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3. New trends of drug abuse in custodial settings: A systematic review on the misuse of over-the-counter drugs, prescription-only-medications, and new psychoactive substances

Author

Chiappini, Stefania, Vaccaro, Giorgia, Mosca, Alessio, Miuli, Andrea, Stigliano, Gianfranco, Stefanelli, Giulia, Giovannetti, Giulia, Carullo, Rosalba, d’Andrea, Giacomo, Di Carlo, Francesco, Cavallotto, Clara, Pettorruso, Mauro, Di Petta, Gilberto, Corkery, John Martin, Guirguis, Amira, Stair, Jacqueline L., Martinotti, Giovanni, Fazel, Seena, and Schifano, Fabrizio

Published
2024
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5. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Aguglia, Eugenio, Aguglia, Andrea, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Barbato, Angelo, Barbui, Corrado, Bartoli, Francesco, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callegari, Camilla, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandro, Carbone, Elvira, Carosielli, Doriana, Carrà, Giuseppe, Cartabia, Massimo, Caselli, Ivano, Cavaleri, Daniele, Cavallotti, Simone, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, D'Agostino, Armando, D'Avanzo, Barbara, De Fazio, Pasquale, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Gari, Matteo, Gastaldon, Chiara, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Ielmini, Marta, Ingrosso, Gianmarco, Isella, Celeste, Lax, Annamaria, Mammarella, Silvia, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Monti, Igor, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Ostuzzi, Giovanni, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Rodolico, Alessandro, Romito, Samantha, Ronchi, Barbara, Roncone, Rita, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sterzi, Enrico, Sturiale, Serena, Tambelli, Antonio, Tettamanti, Mauro, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Canozzi, Andrea, Carbone, Elvira Anna, Caruso, Rosangela, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, de Filippis, Renato, Martinotti, Giovanni, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, and Amaddeo, Francesco

Published
2024
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8. Exploring vortioxetine combination with intranasal esketamine: A feasible alternative to SSRI/SNRI? - Insights from the REAL-ESK study.

Author

d'Andrea, Giacomo, Miuli, Andrea, Pettorruso, Mauro, Cavallotto, Clara, Marrangone, Carlotta, Cocco, Alessio, De Filippis, Sergio, Martiadis, Vassillis, Andriola, Ileana, Barlati, Stefano, Vita, Antonio, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Di Lorenzo, Giorgio, and Martinotti, Giovanni

Subjects
*MENTAL depression, *PSYCHIATRIC rating scales, *SEROTONIN uptake inhibitors, *INTRANASAL medication, *RANDOMIZED controlled trials
Abstract

Treatment-Resistant Depression (TRD) affects almost 30 % of patients with Major Depressive Disorder (MDD). Esketamine Nasal Spray (ESK-NS) has recently been approved for TRD in combination with a Serotonin Specific Reuptake Inhibitor/SSRI or a Serotonin-Norepinephrine Reuptake Inhibitor/SNRI. There is a lack of studies investigating the effectiveness and safety of ESK-NS in combination with other oral antidepressants. To assess the efficacy of Vortioxetine plus ESK-NS in mitigating depressive symptoms and emotional blunting, as well as its tolerability in TRD subjects, compared to the standard-of-care of SSRI/SNRI plus ESK-NS. We conducted a post-hoc analysis of the REAL-ESK study. The study included twenty TRD patients, ten subjects taking Vortioxetine as the main oral antidepressant with ESK-NS, and ten subjects taking SSRI or SNRI with ESK-NS. Psychometric assessments (Montgomery-Åsberg Depression Rating Scale/MADRS, Brief Psychiatric Rating Scale/BPRS) were conducted at baseline(T0), one month(T1), and three months after the treatment initiation(T2). The combination of Vortioxetine and ESK-NS was as effective as the standard-of-care in reducing depressive symptoms, with a higher effect size in reducing emotional blunting at T2. The safety and tolerability profile of the Vortioxetine+ESK-NS combination appeared to be better, with a lower rate of treatment-emergent adverse events. The combination of Vortioxetine and ESK-NS may be a valuable alternative to the standard-of-care SSRI/SNRI plus ESK-NS in TRD patients, particularly regarding the reduction of emotional blunting and potentially a better safety and tolerability profile. Further randomized controlled trials with larger sample sizes and prospective designs are needed to confirm these findings. • Esketamine nasal spray (ESK-NS) is a new treatment for TRD. • Standard-of-care combines ESK-NS with SSRIs or SNRIs. • We compared the effectiveness of Vortioxetine + ESK-NS vs. SSRI/SNRI + ESK-NS. • We found similar antidepressant effect with a better safety profile for Vortioxetine. • Vortioxetine + ESK-NS was more effective against emotional blunting. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Methylphenidate abuse and misuse in patients affected with a psychiatric disorder and a substance use disorder: a systematic review.

