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According to recent research published in the Journal of Cell Science, 'Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of membrane proteins that are essential for cell proliferation and [...]

According to a study from Marseille, France, 'Maternally inherited diabetes and deafness (MIDD) and myoencephalopathy, lactic acidosis, stroke-like episodes (MELAS) syndromes are characterized by the same A3243G mutation of mitochondrial [...]

'Mitochondria are integral components of cellular calcium (Ca2+) signaling. Calcium stimulates mitochondrial adenosine 5'-triphosphate production, but can also initiate apoptosis,' scientists in the United States report (see also RNA Research). [...]

According to recent research published in the journal BMC Medical Genetics, 'Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are the most frequent forms of hereditary optic [...]

According to recent research published in the journal Cell Metabolism, 'Mutations in the transcription factor Pdx1 cause maturity-onset diabetes of the young 4 (MODY4). Islet transduction with dominant-negative Pdx1 (RIPDN79PDX1) [...]

Current study results from the report, 'Diagnosis and therapy in neuromuscular disorders: diagnosis and new treatments in mitochondrial diseases,' have been published. According to a study from London, the United [...]

'Cockayne syndrome (CS) is a complex, progressive disease that involves neurological and developmental impairment and premature aging. The majority of CS patients have mutations in the CSB gene,' scientists in [...]

'Helicobacter pylori is a major cause of gastric carcinoma. To investigate a possible link between bacterial infection and genetic instability of the host genome, we examined the effect of H. [...]

According to recent research from Melbourne, Australia, 'Damaged mitochondria generate an excess of superoxide, which may mediate tissue injury in diabetes. We hypothesized that in diabetic nephropathy, advanced glycation end-products [...]

'Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function,' scientists writing in the journal Molecular Cell report (see also Parkinson Disease). 'We investigated [...]

According to recent research from Tokyo, Japan, 'Blockade of angiotensin(Ang) II has been shown to prevent new-onset type 2 diabetes. We focused on the effects of AngII on muscle mitochondria, [...]

According to recent research published in the journal Human Molecular Genetics, 'In humans, MPV17 mutations are responsible for severe mitochondrial depletion syndrome, mainly affecting the liver and the nervous system. [...]

According to a study from Antwerp, Belgium, 'Specific mitochondrial DNA (mtDNA) mutations in 12SrRNA and tRNASer(UCN) cause non-syndromic hearing loss (NSHL). In this study, we screened 466 hearing loss (HQ [...]

According to a study from Helsinki, Finland, 'Mitochondrial DNA depletion syndrome (MDS) is a severe recessively inherited disease of childhood. It manifests most often in infancy, is rapidly progressive and [...]

According to recent research published in the journal Cardiovascular Research, ' Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated [...]

According to recent research from Padua, Italy, 'Mutations in mitochondrial DNA (mtDNA) tRNA genes can be considered functionally recessive because they result in a clinical or biochemical phenotype only when [...]

According to recent research from Aarhus, Denmark, 'The mitochondrial chaperonin heat shock protein 60 (Hsp60) assists the folding of a subset of proteins localized in mitochondria and is an essential [...]

According to recent research from Milan, Italy, 'Cytochrome c oxidase (COX) deficiency, one of the most common respiratory-chain defects in humans, has been associated with mutations in either mitochondrial DNA [...]

Current study results from the report, 'A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene,' have been published (see also Retinitis [...]

Researchers detail in 'mtDNA evidence: genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China,' new data in esophageal cancer [...]

Data detailed in 'Long-term outcome of Leigh syndrome caused by the NARP-T8993C mtDNA mutation' have been presented (see also Leigh Disease). 'Mutations at mitochondrial DNA (mtDNA) nucleotide 8993 can cause [...]

New investigation results, 'Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats,' are detailed in a study published [...]

Scientists discuss in 'Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency' new findings in cell biology (see also Cell Biology). According to recent research published in [...]

Researchers detail in 'Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan,' new data in cerebellar ataxia. According to recent research published [...]

Investigators in the United States and France have published new neurology data. Study 1: Scientists review the role of mitochondria in inherited neurodegenerative diseases in a recent issue of the [...]

Neurology research advances have been reported from the United States and France. Study 1: Scientists review the role of mitochondria in inherited neurodegenerative diseases in a recent issue of the [...]

Data on diabetes genomics and genetics are outlined in reports from Croatia, Belgium and Norway. Study 1: A mitochondrial DNA point mutation A3243G in Croatian patients having type 2 diabetes [...]