Ikuo, additional, Seyama, Koichiro, additional, Mima, Yasuko, additional, Nakano, Mayo, additional, Kawakami, Takashige, additional, Miyataka, Hideki, additional, Kasai, Yusuke, additional, and Imagawa, Hiroshi, additional

Published
2015
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24. An Integrative Study of the Genetic, Social and Environmental Determinants of Chronic Kidney Disease Characterized by Tubulointerstitial Damages in the North Central Region of Sri Lanka

Author

Nanayakkara, Shanika, primary, Senevirathna, STMLD, additional, Abeysekera, Tilak, additional, Chandrajith, Rohana, additional, Ratnatunga, Neelakanthi, additional, Gunarathne, EDL, additional, Yan, Junxia, additional, Hitomi, Toshiaki, additional, Muso, Eri, additional, Komiya, Toshiyuki, additional, Harada, Kouji H., additional, Liu, Wanyang, additional, Kobayashi, Hatasu, additional, Okuda, Hiroko, additional, Sawatari, Hideyuki, additional, Matsuda, Fumihiko, additional, Yamada, Ryo, additional, Watanabe, Takao, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Koizumi, Akio, additional

Published
2014
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25. Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh

Author

Karim, Md Rezaul, Rahman, Mashiur, Islam, Khairul, Al Mamun, Abdullah, Hossain, Shakhawoat, Hossain, Ekhtear, Aziz, Abdul, Yeasmin, Fouzia, Agarwal, Smita, Hossain, Md Imam, Saud, Zahangir Alam, Nikkon, Farjana, Hossain, Mostaque, Mandal, Abul, Jenkins, Richard O., Haris, Parvez I., Miyataka, Hideki, Himeno, Seiichiro, Hossain, Khaled, Karim, Md Rezaul, Rahman, Mashiur, Islam, Khairul, Al Mamun, Abdullah, Hossain, Shakhawoat, Hossain, Ekhtear, Aziz, Abdul, Yeasmin, Fouzia, Agarwal, Smita, Hossain, Md Imam, Saud, Zahangir Alam, Nikkon, Farjana, Hossain, Mostaque, Mandal, Abul, Jenkins, Richard O., Haris, Parvez I., Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Abstract

Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in the individuals exposed to arsenic in Bangladesh. A total of 324 study subjects, 218 from arsenic-endemic areas and 106 from nonendemic areas in Bangladesh, were recruited. Drinking water, hair, nail, and blood samples were collected from the study subjects for analysis. Total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were lower in arsenic-endemic subjects than those of nonendemic subjects. Oxidized LDL (Ox-LDL), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) levels were significantly higher in arsenic-endemic subjects than those in nonendemic subjects. All these circulating molecules showed significant correlations with arsenic exposure (water, hair, and nail arsenic concentrations), and all these relations were significant before and after adjusting for relevant covariates. Among the circulating molecules tested in this study, HDL, Ox-LDL, and CRP showed dose-response relationships with arsenic exposure. Ox-LDL/ HDL ratios were increased with the increasing concentrations of arsenic in the water, hair, and nails. Furthermore, non-HDL cholesterol and TC/ HDL ratios were significantly correlated with arsenic exposure before and after adjusting for relevant covariates. Thus, all the observed associations may be the major features of arsenic exposure-related atherosclerosis leading to CVD., FundingMinistry of Science and Technology, Government of the People’s Republic of Bangladesh (39.009.006.01.00.042.2012-2013/ES-21/558); The Academy of Science for the Developing World (Ref- 09-153 RG/BIO/AS_I; UNESCO FR: 3240230321); Grant-in-Aid for Scientific Research B, Japan (22390127 and 24406009); Heiwa Nakajima Foundation, Japan.