Author

Chiappini, Stefania, Gramuglia, Pietro Domenico, Mosca, Alessio, Cavallotto, Clara, Miuli, Andrea, Corkery, John Martin, Guirguis, Amira, Schifano, Fabrizio, and Martinotti, Giovanni

Subjects
PEOPLE with mental illness, ALCOHOLISM, MENTAL illness, CENTRAL nervous system stimulants, MARIJUANA abuse
Abstract

Background: Methylphenidate (MPH), a central nervous system stimulant primarily prescribed for attention-deficit/hyperactivity disorder (ADHD), has seen increasing rates of misuse and abuse, particularly in patients with dual diagnosis (co-occurring psychiatric disorders and substance use disorders/SUDs). The heightened risk of dependence and adverse effects in these vulnerable populations warrants a systematic review to assess the prevalence and pattern of abuse/misuse of MPH among patients within this population and to understand potential risk factors, patterns of misuse, and outcomes, including the impact on psychiatric symptoms and overall mental health, the effects on SUD (e.g., exacerbation or mitigation of symptoms), and the incidence of adverse events and complications (e.g., cardiovascular issues, psychological effects). Methodology: A systematic review was conducted in August-September 2024 using both PubMed and Scopus databases. The following search strategy was used: TITLE-ABS-KEY (methylphenidate OR Ritalin OR Concerta) AND TITLE-ABS-KEY (abuse OR misuse OR dependency OR addiction) AND TITLE-ABS-KEY (dual diagnosis OR comorbid psychiatric disorder OR psychiatric disorder AND substance use disorder). The systematic review was structured in accordance with the PRISMA guidelines and identified studies were assessed by title/abstract and full text screening against eligibility criteria. Results: A total of 12 studies were selected for analysis after screening for relevance, quality, and adherence to inclusion criteria. Findings indicated that individuals with psychiatric disorders, particularly conduct disorder (N=593/1551 individuals), mood disorder (N=90/1551 individuals), anxiety disorder (N=66/1551 individuals), personality disorder (N=44/1551 individuals) and major depression disorder (N=40/1551 individuals), were more likely to misuse MPH. Co-occurring SUD, especially involving Alcohol Use Disorder (N=475/1551 individuals), Cannabis Use Disorder (N=371/1551 individuals), Nicotine Use Disorder (N=343/1551 individuals), Cocaine Use Disorder (N=68/1551 individuals), significantly elevated the risk. Misuse often involved higher doses than prescribed (N=84/1551 individuals) or using non-oral routes of administration (N=20/1551 individuals; e.g., snorting). Adverse outcomes included heightened risk of gastrointestinal events (N=201/1551 individuals), cardiovascular events (N=108/1551 individuals), psychosis (N=69/1551 individuals), and exacerbation of psychiatric symptoms (N=1082/1551 individuals). Conclusion: MPH misuse and abuse are significant concerns in patients with psychiatric disorders and SUD. Risk factors include impulsivity, history of substance abuse, and access to prescription stimulants. Integrated therapeutic approaches and stricter prescription monitoring are recommended to mitigate misuse risks. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024576724. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Delirium in COVID-19 patients: a multicentric observational study in Italy

