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544 results on '"Miyamoto, Michael"'

1. Increases in regional brain volume across two native South American male populations

Author

Chaudhari, Nikhil N., Imms, Phoebe E., Chowdhury, Nahian F., Gatz, Margaret, Trumble, Benjamin C., Mack, Wendy J., Law, E. Meng, Sutherland, M. Linda, Sutherland, James D., Rowan, Christopher J., Wann, L. Samuel, Allam, Adel H., Thompson, Randall C., Michalik, David E., Miyamoto, Michael, Lombardi, Guido, Cummings, Daniel K., Seabright, Edmond, Alami, Sarah, Garcia, Angela R., Rodriguez, Daniel E., Gutierrez, Raul Quispe, Copajira, Adrian J., Hooper, Paul L., Buetow, Kenneth H., Stieglitz, Jonathan, Gurven, Michael D., Thomas, Gregory S., Kaplan, Hillard S., Finch, Caleb E., and Irimia, Andrei

Published
2024
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2. Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.

Author

Kaplan, Hillard, Hooper, Paul, Gatz, Margaret, Mack, Wendy, Law, E, Chui, Helena, Sutherland, M, Sutherland, James, Rowan, Christopher, Wann, L, Allam, Adel, Thompson, Randall, Michalik, David, Lombardi, Guido, Miyamoto, Michael, Eid Rodriguez, Daniel, Copajira Adrian, Juan, Quispe Gutierrez, Raul, Beheim, Bret, Cummings, Daniel, Seabright, Edmond, Alami, Sarah, R Garcia, Angela, Buetow, Kenneth, Thomas, Gregory, Finch, Caleb, Stieglitz, Jonathan, Trumble, Benjamin, Irimia, Andrei, and Gurven, Michael

Subjects
Tsimane, brain volume, evolutionary medicine, mismatch, Humans, United States, Cross-Sectional Studies, Aging, Cardiovascular System, Brain, South America
Abstract

Little is known about brain aging or dementia in nonindustrialized environments that are similar to how humans lived throughout evolutionary history. This paper examines brain volume (BV) in middle and old age among two indigenous South American populations, the Tsimane and Moseten, whose lifestyles and environments diverge from those in high-income nations. With a sample of 1,165 individuals aged 40 to 94, we analyze population differences in cross-sectional rates of decline in BV with age. We also assess the relationships of BV with energy biomarkers and arterial disease and compare them against findings in industrialized contexts. The analyses test three hypotheses derived from an evolutionary model of brain health, which we call the embarrassment of riches (EOR). The model hypothesizes that food energy was positively associated with late life BV in the physically active, food-limited past, but excess body mass and adiposity are now associated with reduced BV in industrialized societies in middle and older ages. We find that the relationship of BV with both non-HDL cholesterol and body mass index is curvilinear, positive from the lowest values to 1.4 to 1.6 SDs above the mean, and negative from that value to the highest values. The more acculturated Moseten exhibit a steeper decrease in BV with age than Tsimane, but still shallower than US and European populations. Lastly, aortic arteriosclerosis is associated with lower BV. Complemented by findings from the United States and Europe, our results are consistent with the EOR model, with implications for interventions to improve brain health.

Published
2023

3. Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager‐horticulturalists

Author

Gatz, Margaret, Mack, Wendy J, Chui, Helena C, Law, E Meng, Barisano, Giuseppe, Sutherland, M Linda, Sutherland, James D, Rodriguez, Daniel Eid, Gutierrez, Raul Quispe, Adrian, Juan Copajira, Cuata, Jesus Bani, Borenstein, Amy R, Walters, Ellen E, Irimia, Andrei, Rowan, Christopher J, Wann, L Samuel, Allam, Adel H, Thompson, Randall C, Miyamoto, Michael I, Michalik, David E, Cummings, Daniel K, Seabright, Edmond, Garcia, Angela R, Hooper, Paul L, Kraft, Thomas S, Finch, Caleb E, Thomas, Gregory S, Stieglitz, Jonathan, Trumble, Benjamin C, Gurven, Michael D, and Kaplan, Hillard

Subjects
Dementia, Behavioral and Social Science, Alzheimer's Disease, Aging, Mental Health, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Biomedical Imaging, Neurodegenerative, Brain Disorders, Acquired Cognitive Impairment, Clinical Research, Mental health, Neurological, Good Health and Well Being, Humans, Prevalence, Bolivia, Cognitive Dysfunction, Neuroimaging, Alzheimer Disease, Disease Progression, cognitive dysfunction, dementia, mental status and dementia tests, Moseten, Tsimane, Clinical Sciences, Geriatrics
Abstract

IntroductionWe evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.MethodsParticipants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.ResultsTsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia.DiscussionThe prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.

