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2. Metabolic Profile of Adaptive Immune Cells

Author

Domínguez-Amorocho, Omar, Soto-Heredero, Gonzalo, Mittelbrunn, María, Camara, Niels Olsen Saraiva, editor, Alves-Filho, Jose C, editor, Moraes-Vieira, Pedro Manoel Mendes de, editor, and Andrade-Oliveira, Vinicius, editor

Published
2022
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5. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

Author

Mateescu, Bogdan, Kowal, Emma J. K., Van Balkom, Bas W. M. Emma J. K., Bartel, Sabine, Bhattacharyya, Suvendra N., Buzás, Edit I., Buck, Amy H., Candia, Paola de, Chow, Franklin W. N., Das, Saumya, Driedonks, Tom A. P., Fernández Messina, Lola María, Haderk, Franziska, Hill, Andrew F., Jones, Jennifer C., Van Keuren‐Jensen, Kendall R., Lai, Charles P., Lässer, Cecilia, di Liegro, Italia, Lunavat, Taral R., Lorenowicz, Magdalena J., Maas, Sybren L. N., Mäger, Imre, Mittelbrunn, Maria, Momma, Stefan, Mukherjee, Kamalika, Nawaz, Muhammad, Pegtel, D. Michiel, Pfaffl, Michael W., Schiffelers, Raymond M., Tahara, Hidetoshi, Théry, Clotilde, Tosar, Juan Pablo, Wauben, Marca H. M., Witwer, Kenneth W., Nolte‐'t Hoen, Esther N. M., Mateescu, Bogdan, Kowal, Emma J. K., Van Balkom, Bas W. M. Emma J. K., Bartel, Sabine, Bhattacharyya, Suvendra N., Buzás, Edit I., Buck, Amy H., Candia, Paola de, Chow, Franklin W. N., Das, Saumya, Driedonks, Tom A. P., Fernández Messina, Lola María, Haderk, Franziska, Hill, Andrew F., Jones, Jennifer C., Van Keuren‐Jensen, Kendall R., Lai, Charles P., Lässer, Cecilia, di Liegro, Italia, Lunavat, Taral R., Lorenowicz, Magdalena J., Maas, Sybren L. N., Mäger, Imre, Mittelbrunn, Maria, Momma, Stefan, Mukherjee, Kamalika, Nawaz, Muhammad, Pegtel, D. Michiel, Pfaffl, Michael W., Schiffelers, Raymond M., Tahara, Hidetoshi, Théry, Clotilde, Tosar, Juan Pablo, Wauben, Marca H. M., Witwer, Kenneth W., and Nolte‐'t Hoen, Esther N. M.

Abstract

Acknowledgements We thank all participants of the 2015 ISEV workshop on EV-RNA for their valuable input in roundtable discussions, which formed the basis for this position paper. We are grateful to Dr P. Vader for preparing Figure 3., The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids. RNA-containing EV are in the limelight for their capacity to communicate genetically encoded messages to other cells, their suitability as candidate biomarkers for diseases, and their use as therapeutic agents. Although EV-RNA has attracted enormous interest from basic researchers, clinicians, and industry, we currently have limited knowledge on which mechanisms drive and regulate RNA incorporation into EV and on how RNA-encoded messages affect signalling processes in EV-targeted cells. Moreover, EV-RNA research faces various technical challenges, such as standardisation of EV isolation methods, optimisation of methodologies to isolate and characterise minute quantities of RNA found in EV, and development of approaches to demonstrate functional transfer of EV-RNA in vivo. These topics were discussed at the 2015 EV-RNA workshop of the International Society for Extracellular Vesicles. This position paper was written by the participants of the workshop not only to give an overview of the current state of knowledge in the field, but also to clarify that our incomplete knowledge – of the nature of EV(-RNA)s and of how to effectively and reliably study them – currently prohibits the implementation of gold standards in EV-RNA research. In addition, this paper creates awareness of possibilities and limitations of currently used strategies to investigate EV-RNA and calls for caution in interpretation of the obtained data., Depto. de Biología Celular, Fac. de Ciencias Biológicas, TRUE, pub