Author

Martinotti, Giovanni, Bonanni, Laura, Barlati, Stefano, Miuli, Andrea, Sepede, Gianna, Prestia, Davide, Trabucco, Alice, Palumbo, Claudia, Massaro, Alessandra, Olcese, Martina, D’Ardes, Damiano, Cipollone, Francesco, Amore, Mario, Bondi, Emi, Russo, Mirella, Carrarini, Claudia, Onofrj, Marco, Sensi, Stefano Luca, Vita, Antonio, and di Giannantonio, Massimo

Published
2021
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15. Club Drugs and Psychiatric Outcomes: A Descriptive Case Series from Spain.

Author

Montemitro, Chiara, Mosca, Alessio, Chiappini, Stefania, Miuli, Andrea, Schifano, Fabrizio, Montano, Maria Josè Gordillo, Villar, Cristina Merino del, Allegretti, Rita, Marrangone, Carlotta, Di Petta, Gilberto, De Berardis, Domenico, Pettorruso, Mauro, and Martinotti, Giovanni

Subjects
DRUG abuse, DRUGS of abuse, PSYCHIATRIC drugs, SUBSTANCE abuse, PERSONALITY
Abstract

Background: illegal drugs significantly contribute to global health issues, with health complications often occurring not only in regular users with Substance Use Disorders (SUDs) but also in first-time and occasional users. Methods: this study examines five clinical cases from a public hospital in Ibiza, Spain, where patients presented with acute psychiatric symptoms due to recreational drug use. Results: Contrary to previous studies on SUDs, our patients typically had higher education levels and stable employment. Most of them used multiple substances, with cannabis, cocaine, and alcohol being the most frequently used. There was also a common occurrence of consuming drugs with uncertain contents. Upon admission, typical symptoms included aggression, hallucinations, mood swings, and disorientation in time and space. Conclusions: Our findings underscore the significant mental health risks posed by illicit drugs, even for individuals with no prior psychiatric history. Factors like the drug's potency, frequency and amount of use, past mental health issues, personality traits, and previous traumatic experiences might influence the onset of these symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, Giovanni, primary, Gastaldon, Chiara, additional, Tettamanti, Mauro, additional, Cartabia, Massimo, additional, Monti, Igor, additional, Aguglia, Andrea, additional, Aguglia, Eugenio, additional, Bartoli, Francesco, additional, Callegari, Camilla, additional, Canozzi, Andrea, additional, Carbone, Elvira Anna, additional, Carrà, Giuseppe, additional, Caruso, Rosangela, additional, Cavallotti, Simone, additional, Chiappini, Stefania, additional, Colasante, Fabrizio, additional, Compri, Beatrice, additional, D'Agostino, Armando, additional, De Fazio, Pasquale, additional, de Filippis, Renato, additional, Gari, Matteo, additional, Ielmini, Marta, additional, Ingrosso, Gianmarco, additional, Mammarella, Silvia, additional, Martinotti, Giovanni, additional, Rodolico, Alessandro, additional, Roncone, Rita, additional, Sterzi, Enrico, additional, Tarsitani, Lorenzo, additional, Tiberto, Elisa, additional, Todini, Liliana, additional, Amaddeo, Francesco, additional, D'Avanzo, Barbara, additional, Barbato, Angelo, additional, Barbui, Corrado, additional, Alessi, Maria Chiara, additional, Avincola, Gabriele, additional, Bachi, Bianca, additional, Bernasconi, Gianna, additional, Birgillito, Andrea, additional, Bisso, Emanuele, additional, Bonora, Stefano, additional, Calabrese, Angela, additional, Callovini, Tommaso, additional, Canestro, Aurelia, additional, Canonico, Salvo, additional, Capogrosso, Chiara Alessandro, additional, Carbone, Elvira, additional, Carosielli, Doriana, additional, Caselli, Ivano, additional, Cavaleri, Daniele, additional, Cavallotto, Clara, additional, Cesca, Marco, additional, Chiarenza, Cecilia, additional, Cioni, Riccardo Matteo, additional, Coloccini, Sara, additional, Cruciata, Marco, additional, Cumerlato, Claudia, additional, De Filippis, Renato, additional, De Palma, Manuela, additional, Del Vecchio, Sasha, additional, Della Rocca, Bianca, additional, Di Natale, Chiara, additional, D'Onofrio, Ettore, additional, Espa, Irene, additional, Fior, Giulia, additional, Gancitano, Marta, additional, Giordano, Barbara, additional, Giusti, Laura, additional, Grassi, Luigi, additional, Guzzi, Pierluca, additional, Isella, Celeste, additional, Lax, Annamaria, additional, Marano, Leonardo, additional, Marconi, Federico, additional, Marella, Marco, additional, Metelli, Alessia, additional, Michencig, Giulia, additional, Miuli, Andrea, additional, Moncada, Alessandro, additional, Morello, Pietro, additional, Moretti, Federico, additional, Morreale, Marco, additional, Mosca, Alessio, additional, Nasti, Christian, additional, Nosé, Michela, additional, Ogheri, Filippo, additional, Oresti, Margherita, additional, Ornaghi, Alessandra, additional, Ostuzzi, Giovanni, additional, Palpella, Dario, additional, Pancheri, Corinna, additional, Papola, Davide, additional, Passeri, Silvia, additional, Pettorusso, Mauro, additional, Piacenti, Susanna, additional, Pinucci, Irene, additional, Pugliese, Valentina, additional, Purgato, Marianna, additional, Rania, Marianna, additional, Robbi, Federica, additional, Romito, Samantha, additional, Ronchi, Barbara, additional, Roselli, Valentina, additional, Segura-Garcia, Cristina, additional, Signorelli, Maria Salvina, additional, Simonelli, Gabriele, additional, Sociali, Antonella, additional, Sturiale, Serena, additional, Tambelli, Antonio, additional, Todesco, Beatrice, additional, Trabucco, Alice, additional, Turrini, Giulia, additional, Villa, Veronica, additional, Wiedenmann, Federico, additional, Zambuto, Luca, additional, Zanini, Elisa, additional, Zannini, Chiara, additional, and Zerbinati, Luigi, additional

