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712 results on '"Miyamoto, Akio"'

7. Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle

Author

Akthar, Ihshan, primary, Kim, Yejin, additional, Umehara, Takashi, additional, Kanno, Chihiro, additional, Sasaki, Motoki, additional, Marey, Mohamed Ali, additional, Yousef, Mohamed Samy, additional, Haneda, Shingo, additional, Shimada, Masayuki, additional, and Miyamoto, Akio, additional

Published
2023
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14. Ovarian sex steroid and epithelial control of immune responses in the uterus and oviduct: human and animal models†

Author

Kowsar, Rasoul, Sadeghi, Khaled, Hashemzadeh, Farzad, and Miyamoto, Akio

Abstract

The female reproductive tract (FRT), including the uterus and oviduct (Fallopian tube), is responsible for maintaining an optimal microenvironment for reproductive processes, such as gamete activation and transportation, sperm capacitation, fertilization, and early embryonic and fetal development. The mucosal surface of the FRT may be exposed to pathogens and sexually transmitted microorganisms due to the opening of the cervix during mating. Pathogens and endotoxins may also reach the oviduct through the peritoneal fluid. To maintain an optimum reproductive environment while recognizing and killing pathogenic bacterial and viral agents, the oviduct and uterus should be equipped with an efficient and rigorously controlled immune system. Ovarian sex steroids can affect epithelial cells and underlying stromal cells, which have been shown to mediate innate and adaptive immune responses. This, in turn, protects against potential infections while maintaining an optimal milieu for reproductive events, highlighting the homeostatic involvement of ovarian sex steroids and reproductive epithelial cells. This article will discuss how ovarian sex steroids affect the immune reactions elicited by the epithelial cells of the non-pregnant uterus and oviduct in the bovine, murine, and human species. Finally, we propose that there are regional and species-specific differences in the immune responses in FRT.

Published
2024
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32. Possible impact of neutrophils on immune responses during early pregnancy in ruminants

Author

Fiorenza, Mariani Farias, Amaral, Carolina dos Santos, Anunciação, Adriana Raquel de Almeida da, Portela, Valério Valdetar Marques, Marey, Mohammed Ali, Miyamoto, Akio, and Antoniazzi, Alfredo Quites

Subjects
inflammation, cattle, chemical and pharmacologic phenomena, interferon tau, innate cells
Abstract

The interaction between early embryo and maternal immune system for the establishment of pregnancy is the focus of several studies; however, it remains unclear. The maternal immune response needs to keep a balance between avoiding any damage to the conceptus and maintaining its function in combating microbes as well. When conceptus-maternal crosstalk cannot achieve this balance, pregnancy losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. In ruminants, the embryo reacts with the maternal system mainly via interferon tau (IFNT) release. IFNT can act locally on the embryo and endometrial cells and systemically in several tissues and cells to regulate their response via the expression of interferon-stimulated genes (ISGs). Also, IFNT can induce the expression of inflammatory-related genes in immune cells. Day 7 embryo induces a shift in the maternal immune response towards anti-inflammatory (Th2) immune responses. During maternal recognition of pregnancy, peripheral mononuclear cells (PBMCs) and polymorphonuclear cells (PMNs) express markers that configure an anti-inflammatory response. However, PMNs response is more sensitive to the effects of IFNT. PMNs are more likely to express interferon-stimulated genes (ISGs), transforming growth factor-beta (TGFB), interleukin 10 (IL10), and arginase-1 (ARG1), configuring one of the most rapid immune responses to early pregnancy. This review focus on the local and peripheral immune responses during early pregnancy in ruminants, mainly the PMNs function in the immune system.

Published
2021

36. Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy

Author

Fiorenza, Mariani F., primary, Marey, Mohamed A., additional, Rashid, Mohammad B., additional, Zinnah, Mohammad A., additional, Ma, Dongxue, additional, Morillo, Vernadyn A., additional, Kusama, Kazuya, additional, Shimada, Masayuki, additional, Imakawa, Kazuhiko, additional, Antoniazzi, Alfredo Q., additional, and Miyamoto, Akio, additional

Published
2021
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44. Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium

Author

Elesh, Ibrahim Fouad, primary, Marey, Mohamed Ali, additional, Zinnah, Mohammed Ali, additional, Akthar, Ihshan, additional, Kawai, Tomoko, additional, Naim, Fayrouz, additional, Goda, Wael, additional, Rawash, Abdel Rahman A., additional, Sasaki, Motoki, additional, Shimada, Masayuki, additional, and Miyamoto, Akio, additional

Published
2021
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49. Peptidoglycan disrupts early embryo-maternal crosstalk via suppression of ISGs expression induced by interferon-tau in the bovine endometrium

Author

Zinnah, Mohammad A., primary, Marey, Mohamed A., additional, Akhtar, Ihshan, additional, Elesh, Ibrahim F., additional, Matsuno, Yuta, additional, Elweza, Ahmed E., additional, Ma, Dongxue, additional, Fiorenza, Mariani, additional, Sasaki, Motoki, additional, Shimada, Masayuki, additional, Imakawa, Kazuhiko, additional, and Miyamoto, Akio, additional

Published
2020
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