Published
2023

4. Very Low Prevalence and Incidence of Atrial Fibrillation among Bolivian Forager-Farmers.

Author

Rowan, Christopher J, Eskander, Michael A, Seabright, Edmond, Rodriguez, Daniel Eid, Linares, Edhitt Cortez, Gutierrez, Raul Quispe, Adrian, Juan Copajira, Cummings, Daniel, Beheim, Bret, Tolstrup, Kirsten, Achrekar, Abinash, Kraft, Thomas, Michalik, David E, Miyamoto, Michael I, Allam, Adel H, Wann, L Samuel, Narula, Jagat, Trumble, Benjamin C, Stieglitz, Jonathan, Thompson, Randall C, Thomas, Gregory S, Kaplan, Hillard S, and Gurven, Michael D

Subjects
Clinical Sciences, Public Health and Health Services
Abstract

BackgroundAtrial fibrillation is the most common arrhythmia in post-industrialized populations. Older age, hypertension, obesity, chronic inflammation, and diabetes are significant atrial fibrillation risk factors, suggesting that modern urban environments may promote atrial fibrillation.ObjectiveHere we assess atrial fibrillation prevalence and incidence among tropical horticulturalists of the Bolivian Amazon with high levels of physical activity, a lean diet, and minimal coronary atherosclerosis, but also high infectious disease burden and associated inflammation.MethodsBetween 2005-2019, 1314 Tsimane aged 40-94 years (52% female) and 534 Moseten Amerindians aged 40-89 years (50% female) underwent resting 12-lead electrocardiograms to assess atrial fibrillation prevalence. For atrial fibrillation incidence assessment, 1059 (81% of original sample) Tsimane and 310 Moseten (58%) underwent additional ECGs (mean time to follow up 7.0, 1.8 years, respectively).FindingsOnly one (male) of 1314 Tsimane (0.076%) and one (male) of 534 Moseten (0.187%) demonstrated atrial fibrillation at baseline. There was one new (female) Tsimane case in 7395 risk years for the 1059 participants with >1 ECG (incidence rate = 0.14 per 1,000 risk years). No new cases were detected among Moseten, based on 542 risk years.ConclusionTsimane and Moseten show the lowest levels of atrial fibrillation ever reported, 1/20 to ~1/6 of rates in high-income countries. These findings provide additional evidence that a subsistence lifestyle with high levels of physical activity, and a diet low in processed carbohydrates and fat is cardioprotective, despite frequent infection-induced inflammation. Findings suggest that atrial fibrillation is a modifiable lifestyle disease rather than an inevitable feature of cardiovascular aging.

Published
2021

5. Strong phenotypic divergence in spite of low genetic structure in the endemic Mangrove Warbler subspecies (Setophaga petechia xanthotera) of Costa Rica

Author

Chavarria‐Pizarro, Tania, Gomez, Juan Pablo, Ungvari‐Martin, Judit, Bay, Rachael, Miyamoto, Michael M, and Kimball, Rebecca

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Genetics, Underpinning research, 1.1 Normal biological development and functioning, ecological genomics, environmental gradient, gene flow, Mangrove Warbler, phenotypic divergence, P-ST-F-ST, PST–FST, Evolutionary biology, Ecological applications
Abstract

Despite the enormous advances in genetics, links between phenotypes and genotypes have been made for only a few nonmodel organisms. However, such links can be essential to understand mechanisms of ecological speciation. The Costa Rican endemic Mangrove Warbler subspecies provides an excellent subject to study differentiation with gene flow, as it is distributed along a strong precipitation gradient on the Pacific coast with no strong geographic barriers to isolate populations. Mangrove Warbler populations could be subject to divergent selection driven by precipitation, which influences soil salinity levels, which in turn influences forest structure and food resources. We used single nucleotide polymorphisms (SNPs) and morphological traits to examine the balance between neutral genetic and phenotypic divergence to determine whether selection has acted on traits and genes with functions related to specific environmental variables. We present evidence showing: (a) associations between environmental variables and SNPs, identifying candidate genes related to bill morphology (BMP) and osmoregulation, (b) absence of population genetic structure in neutrally evolving markers, (c) divergence in bill size across the precipitation gradient, and (d) strong phenotypic differentiation (P ST) which largely exceeds neutral genetic differentiation (F ST) in bill size. Our results indicate an important role for salinity, forest structure, and resource availability in maintaining phenotypic divergence of Mangrove Warblers through natural selection. Our findings add to the growing body of literature identifying the processes involved in phenotypic differentiation along environmental gradients in the face of gene flow.