Published
2024
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19. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, and Zerbinati, Luigi

Abstract

Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depress

Published
2024

21. Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature

Author

Mosca, Alessio, primary, Chiappini, Stefania, additional, Miuli, Andrea, additional, Mancusi, Gianluca, additional, Santovito, Maria Chiara, additional, Di Carlo, Francesco, additional, Pettorruso, Mauro, additional, Corkery, John M., additional, Canessa, Carlos, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional

Published
2023
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22. Corrigendum to “Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine” [Brain Stimul 16 (2023)]

Author

Pettorruso, Mauro, primary, d’Andrea, Giacomo, additional, Di Carlo, Francesco, additional, De Risio, Luisa, additional, Zoratto, Francesca, additional, Miuli, Andrea, additional, Benatti, Beatrice, additional, Vismara, Matteo, additional, Pompili, Enrico, additional, Nicolò, Giuseppe, additional, Niolu, Cinzia, additional, Siracusano, Alberto, additional, Sensi, Stefano L., additional, Dell’Osso, Bernardo, additional, Di Lorenzo, Giorgio, additional, Martinotti, Giovanni, additional, Giovannetti, Giulia, additional, Stefanelli, Giulia, additional, Cavallotto, Clara, additional, Susini, Ottavia, additional, Carullo, Rosalba, additional, Mancusi, Gianluca, additional, Di Marco, Ornella, additional, Santorelli, Mario, additional, Martino, Fabrizio, additional, Nicita, Alessia, additional, Bernabei, Laura, additional, Tarallo, Federica, additional, Corrado, Alessandra, additional, and Carlone, Luca, additional

Published
2023
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25. Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine

