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Your search keyword '"Mitra, Mayur S."' showing total 8 results
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8 results on '"Mitra, Mayur S."'

1. Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Author

Yadav, Rajbharan, Sukumaran, Siddharth, Lutman, Jeff, Mitra, Mayur S., Halpern, Wendy, Sun, Tianhe, Setiadi, A. Francesca, Neighbors, Margaret, Sheng, X. Rebecca, Yip, Victor, Shen, Ben-Quan, Liu, Chang, Han, Lyrialle, Ovacik, Ayse Meric, Wu, Yan, Glickstein, Sara, Kunder, Rebecca, Arron, Joseph R., Pan, Lin, Kamath, Amrita V., and Stefanich, Eric G.

Published
2023
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5. Translational and pharmacokinetic‐pharmacodynamic application for the clinical development of GDC‐0334, a novel TRPA1 inhibitor

Author

Chan, Phyllis, primary, Ding, Han Ting, additional, Liederer, Bianca M., additional, Mao, Jialin, additional, Belloni, Paula, additional, Chen, Liuxi, additional, Gao, Simon S., additional, Joseph, Victory, additional, Yang, Xiaoying, additional, Lin, Joseph S., additional, Mitra, Mayur S., additional, Putnam, Wendy S., additional, Quartino, Angelica, additional, Bauer, Rebecca N., additional, and Pan, Lin, additional

Published
2021
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7. A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

Author

Mitra, Mayur S, primary, Lancaster, Karla, primary, Adedeji, Adeyemi O, primary, Palanisamy, Gopinath S, primary, Dave, Rutwij A, primary, Zhong, Fiona, primary, Holdren, Matthew S, primary, Turley, Shannon J, primary, Liang, Wei-Ching, primary, Wu, Yan, primary, Meng, Y Gloria, primary, Vernes, Jean-Michel, primary, and Schutten, Melissa M, primary

Published
2020
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8. Foreign Body Reaction, Retinal Degeneration, and Epiretinal Membranes Associated With Intravitreal Administration of PLGA Rods.

Author

Booler H, Larsen T, Shelton A, Bansteev V, and Mitra MS

Subjects
Animals, Foreign-Body Reaction, Humans, Intravitreal Injections, Macaca fascicularis, Epiretinal Membrane chemically induced, Retinal Degeneration chemically induced
Abstract

Long-acting delivery platforms for intravitreal therapies are an active area of research in ophthalmic drug development. The aim of these platforms is to decrease the burden of intravitreal therapies for patients, by increasing the period between intravitreal injections. This brief communication describes the in-life, histologic and immunohistochemical findings associated with repeat-dose intravitreal administration of poly D, L sustained lactide-co-glycolide polymeric rods, an intravitreal depot, in the cynomolgus monkey ( Macaca fascicularis ). These nonclinical investigations illustrate a pattern of foreign body reaction around intravitreal depots at the temporal pars plana and demonstrated the histopathologic and immunohistologic features of retinal degeneration and epiretinal membrane formation in the inferior retina.

Published
2021
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