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6. Prevalence of common aneuploidy in twin pregnancies

Author

Konishi, Akiko, Samura, Osamu, Muromoto, Jin, Okamoto, Yoko, Takahashi, Hironori, Kasai, Yasuyo, Ichikawa, Mayuko, Yamada, Naoki, Kato, Noriko, Sato, Hiroshi, Hamada, Hiromi, Nakanami, Naoyuki, Machi, Maya, Ichizuka, Kiyotake, Sunami, Rei, Tanaka, Toshitaka, Yonetani, Naoto, Kamei, Yoshimasa, Nagamatsu, Takeshi, Matsumoto, Mariko, Tairaku, Shinya, Fujiwara, Arisa, Nakamura, Hiroaki, Harada, Takashi, Watanabe, Takafumi, Sasaki, Shoko, Kawaguchi, Satoshi, Minami, Sawako, Ogawa, Masaki, Miura, Kiyonori, Suzumori, Nobuhiro, Kojima, Junya, Kotani, Tomomi, Sasaki, Rumi, Baba, Tsukasa, Toyofuku, Aya, Endo, Masayuki, Takeshita, Naoki, Taketani, Takeshi, Sase, Masakatsu, Matsubara, Keiichi, Hayata, Kei, Hamada, Yoshinobu, Egawa, Makiko, Kakinuma, Toshiyuki, Matsushima, Sachio, Kitagawa, Michihiro, Shiga, Tomomi, Kurashina, Ryuhei, Hamada, Hironori, Takagi, Hiroaki, Kondo, Akane, Miharu, Norio, Yamashita, Michiko, Horiya, Madoka, Morimoto, Keiji, Takahashi, Ken, Okamoto, Aikou, Sekizawa, Akihiko, and Sago, Haruhiko

Published
2022
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9. Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Takeda, Eri, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Nakayama, Setsuko, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Yamaguchi, Masayuki, Tairaku, Shinya, Maeda, Kazuhisa, Kaji, Takashi, Okamoto, Yoko, Endo, Masayuki, Ogawa, Masaki, Kasai, Yasuyo, Ichizuka, Kiyotake, Yamada, Naoki, Ida, Akinori, Miharu, Norio, Kawaguchi, Satoshi, Hasuo, Yasuyuki, Okazaki, Tetsuya, Ichikawa, Mayuko, Izumi, Shunichiro, Kuno, Naohiko, Yotsumoto, Junko, Nishiyama, Miyuki, Shirato, Nahoko, Hirose, Tatsuko, and Sago, Haruhiko

Published
2021
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10. HTLV-1 targets human placental trophoblasts in seropositive pregnant women

Author

Tezuka, Kenta, Fuchi, Naoki, Okuma, Kazu, Tsukiyama, Takashi, Miura, Shoko, Hasegawa, Yuri, Nagata, Ai, Komatsu, Nahoko, Hasegawa, Hiroo, Sasaki, Daisuke, Sasaki, Eita, Mizukami, Takuo, Kuramitsu, Madoka, Matsuoka, Sahoko, Yanagihara, Katsunori, Miura, Kiyonori, and Hamaguchi, Isao

Subjects
Viral research, Disease transmission -- Development and progression, Maternal-fetal exchange -- Research, Perinatal infection -- Development and progression, Trophoblasts -- Health aspects, HTLV-I infections -- Development and progression, Health care industry
Abstract

Human T cell leukemia virus type 1 (HTLV-1) is mainly transmitted vertically through breast milk. The rate of mother-to-child transmission (MTCT) through formula feeding, although significantly lower than through breastfeeding, is approximately 2.4%-3.6%, suggesting the possibility of alternative transmission routes. MTCT of HTLV-1 might occur through the uterus, birth canal, or placental tissues; the latter is known as transplacental transmission. Here, we found that HTLV-1 proviral DNA was present in the placental villous tissues of the fetuses of nearly half of pregnant carriers and in a small number of cord blood samples. An RNA ISH assay showed that HTLV-1-expressing cells were present in nearly all subjects with HTLV- 1positive placental villous tissues, and their frequency was significantly higher in subjects with HTLV-1-positive cord blood samples. Furthermore, placental villous trophoblasts expressed HTLV-1 receptors and showed increased susceptibility to HTLV-1 infection. In addition, HTLV-1-infected trophoblasts expressed high levels of viral antigens and promoted the de novo infection of target T cells in a humanized mouse model. In summary, during pregnancy of HTLV-1 carriers, HTLV-1 was highly expressed in placental villous tissues, and villous trophoblasts showed high HTLV-1 sensitivity, suggesting that MTCT of HTLV-1 occurs through the placenta., Introduction Human T cell leukemia virus type 1 (HTLV-1) infection is endemic in Japan, the southern Unites States, central Australia, the Caribbean, Jamaica, South America, and equatorial Africa (1, 2). [...]