Published
2019

7. Left main and triple vessel dissection 2 months postpartum

Author

Shahandeh, Negeen, Miyamoto, Michael I, and Tobis, Jonathan

Subjects
Heart Disease, Heart Disease - Coronary Heart Disease, Cardiovascular, Atherosclerosis, Acute Coronary Syndrome, Adult, Angina Pectoris, Cardiovascular Agents, Coronary Angiography, Coronary Vessel Anomalies, Drug-Eluting Stents, Female, Humans, Percutaneous Coronary Intervention, Postpartum Period, Pregnancy, Treatment Outcome, Ultrasonography, Interventional, Vascular Diseases, complications, coronary aneurysm, dissection, perforation, imaging, intravascular ultrasound, left main coronary disease, percutaneous coronary intervention, pregnancy, cardiovascular complications, coronary aneurysm/dissection/perforation, imaging, intravascular ultrasound, pregnancy, cardiovascular complications, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome. The majority of cases reported in the literature involve a single vessel; multivessel and left main (LM) coronary artery involvement is rare. We present a case of triple vessel and LM SCAD in a postpartum patient and review the literature regarding percutaneous coronary intervention in the setting of SCAD.

Published
2019

9. Abstract 13660: Lp(a) is Associated With Coronary Artery Calcification in a Population With Exceptionally Low Cardiovascular Disease Risk

Author

Trumble, Benjamin C, Thompson, Randall C, Elizalde, Caden A, Miyamoto, Michael, Stieglitz, Jonathan, Wann, Samuel S, Allam, Adel, Rowan, Chris, Cummings, Daniel, Sutherland, M Linda, Sutherland, James, Eid Rodriguez, Daniel, Michalik, David E, Lombardi, Guido, Seabright, Edward, Alami, Sarah, Garcia, Angela R, Beheim, Bret, Hooper, Paul, Finch, Caleb, Buetow, Kenneth, Gurven, Michael, Kaplan, Hillard, and Thomas, Gregory S

Published
2022
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11. Atherosclerosis in ancient mummified humans: the global HORUS study.

Author

Thompson, Randall C, Sutherland, M Linda, Allam, Adel H, Paladin, Alice, Zink, Albert R, Wann, L Samuel, Sutherland, James D, Frohlich, Bruno, Hunt, David, Miyamoto, Michael I, Rowan, Christopher J, Michalik, David E, Finch, Caleb E, Lombardi, Guido P, Soliman, Muhammad Al-Tohamy, Monge, Janet M, Vallodolid, Clide M, Cox, Samantha L, Abdel-Maksoud, Gomaa, and Badr, Ibrahim

Subjects
ATHEROSCLEROSIS, CORONARY artery calcification, ARTERIAL calcification, ATHEROSCLEROTIC plaque
Abstract

This article, published in the European Heart Journal, presents the findings of the HORUS study, which aimed to investigate the presence of atherosclerosis in ancient mummified humans. The study analyzed whole body CT scans of mummies from seven different cultures, including Egyptian, Peruvian, Bolivian, Unangan/Aleutian Islander, Greenlandic Inuit, ancestral Puebloan, and Middle-Ages Gobi Desert pastoralists. The results showed that atherosclerosis was present in all cultures except for one Indigenous Australian mummy. The study suggests that atherosclerosis has been a part of human populations for thousands of years and supports the existence of an innate human predisposition to the disease. [Extracted from the article]

Published
2024
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21. Genome Map: Comparative Genomics-Mammalian Radiations

Author

O'Brien, Stephen J., Eisenberg, John F., Miyamoto, Michael, Hedges, S. Blair, Kumar, Sudhir, Wilson, Don E., Menotti-Raymond, Marilyn, Murphy, William J., Nash, WilliEam G., Lyons, Leslie A., Menninger, Joan C., Stanyon, Roscoe, Wienberg, Johannes, Copeland, Neal G., Jenkins, Nancy A., Gellin, Joel, Yerle, Martine, Andersson, Leif, Womack, James, Broad, Thomas, Postlethwait, John, Serov, Oleg, Bailey, Ernie, James, Michael R., Watanabe, Takeshi K., Wakefield, Matthew J., and Graves, Jennifer Marshall

Published
1999

25. How B-Type Natriuretic Peptide (BNP) and Body Weight Changes Vary in Heart Failure With Preserved Ejection Fraction Compared With Reduced Ejection Fraction: Secondary Results of the HABIT (HF Assessment With BNP in the Home) Trial

Author

Maisel, Alan S., Shah, Kevin S., Barnard, Denise, Jaski, Brian, Frivold, Geir, Marais, John, Azer, Maged, Miyamoto, Michael I., Lombardo, Dawn, Kelsay, Damon, Iqbal, Navaid, Taub, Pam R., Kupfer, Ken, Lee, Elizabeth, Clopton, Paul, Zile, Michael, and Greenberg, Barry

Published
2016
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26. Pathway‐based genome analysis of cognitive impairment in a forager‐horticulturalist South American population

