Search

Your search keyword '"Miyamoto, Shelley D."' showing total 437 results
Start Over Author "Miyamoto, Shelley D."
437 results on '"Miyamoto, Shelley D."'

4. Research Gaps in Pediatric Heart Failure: Defining the Gaps and Then Closing Them Over the Next Decade

Author

AMDANI, SHAHNAWAZ, AUERBACH, SCOTT R., BANSAL, NEHA, CHEN, SHARON, CONWAY, JENNIFER, SILVA, JULIE PIRES DA, DESHPANDE, SHRIPRASAD R., HOOVER, JESSICA, LIN, KIMBERLY Y., MIYAMOTO, SHELLEY D., PURI, KRITI, PRICE, JACK, SPINNER, JOSEPH, WHITE, RACHEL, ROSSANO, JOSEPH W., BEARL, DAVID W., COUSINO, MELISSA K., CATLIN, PERRY, HIDALGO, NICOLAS CORRAL, GODOWN, JUSTIN, KANTOR, PAUL, MASARONE, DANIELE, PENG, DAVID M., REA, KELLY E., SCHUMACHER, KURT, SHADDY, ROBERT, SHEA, ERIN, TAPIA, HENRY VALORA, VALIKODATH, NISHMA, ZAFAR, FARHAN, and HSU, DAPHNE

Published
2024
Full Text
View/download PDF

5. The teammate trial: Study design and rationale tacrolimus and everolimus against tacrolimus and MMF in pediatric heart transplantation using the major adverse transplant event (MATE) score

Author

Almond, Christopher S., Sleeper, Lynn A., Rossano, Joseph W., Bock, Matthew J., Pahl, Elfriede, Auerbach, Scott, Lal, Ashwin, Hollander, Seth A., Miyamoto, Shelley D., Castleberry, Chesney, Lee, Joanne, Barkoff, Lynsey M., Gonzales, Selena, Klein, Gloria, and Daly, Kevin P.

Published
2023
Full Text
View/download PDF

15. Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy

Author

Blakeslee, Weston W, Demos-Davies, Kimberly M, Lemon, Douglas D, Lutter, Katharina M, Cavasin, Maria A, Payne, Sam, Nunley, Karin, Long, Carlin S, McKinsey, Timothy A, and Miyamoto, Shelley D

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Pediatric, Heart Disease, Perinatal Period - Conditions Originating in Perinatal Period, Adaptation, Physiological, Adolescent, Animals, Animals, Newborn, Case-Control Studies, Child, Female, Gene Expression Regulation, Enzymologic, Heart Defects, Congenital, Heart Ventricles, Histone Deacetylases, Humans, Hypertrophy, Right Ventricular, Infant, Isoenzymes, Male, Rats, Sprague-Dawley, Signal Transduction, Ventricular Function, Right, Ventricular Remodeling, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics, Paediatrics
Abstract

BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease of right ventricular morphology, as well as in a rodent model of right ventricular hypertrophy (RVH).MethodsHomogenates of right ventricle (RV) explants from non-failing controls and children born with a SV were assayed for HDAC catalytic activity and HDAC isoform expression. Postnatal 1-day-old rat pups were placed in hypoxic conditions, and echocardiographic analysis, gene expression, HDAC catalytic activity, and isoform expression studies of the RV were performed.ResultsClass I, IIa, and IIb HDAC catalytic activity and protein expression were elevated in the hearts of children born with a SV. Hypoxic neonatal rats demonstrated RVH, abnormal gene expression, elevated class I and class IIb HDAC catalytic activity, and protein expression in the RV compared with those in the control.ConclusionsThese data suggest that myocardial HDAC adaptations occur in the SV heart and could represent a novel therapeutic target. Although further characterization of the hypoxic neonatal rat is needed, this animal model may be suitable for preclinical investigations of pediatric RV disease and could serve as a useful model for future mechanistic studies.

Published
2017

16. Heart Failure

Author

Nakano, Stephanie J., da Cruz, Eduardo M., Tissot, Cécile, Miyamoto, Shelley D., Munoz, Ricardo A., editor, Morell, Victor O., editor, da Cruz, Eduardo M., editor, Vetterly, Carol G., editor, and da Silva, Jose Pedro, editor

Published
2020
Full Text
View/download PDF

17. Pericardial Diseases

Author

Tissot, Cécile, Phelps, Christina M., da Cruz, Eduardo M., Miyamoto, Shelley D., Munoz, Ricardo A., editor, Morell, Victor O., editor, da Cruz, Eduardo M., editor, Vetterly, Carol G., editor, and da Silva, Jose Pedro, editor

Published
2020
Full Text
View/download PDF

18. Longitudinal Changes in Estimated Glomerular Filtration Rate Following Repeat Heart Transplant in Children and Young Adults.

