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Extracorporeal shock wave lithotripsy (ESWL) without endoscopic sphincterotomy (EST) for pancreatic duct stones was performed in two patients with chronic pancreatitis. Case 1 was a 37-year-old man. Pancreatic stones were observed in the pancreatic head and tail region with a persistent pancreatic fistula. ESWL without EST for pancreatolithiasis was performed two times. Almost all the stones in the pancreatic head were disintegrated without any complications by ESWL (4700 shock waves at 24.0 KV) under fluoroscopic control using a lithotriptor (Dornier MLF 5000). Consequently, the fistula closed and the pancreatic exocrine function recovered. Case 2 was a 65-year-old woman suffering from chronic relapsing pancreatitis with calcified stones in the pancreatic head region. ESWL (5700 shock waves at 23.0 KV) without EST produced complete disintegration of the stones without any complications. Seven days later, almost all of the stones in the pancreatic head were diminished. Thereafter, we observed not only amelioration of the symptoms of pancreatitis but also improvement in pancreatic exocrine function. Thus, ESWL treatment without EST was a safe and effective method for pancreatolithiasis and should be considered a high-priority non-surgical treatment for pancreatolithiasis., Acta medica Nagasakiensia. 1996, 41(3-4), p.80-83

Differences in the proliferative activity of cancer cells between the primary lesion and the metastatic lymph node of solid tumors were studied in subcutaneously transplanted rat tumor AH109A and human gastric cancer. The cellular RNA content (RNA index, RI), colony formation assay (plating efficiency, PE) and Brdurd labeling index (L1) were used as indicators for the proliferative activity of cancer cells, In the experiment with transplanted rat tumor, RI, PE, and LI fell off significantly over time at 1, 2 and 3 weeks after transplantation. On comparison of the primary lesion and the meta static lymph node, the DNA index (DI) remained unchanged but RI increased significantly in the metastatic lymph node. PE and LI Likewise showed significantly high values in the metastatic lesion, When the DNA-RNA indices for 19 cases of human gastric cancer were studied, DI remained almost unchanged in the primary lesion and the metastatic lymph node but RI showed high values in the lymph node. Therefore, the proliferative activity of cancer cells is considered to be higher in the metastatic lymph node than in the primary lesion, which is very significant for the progression of the tumor. On the other hand, chemotherapy can be expected to be more effective in the metastatic lymph node than in the primary lesion. The present study may provide a theoretical basis for reduction surgery on the primary lesion followed by other techniques on the secondary lesion., Acta Medica Nagasakiensia. 1993, 38(1), p.21-27

A case of gastritis cystica polyposa is presented. A 45-year-old woman developed gastritis cystica polyposa at the gastroduodenostomy anastomotic site four years after Billroth II gastrectomy for adenomatous polyp. There was no association of gastric cancer in the lesion., Acta medica Nagasakiensia. 1990, 35(1-4), p.29-32

Two patients with rectal cancer induced by irradiation for the treatment of uterine cancer were reported. Surgical outcome for radiation-induced cancer was satisfactory as far as the primary focus was well controlled. Definition of radiation-induced cancer also was discussed. It is the most important factor to be a long time interval of more than 10 years by detection of rectal cancer after irradiation and to reveal a histologic pattern concerning irradiation tissue damage., Acta medica Nagasakiensia. 1988, 33(1-4), p.83-86

Acta Medica Nagasakiensia. 1986, 31(1-4), p.333-337

A 60-year-old, Japanese woman, with congenital web-like tracheal stenosis surgically treated. Successful relief from tracheal stenosis was obstained. Detection in adulthood and chance of the treatment for congenital tracheal stenosis is very rare. As far as this case is concerned, delay in detection and treatment is discussed of congenital tracheal stenosis., Acta medica Nagasakiensia. 1985, 30(1-3), p.256-260

An unusual case of gastric cancer associated with a huge metastasis to the paratracheal lymph node is presented. The 57-year-old female patient with such a metastatic disease was managed by surgery and immunochemotherapy. Histologic examination of the stomach and involved lymph nodes showed a poorly differentiated adenocarcinoma., Acta Medica Nagasakiensia. 1987, 32(1-4), p.151-156

Out of 390 patients with early gastric cancer (EGC) who underwent gastric resection between Jan. 1968 and Jul. 1987, four patients developed pyloric stenosis and one patient developed prepyloric stenosis. Macroscopic types of EGC were II c in three cases and II c + III in two cases. Histologic types were tubular adenocarcinoma in four patients, and poorly differentiated adenocarcinoma in one patient. Cancer existed just right on or immediately adjacent to the pyloric ring in all patients; and extended transversely to the gastric axis in four patients, and longitudinally in one patient. An associated open ulcer and/or ulcer scar in the cancer lesion was seen in four patients, and submucosal fibrosis in three patients to a variety of degree, both of which were thought to be greatly attributed to pyloric or prepyloric stenosis. A duodenal ulcer was not present in any patients., Acta medica Nagasakiensia. 1988, 33(1-4), p.179-184

Acta Medica Nagasakiensia. 1986, 31(1-4), p.136-142