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4. Factor Space and Spectrum for Medical Hyperspectral Image Segmentation

Author

Yun, Boxiang, Li, Qingli, Mitrofanova, Lubov, Zhou, Chunhua, Wang, Yan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Greenspan, Hayit, editor, Madabhushi, Anant, editor, Mousavi, Parvin, editor, Salcudean, Septimiu, editor, Duncan, James, editor, Syeda-Mahmood, Tanveer, editor, and Taylor, Russell, editor

Published
2023
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6. CD68-Negative Histiocytoses with Cardiac Involvement, Associated with COVID-19.

Author

Mitrofanova, Lubov, Korneva, Lubov, Makarov, Igor, Bortsova, Maria, Sitnikova, Maria, Ryzhkova, Daria, Kudlay, Dmitry, and Starshinova, Anna

Subjects
*MYELOID cells, *COVID-19, *DENDRITIC cells, *SARS-CoV-2, *HISTIOCYTOSIS
Abstract

Histiocytoses are rare diseases characterised by infiltration of affected organs by myeloid cells with a monocyte or dendritic cell phenotype. Symptoms can range from self-resolving localised forms to multisystemic lesions requiring specific treatment. To demonstrate extremely rare cases of CD68-negative cardiac histiocytosis with expression of SARS-CoV-2 antigen in infiltrate cells. We demonstrated a case of Erdheim–Chester disease in a 67-year-old man with pericardial involvement and positive dynamics with vemurafenib treatment, an autopsy case of xanthogranulomatous myopericarditis in a 63-year-old man, surgical material of xanthogranulomatous constrictive pericarditis in a 57-year-old man, and an autopsy case of xanthogranulomatosis in a 1-month-old girl. In all cases, xanthogranuloma cells expressed CD163, many of them spike protein SARS-CoV-2, while CD68 expression was detected only in single cells. In this article, we demonstrated four cases of extremely rare CD68-negative cardiac xanthogranulomatosis in three adults and one child with expression of the spike protein SARS-CoV-2 in M2 macrophages. This potential indirect association between COVID-19 and the development of histiocytosis in these patients warrants further investigation. To substantiate this hypothesis, more extensive research is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Are Endomyocardial Ventricular Biopsies Useful for Assessing Myocardial Fibrosis?

Author

Makarov, Igor, Voronkina, Daria, Gurshchenkov, Alexander, Ryzhkov, Anton, Starshinova, Anna, Kudlay, Dmitry, and Mitrofanova, Lubov

Subjects
FIBROSIS, MYOCARDIAL ischemia, CORONARY disease, HYPERTROPHIC cardiomyopathy, CARDIOVASCULAR diseases, HEART transplantation, HYPERTENSIVE crisis
Abstract

Myocardial fibrosis is an important factor in the progression of cardiovascular diseases. However, there is still no universal lifetime method of myocardial fibrosis assessment that has a high prognostic significance. The aim of the study was to determine the significance of ventricular endomyocardial biopsies for the assessment of myocardial fibrosis and to identify the severity of myocardial fibrosis in different cardiovascular diseases. Material and Methods: Endomyocardial biopsies (EMBs) of 20 patients with chronic lymphocytic myocarditis (CM), endomyocardial fragments obtained during septal reduction of 21 patients with hypertrophic cardiomyopathy (HCM), and 36 patients with a long history of hypertensive and ischemic heart disease (HHD + IHD) were included in the study. The control group was formed from EMBs taken on 12–14 days after heart transplantation (n = 28). Also, for one patient without clinical and morphological data for cardiovascular pathology, postmortem myocardial fragments were taken from typical EMB and septal reduction sites. The relative area of fibrosis was calculated as the ratio of the total area of collagen fibers to the area of the whole biopsy. Endocardium and subendocardial fibrosis were not included in the total biopsy area. Results: The relative fibrosis area in the EMBs in the CM patient group was 5.6 [3.3; 12.6]%, 11.1 [6.6; 15.9]% in the HHD + IHD patient group, 13.4 [8.8; 16.7]% in the HCM patient group, and 2.7 [1.5; 4.6]% in the control group. When comparing the fibrosis area of the CM patients in repeat EMBs, it was found that the fibrosis area in the first EMBs was 7.6 [4.8; 12.0]%, and in repeat EMBs, it was 5.3 [3.2; 7.6]%. No statistically significant differences were found between the primary and repeat EMBs (p = 0.15). In ROC analysis, the area of fibrosis in the myocardium of 1.1% (or lower than one) was found to be highly specific for the control group of patients compared to the study patients. Conclusions: EMB in the assessment of myocardial fibrosis has a questionable role because of the heterogeneity of fibrotic changes in the myocardium. [ABSTRACT FROM AUTHOR]