Author

Pettorruso, Mauro, primary, d’Andrea, Giacomo, additional, Di Carlo, Francesco, additional, De Risio, Luisa, additional, Zoratto, Francesca, additional, Miuli, Andrea, additional, Benatti, Beatrice, additional, Vismara, Matteo, additional, Pompili, Enrico, additional, Nicolò, Giuseppe, additional, Niolu, Cinzia, additional, Siracusano, Alberto, additional, Sensi, Stefano S., additional, Dell’Osso, Bernardo, additional, Di Lorenzo, Giorgio, additional, Martinotti, Giovanni, additional, Giovannetti, Giulia, additional, Stefanelli, Giulia, additional, Cavallotto, Clara, additional, Susini, Ottavia, additional, Carullo, Rosalba, additional, Mancusi, Gianluca, additional, Di Marco, Ornella, additional, Santorelli, Mario, additional, Martino, Fabrizio, additional, Nicita, Alessia, additional, Bernabei, Laura, additional, Tarallo, Federica, additional, Corrado, Alessandra, additional, and Carlone, Luca, additional

Published
2023
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26. Transcranial Direct Current Stimulation Reduces Craving in Substance Use Disorders: A Double-blind, Placebo-Controlled Study

Author

Martinotti, Giovanni, Lupi, Matteo, Montemitro, Chiara, Miuli, Andrea, Di Natale, Chiara, Spano, Maria Chiara, Mancini, Valerio, Lorusso, Marco, Stigliano, Gianfranco, Tambelli, Antonio, Di Carlo, Francesco, Di Caprio, Lucia, Fraticelli, Silvia, Chillemi, Eleonora, Pettorruso, Mauro, Sepede, Gianna, and di Giannantonio, Massimo

Published
2019
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27. Could Cariprazine Be a Possible Choice for High Functioning Autism? A Case Report.

Author

Miuli, Andrea, Marrangone, Carlotta, Di Marco, Ornella, Pasino, Arianna, Stigliano, Gianfranco, Mosca, Alessio, Pettorruso, Mauro, Schifano, Fabrizio, and Martinotti, Giovanni

Subjects
*ANTIPSYCHOTIC agents, *AUTISM, *AGGRESSION (Psychology), *AFFECTIVE disorders, *DOPAMINERGIC mechanisms
Abstract

This case report was conducted by searching for the following keywords on PubMed: High Functioning Autism, Autism Spectrum Disorder, cariprazine, aripiprazole, partial agonist antipsychotic, DRD2/DRD3. High Functioning Autism (HFA) is a neurodevelopmental disorder characterized by the core symptoms of autism spectrum disorder (ASD) with average intellectual abilities, behavioral symptoms such as irritability, hyperactivity, aggressiveness and mood symptoms. HFA is not a term used in the Diagnostic and Statistical Manual of mental disorders (DSM), but it is commonly used to identify patients diagnosed with Autistic Disorder (AD) or Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) with average or above average intellectual abilities. Several factors are involved in HFA development, including environmental and genetic factors. In particular, over the last several decades, dopaminergic signaling system dysfunction has been highlighted as being responsible for behavioral patterns. Nowadays, symptoms of ASD lack a specific pharmacological treatment. The only medications approved by the Food and Drug Administration (FDA) for symptoms associated with ASD, in particular the irritability, are risperidone and aripiprazole. According to the hypothesis that dopamine receptor DRD2 and DRD3 might be involved in impulsive behavior, stereotypy, repetitive behaviors and language impairment, cariprazine could be a therapeutic option. This molecule is primarily characterized by DRD3 partial agonism and serotonin 5-HT1A partial agonism, with a lower ability to activate DRD2 than other third-generation antipsychotics, such as aripiprazole. We have reported here a case study of treatment of HFA with cariprazine. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Investigating the Role of Maintenance TMS Protocols for Major Depression: Systematic Review and Future Perspectives for Personalized Interventions

