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2. High Internal Atrial Defibrillation Threshold Is Related to a High Risk of Recurrence After Catheter Ablation for Long-Standing Persistent Atrial Fibrillation But Not for Persistent Atrial Fibrillation

Author

Imaoka, Takuro, Kanzaki, Yasunori, Morita, Yasuhiro, Watanabe, Naoki, Furui, Koichi, Yoshioka, Naoki, Shibata, Naoki, Yamauchi, Ryota, Miyazawa, Hiroyuki, Shimojo, Kazuki, Sakamoto, Gaku, Ohi, Takuma, Goto, Hiroki, Mitsuhashi, Hirotsugu, and Morishima, Itsuro

Published
2022
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3. Excimer laser coronary angioplasty versus manual aspiration thrombectomy in patients with ST-segment elevation myocardial infarction: analyzed by nuclear scintigraphy

Author

Shimojo, Kazuki, primary, Shibata, Naoki, additional, Takagi, Kensuke, additional, Mitsuhashi, Hirotsugu, additional, Morita, Yasuhiro, additional, Kanzaki, Yasunori, additional, Watanabe, Naoki, additional, Yoshioka, Naoki, additional, Miyazawa, Hiroyuki, additional, Imaoka, Takuro, additional, Sakamoto, Gaku, additional, Ohi, Takuma, additional, Goto, Hiroki, additional, Karasawa, Hoshito, additional, and Morishima, Itsuro, additional

Published
2022
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14. High Atrial Defibrillation Threshold is Related to a Risk of Recurrence after Catheter Ablation For Long-Standing Persistent Atrial Fibrillation But Not for Persistent Atrial Fibrillation

Author

Imaoka, Takuro, primary, Kanzaki, Yasunori, additional, Morita, Yasuhiro, additional, Watanabe, Naoki, additional, Furui, Koichi, additional, Yoshioka, Naoki, additional, Shibata, Naoki, additional, Yamauchi, Ryota, additional, Miyazawa, Hiroyuki, additional, Shimojo, Kazuki, additional, Sakamoto, Gaku, additional, Ohi, Takuma, additional, Goto, Hiroki, additional, Mitsuhashi, Hirotsugu, additional, and Morishima, Itsuro, additional

Published
2021
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17. Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study

Author

Matsudaira, Kyoko, Maeda, Kengo, Okumura, Naoki, Yoshikawa, Daiji, Morita, Yasuhiro, Mitsuhashi, Hirotsugu, Ishii, Hideki, Kondo, Takahisa, Murohara, Toyoaki, and on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group

Subjects
cardiovascular diseases
Abstract

Background: Vascular endothelial growth factor (VEGF) is induced by myocardial ischemia and is thought to facilitate cardiovascular repair after acute myocardial infarction (AMI). However, the association between the plasma VEGF levels and clinical outcome in AMI patients is unclear. Methods and Results: We evaluated 879 AMI patients undergoing successful primary revascularization within 24h of symptom onset. The patients were classified into 3 groups according to tertiles of plasma VEGF levels at 7 days after the onset of AMI. Major adverse cardiovascular and cerebrovascular events (MACCE), defined as cardiac death, recurrent acute coronary syndrome, hospital readmission for heart failure, or stroke, were assessed during the 6-month follow-up period. The incidence of MACCE was the least frequent in the middle tertile. Compared to the middle tertile, patients in the low tertile were at a significantly higher risk for MACCE even after adjusting for baseline characteristics (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.18-6.06, P=0.019). An absence of statin treatment before onset and a younger age (HR 0.54, 0.87; 95%CI 0.33-0.90, 0.76-0.99; P=0.017, 0.037; respectively) were significantly associated with low VEGF. Conclusions: Low plasma VEGF levels at 7 days after the onset of AMI were associated with a significantly increased risk for MACCE during 6 months of follow-up., 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 松平京子氏の博士論文として提出された

Published
2012

18. CHANGES IN ACTIVITIES OF DAILY LIVING,PHYSICAL FITNESS, AND DEPRESSIVE SYMPTOMS AFTER SIX-MONTH PERIODIC WELL-ROUNDED EXERCISE PROGRAMS FOR OLDER ADULTS LIVING IN NURSING HOMES OR SPECIAL NURSING FACILITIES

Author

OUYANG, PEI, YATSUYA, HIROSHI, TOYOSHIMA, HIDEAKI, OTSUKA, REI, WADA, KEIKO, MATSUSHITA, KUNIHIRO, ISHIKAWA, MIYUKI, YUANYING, Li, HOTTA, YO, MITSUHASHI, HIROTSUGU, MURAMATSU, TAKASHI, KASUGA, NORIKATSU, and TAMAKOSHI, KOJI

