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In recent decades, probiotic products have been increasingly used to prevent certain gastro-intestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.

Quality management is very important segment of business in pharmaceutical industry which primary objective is to provide a quality product to customer for the purpose of preserving human health. The increasing number of companies apply numerous quality systems, hence the need for a comparative review of quality management systems and its optimization in order to find suitable model for the integration of these systems. The improvement of integrated management and quality systems has become an imperative of company's business development and survival. It is economically acceptable to use synergy potential in the field of quality management for the purpose of significantly improving company's business competitive position with a relatively small investment. In addition to this, with the integration of different management systems companies become more agile, profitable and more competitive, which is a condition for its survival on the global marketplace. Integrated management systems combine all the components of management systems into a coherent system thus enabling the achievement of company's policy and goals. Basically, there are three approaches for establishment of integrated quality management systems: the Sequential approach, Parallel approach and Combined approach.

Probiotic pharmaceutical preparations are more and more popular because of the increasing level of evidence of their beneficial effect on human health. The goal of this study was to determine and develop the encapsulated probiotic formulation with the optimal filling amount of active ingredient - Lactobacillus plantarum that would, in combination with other active ingredients: iron, vitamin C and excipient starch, fulfil requirements for therapeutic action while maintaining process parameters’ requirements of manufacturing as well. The optimal formulation of a multicomponent probiotic-based formulation that fulfils requirements for sustaining all active ingredients while respecting technological process requirements, will enable a routine pharmaceutical manufacturing that could yield both efficient and safe dietary products.