Author

d’Andrea, Giacomo, primary, Mancusi, Gianluca, additional, Santovito, Maria Chiara, additional, Marrangone, Carlotta, additional, Martino, Fabrizio, additional, Santorelli, Mario, additional, Miuli, Andrea, additional, Di Carlo, Francesco, additional, Signorelli, Maria Salvina, additional, Clerici, Massimo, additional, Pettorruso, Mauro, additional, and Martinotti, Giovanni, additional

Published
2023
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29. Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine

Author

Giovannetti, Giulia, Stefanelli, Giulia, Cavallotto, Clara, Susini, Ottavia, Carullo, Rosalba, Mancusi, Gianluca, Di Marco, Ornella, Santorelli, Mario, Martino, Fabrizio, Nicita, Alessia, Bernabei, Laura, Tarallo, Federica, Corrado, Alessandra, Carlone, Luca, Pettorruso, Mauro, d’Andrea, Giacomo, Di Carlo, Francesco, De Risio, Luisa, Zoratto, Francesca, Miuli, Andrea, Benatti, Beatrice, Vismara, Matteo, Pompili, Enrico, Nicolò, Giuseppe, Niolu, Cinzia, Siracusano, Alberto, Sensi, Stefano S., Dell’Osso, Bernardo, Di Lorenzo, Giorgio, and Martinotti, Giovanni

Published
2023
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30. High-Risk Gaming Is Associated with Frequent Substance Use: An Exploratory Survey among Young Adults

Author

Di Carlo, Francesco, primary, Verrastro, Valeria, additional, Alessi, Maria Chiara, additional, Sociali, Antonella, additional, Altomare, Arianna Ida, additional, Di Natale, Chiara, additional, Stigliano, Gianfranco, additional, Miuli, Andrea, additional, Lalli, Aliseo, additional, Di Petta, Gilberto, additional, Chiappini, Stefania, additional, Pettorruso, Mauro, additional, Bowden-Jones, Henrietta, additional, Griffiths, Mark D, additional, and Martinotti, Giovanni, additional

Published
2023
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31. The Benzydamine Experience: A Systematic Review of Benzydamine Abuse

Author

Schifano Fabrizio, Corkery John Martin, Pettorruso Mauro, Di Giannantonio Massimo, Martinotti Giovanni, Chiappini Stefania, Guirguis Amira, Miuli Andrea, and Mosca Alessio

Subjects
0301 basic medicine, Drug, Benzydamine, medicine.medical_specialty, media_common.quotation_subject, Anti-Inflammatory Agents, Recreational use, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Drug reaction, Medical prescription, Psychiatry, Retrospective Studies, media_common, Pharmacology, Health professionals, business.industry, General Medicine, Psychiatry and Mental health, 030104 developmental biology, Psychotic Disorders, Neurology, Molecular mechanism, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug, Psychopathology
Abstract

Background: Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. Objective: The aim of this study was to investigate how the misuse of BZY has been reported, illustrating its psychotropic molecular mechanism, and studying its psychopathological effects. Methods: We firstly conducted a systematic review of the literature concerning the abuse of BZY and its effects. For data gathering purposes, both PRISMA and PROSPERO guidelines were followed. All research methods were approved by PROSPERO (identification code CRD42020187266). Second, we analysed BZY-related data from the European Monitoring Agency (EMA) Adverse Drug Reactions (ADRs) database recorded during 2005-2020 regarding its abuse. Results: Eleven articles, published during 1997-2019, were included in our systematic review, including five case reports, four surveys, and two retrospective case series analyses. While nine articles dealt with the recreational use of BZY, two described an oral overdose of the drug. When specified, dosages of BZY consumed ranged from 500 to 1500mg. The EMA dataset contained three cases of BZY abuse. Conclusion: Results from the systematic review showed BZY might be diverted for typical hallucinogenic properties occurring at high dosages. Healthcare professionals should be warned about a possible misuse/abuse of a commonly prescribed anti-inflammatory drug and be vigilant when prescribing it. Physicians working in emergency units should know that psychotic symptoms may be related to BZY abuse.