Subjects
Older adults, Activities of daily living, Physical fitness, Well-rounded exercise program
Abstract

A 6-month, twice weekly, well-rounded exercise program (47 sessions in total) comprised of a combination of aerobic, resistance and lexibility training was provided for institutionalized older adults aged 60 to 93. We analyzed the data of 18 older adults who could stand and had attended more than 10% of the classes (mean participation rate: 54%) to examine changes in activities of daily living (ADL), physical fitness tests and depressive moods. The mean (± standard deviation, range) age of the participants was 71.3 (±15.6, 60–93) in men and 85.9 (±5.8, 72–93) in women. Significant improvement in ADL of the hand manipulation domain and borderline significant improvement in ADL of the mobility domain were observed (McNemar test p=0.011 and 0.072, respectively). A 6-minute walk distance increased significantly from 151.6 m to 236.6 m (p=0.01, paired t-test), and the result of the Soda Pop test, which tests hand-eye coordination, also improved significantly from 35.2 sec to 25.3 sec (p=0.01, paired t-test). These findings suggest that such a program could be effective in improving the ADL and physical fitness of the elderly.

Published
2009

19. Paradoxical high augmentation index in females with diabetes mellitus

Author

Nishizaki, Yuji, primary, Mizuno, Atsushi, additional, Miyauchi, Katsumi, additional, Okazaki, Shinya, additional, Yamazoe, Masahiro, additional, Komatsu, Ikki, additional, Asano, Taku, additional, Konishi, Hirokazu, additional, Naito, Ryo, additional, Tamura, Hiroshi, additional, Mitsuhashi, Hirotsugu, additional, Nishi, Yutaro, additional, Niwa, Koichiro, additional, and Daida, Hiroyuki, additional

Published
2017
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20. Validity of perceived mental stress evaluated from job stressors, and the associations between perceived mental stress and lifestyle

Author

Otsuka, Rei, Toyoshima, Hideaki, Tamakoshi, Koji, Morimoto, Yusuke, Wada, Keiko, Matsushita, Kunihiro, Takefuji, Seiko, Hotta, Yo, Mitsuhashi, Hirotsugu, Sugiura, Kaichiro, OuYang, Pei, and Yatsuya, Hiroshi

Subjects
妥当性, Job Stressor, Worker's Cohort, 自覚的ストレス, 仕事のストレス要因, Perceived Mental Stress, Lifestyle, 職域コホート, 生活習慣, Validity
Abstract

簡易な質問と解答肢で把握された精神的ストレスの自覚(以下、自覚的ストレス)が、仕事のストレス要因といかなる関連性を有しているかを検討し、ストレス指標としての妥当性を評価した。また自覚的ストレスと生活習慣との関連性を検討した。対象者は2002年に愛知県内某自治体に属する35歳以上の男女6,627人(男性5,159人、女性1,468人)である。自覚的ストレスは、「日ごろストレスが多いと思われますか」の質問に対する４つの選択肢、「かなり多い」、「やや多い」、「ふつう」、「少ない」から評価した。仕事のストレス要因(即ち、ストレッサー)は6項目(仕事の負担度、裁量度、技術の低活用、対人関係、職場環境、仕事の適合性)について、その有無を「職業性ストレス簡易調査票」を用いて評価した。仕事のストレス要因は、男では6項目全て、女では技術の低活用を除く5項目が、自覚的ストレスと有意な正の関連性を示した。このことから単一の質問と4つの主観に基づく選択肢で捉えた自覚的ストレスは、個人のストレス量を表す指標として妥当性をもつと考えた。また日常の生活習慣では、男女とも交替勤務や深夜勤務があること、長時間の残業、寝つきの愁訴あり、短い睡眠時間、運動習慣が無いこと、生きがい・はりのなさ、悩み事の相談相手がいないことが自覚的ストレスの増大と関与した。自覚的ストレスは日常生活での精神的・身体的ストレス反応や対処、社会的支援との間に順当な関連性を示した。, To assess the validity of a simple 4-point scale of perceived mental stress, we analyzed relationships of perceived mental stress with 6 job stressors: demand, control, skill underutilization, workplace human relations, physical environment, and job satisfaction. We also examined the association of lifestyle with perceived mental stress. Study subjects were 5,159 male and 1,468 female Japanese workers aged 35 years and above in 2002. Awareness of stress was assessed by the question: "Do you have much stress in your life?", and participants were asked to select one among 4 responses: 'very much', 'much', 'ordinary', or 'little'. Six job stressors were assessed by a Simple Questionnaire Concerning Work Related Stress. There were positive associations between perceived mental stress and all 6 job stressors in men, and 5 job stressors except skill underutilization in women. Therefore, we considered that a simple 4-point scale of perceived mental stress was reliable to evaluate individual stress. The subjects with highly perceived stress were more likely to have shift time or midnight work, and to have overtime work. The sleep duration on weekdays tended to decrease, the proportion of of subjects with two or more sleep-related complaints tended to increase, and physical activity tended to decrease according to the increase in the level of perceived stress. The proportion of subjects who lacked confidants, and who lost ikigai (subjective well-being) was linearly associated with an increased level of perceived stress. Perceived mental stress has a reasonable association with the individual's daily mental and physical stress reaction and coping, as well as social support.