Published
2024

13. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

Author

Osorio, Fernando G., Soria-Valles, Clara, Santiago-Fernandez, Olaya, Bernal, Teresa, Mittelbrunn, Maria, Colado, Enrique, Rodriguez, Francisco, Bonzon-Kulichenko, Elena, Vazquez, Jesus, Porta-de-la-Riva, Montserrat, Ceron, Julian, Fueyo, Antonio, Li, Juan, Green, Anthony R., Freije, Jose M.P., and Lopez-Otin, Carlos

Subjects
Insulin-like growth factor I -- Physiological aspects -- Genetic aspects -- Research, Gene mutation -- Physiological aspects -- Research, Myeloproliferative disorders -- Development and progression -- Genetic aspects -- Research, Biological sciences, Health
Abstract

AIRAPL (arsenite-inducible RNA-associated protein-like) is an evolutionarily conserved regulator of cellular proteostasis linked to longevity in nematodes, but its biological function in mammals is unknown (1-3). We show herein that AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process. Proteomic analysis of AIRAPL-deficient mice revealed that this protein exerts its antineoplastic function through the regulation of the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. We demonstrate that AIRAPL interacts with newly synthesized insulin-related growth factor-1 receptor (IGF1R) polypeptides, promoting their ubiquitination and proteasome-mediated degradation. Accordingly, genetic and pharmacological IGF1R inhibitory strategies prevent the hematological disease found in AIRAPL-deficient mice as well as that in mice carrying the [Jak2.sup.V617F] mutation, thereby demonstrating the causal involvement of this pathway in the pathogenesis of myeloproliferative neoplasms (4-6). Consistent with its proposed role as a tumor suppressor of myeloid transformation, AIRAPL expression is widely abrogated in human myeloproliferative disorders. Collectively, these findings support the oncogenic relevance of proteostasis deregulation in hematopoietic cells, and they unveil novel therapeutic targets for these frequent hematological neoplasias., Protein homeostasis is essential for a proper response to cellular stress conditions (7). Regulatory mechanisms of protein quality control preserve the stability and functionality of the cellular proteome (8-10), and [...]

Published
2016

14. Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm

Author

Roldán-Montero, Raquel, primary, Pérez-Sáez, Juan M., additional, Cerro-Pardo, Isabel, additional, Oller, Jorge, additional, Martinez-Lopez, Diego, additional, Nuñez, Estefania, additional, Maller, Sebastian M., additional, Gutierrez-Muñoz, Carmen, additional, Mendez-Barbero, Nerea, additional, Escola-Gil, Joan C., additional, Michel, Jean-Baptiste, additional, Mittelbrunn, Maria, additional, Vázquez, Jesús, additional, Blanco-Colio, Luis M., additional, Rabinovich, Gabriel A., additional, and Martin-Ventura, Jose L., additional

Published
2022
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19. The role of T cells in age-related diseases

Author

Carrasco, Elisa, primary, Gómez de las Heras, Manuel M., additional, Gabandé-Rodríguez, Enrique, additional, Desdín-Micó, Gabriela, additional, Aranda, Juan Francisco, additional, and Mittelbrunn, Maria, additional

Published
2021
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20. Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

Author

Navarro, Maria N., Gómez de las Heras, Manuel M., Mittelbrunn, Maria, Ministerio de Ciencia e Innovación (España), European Research Council, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Investigación Hospital 12 de Octubre, Fundación Ramón Areces, and Banco Santander

Subjects
lymphocytes, 0301 basic medicine, Autoimmunity, Inflammation, CD38, Nicotinamide adenine dinucleotide, Cofactor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, NAD+, medicine, Sirtuins, Pharmacology, Experimental autoimmune encephalomyelitis, biology, T Cells, Adenosine diphosphate ribose, Immunity, Metabolism, NAD, 3. Good health, Cell biology, Ageing, 030104 developmental biology, chemistry, inflammation, biology.protein, NAD+ kinase, medicine.symptom, Energy Metabolism, 030217 neurology & neurosurgery
Abstract