Author

Garcia, Angela R, primary, Lu, Yih‐Kuang, additional, Gatz, Margaret, additional, Rodriguez, Daniel Eid, additional, Gutierrez, Raul Quispe, additional, Adrian, Juan J Copajira, additional, Cuata, Jesus Bani, additional, Sutherland, M Linda, additional, Sutherland, James D, additional, Cummings, Daniel K, additional, Kraft, Thomas, additional, Mack, Wendy J, additional, Chui, Helena C, additional, Law, Meng, additional, Barisano, Giuseppe, additional, Borenstein, Amy R, additional, Irimia, Andrei, additional, Walters, Ellen E, additional, Thomas, Gregory S, additional, Thompson, Randall C, additional, Miyamoto, Michael I, additional, Michalik, David E, additional, Wann, L Samuel, additional, Allam, Adel H, additional, Rowan, Christopher J, additional, Highland, Heather M, additional, North, Kari E, additional, Finch, Caleb E, additional, Stieglitz, Jonathan, additional, Gurven, Michael D, additional, Trumble, Benjamin C, additional, Kaplan, Hillard, additional, and Buetow, Kenneth, additional

Published
2022
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29. Why Did Ancient People Have Atherosclerosis?: From Autopsies to Computed Tomography to Potential Causes

Author

Thomas, Gregory S., Wann, L. Samuel, Allam, Adel H., Thompson, Randall C., Michalik, David E., Sutherland, M. Linda, Sutherland, James D., Lombardi, Guido P., Watson, Lucia, Cox, Samantha L., Valladolid, Clide M., Abd el-Maksoud, Gomaa, Al-Tohamy Soliman, Muhammad, Badr, Ibrahem, el-Halim Nur el-din, Abd, Clarke, Emily M., Thomas, Ian G., Miyamoto, Michael I., Kaplan, Hillard S., Frohlich, Bruno, Narula, Jagat, Stewart, Alexandre F.R., Zink, Albert, and Finch, Caleb E.

Published
2014
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30. Atherosclerosis in Ancient and Modern Egyptians: The Horus Study

Author

Allam, Adel H., Mandour Ali, Mohamed A., Wann, L. Samuel, Thompson, Randall C., Sutherland, M. Linda, Sutherland, James D., Frohlich, Bruno, Michalik, David E., Zink, Albert, Lombardi, Guido P., Watson, Lucia, Cox, Samantha L., Finch, Caleb E., Miyamoto, Michael I., Sallam, Sallam L., Narula, Jagat, and Thomas, Gregory S.

Published
2014
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31. Genomic Correlates of Atherosclerosis in Ancient Humans

Author

Zink, Albert, Wann, L. Samuel, Thompson, Randall C., Keller, Andreas, Maixner, Frank, Allam, Adel H., Finch, Caleb E., Frohlich, Bruno, Kaplan, Hillard, Lombardi, Guido P., Sutherland, M. Linda, Sutherland, James D., Watson, Lucia, Cox, Samantha L., Miyamoto, Michael I., Narula, Jagat, Stewart, Alexandre F.R., Thomas, Gregory S., and Krause, Johannes

Published
2014
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32. Computed Tomographic Evidence of Atherosclerosis in the Mummified Remains of Humans From Around the World

Author

Thompson, Randall C., Allam, Adel H., Zink, Albert, Wann, L. Samuel, Lombardi, Guido P., Cox, Samantha L., Frohlich, Bruno, Sutherland, M. Linda, Sutherland, James D., Frohlich, Thomas C., King, Samantha I., Miyamoto, Michael I., Monge, Janet M., Valladolid, Clide M., el-Halim Nur el-din, Abd, Narula, Jagat, Thompson, Adam M., Finch, Caleb E., and Thomas, Gregory S.

Published
2014
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36. Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager‐horticulturalists

Author

Gatz, Margaret, primary, Mack, Wendy J., additional, Chui, Helena C., additional, Law, E. Meng, additional, Barisano, Giuseppe, additional, Sutherland, M. Linda, additional, Sutherland, James D., additional, Eid Rodriguez, Daniel, additional, Quispe Gutierrez, Raul, additional, Copajira Adrian, Juan, additional, Bani Cuata, Jesus, additional, Borenstein, Amy R., additional, Walters, Ellen E., additional, Irimia, Andrei, additional, Rowan, Christopher J., additional, Wann, L. Samuel, additional, Allam, Adel H., additional, Thompson, Randall C., additional, Miyamoto, Michael I., additional, Michalik, David E., additional, Cummings, Daniel K., additional, Seabright, Edmond, additional, Garcia, Angela R., additional, Hooper, Paul L., additional, Kraft, Thomas S., additional, Finch, Caleb E., additional, Thomas, Gregory S., additional, Stieglitz, Jonathan, additional, Trumble, Benjamin C., additional, Gurven, Michael D., additional, and Kaplan, Hillard, additional

Published
2022
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