Published
2006

22. Hydrophilic polymer embolization: another differential diagnosis of iatrogenic leg embolization after transcatheter aortic valve replacement.

Author

Komatsu, Ikki, Mitsuhashi, Hirotsugu, Nakaoka, Mikihiko, and Komiyama, Nobuyuki

Abstract

In daily practice, the iatrogenic complication hydrophilic polymer embolization (HPE) is under-recognized. An 86-year-old male experienced a distal foot embolization after transcatheter aortic valve replacement. Rashes appeared only in the access side foot just after the procedure. Gradual worsening of the rashes was first thought to be cholesterol crystal embolization (CCE), but a pathological examination revealed HPE. The clinical course following the diagnosis was uneventful without notable treatment. We experienced a rare but important alternative differential diagnosis of CCE after catheter intervention. [ABSTRACT FROM AUTHOR]

Published
2017
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23. Mineral Corticoid Receptor Antagonists Have an Important Role in Combination Therapy with Vasopressin Receptor Antagonists for Hospitalized Heart Failure Patients

Author

Nishihata, Yosuke, primary, Yamazoe, Masahiro, additional, Asano, Taku, additional, Mizuno, Atsushi, additional, Nakazato, Ryo, additional, Mitsuhashi, Hirotsugu, additional, Yokoyama, Yasuhiro, additional, Niinuma, Hiroyuki, additional, Nishi, Yutaro, additional, and Niwa, Koichiro, additional

Published
2014
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29. Uric Acid and Left Ventricular Hypertrophy in Japanese Men

Author

Mitsuhashi, Hirotsugu, primary, Yatsuya, Hiroshi, additional, Matsushita, Kunihiro, additional, Zhang, Huiming, additional, Otsuka, Rei, additional, Muramatsu, Takashi, additional, Takefuji, Seiko, additional, Hotta, Yo, additional, Kondo, Takahisa, additional, Murohara, Toyoaki, additional, Toyoshima, Hideaki, additional, and Tamakoshi, Koji, additional

Published
2009
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34. Abstract 3595: Inverse Association of Adiponectin with Insulin Resistance is Attenuated with the Escalation of Insulin Resistance: a Possible Finding of Adiponectin Resistance

Author

Matsushita, Kunihiro, primary, Yatsuya, Hiroshi, additional, Tamakoshi, Koji, additional, Muramatsu, Takashi, additional, Mitsuhashi, Hirotsugu, additional, Shibata, Rei, additional, Kondo, Takahisa, additional, Murohara, Toyoaki, additional, and Toyoshima, Hideaki, additional

Published
2007
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37. Adiponectin Level and Left Ventricular Hypertrophy in Japanese Men

Author

Mitsuhashi, Hirotsugu, primary, Yatsuya, Hiroshi, additional, Tamakoshi, Koji, additional, Matsushita, Kunihiro, additional, Otsuka, Rei, additional, Wada, Keiko, additional, Sugiura, Kaichiro, additional, Takefuji, Seiko, additional, Hotta, Yo, additional, Kondo, Takahisa, additional, Murohara, Toyoaki, additional, and Toyoshima, Hideaki, additional

Published
2007
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39. The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state

Author

Tamakoshi, Koji, primary, Yatsuya, Hiroshi, additional, Wada, Keiko, additional, Matsushita, Kunihiro, additional, Otsuka, Rei, additional, Yang, Pei Ou, additional, Sugiura, Kaichiro, additional, Hotta, Yo, additional, Mitsuhashi, Hirotsugu, additional, Takefuji, Seiko, additional, Kondo, Takaaki, additional, and Toyoshima, Hideaki, additional

Published
2006
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43. CoreValve Prosthesis Depth: What is the Optimal Measurement Target?