Published
2024
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10. High Risk of Heart Tumors after COVID-19

Author

Mitrofanova, Lubov, primary, Makarov, Igor, additional, Goncharova, Ekaterina, additional, Makarova, Taiana, additional, Starshinova, Anna, additional, Kudlay, Dmitry, additional, and Shlaykhto, Evgeny, additional

Published
2023
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15. Comparative Study of the Myocardium of Patients from Four COVID-19 Waves

Author

Mitrofanova, Lubov Borisovna, primary, Makarov, Igor Aleksandrovich, additional, Gorshkov, Andrey Nikolaevich, additional, Runov, Andrey Leonidovich, additional, Vonsky, Maxim Sergeevich, additional, Pisareva, Maria Mikhailovna, additional, Komissarov, Andrey Borisovich, additional, Makarova, Taiana Alekseevna, additional, Li, Qingli, additional, Karonova, Tatiana Leonidovna, additional, Konradi, Alexandra Olegovna, additional, and Shlaykhto, Evgeny Vladimirovich, additional

Published
2023
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18. Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology

Author

Basso, Cristina, Aguilera, Beatriz, Banner, Jytte, Cohle, Stephan, d’Amati, Giulia, de Gouveia, Rosa Henriques, di Gioia, Cira, Fabre, Aurelie, Gallagher, Patrick J., Leone, Ornella, Lucena, Joaquin, Mitrofanova, Lubov, Molina, Pilar, Parsons, Sarah, Rizzo, Stefania, Sheppard, Mary N., Mier, Maria Paz Suárez, Kim Suvarna, S., Thiene, Gaetano, van der Wal, Allard, Vink, Aryan, Michaud, Katarzyna, and on behalf of the Association for European Cardiovascular Pathology

Published
2017
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22. New Scenarios in Heart Transplantation and Persistency of SARS-CoV-2 (Case Report).

Author

Mitrofanova, Lubov, Makarov, Igor, Gorshkov, Andrey, Vorobeva, Olga, Simonenko, Maria, Starshinova, Anna, Kudlay, Dmitry, and Karonova, Tatiana

Subjects
*HEART, *HEART transplantation, *SARS-CoV-2, *HEART transplant recipients, *TRANSPLANTATION of organs, tissues, etc., *CARDIAC patients
Abstract

Heart transplantation is a treatment of choice for patients with severe heart failure. Infection transmission from a donor to a recipient remains a prominent problem in organ transplantation. However, the risk of SARS-CoV-2 transmission in nonlung organ transplantation is still unclear. In this article we presented a case of a 28-year-old pregnant woman who developed heart failure soon after recovery from a SARS-CoV-2 infection in the third trimester of gestation. In the postpartum period, the heart disease worsened and the patient required cardiac transplantation. We examined the recipient's heart and made a diagnosis of left ventricular noncompaction cardiomyopathy. Immunohistochemical analysis showed SARS-CoV-2 antigen expression in the donor's heart before transplantation, and after the transplantation, an endomyocardial biopsy was taken. Moreover, an ultrastructural assessment of the endomyocardial specimen revealed endothelial and pericyte injury and a single particle on the surface of the endothelium consistent with SARS-CoV-2 viral particles. Recent findings in the literature associated these damages with SARS-CoV-2 infection. The present study describes the rare case of SARS-CoV-2 transmission from donor to postpartum recipient through a heart transplant and demonstrates the importance of endomyocardial biopsy before and after heart transplantation. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review

