136 results on '"Mitschler, Andre"'
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2. Enantiomer Discrimination Illustrated by High-Resolution Crystal Structures of the Human Nuclear Receptor hRARγ
3. The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
4. X-rays-Induced Cooperative Atomic Movement in a Protein Crystal
5. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
6. Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family
7. Quantum Model of Catalysis Based on a Mobile Proton Revealed by Subatomic X-Ray and Neutron Diffraction Studies of h-Aldose Reductase
8. X-rays-Induced Cooperative Atomic Movement in a Protein Crystal
9. Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
10. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes
11. Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications
12. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
13. Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
14. Probing The Roles Of Two Tryptophans Surrounding The Unique Zinc Coordination Site In Lipase Family I.5
15. Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
16. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
17. Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction
18. 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors
19. An ab initio fully deuterated tiny crystal (1x0.25x0.20mm) allows neutron data collection at room temperature up to 1.90Å
20. High resolution neutron and X-ray diffraction RT studies of an H-FABP – Oleic acid complex: study of the internal water cluster and the ligand binding by a transferred multipolar electron density distribution
21. New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
22. UHR PX and NPC studies of H-FABP water network with tiny perdeuterated crystals
23. Perdeuteration: Vital to visualising solvent in neutron crystallography?
24. Radiation-induced disorder of a protein crystal
25. Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury
26. Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface
27. Neutron macromolecular crystallography with LADI-III
28. X-ray-induced deterioration of disulfide bridges at atomic resolution
29. Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies
30. High-resolution X-ray and neutron data collection on antifreeze protein
31. Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein
32. Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 Å Resolution: Implications for the Inhibition Mechanism
33. Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat
34. Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat Complex
35. Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity
36. Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications
37. High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
38. The crystallographic structure of the aldose reductase–IDD552 complex shows direct proton donation from tyrosine 48
39. Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis
40. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with fidarestat and minalrestat: Implications for the binding of cyclic imide inhibitors
41. X-ray crystallography at subatomic resolution
42. Crystallization and preliminary x‐ray analysis of Escherichia coli methionyl‐tRNAfMet formyltransferase
43. Crystallization and preliminary X-ray analysis ofEscherichia colimethionyl–tRNA fMet formyltransferase
44. Crystallization and preliminary X-ray analysis ofEscherichia coli methionyl–tRNAfMet formyltransferase
45. Discoveryof (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoicAcid and Congeners As Highly Potent Inhibitors of Human ArginasesI and II for Treatment of Myocardial Reperfusion Injury.
46. Crystal and molecular structure of a new eight-membered tetraphospha-macrocycle, (–PCPh⁼CMeCMe⁼C–)4.
47. THE CRYSTAL AND MOLECULAR STRUCTURE OF A SERIES OF OXO MOLYBDENUM DITHIOCARBAMATES.
48. Reaction of 1-alkyl-1,1'-diphosphaferrocene monoanions with acyl chlorides. Synthesis and zwitterionic structure of stable .lambda.3,.lambda.5-diphosphaferrocenes
49. Electronic structure of chromium hexacarbonyl at liquid nitrogen temperature. 2. Experimental study (x-ray and neutron diffraction) of .sigma. and .pi. bonding
50. Synthesis of new heteropolymetallic compounds with carbonylmetallate anions as bridges between two palladium atoms: x-ray crystal structures of [{PdNMe2CH2C6H4}2.mu.-{Co(CO)4}.mu.Cl] and [{PdNMe2CH2C6H4}2.mu.-{Mo(CO)3(.eta.-C5H5)}.mu.Cl]
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