Published
2021
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37. What role for cognitive remediation in the treatment of depressive symptoms? A superiority and noninferiority meta‐analysis for clinicians

Author

Sociali, Antonella, primary, Borgi, Marta, additional, Pettorruso, Mauro, additional, Di Carlo, Francesco, additional, Di Natale, Chiara, additional, Tambelli, Antonio, additional, Alessi, Maria C., additional, Ciavoni, Laura, additional, Mosca, Alessio, additional, Miuli, Andrea, additional, Sensi, Stefano L., additional, Martinotti, Giovanni, additional, Zoratto, Francesca, additional, and Di Giannantonio, Massimo, additional

Published
2022
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38. Investigating the Role of Maintenance TMS Protocols for Major Depression: Systematic Review and Future Perspectives for Personalized Interventions.

Author

d'Andrea, Giacomo, Mancusi, Gianluca, Santovito, Maria Chiara, Marrangone, Carlotta, Martino, Fabrizio, Santorelli, Mario, Miuli, Andrea, Di Carlo, Francesco, Signorelli, Maria Salvina, Clerici, Massimo, Pettorruso, Mauro, and Martinotti, Giovanni

Subjects
MENTAL depression, TRANSCRANIAL magnetic stimulation, PATIENT compliance, WEB databases, SCIENCE databases, DISEASE relapse
Abstract

Repetitive Transcranial Magnetic Stimulation (rTMS) has been approved by the FDA as an effective intervention for Treatment-Resistant Depression (TRD). However, there is little evidence about maintenance protocol necessity. The aim of this systematic review is to identify, characterize, and evaluate the current maintenance TMS protocols for MDD and TRD patients who have received acute treatment. A literature search was conducted following the PRISMA guidelines of 2015 on PubMed, Scopus, and Web of Science databases for publications up to March 2022. Fourteen articles were included. High protocol heterogeneity was observed. Most studies highlighted significant efficacy of maintenance protocols in decreasing relapse risk, suggesting that administering two or fewer stimulations per month is ineffective in sustaining an antidepressant effect or in reducing the risk of relapse in responder patients. The risk of relapse was most pronounced after five months from the acute treatment. Maintenance TMS appears to be a resourceful strategy to maintain acute antidepressant treatment effects, significantly reducing relapse risk. The ease of administering and the ability to monitor treatment adherence should be considered when evaluating the future use of maintenance TMS protocols. Further studies are needed to clarify the clinical relevance of overlapping acute TMS effects with maintenance protocols and to evaluate their long-term effectiveness. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Misuse of Anticholinergic Medications: A Systematic Review

Author

Chiappini, Stefania, primary, Mosca, Alessio, additional, Miuli, Andrea, additional, Semeraro, Francesco Maria, additional, Mancusi, Gianluca, additional, Santovito, Maria Chiara, additional, Di Carlo, Francesco, additional, Pettorruso, Mauro, additional, Guirguis, Amira, additional, Corkery, John Martin, additional, Martinotti, Giovanni, additional, Schifano, Fabrizio, additional, and Di Giannantonio, Massimo, additional

Published
2022
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40. Impact of Sleep Disorders and Disease Duration on Neurotrophins Levels in Cocaine Use Disorder

Author

Miuli, Andrea, primary, Mancusi, Gianluca, additional, Pettorruso, Mauro, additional, Di Carlo, Francesco, additional, Clemente, Katia, additional, Di Meo, Ilenia, additional, d’Andrea, Antea, additional, Pernaci, Giulia, additional, Di Crosta, Teresa, additional, d’Andrea, Giacomo, additional, Martinotti, Giovanni, additional, and di Giannantonio, Massimo, additional

Published
2022
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42. Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis

Author

Miuli, Andrea, primary, Sepede, Gianna, additional, Stigliano, Gianfranco, additional, Mosca, Alessio, additional, Di Carlo, Francesco, additional, d’Andrea, Giacomo, additional, Lalli, Aliseo, additional, Spano, Maria Chiara, additional, Pettorruso, Mauro, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional

Published
2021
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43. Therapeutic Potentials of Ketamine and Esketamine in Obsessive–Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature

Author

Martinotti, Giovanni, primary, Chiappini, Stefania, additional, Pettorruso, Mauro, additional, Mosca, Alessio, additional, Miuli, Andrea, additional, Di Carlo, Francesco, additional, D’Andrea, Giacomo, additional, Collevecchio, Roberta, additional, Di Muzio, Ilenia, additional, Sensi, Stefano L., additional, and Di Giannantonio, Massimo, additional

Published
2021
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45. Use and knowledge of novel synthetic opioids: An Italian survey.

Author

Stigliano, Gianfranco, Miuli, Andrea, Vizziello, Alessandra, Altomare, Arianna Ida, Lalli, Aliseo, Alessi, Maria Chiara, Sociali, Antonella, Rucco, Annarita, Vannini, Chiara, Martinotti, Giovanni, and di Giannantonio, Massimo

Subjects
*NARCOTICS, *RISK-taking behavior, *SUBSTANCE abuse, *SCIENTIFIC observation, *RESEARCH methodology, *CROSS-sectional method, *DRUG abuse, *FENTANYL, *SYNTHETIC drugs, *HEALTH literacy, *SURVEYS, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *SOCIODEMOGRAPHIC factors, *PUBLIC opinion
Abstract

The recreational use of novel synthetic opioids (NSOs) is increasing, especially among the youngest part of the population. We conducted a naturalistic observational survey. The main outcome was to assess the use and the knowledge of NSOs among the youngest population in Italy. A sociodemographic questionnaire was also administrated. Nine hundred twenty questionnaires were completed. Fentanyl was the most used NSO (1.63% of the subjects). In all, 14.3% of the sample revealed awareness of NSOs. Although the diffusion in Italy is small, the large knowledge of NSOs requires future monitoring of this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Corrigendum to “Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine” [Brain Stimul 16 (2023)]

Author

Giovannetti, Giulia, Stefanelli, Giulia, Cavallotto, Clara, Susini, Ottavia, Carullo, Rosalba, Mancusi, Gianluca, Di Marco, Ornella, Santorelli, Mario, Martino, Fabrizio, Nicita, Alessia, Bernabei, Laura, Tarallo, Federica, Corrado, Alessandra, Carlone, Luca, Pettorruso, Mauro, d’Andrea, Giacomo, Di Carlo, Francesco, De Risio, Luisa, Zoratto, Francesca, Miuli, Andrea, Benatti, Beatrice, Vismara, Matteo, Pompili, Enrico, Nicolò, Giuseppe, Niolu, Cinzia, Siracusano, Alberto, Sensi, Stefano L., Dell’Osso, Bernardo, Di Lorenzo, Giorgio, and Martinotti, Giovanni

Published
2023
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48. Use and knowledge of novel synthetic opioids: An Italian survey

Author

Stigliano, Gianfranco, primary, Miuli, Andrea, additional, Vizziello, Alessandra, additional, Altomare, Arianna Ida, additional, Lalli, Aliseo, additional, Alessi, Maria Chiara, additional, Sociali, Antonella, additional, Rucco, Annarita, additional, Vannini, Chiara, additional, Martinotti, Giovanni, additional, and di Giannantonio, Massimo, additional

Published
2020
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49. Hopelessness, Dissociative Symptoms, and Suicide Risk in Major Depressive Disorder: Clinical and Biological Correlates

Author

Pettorruso, Mauro, primary, d’Andrea, Giacomo, additional, Martinotti, Giovanni, additional, Cocciolillo, Fabrizio, additional, Miuli, Andrea, additional, Di Muzio, Ilenia, additional, Collevecchio, Rebecca, additional, Verrastro, Valeria, additional, De-Giorgio, Fabio, additional, Janiri, Luigi, additional, di Giannantonio, Massimo, additional, Di Giuda, Daniela, additional, and Camardese, Giovanni, additional

Published
2020
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