Published
2020
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11. Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations

Author

Kuramitsu, Madoka, primary, Momose, Haruka, additional, Uchida, Yuichiro, additional, Ishitsuka, Kenji, additional, Kubota, Ryuji, additional, Tokunaga, Masahito, additional, Utsunomiya, Atae, additional, Umekita, Kunihiko, additional, Hashikura, Yuuki, additional, Nosaka, Kisato, additional, Koh, Ki-Ryang, additional, Nakamura, Hitomi, additional, Sagara, Yasuko, additional, Sobata, Rieko, additional, Satake, Masahiro, additional, Nagata, Koh, additional, Hasegawa, Yuri, additional, Sasaki, Daisuke, additional, Hasegawa, Hiroo, additional, Sato, Tomoo, additional, Yamano, Yoshihisa, additional, Hiraga, Kou, additional, Tezuka, Kenta, additional, Ikebe, Emi, additional, Matsuoka, Sahoko, additional, Okuma, Kazu, additional, Watanabe, Toshiki, additional, Miura, Kiyonori, additional, and Hamaguchi, Isao, additional

Published
2023
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15. Identification of pregnancy associated placenta-specific circRNA

Author

Murakami, Toru, primary, Eishi, Chiaki, additional, Shigematsu, Yusuke, additional, Matsumura, Asako, additional, Nagata, Koh, additional, Miyashita, Noriko, additional, Matsumoto, Kanako, additional, Kitajima, Yuriko, additional, Hasegawa, Yuri, additional, and Miura, Kiyonori, additional

Published
2023
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16. A case of fetal growth restriction with placental confined mosaicism

Author

Nunoshita, Kyoko, primary, Hasegawa, Yuri, additional, Kobashikawa, Saki, additional, Nishi, Masaki, additional, Eishi, Chiaki, additional, Shigematsu, Yusuke, additional, Miyashita, Noriko, additional, Shigetomi, Noriko, additional, Kajimura, Itsuki, additional, Nagata, Ai, additional, Morisaki, Sachiko, additional, and Miura, Kiyonori, additional

Published
2023
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19. Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Ebara, Takeshi, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Izumi, Haruna, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Yamashita, Takahiro, Okai, Takashi, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Tanemoto, Tomohiro, Fukushima, Akimune, Haino, Kazufumi, Tairaku, Shinya, Matsubara, Keiichi, Maeda, Kazutoshi, Kaji, Takashi, Ogawa, Masanobu, Osada, Hisao, Nishizawa, Haruki, Okamoto, Yoko, Kanagawa, Takeshi, Kakigano, Aiko, Kitagawa, Michihiro, Ogawa, Masaki, Izumi, Shunichiro, Katagiri, Yukiko, Takeshita, Naoki, Kasai, Yasuyo, Naruse, Katsuhiko, Neki, Reiko, Masuyama, Hisashi, Hyodo, Maki, Kawano, Yukie, Ohba, Takashi, Ichizuka, Kiyotake, Nagamatsu, Takeshi, Watanabe, Atsushi, Shirato, Nahoko, Yotsumoto, Junko, Nishiyama, Miyuki, Hirose, Tatsuko, and Sago, Haruhiko

Published
2018
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22. Concomitant cancer surgery and risk-reducing surgery for noninvasive breast cancer diagnosed during surveillance for undiagnosed hereditary breast and ovarian cancer (HBOC) syndrome: A case report

Author

Tanaka, Aya, primary, Matsumoto, Megumi, additional, Takao, Mami, additional, Miura, Shoko, additional, Hasegawa, Yuri, additional, Otsubo, Ryota, additional, Hayashi, Hiroko, additional, Isomoto, Ichiro, additional, Miura, Kiyonori, additional, and Nagayasu, Takeshi, additional

Published
2023
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23. Dysgerminoma of the Left Ovary in a Patient with Balanced Translocation 46X, t(X:1) (q22;q21): A Case Report

