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253 results on '"Mittleman, Guy"'

3. The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia

Author

Calton, Michele A, Howard, Jeremy R, Harper, Ronald M, Goldowitz, Dan, and Mittleman, Guy

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Lung, Neurodegenerative, Infant Mortality, Pediatric, Neurosciences, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, cerebellum, Purkinje cells, disordered breathing, sudden death, SIDS, SUDC, SUDEP, Clinical Sciences, Psychology, Clinical sciences, Biological psychology
Abstract

The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing patterns in 12 wild-type (WT) and Lurcher mutant mice with 100% developmental cerebellar Purkinje cell loss under baseline (room air), and recovery from hypercapnia, a concern in sudden death events. Six mutant and six WT mice were exposed to 4-min blocks of increasing CO2 (2, 4, 6, and 8%), separated by 4-min recovery intervals in room air. Breath-by-breath patterns, including depth of breathing and end-expiratory pause (EEP) durations during recovery, were recorded. No baseline genotypic differences emerged. However, during recovery, EEP durations significantly lengthened in mutants, compared to WT mice, following the relatively low levels of CO2 exposure. Additionally, mutant mice exhibited signs of post-sigh disordered breathing during recovery following each exposure. Developmental cerebellar Purkinje cell loss significantly affects compensatory breathing patterns following mild CO2 exposure, possibly by inhibiting recovery from elevated CO2. These data implicate cerebellar Purkinje cells in the ability to recover from hypercarbia, suggesting that neuropathologic changes or loss of these cells contribute to inadequate ventilatory recovery to increased environmental CO2. Multiple disorders, including sudden infant death syndrome (SIDS) and sudden unexpected death in epilepsy (SUDEP), appear to involve both cardiorespiratory failure and loss or injury to cerebellar Purkinje cells; the findings support the concept that such neuropathology may precede and exert a prominent role in these fatal events.

Published
2016

11. Opiate responses are controlled by interactions ofOprm1andFgf12loci in rodents: Correspondence to human GWAS findings

Author

Lemen, Paige M., primary, Zuo, Yanning, additional, Hatoum, Alexander S., additional, Dickson, Price E., additional, Mittleman, Guy, additional, Agrawal, Arpana, additional, Reiner, Benjamin C., additional, Berrettini, Wade, additional, Ashbrook, David G., additional, Gunturkun, Mustafa Hakan, additional, Mulligan, Megan K., additional, Williams, Robert W, additional, Telese, Francesca, additional, and Chen, Hao, additional

Published
2022
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16. Consensus Paper: Pathological Role of the Cerebellum in Autism

Author

Fatemi, S. Hossein, Aldinger, Kimberly A., Ashwood, Paul, Bauman, Margaret L., Blaha, Charles D., Blatt, Gene J., Chauhan, Abha, Chauhan, Ved, Dager, Stephen R., Dickson, Price E., Estes, Annette M., Goldowitz, Dan, Heck, Detlef H., Kemper, Thomas L., King, Bryan H., Martin, Loren A., Millen, Kathleen J., Mittleman, Guy, Mosconi, Matthew W., Persico, Antonio M., Sweeney, John A., Webb, Sara J., and Welsh, John P.

Published
2012
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39. Reinforcer magnitude and progressive ratio responding in the rat: effects of increased effort, prefeeding, and extinction

Author

Skjoldager, Paul, Pierre, Peter J., and Mittleman, Guy

Subjects
Reinforcement (Psychology) -- Research, Rats -- training, Extinction (Psychology) -- Research, Education, Psychology and mental health
Abstract

Larger reinforcement magnitude was found to increase efficiency of progressive-ratio lever-press responding as well as resistance to effort, but did not affect resistance to prefeeding in three experiments with rats. Extinction was more rapid in the group with larger magnitude of reinforcement. In addition, acquisition of the lever-press response was not affected by reinforcement magnitude. The reinforcement magnitudes tested were one versus three sucrose pellets.

Published
1993

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