Author

Morgacheva, Daria, primary, Daks, Alexandra, additional, Smirnova, Anna, additional, Kim, Aleksandr, additional, Ryzhkova, Daria, additional, Mitrofanova, Lubov, additional, Staliarova, Alena, additional, Omelina, Evgeniya, additional, Pindyurin, Alexey, additional, Fedorova, Olga, additional, Shuvalov, Oleg, additional, Petukhov, Alexey, additional, and Dinikina, Yulia, additional

Published
2022
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25. Congenital hyperinsulinism: the significance of visual evaluation of positron emission tomography and the role of the surgeon in determining the limits of pancreatic resection

Author

Sukhotskaya, Anna A., primary, Bairov, Vladimir G., additional, Mitrofanova, Lubov B., additional, Perminova, Anastasiya A., additional, Rijkova, Darya V., additional, Nikitina, Irina L., additional, Amidhonova, Surayo A., additional, and Kagantsov, Ilya M., additional

Published
2022
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28. Pulmonary and Systemic Hemodynamics following Multielectrode Radiofrequency Catheter Renal Denervation in Acutely Induced Pulmonary Arterial Hypertension in Swine

Author

Vakhrushev, Aleksandr D., primary, Сondori Leonardo, Heber Ivan, additional, Goncharova, Natalia S., additional, Korobchenko, Lev E., additional, Mitrofanova, Lubov B., additional, Andreeva, Elizaveta M., additional, Koshevaya, Elena G., additional, Lebedev, Dmitry S., additional, and Mikhaylov, Evgeny N., additional

Published
2021
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29. The coincidence of two rare diseases with opposite metabolic phenotype: a child with congenital hyperinsulinism and Bloom syndrome

Author

Melikyan, Maria, primary, Gubaeva, Diliara, additional, Nikitina, Irina, additional, Ryzhkova, Daria, additional, Mitrofanova, Lubov, additional, Yukhacheva, Daria, additional, Pershin, Dmitry, additional, Shcherbina, Anna, additional, Vasilyev, Evgeniy, additional, Proshchina, Alexandra, additional, Krivova, Yuliya, additional, and Tiulpakov, Anatoly, additional

Published
2021
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32. An Ovine Model for Percutaneous Pulmonary Artery Laser Denervation: Perivascular Innervation and Ablation Lesion Characteristics

Author

Condori Leandro, Heber Ivan, primary, Koshevaya, Elena G., additional, Mitrofanova, Lubov B., additional, Vakhrushev, Aleksandr D., additional, Goncharova, Natalia S., additional, Korobchenko, Lev E., additional, Andreeva, Elizaveta M., additional, Lebedev, Dmitry S., additional, and Mikhaylov, Evgeny N., additional

Published
2021
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33. B-PO02-050 FIRST EXPERIENCE WITH A SINGLE CONDUIT MULTI-PRONG LEAD TO PROVIDE SEQUENTIAL PHYSIOLOGIC PACING IN AN ANIMAL MODEL

Author

Orlov, Michael V., primary, Gorev, Maxim, additional, Vijayaraman, Pugazhendhi, additional, Lebedev, Dmitry S., additional, Mitrofanova, Lubov B., additional, Prikhodko, Nikita, additional, Starostin, Andrei, additional, Murashova, Lada, additional, Makharinsky, Daniel, additional, and Makharinsky, Leonid, additional

Published
2021
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34. Additional file 1 of Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility

Author

Goncharova, Natalia S., Condori Leandro, Heber Ivan, Vakhrushev, Aleksandr D., Koshevaya, Elena G., Skorik, Yury A., Mitrofanova, Lubov B., Murashova, Lada A., Korobchenko, Lev E., Andreeva, Elizaveta M., Lebedev, Dmitry S., Moiseeva, Olga M., and Mikhaylov, Evgeny N.