Author

Nagata, Koh, Shimada, Takako, Eishi, Chiaki, Nishi, Masaki, Murakami, Toru, Ohashi, Kazuaki, Kajimura, Itsuki, Miura, Kiyonori, Nagata, Koh, Shimada, Takako, Eishi, Chiaki, Nishi, Masaki, Murakami, Toru, Ohashi, Kazuaki, Kajimura, Itsuki, and Miura, Kiyonori

Abstract

We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and a large tumor in the pelvis was discovered. She was admitted to our hospital for further examination of the pelvic tumor. She underwent laparotomy and was diagnosed with stage IIIA1 dysgerminoma (pT3apN0pM0) of the left ovary. Young female patients without the Y chromosome who are treated for primary amenorrhea may also develop malignant germ cell tumors; therefore, gynecologists should provide hormone replacement therapy and periodic pelvic evaluation., International Medical Case Reports Journal, 16, pp.117-122; 2023

Published
2023

24. AMH producing purely cystic virilizing adult granulosa cell tumor in 17years old girl: a case report and review of literatures

Author

Kitajima, Michio, Kajimura, Itsuki, Kitajima, Yuriko, Murakami, Naoko, Matsumura, Asako, Matsumoto, Kanako, Harada, Ayumi, Hasegawa, Yuri, Miura, Kiyonori, Kitajima, Michio, Kajimura, Itsuki, Kitajima, Yuriko, Murakami, Naoko, Matsumura, Asako, Matsumoto, Kanako, Harada, Ayumi, Hasegawa, Yuri, and Miura, Kiyonori

Abstract

Background: Androgen-producing granulosa cell tumor in adolescent girl is rare condition and clinical characteristics are not fully elucidated. Case presentation: Seventeen years old girl complained of secondary amenorrhea was referred to our out-patient consultation. Markedly elevated serum testosterone, LH, and AMH levels were noted. Mild hirsutism and clitoromegaly were presented. Transabdominal ultrasonography and MRI revealed cystic mass occupied pelvic cavity probably originated from left ovary. Right ovary showed polycystic appearance. Laparoscopic left ovarian cystectomy was performed. After the surgery, her menstruation resumed along with normalized hormonal parameters, and clinical hyperandrogenism were improved. Since the scarcity of cellular lining of inner cyst wall, definitive pathological diagnosis was difficult. After the consultation with gynecological pathologist, the tumor was diagnosed as sex cord stromal tumor, highly suspicious for adult granulosa cell tumor. Residual left salpingo-oophorectomy was performed by additional laparoscopic surgery. Her serum testosterone and AMH levels were remained low with regular menstrual cycles and no evidence of recurrence. Conclusions: Androgen-producing cystic granulosa cell tumor is rare gynecological disorders, which need both gynecologic oncological and endocrinological approach. Its clinical manifestations may bring some clues to the pathogenesis of ovulatory dysfunctions, such as polycystic ovary syndrome., Journal of ovarian research, 16(1), art. no. 52; 2023

Published
2023

25. Dysgerminoma of the Left Ovary in a Patient with Balanced Translocation 46X, t(X:1) (q22;q21): A Case Report

Author

Nagata,Koh, Shimada,Takako, Eishi,Chiaki, Nishi,Masaki, Murakami,Toru, Ohashi,Kazuaki, Kajimura,Itsuki, Miura,Kiyonori, Nagata,Koh, Shimada,Takako, Eishi,Chiaki, Nishi,Masaki, Murakami,Toru, Ohashi,Kazuaki, Kajimura,Itsuki, and Miura,Kiyonori

Abstract

Koh Nagata, Takako Shimada, Chiaki Eishi, Masaki Nishi, Toru Murakami, Kazuaki Ohashi, Itsuki Kajimura, Kiyonori Miura Obstetrics and Gynecology, Nagasaki University Hospital, Nagasaki, JapanCorrespondence: Koh Nagata, Obstetrics and Gynecology, Nagasaki University Hospital, Nagasaki, Japan, Tel +81 95 819 7363, Fax +81 95 819 7365, Email k.nagata.nagasaki.obgyn@gmail.comAbstract: We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and a large tumor in the pelvis was discovered. She was admitted to our hospital for further examination of the pelvic tumor. She underwent laparotomy and was diagnosed with stage IIIA1 dysgerminoma (pT3apN0pM0) of the left ovary. Young female patients without the Y chromosome who are treated for primary amenorrhea may also develop malignant germ cell tumors; therefore, gynecologists should provide hormone replacement therapy and periodic pelvic evaluation.Keywords: primary amenorrhea, balanced translocation, dysgerminoma