Author

Wolff R, Radhakrishnan S, Mitsuhashi H, Zavodni A, Roifman I, Sparkes JD, Fremes SE, Bakar-Irwin S, Hansen MS, and Strauss BH

Subjects
Aged, 80 and over, Angiography, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Atrioventricular Block etiology, Atrioventricular Block therapy, Bundle-Branch Block etiology, Bundle-Branch Block therapy, Cardiac Pacing, Artificial, Echocardiography, Electrocardiography, Female, Humans, Male, Postoperative Complications surgery, Retrospective Studies, Transcatheter Aortic Valve Replacement adverse effects, Aortic Valve diagnostic imaging, Aortic Valve surgery, Heart Valve Prosthesis adverse effects, Postoperative Complications diagnostic imaging, Transcatheter Aortic Valve Replacement instrumentation
Abstract

Background and Aim of the Study: A major drawback of the transcatheter aortic valve replacement (TAVR) procedure using the self-expandable Medtronic CoreValve (MCV) prosthesis is the high incidence of conduction disturbances and the need for postprocedural permanent pacemaker (PPM) implantation. The depth of prosthesis implantation may be an important contributing factor. The study aim was to determine the relationship between angiographic measurements of the MCV prosthesis depth and the occurrence of new conduction disturbances and need for PPM after TAVR., Methods: A retrospective analysis was conducted of 157 consecutive patients who had undergone TAVR procedures with the MCV between 2009 and 2013. Patients with pre-existing pacemakers (n = 27) were excluded. Prosthesis depth was defined as the angiographic distance from the lowest part of the prosthesis to the base of the non-coronary cusp (NCcD) and the base of the left coronary cusp (LCcD)., Results: A 26 mm MCV was implanted in 50% of patients, and a 29 mm MCV in 38%. The rate of new ≥2nd degree atrioventricular block (AVB) after TAVR was 5%, and the incidence of new left ventricular bundle branch block (LBBB) was 23%. PPMs were implanted in 13 patients (10%) within 30 days after the procedure. Freedom from new ≥2nd degree AVB, LBBB and the need for PPM after TAVR was significantly higher among patients with NCcD <6 mm or LCcD <8 mm (90% and 89%, respectively) compared to patients with NCcD ≥6 mm or LCcD ≥8 mm (53% and 54%, respectively) (p <0.0001)., Conclusions: Prosthesis depth, measured relative to either the NCcD or LCcD, strongly predicted the occurrence of conduction disturbances and the need for PPM following TAVR with the MCV prosthesis.

Published
2016

44. Impact of adiponectin and leptin on long-term adverse events in Japanese patients with acute myocardial infarction. Results from the Nagoya Acute Myocardial Infarction Study (NAMIS).

Author

Morita Y, Maeda K, Kondo T, Ishii H, Matsudaira K, Okumura N, Mitsuhashi H, Shibata R, and Murohara T

Subjects
Aged, Asian People, Female, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Myocardial Infarction diagnosis, Myocardial Infarction epidemiology, Myocardial Infarction surgery, Prognosis, Time Factors, Adiponectin blood, Leptin blood, Myocardial Infarction blood, Percutaneous Coronary Intervention
Abstract

Background: Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear., Methods and Results: This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33-3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43-0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45-0.76), P<0.001, respectively]. The leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up in a multivariable analysis [adjusted hazard ratio 0.60 (95% CI 0.43-0.83), P=0.002]., Conclusions: Higher adiponectin and lower leptin levels are associated with a high incidence of adverse events in Japanese patients after AMI, and the leptin to adiponectin ratio independently predicts prognosis after AMI.

Published
2013
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45. Changes in activities of daily living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities.

Author

Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Yuanying L, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, and Tamakoshi K

Subjects
Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Muscle Strength, Nursing Homes, Activities of Daily Living, Depression prevention & control, Exercise, Physical Fitness
Abstract

A 6-month, twice weekly, well-rounded exercise program (47 sessions in total) comprised of a combination of aerobic, resistance and flexibility training was provided for institutionalized older adults aged 60 to 93. We analyzed the data of 18 older adults who could stand and had attended more than 10% of the classes (mean participation rate: 54%) to examine changes in activities of daily living (ADL), physical fitness tests and depressive moods. The mean (+/- standard deviation, range) age of the participants was 71.3 (+/- 15.6, 60-93) in men and 85.9 (+/- 5.8, 72-93) in women. Significant improvement in ADL of the hand manipulation domain and borderline significant improvement in ADL of the mobility domain were observed (McNemar test p = 0.011 and 0.072, respectively). A 6-minute walk distance increased significantly from 151.6 m to 236.6 m (p = 0.01, paired t-test), and the result of the Soda Pop test, which tests hand-eye coordination, also improved significantly from 35.2 sec to 25.3 sec (p = 0.01, paired t-test). These findings suggest that such a program could be effective in improving the ADL and physical fitness of the elderly.

Published
2009

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