1. Sesquiterpene and Sorbicillinoid Glycosides from the Endophytic Fungus Trichoderma longibrachiatum EN-586 Derived from the Marine Red Alga Laurencia obtusa .
- Author
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Wang Y, Li XM, Yang SQ, Zhang FZ, Wang BG, Li HL, and Meng LH
- Subjects
- Bacteria drug effects, Bacteria growth & development, Mitosporic Fungi drug effects, Mitosporic Fungi growth & development, Molecular Structure, Anti-Infective Agents chemistry, Anti-Infective Agents isolation & purification, Anti-Infective Agents pharmacology, Endophytes chemistry, Glycosides chemistry, Glycosides isolation & purification, Glycosides pharmacology, Hypocreales chemistry, Laurencia microbiology, Polyketides chemistry, Polyketides isolation & purification, Polyketides pharmacology, Resorcinols chemistry, Resorcinols isolation & purification, Resorcinols pharmacology, Sesquiterpenes chemistry, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology
- Abstract
An unusual sesquiterpene glycoside trichoacorside A ( 1 ) and two novel sorbicillinoid glycosides sorbicillisides A ( 2 ) and B ( 3 ), together with a known compound sorbicillin ( 4 ), were isolated and identified from the culture extract of an endophytic fungus Trichoderma longibrachiatum EN-586, obtained from the marine red alga Laurencia obtusa . Trichoacorside A ( 1 ) is the first representative of a glucosamine-coupled acorane-type sesquiterpenoid. Their structures were elucidated based on detailed interpretation of NMR and mass spectroscopic data. The absolute configurations were determined by X-ray crystallographic analysis, chemical derivatization, and DP4+ probability analysis. The antimicrobial activities of compounds 1 - 4 against several human, aquatic, and plant pathogens were evaluated.
- Published
- 2022
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