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13. Hepatologie

Author

Löke, S., Brede, H. D., Möller, B., Hopf, U., Shirpai, M., Lobeck, H., Theilmann, L., Gmelin, K., Will, H., Renz, M., Czygan, P., Roggendorf, M., Kommerell, B., Rasenack, J., Pausch, J., Gerok, W., Poralla, T., Hütteroth, T. H., Meyer zum Büschenfelde, K.-H., Holstege, A., Staritz, M., Ewe, K., Schulz, R., Hahn, U., Schuppan, D., Hahn, E. G., Riecken, E. G., Stellaard, F., Sackmann, M., Sauerbruch, T., Paumgartner, G., Wietholtz, H., Miltenberger, C., Buscher, H. P., Maurer, P., Bartel, J. H., Miing, D., Dölle, W., Berg, P. A., Penner, E., Hitchman, E., Bakos, S., Reichlin, M., Burghardt, W., Schweisfurth, H., Wernze, H., Loewe, Ch., Riecken, E. O., Klein, Chr.-P., Grein, N., Heinrich, R., Dette, S., Günderoth-Palmowski, M., Grauer, W., Schomerus, H., Grün, M., Goerig, M., Höfler, B., Peter, G., Hain, P., Werner, E., Spörle, A., Beyermann, P., Lippold, R., Okonek, S., Theile, U., Rühlmann, Th., Rebhuhn, S., Stremmel, W., Borchard, F., Teschke, R., Hödtke, R., Berk, P. D., Strohmeyer, G., Schölmerich, J., Kitamura, S., Miyai, K., Miehlke, Klaus, editor, and Bergmann, J. F.

Published
1984
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21. UCSD's MedPics: implementation and impact on the curriculum

Author

Hoffman, H. M., Irwin, A. E., Baird, S., Bloor, C. M., Miyai, K., and Savoia, M. C.

Subjects
Histology, education, Image Processing, Computer-Assisted, Pathology, Humans, Curriculum, Hematology, California, Schools, Medical, Research Article, Computer-Assisted Instruction, Education, Medical, Undergraduate, Program Evaluation
Abstract

MedPics is a computer-based image delivery system with supporting text fields and on-screen graphics to assist in key feature identification. It has been used by the University of California, San Diego as an integral part of the Human Disease course since 1992. Initially created to support pathology and histology, the program has now expanded to include hematology. MedPics has had a positive impact on the second year curriculum for which it was created. Moreover, use of this program has improved student attitudes toward computer-based resources and increased faculty interest in instructional development.

Published
1993

25. A Hamartoma of the Colon with Unusual Features

Author

Davis E, Miyai K, and Chow C

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Pathology, medicine.medical_specialty, Unusual case, medicine.diagnostic_test, business.industry, Hamartoma, Gastroenterology, Colonoscopy, Sigmoid colon, medicine.disease, digestive system diseases, Polypoid Lesion, Lesion, medicine.anatomical_structure, Colonic Neoplasms, otorhinolaryngologic diseases, medicine, Humans, medicine.symptom, business, Aged
Abstract

An unusual case of colonic hamartoma in a 67-year-old man is reported. Colonoscopy polyp surveillance revealed a polypoid lesion of the sigmoid colon which had the characteristics of a hamartoma on microscopic examination. The lesion, which was classified as a colonic hamartoma, is described. Review of the literature revealed no previous report of such a colonic poylp.

Published
1991

42. Cutaneous Biology Prolonged recovery of ultraviolet B-irradiated skin in neuropsin ( KLK8)-deficient mice.

Author

Kirihara, T., Matsumoto-Miyai, K., Nakamura, Y., Sadayama, T., Yoshida, S., and Shiosaka, S.

Subjects
*EPIDERMIS, *KALLIKREIN, *KERATINOCYTES, *SERINE proteinases
Abstract

Neuropsin ( KLK8), a serine protease of the kallikrein family, is thought to be involved in the function of keratinocytes, i.e. migration, differentiation and desquamation. However, how neuropsin participates is still unknown. To observe the epidermal function of serine protease in neuropsin-deficient mice. We irradiated the skin of neuropsin-deficient mice with ultraviolet light to induce acute inflammation and compared the morphology with that of wild-type mice. We observed a phenotypic change in the epidermis. An acute inflammatory dose of ultraviolet light induced a marked increase in neuropsin mRNA expression in the skin. The signal intensity of the mRNA expression was highest on day 2–3 after irradiation, when keratinocytes were aligned irregularly in the recovery period. Morphological comparison between neuropsin –/– and +/+ mice revealed that an irregular alignment of cells in the thickened epidermis was obvious on day 2 after irradiation in the wild-type mice, whereas it was prolonged for at least 2 days in the neuropsin-deficient mice. The stratum corneum of neuropsin-deficient mice was remarkably thicker than that of the wild-type mice at 5, 14 and 21 days after irradiation. The increase, as a response to this stimulus, in involucrin immunoreactivity, a marker for cell envelope assembly, was delayed in the mutant mice. Thus, neuropsin might be involved early in the process of differentiation, such as in the assembly of the cell envelope, but not in migration and desquamation. [ABSTRACT FROM AUTHOR]

Published
2003
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