Author

Chan, Melvin, Silveira, Lori, Patterson, Daniel J., Bock, Margret E., Pietra, Biagio A., Everitt, Melanie D., Simpson, Kathleen E., Miyamoto, Shelley D., and Auerbach, Scott R.

Subjects
ACUTE kidney failure, GLOMERULAR filtration rate, CHRONIC kidney failure, LOGISTIC regression analysis, YOUNG adults
Abstract

Background: Chronic kidney disease (CKD) is common after heart transplantation (HT). There are scarce studies looking at longitudinal changes in estimated glomerular filtration rate (eGFR) after repeat HT (RT) and risk factors for the presence of CKD3 post‐RT. Methods: First‐time HT recipients (FT) were matched with RT, based on age at transplant, sex, race, and transplant era. eGFR was derived from CKiD‐U25 formula using creatinine. Changes in eGFR were measured within and between patients using a mixed effects model. Logistic regression and survival analysis were performed to identify significant risk factors for CKD3 presence post‐RT. Results: The unmatched cohort included 393 HT recipients and 47 RT. 29 patients in both groups with at least 2 years of follow‐up data underwent matching. Over 6 years, the mean eGFR for FT and RT did not significantly change overtime. For those with CKD3 or higher prior to RT, 73% improved to CKD2 or lower at 2 years post‐RT. Risk factors for CKD3 post‐RT included female sex (OR 17.5 [1.7–181.9], p = 0.017) and greater than two acute kidney injuries (AKI) between FT and RT (OR 1.77 [1.06–2.95], p = 0.03). Approximately 50% of females and those with greater than two AKIs maintained or developed CKD3 at 7.5 and 3 years, respectively. Conclusion: This study provides data on longitudinal changes in eGFR over 6 years and finds that female sex and repeat HT recipients with greater 2 AKIs between transplants are at greatest risk for CKD3 presence post‐RT. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Feasibility of a Pilot Randomized Controlled Trial

Author

Grady, Kathleen L., Andrei, Adin-Cristian, Shankel, Tamara, Chinnock, Richard, Miyamoto, Shelley D., Ambardekar, Amrut V., Anderson, Allen, Addonizio, Linda, Latif, Farhana, Lefkowitz, Debra, Goldberg, Lee R., Hollander, Seth A., Pham, Michael, Van't Hof, Kathleen, Weissberg-Benchell, Jill, Yancy, Clyde, Liu, Menghan, Melody, Nichole, and Pahl, Elfriede

Published
2019
Full Text
View/download PDF

44. Changes in estimated glomerular filtration rate over the first year following repeat heart transplant in children and young adults.

Author

Chan, Melvin, Silveira, Lori, Patterson, Daniel J., Bock, Margret E., Pietra, Biagio A., Everitt, Melanie D., Simpson, Kathleen E., Miyamoto, Shelley D., and Auerbach, Scott R.

Subjects
GLOMERULAR filtration rate, HEART transplantation, YOUNG adults, HEART transplant recipients, CARDIO-renal syndrome
Abstract

Background: Renal function is reduced in patients undergoing heart transplant due to hemodynamic compromise, cardiorenal syndrome, and nephrotoxin exposure. No current studies evaluate renal function in retransplants. Methods: We reviewed all heart transplants at our center from 1995 to 2021 and matched first‐time heart transplants with retransplants, based on age at transplant, sex, and race. Estimated glomerular filtration rate (eGFR) was derived from CKiD‐U25 calculator using creatinine and measured prior to transplant, 1‐week post‐transplant, 1–3, 6, and 12 months post‐transplant, and recent follow‐up. Changes in eGFR were measured within and between patients using a piecewise linear mixed effect model with matching. Exploratory univariate analysis was performed to evaluate pre‐transplant risk factors for decreased eGFR. Results: The unmatched cohort included 393 heart transplant recipients, with 47 being retransplants. Thirty‐eight patients in both groups with at least 1 year of follow‐up underwent matching. Both retransplants and first‐time transplants had an initial decline in eGFR. eGFR rebounded to baseline or above baseline at 1–3 months post‐transplant, but eGFR in retransplants remained significantly lower. At 1‐year post‐transplant, the average eGFR was 67.8 ± 4.3 mL/min/1.73 m2 versus 104.7 ± 4.3 mL/min/1.73 m2 (p <.001) in the retransplants and first‐time transplants group, respectively. Conclusion: This study provides data on anticipated renal trajectory following retransplantation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Heart Transplantation

Author

Miyamoto, Shelley D., Campbell, David N., Auerbach, Scott R., Da Cruz, Eduardo M., editor, Ivy, Dunbar, editor, and Jaggers, James, editor

Published
2014
Full Text
View/download PDF

50. Congestive Heart Failure

Author

Tissot, Cécile, da Cruz, Eduardo M., Miyamoto, Shelley D., Da Cruz, Eduardo M., editor, Ivy, Dunbar, editor, and Jaggers, James, editor

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results