Published
2023

26. Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

Author

Okuma, Kazu, Kuramitsu, Madoka, Niwa, Toshihiro, Taniguchi, Tomokuni, Masaki, Yumiko, Ueda, Gohzoh, Matsumoto, Chieko, Sobata, Rieko, Sagara, Yasuko, Nakamura, Hitomi, Satake, Masahiro, Miura, Kiyonori, Fuchi, Naoki, Masuzaki, Hideaki, Okayama, Akihiko, Umeki, Kazumi, Yamano, Yoshihisa, Sato, Tomoo, Iwanaga, Masako, Uchimaru, Kaoru, Nakashima, Makoto, Utsunomiya, Atae, Kubota, Ryuji, Ishitsuka, Kenji, Hasegawa, Hiroo, Sasaki, Daisuke, Koh, Ki-Ryang, Taki, Mai, Nosaka, Kisato, Ogata, Masao, Naruse, Isao, Kaneko, Noriaki, Okajima, Sara, Tezuka, Kenta, Ikebe, Emi, Matsuoka, Sahoko, Itabashi, Kazuo, Saito, Shigeru, Watanabe, Toshiki, and Hamaguchi, Isao

Published
2020
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28. Four conserved amino acids on human papillomavirus E6 predict clinical high‐risk types.

Author

Niiya, Akari, Hamaguchi, Yo, Mishima, Hiroyuki, Miura, Shoko, Komatsu, Nahoko, Nagata, Koh, Hasegawa, Yuri, Miura, Kiyonori, and Yoshiura, Koh‐ichiro

Subjects
HUMAN papillomavirus, AMINO acids, CARCINOGENICITY, PAPILLOMAVIRUSES
Abstract

Human papillomavirus (HPV) types included in the genus alpha papillomavirus (alpha‐HPVs) are subdivided into high‐ and low‐risk HPVs associated with tumorigenicity. According to conventional risk classification, over 30 alpha‐HPVs remain unclassified and HPV groups phylogenetically classified using the L1 gene do not exactly correspond to the conventional risk classification groups. Here, we propose a novel cervical lesion progression risk classification strategy. Using four E6 risk distinguishable amino acids (E6‐RDAAs), we successfully expanded the conventional classification to encompass alpha‐HPVs and resolve discrepancies. We validated our classification system using alpha‐HPV‐targeted sequence data of 325 cervical swab specimens from participants in Japan. Clinical outcomes significantly correlated with the E6‐RDAA classification. Four of five HPV types in the data set that were not conventionally classified (HPV30, 34, 67, and 69) were high‐risk according to our classification criteria. This report sheds light on the carcinogenicity of rare genital HPV types using a novel risk classification strategy. [ABSTRACT FROM AUTHOR]

Published
2023
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29. “Welcome to OBGYN World!” A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology

Author

Miyake, Ryuta, primary, Komatsu, Hiroaki, additional, Ihira, Kei, additional, Hasegawa, Akihiro, additional, Maeda, Yuto, additional, Takemori, Satoshi, additional, Noguchi, Masashi, additional, Dofutsu, Mihoko, additional, Onodera, Yohei, additional, Shinagawa, Manaka, additional, Suemitsu, Tokumasa, additional, Sugita, Yosuke, additional, Higuchi, Yayoi, additional, Izaki, Nanae, additional, Kodera, Chisato, additional, Nagase, Yoshikazu, additional, Odawara, Kei, additional, Ogura, Junpei, additional, Osaku, Daiken, additional, Ohsuga, Takuma, additional, Enomoto, Naosuke, additional, Kanai, Takahiro, additional, Mishima, Sakurako, additional, Morita, Keiko, additional, Otsuka, Satoyo, additional, Suzuki, Kensuke, additional, Miura, Kiyonori, additional, and Yoshida, Yoshio, additional

Published
2022
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35. Association of online activities with obstetrics and gynecology specialty choice: a nationwide online survey

Author

Maeda, Yuto, primary, Hasegawa, Akihiro, additional, Miyake, Ryuta, additional, Dofutsu, Mihoko, additional, Higuchi, Yayoi, additional, Osaku, Daiken, additional, Suemitsu, Tokumasa, additional, Onodera, Yohei, additional, Shozu, Makio, additional, Miura, Kiyonori, additional, Yoshida, Yoshio, additional, Komatsu, Hiroaki, additional, and Watari, Hidemichi, additional