Metabolism is dynamically regulated to accompany immune cell function, and altered immunometabolism can result in impaired immune responses. Concomitantly, the pharmacological manipulation of metabolic processes offers an opportunity for therapeutic intervention in inflammatory disorders. The nicotinamide adenine dinucleotide (NAD+) is a critical metabolic intermediate that serves as enzyme cofactor in redox reactions, and is also used as a co-substrate by many enzymes such as sirtuins, adenosine diphosphate ribose transferases and synthases. Through these activities, NAD+ metabolism regulates a broad spectrum of cellular functions such as energy metabolism, DNA repair, regulation of the epigenetic landscape and inflammation. Thus, the manipulation of NAD+ availability using pharmacological compounds such as NAD+ precursors can have immune-modulatory properties in inflammation. Here, we discuss how the NAD+ metabolism contributes to the immune response and inflammatory conditions, with a special focus on multiple sclerosis, inflammatory bowel diseases and inflammageing, Spanish Ministry of Science and Innovation (PID2019-110511RB-I00) to M.N.N, and the H2020-EU.1.1, European Research Council (ERC-2016-StG 715322-EndoMitTalk), Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI19/855) to M.M, Fondo Europeo de Desarrollo Regional (FEDER) to M.M and M.N.N. M.M.GH was funded by the Spanish Ministry of Science, Innovation and Universities (FPU19/02576). M.M. is supported by the Miguel Servet program (CPII19/00014, Fundación de Investigación del Hospital 12 de Octubre). Institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSO are also acknowledged.

Published
2021
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22. Inap

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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23. Interferon-Inducible RNA-Dependent Protein Kinase

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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24. Integrin α1 (ITGA1)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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25. Interferon-Inducible eIF2α Kinase

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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26. Icmt (Isoprenylcysteine Carboxyl Methyltransferase)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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27. IL-1 Inducible Nuclear Ankyrin-Repeat Protein (INAP)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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28. Integrin Alpha 11

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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29. Inositol 1,4,5-trisphosphate-associated cGMP kinase substrate

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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30. Interleukin-7

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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31. int-2

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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32. Integrin-Associated Protein

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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33. Insulin-like Growth Factor Receptor Type I (IGF1R) Signaling and Inflammation

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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34. Interferon Regulatory Factor 5, IRF5

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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35. Inositol Polyphosphate-5-Phosphatase, 145 kDa

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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36. Integrin Alpha 4

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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37. ITPK1 (Inositol 1,3,4-Triphosphate 5/6 Kinase)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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38. Integrin Alpha 4 (Itga 4)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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39. IFN-β2

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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40. Integrin-Associated Signal Transducer

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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41. IFN-Gamma

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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42. Immune IFN

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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43. IkB-zeta

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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44. Inositol 3,4,5,6-Tetrakisphosphate 1-Kinase

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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45. Interleukin-1 Signal Transducer

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

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2012
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46. Inhibitor of DNA Binding 4 (ID4)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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47. IP-10

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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48. IP3 Receptor–Associated cGMP Kinase Substrate A

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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49. Inhibitor of Apoptosis (IAP) Proteins

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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50. Ionotropic Glutamate Receptors (AMPA, Kainate and NMDA Receptors)

Author

Appleton, Kathryn M., primary, Cushman, Ian, additional, Peterson, Yuri K., additional, Manavalan, Balachandran, additional, Basith, Shaherin, additional, Choi, Sangdun, additional, Kimura, Akihiro, additional, Naka, Tetsuji, additional, Kishimoto, Tadamitsu, additional, Seddon, Benedict, additional, Traver, Maria, additional, Taylor, Gregory A., additional, Gyrd-Hansen, Mads, additional, Blandino, Giovanni, additional, Fontemaggi, Giulia, additional, Grillo, Michael A., additional, Koulen, Peter, additional, Annenkov, Alexander, additional, Zeltz, Cédric, additional, Gullberg, Donald, additional, Mittelbrunn, Maria, additional, Sánchez-Madrid, Francisco, additional, Kerr, Bethany A., additional, Byzova, Tatiana V., additional, Heino, Jyrki, additional, Lin, Fan-ching, additional, Young, Howard A., additional, Taylor, Colin W., additional, Barnes, Betsy J., additional, Zhou, Yixing, additional, Schenk, Tobias M. H., additional, Shears, Stephen B., additional, Sengar, Ameet S., additional, Salter, Michael W., additional, and Egan, Sean E., additional

Published
2012
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