Published
2013
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26. Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh

Author

Islam, Khairul, Haque, Abedul, Karim, Rezaul, Fajol, Abul, Hossain, Ekhtear, Salam, Kazi Abdus, Ali, Nurshad, Saud, Zahangir Alam, Rahman, Matiar, Rahman, Mashiur, Sultana, Papia, Hossain, Mostaque, Akhand, Anwarul Azim, Mandal, Abul, Miyataka, Hideki, Himeno, Seiichiro, Hossain, Khaled, Islam, Khairul, Haque, Abedul, Karim, Rezaul, Fajol, Abul, Hossain, Ekhtear, Salam, Kazi Abdus, Ali, Nurshad, Saud, Zahangir Alam, Rahman, Matiar, Rahman, Mashiur, Sultana, Papia, Hossain, Mostaque, Akhand, Anwarul Azim, Mandal, Abul, Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Published
2011

27. Association between arsenic exposure and plasma cholinesterase activity : a population based study in Bangladesh

Author

Ali, Nurshad, Hoque, Md Ashraful, Haque, Abedul, Abdus Salam, Kazi, Karim, Md Rezaul, Rahman, Aminur, Islam, Khairul, Alam Saud, Zahangir, Khalek, Md Abdul, Azim Akhand, Anwarul, Hossain, Mostaque, Mandal, Abul, Miyataka, Hideki, Himeno, Seiichiro, Hossain, Khaled, Ali, Nurshad, Hoque, Md Ashraful, Haque, Abedul, Abdus Salam, Kazi, Karim, Md Rezaul, Rahman, Aminur, Islam, Khairul, Alam Saud, Zahangir, Khalek, Md Abdul, Azim Akhand, Anwarul, Hossain, Mostaque, Mandal, Abul, Miyataka, Hideki, Himeno, Seiichiro, and Hossain, Khaled

Abstract

Background: Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause for liver damage, cancers, neurological disorders and several other ailments. The relationship between plasma cholinesterase (PChE) activity and arsenic exposure has not yet been clearly documented. However, decreased PChE activity has been found in patients suffering liver dysfunction, heart attack, cancer metastasis and neurotoxicity. Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh. Methods: A total of 141 Bangladeshi residents living in arsenic endemic areas with the mean arsenic exposure of 14.10 ± 3.27 years were selected as study subjects and split into tertile groups based on three water arsenic concentrations: low (< 129 μg/L), medium (130-264 μg/L) and high (> 265 μg/L). Study subjects were further sub-divided into two groups (≤50 μg/L and > 50 μg/L) based on the recommended upper limit of water arsenic concentration (50 μg/L) in Bangladesh. Blood samples were collected from the study subjects by venipuncture and arsenic concentrations in drinking water, hair and nail samples were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). PChE activity was assayed by spectrophotometer. Results: Arsenic concentrations in hair and nails were positively correlated with the arsenic levels in drinking water. Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails. The average levels of PChE activity in low, medium and high arsenic exposure groups were also significantly different between each group. Lower levels of PChE activity were also observed in the > 50 μg/L group compared to the ≤50 μg/L group. Moreover, P

Published
2010
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30. Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh

Author

Islam, Khairul, primary, Haque, Abedul, additional, Karim, Rezaul, additional, Fajol, Abul, additional, Hossain, Ekhtear, additional, Salam, Kazi Abdus, additional, Ali, Nurshad, additional, Saud, Zahangir Alam, additional, Rahman, Matiar, additional, Rahman, Mashiur, additional, Sultana, Papia, additional, Hossain, Mostaque, additional, Akhand, Anwarul Azim, additional, Mandal, Abul, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2011
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32. Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh

Author

Ali, Nurshad, primary, Hoque, Md Ashraful, additional, Haque, Abedul, additional, Salam, Kazi Abdus, additional, Karim, Md Rezaul, additional, Rahman, Aminur, additional, Islam, Khairul, additional, Saud, Zahangir Alam, additional, Khalek, Md Abdul, additional, Akhand, Anwarul Azim, additional, Hossain, Mostaque, additional, Mandal, Abul, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional

Published
2010
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