Published
2022
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40. Association of online activities with obstetrics and gynecology specialty choice : a nationwide online survey

Author

Maeda, Yuto, Hasegawa, Akihiro, Miyake, Ryuta, Dofutsu, Mihoko, Higuchi, Yayoi, Osaku, Daiken, Suemitsu, Tokumasa, Onodera, Yohei, Shozu, Makio, Miura, Kiyonori, Yoshida, Yoshio, Komatsu, Hiroaki, 1000010344508, Watari, Hidemichi, Maeda, Yuto, Hasegawa, Akihiro, Miyake, Ryuta, Dofutsu, Mihoko, Higuchi, Yayoi, Osaku, Daiken, Suemitsu, Tokumasa, Onodera, Yohei, Shozu, Makio, Miura, Kiyonori, Yoshida, Yoshio, Komatsu, Hiroaki, 1000010344508, and Watari, Hidemichi

Abstract

Objectives: To investigate the association between online ac-tivities and the number of new obstetrics and gynecology senior residents. Methods: A nationwide web-based, self-administered anon-ymous survey was conducted to investigate recruitment and clerkship activities during the coronavirus disease 2019 pan-demic. An online questionnaire was sent to 576 obstetrics and gynecology training institutions in Japan between De-cember 21, 2020, and January 31, 2021. Overall, 334 institu-tions that gave valid responses were included (response rate: 58.0%). Multivariate logistic regression analysis examined the association between online activities, including recruitment and clerkship activities, and the number of new obstetrics and gynecology senior residents in 2021. The stratified analysis by implementing face-to-face activities was conducted to clarify the association.Results: The number of new senior residents increased in 187 facilities (56.0%) and decreased in 147 facilities (44.0%). The facilities that implemented face-to-face and online activities were 185 (55.4%) and 120 (35.9%), respectively. In multivariate logistic regression analysis, an increased number of new obstetrics and gynecology senior residents was significantly associated with face-to-face activities (adjusted odds ratio (AOR)=2.58, 95% confidence interval (CI): 1.11-5.97, p<.001) but not with online activities. In the stratified analysis, online activities were significantly associated with an increased number of new obstetrics and gynecology senior residents among the facilities without face-to-face activities (AOR=3.81, 95% CI: 1.40-10.32, p=.009) but not among those with face-to-face activities (AOR=0.87, 95% CI: 0.42-1.78).Conclusions: Online activities were associated with an increased number of new obstetrics and gynecology senior residents among the facilities that did not conduct face-to -face activities.

Published
2022

41. Retained products of conception (RPOC) following delivery without placenta previa: Which patients with RPOC show postpartum hemorrhage?

Author

Takahashi, Hironori, primary, Tanaka, Hiroaki, additional, Osuga, Yutaka, additional, Miura, Kiyonori, additional, Saito, Shigeru, additional, Sato, Shoji, additional, Sugawara, Junichi, additional, Ide, Sanae, additional, Koh, Iiji, additional, Yamauchi, Keiko, additional, Okuyama, Ayumi, additional, Okuno, Kentaro, additional, Kuwata, Tomoyuki, additional, Fujieda, Satoko, additional, and Ikeda, Tomoaki, additional

Published
2022
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42. Challenges facing workstyle reform for Japanese obstetricians and gynecologists revealed from time studies

Author

Sekine, Masayuki, primary, Nishijima, Koji, additional, Nakagawa, Satoshi, additional, Suzuki, Yukio, additional, Murakami, Takashi, additional, Kato, Yasuhito, additional, Umazume, Takeshi, additional, Tanaka, Hiroaki, additional, Komatsu, Hiroaki, additional, Doi, Koutaro, additional, Miura, Kiyonori, additional, Kudo, Yoshiki, additional, Unno, Nobuya, additional, Kimura, Tadashi, additional, and Enomoto, Takayuki, additional

Published
2022
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44. Cytomegalovirus (CMV) colitis associated with chemotherapy and molecular targeted therapy for gynecologic cancer: A case report of ovarian cancer

Author

Komatsu, Nahoko, Shimada, Takako, Higashijima-Nagata, Ai, Ohashi, Kazuaki, Abe, Syuhei, and Miura, Kiyonori

Subjects
Chemotherapy in gynecologic cancers, Epithelial Cancer of the Ovary, Infections
Abstract