Abstract

Additional file 1. Supplementary materials (Table S1, Table S2, Table S3, Figure S1).

Published
2021
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36. Case Reports: Emery-Dreifuss Muscular Dystrophy Presenting as a Heart Rhythm Disorders in Children

Author

Kovalchuk, Tatiana, primary, Yakovleva, Elena, additional, Fetisova, Svetlana, additional, Vershinina, Tatiana, additional, Lebedeva, Viktoriya, additional, Lyubimtseva, Tamara, additional, Lebedev, Dmitriy, additional, Mitrofanova, Lubov, additional, Ryzhkov, Anton, additional, Sokolnikova, Polina, additional, Fomicheva, Yuliya, additional, Kozyreva, Alexandra, additional, Zhuk, Sergey, additional, Smolina, Natalia, additional, Zlotina, Anna, additional, Pervunina, Tatiana, additional, Kostareva, Anna, additional, and Vasichkina, Elena, additional

Published
2021
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41. Extended versus limited stimulation-guided pulmonary artery catheter denervation in normotensive pigs: acute hemodynamic effects

Author

Goncharova, Natalia, primary, Vakhrushev, Alexandr, additional, Condori Leandro, Heber Ivan, additional, Voronin, Stepan, additional, Murashova, Lada, additional, Korobchenko, Lev, additional, Andreeva, Elizaveta, additional, Mitrofanova, Lubov, additional, Lebedev, Dmitry, additional, Moiseeva, Olga, additional, and Mikhaylov, Evgeny, additional

Published
2020
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43. Telocytes in the human sinoatrial node

Author

Mitrofanova, Lubov B., Gorshkov, Andrey N., Konovalov, Petr V., and Krylova, Julia S.

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Immunocytochemistry, CD34, 030204 cardiovascular system & hematology, telocytes, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, Immunophenotyping, medicine, Humans, Aged, Sinoatrial Node, confocal laser scanning microscopy, electron microscopy, biology, Chemistry, Sinoatrial node, Original Articles, Cell Biology, Immunogold labelling, Middle Aged, Primary and secondary antibodies, human sinoatrial node, 030104 developmental biology, medicine.anatomical_structure, immunohistochemistry, Transitional Cell, biology.protein, Molecular Medicine, Immunohistochemistry, Original Article, Female
Abstract

The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile myocardium. Immunohistochemistry using antibodies against HCN4 and antibody combinations against CD34 and HCN4 was carried out on 12 specimens. Confocal laser scanning microscopy (CLSM) with two mixtures of primary antibodies, namely CD34/S100 and vimentin/S100, was performed in three cases. In two cases, CLSM was carried out with CD117 antibody. Specimens for electron microscopy and immunocytochemistry with HCN4 immunogold labelling were taken from another three patients. In our study, we found cells with the immunophenotype of telocytes in the SAN. There were twice as many of these cells in the centre of the SAN as in the periphery (20.3 ± 4.8 versus 10.8 ± 4.4 per high‐power field). They had close contact with pacemaker cells and contractile cardiomyocytes and expressed HCN4. The ultrastructural characteristics of these cells are identical to those of telocytes observed earlier in other organs. Our study provides evidence that telocytes are present in the SAN.