Cytomegalovirus (CMV) colitis associated with chemotherapy for gynecologic cancer is rare. We report a case of CMV colitis linked to treatment with paclitaxel/carboplatin (TC) and bevacizumab (BEV) for ovarian cancer. Our patient was a 59-year-old woman who completed one course of TC chemotherapy and one course of TC + BEV as neoadjuvant chemotherapy for advanced ovarian cancer. On the 7th day of TC + BEV therapy, she visited our hospital for continuous diarrhea, abdominal pain, and melena. Grade 4 neutropenia and fever were also detected. She was diagnosed as CMV colitis via colonoscopy and histopathological examination. This is the first case report of CMV colitis complicated by chemotherapy-induced febrile neutropenia during the treatment for gynecologic cancer., Acta medica Nagasakiensia, 65(1), pp.17-19; 2021

Published
2021

49. Genetic counseling for trisomy X syndrome diagnosed by amniocentesis: a case report

Author

Hasegawa, Yuri, Miyata, Mikako, Miura, Shoko, Nagata, Ai, Tomonaga, Chiharu, Shigetomi, Noriko, and Miura, Kiyonori

Subjects
chromosome abnormality, genetic counseling, perinatal diagnosis, trisomy X syndrome
Abstract

[Introduction] Trisomy X is a sex chromosome abnormality that occurs in approximately 1 in 1,000 female births. We provided genetic counseling to a pregnant woman and her husband following the prenatal diagnosis of trisomy X by amniocentesis. [Case] A 27-year-old pregnant woman, gravida 2, para 1, underwent a prenatal checkup by her general practitioner. Nuchal translucency (NT) of 3.4 mm was detected in the fetus at 11 weeks of gestation and had disappeared by 12 weeks of gestation. The pregnant woman and her husband consulted our unit for genetic counseling at 13 weeks of gestation. Although we did not detect any NT or other abnormality in the fetus, the parents were concerned about possible abnormalities and requested amniocentesis. Amniocentesis followed by chromosomal analysis at 16 weeks of gestation revealed a 47, XXX karyotype. We explained the results and characteristics of trisomy X to the couple. The frequency of trisomy X is 1 in 1,000, and it can be characterized by tall stature, developmental delay, learning disability, anxiety, and mood disorders. However, the features of trisomy X vary and we were therefore unable to predict the newborn's precise postnatal physical and psychological characteristics. The couple decided to continue the pregnancy, and a female newborn was delivered at 38 weeks of gestation weighing 2,418 g. The karyotype was confirmed as 47,XXX, but her development to date (age of 2 years) has been normal. [Conclusions] Careful genetic counseling is important for pregnant women and their partners following a prenatal diagnosis of trisomy X., Acta medica Nagasakiensia, 64(1), pp.31-34; 2020

Published
2020

50. Coincidental detection of diffuse large B-cell lymphoma in the inner inguinal lymph node of a woman undergoing laparoscopic pelvic lymph node dissection for uterine endometrial cancer

Author

Ohashi, Kazuaki, Shimada, Takako, Kitajima, Michio, Harada, Ayumi, Kaneuchi, Masanori, and Miura, Kiyonori

Subjects
Uterine endometrial cancer, immune system diseases, hemic and lymphatic diseases, Non-Hodgkin's lymphoma, Pelvic lymph node dissection
Abstract

Simultaneous occurrence of non-Hodgkin's lymphoma (NHL) and solid carcinomas, such as colon, lung, and breast cancers,is relatively rare. We report a case of coincidental detection of diffuse large B-cell lymphoma (DLBCL) in the inner inguinal lymph node of a patient with uterine endometrial cancer FIGO stage IA. The patient was a 69-year-old woman and she visited a primary care doctor presenting with increased vaginal discharge. She was diagnosed as having uterine endometrial carcinoma. Laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection were performed. The final pathologic examination revealed uterine endometrial carcinoma (endometrioid carcinoma grade 1) and DLBCL was detected in the inner inguinal lymph node. No other malignant lymphoma legions were detected by positron emission tomography-computed tomography (PET-CT). She was diagnosed as having uterine endometrial carcinoma FIGO stage IA (pT1apN0pM0) and malignant lymphoma stage I according to the Ann Arbor clinical staging system. She was treated with six cycles of chemotherapy comprising rituximab, cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP) for the malignant lymphoma. The patient remains in complete remission 8 months after completing chemotherapy., Acta medica Nagasakiensia, 63(2), pp.91-94; 2020

Published
2020

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