Published
2017

45. Clinical, genetic, and radionuclide characteristics of the focal form of congenital hyperinsulinism

Author

Gubaeva, Diliara N., primary, Melikyan, Maria A., additional, Ryzhkova, Daria V., additional, Poyda, Mikhail D., additional, Bairov, Vladimir G., additional, Sukhotskaya, Anna A., additional, Sokolov, Yurij Yu., additional, Efremenkov, Artem M., additional, Mitrofanova, Lubov B., additional, Christesen, Henrik, additional, and Nikitina, Irina L., additional

Published
2019
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46. CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease

Author

Kudryavtsev, Igor, primary, Serebriakova, Maria, additional, Zhiduleva, Ekaterina, additional, Murtazalieva, Patimat, additional, Titov, Vladislav, additional, Malashicheva, Anna, additional, Shishkova, Anastasya, additional, Semenova, Daria, additional, Irtyuga, Olga, additional, Isakov, Dmitry, additional, Mitrofanova, Lubov, additional, Moiseeva, Olga, additional, and Golovkin, Alexey, additional

Published
2019
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47. Truncating Variant in Myof Gene Is Associated With Limb-Girdle Type Muscular Dystrophy and Cardiomyopathy

Author

Kiselev, Artem, primary, Vaz, Raquel, additional, Knyazeva, Anastasia, additional, Sergushichev, Alexey, additional, Dmitrieva, Renata, additional, Khudiakov, Aleksandr, additional, Jorholt, John, additional, Smolina, Natalia, additional, Sukhareva, Ksenia, additional, Fomicheva, Yulia, additional, Mikhaylov, Evgeny, additional, Mitrofanova, Lubov, additional, Predeus, Alexander, additional, Sjoberg, Gunnar, additional, Rudenko, Dmitriy, additional, Sejersen, Thomas, additional, Lindstrand, Anna, additional, and Kostareva, Anna, additional

Published
2019
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50. Guidelines for autopsy investigation of sudden cardiac death:2017 update from the Association for European Cardiovascular Pathology

Author

Basso, Cristina, Aguilera, Beatriz, Banner, Jytte, Cohle, Stephan, d'Amati, Giulia, de Gouveia, Rosa Henriques, di Gioia, Cira, Fabre, Aurelie, Gallagher, Patrick J, Leone, Ornella, Lucena, Joaquin, Mitrofanova, Lubov, Molina, Pilar, Parsons, Sarah, Rizzo, Stefania, Sheppard, Mary N, Mier, Maria Paz Suárez, Kim Suvarna, S, Thiene, Gaetano, van der Wal, Allard, Vink, Aryan, Michaud, Katarzyna, Basso, Cristina, Aguilera, Beatriz, Banner, Jytte, Cohle, Stephan, d'Amati, Giulia, de Gouveia, Rosa Henriques, di Gioia, Cira, Fabre, Aurelie, Gallagher, Patrick J, Leone, Ornella, Lucena, Joaquin, Mitrofanova, Lubov, Molina, Pilar, Parsons, Sarah, Rizzo, Stefania, Sheppard, Mary N, Mier, Maria Paz Suárez, Kim Suvarna, S, Thiene, Gaetano, van der Wal, Allard, Vink, Aryan, and Michaud, Katarzyna

Abstract

Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosis of the causes of SCD is now of particular importance. Pathologists are responsible for determining the precise cause and mechanism of sudden death but there is still considerable variation in the way in which they approach this increasingly complex task. The Association for European Cardiovascular Pathology has developed these guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate investigation of SCD. The present version is an update of our original article, published 10 years ago. This is necessary because of our increased understanding of the genetics of cardiovascular diseases, the availability of new diagnostic methods, and the experience we have gained from the routine use of the original guidelines. The updated guidelines include a detailed protocol for the examination of the heart and recommendations for the selection of histological blocks and appropriate material for toxicology, microbiology, biochemistry, and molecular investigation. Our recommendations apply to university medical centers, regionals hospitals, and all healthcare professionals practicing pathology and forensic medicine. We believe that their adoption throughout Europe will improve the standards of autopsy practice, allow meaningful comparisons between different communities and regions, and permit the identification of emerging patterns of diseases causing SCD. Finally, we recommend the development of regional multidisciplinary networks of cardiologists, geneticists, and pathologists. Their role will be to facilitate the identification of index cases with a genetic basis, to screen appropriate family members, and ensure that appropr

Published
2017

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