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Alzheimer’s disease (AD) is a neurodegenerative disease manifested with accumulation of neurotoxic proteins like beta-amyloid (Aβ) and hyperphosphorylated tau. Administration of angiotensin receptor blockers (ARBs) such as Telmisartan has demonstrated to generate significant memory improvement in AD. Azilsartan is an ARB with better bioavailability than Telmisartan. Hence, the present work evaluates the efficacy of Azilsartan against aluminium chloride (AlCl3) induced AD. In the work, albino rats were divided into five groups (n=6). Group I served as control and received saline (10 ml/kg). Group-II was treated with AlCl3 (100 mg/kg) for 42 days; Group-III and IV received Azilsartan (5 mg/kg) and Telmisartan (10 mg/kg) with AlCl3 daily for 42 days. Y-maze, elevated plus maze and radial arm maze were used to evaluate memory functions. This was followed by biochemical and histological studies, along-with determination of Aβ content and anti-oxidant status. AlCl3 was found to significantly (p

Background and Aims: Sedation in paediatric cancer for fractionated radiation treatment (RT) is unique as the child has to be still for accurate delivery of RT, monitoring of the child is from a remote location and sedation is repeated for multiple sessions of RT. The present study was undertaken to compare the efficacy of intranasal dexmedetomidine with oral midazolam and ketamine combination for repeated sedation during fractionated RT in paediatric oncology. Methods: Ninety children aged between 3-6 years, planned for 21 fractions of RT, were randomised to receive intranasal dexmedetomidine 2 mg/kg (group D) or oral midazolam 0.2 mg/kg and ketamine 5 mg/kg (group MK). The 21 sessions of fractionated radiotherapy were divided into three subgroups of seven consecutive exposures 1-7, 8-14 and 15-21 for comparison. The primary endpoint was to determine the incidence of successful sedation. The sedation score achieved, time to satisfactory sedation and discharge, rescue ketamine required, and side effects were secondary endpoints. Results: The incidence of successful sedation in the three successive RT subgroups; sessions: 1-7, 8-14 and 15-21, was 82, 75.6 and 66.7 in group D, as compared to 40, 24.4 and 13.3 in group MK, respectively. (P < 0.001). A decrease in successful sedation was noted in the successive subgroups. Time to successful sedation and discharge was earlier in group D in comparison to MK (P = 0.000). More patients in group MK required rescue ketamine (P = 000). Conclusion: Intranasal dexmedetomidine produces more satisfactory sedation as compared to oral ketamine with midazolam for fractionated RT. Keywords: Dexmedetomidine, intranasal, ketamine, midazolam, radiation treatment, sedation, Author(s): Rekha Das (corresponding author) [1]; Rajat Das [1]; Manoranjan Jena [2]; Janaki Janka [1]; Sunita Mishra [1] INTRODUCTION Oral and intranasal routes for procedural sedation in children undergoing diagnostic [...]

Tannery sludge (TS) contains a number of useful components like Organic carbon, Organic Matter, PO4 3-, Ca2+, Mg2+, and other nutrients essential for plant growth. However, presence of water-soluble toxic metals in TS may cause phytotoxicity. Primary objective of this work was to adopt a bio-chemical strategy for assessing the potential consequences of agricultural application of tannery sludge, via sludge characterization and subsequent bioassay investigations. Heavy metal concentration in the TS was found to be in the order of: Cr (19576±2065.52) > Pb (16.98±2.54) > Cu (1.76±0.20) > Ni (0.98±0.00) > Cd (0.19±0.00) mg kg-1. Further, bioassay tests were performed in terms of germination index (GI), relative seed germination (RSG) and relative root growth (RRG) on Brassica nigra, Vigna radiata, Vigna mungo, Raphanus sativus, and Capsicum frutescens. RSG and RRG were found to be more than 80% whereas, GI was > 66% in all the tested crops exposed to TS extract at 1:5 and 1:10 (w/v) dilutions. Results revealed that the toxicants present in the TS were failed to cause toxicity at early seedling growth and may be used as a soil conditioner after appropriate dilution. However, long term field trails are essential before agricultural utilization. [ABSTRACT FROM AUTHOR]

This paper analyses how community, national and ethnic identities are affirmed, negotiated, marginalized as a part of hegemony-making and resistance in the context of English education in Indian universities. We argue and demonstrate that a complex and ambivalent hegemony that has been operational since the colonial times, continues to shape English education in India. Today, English and English education play a major role in articulating, binding and dividing multiple identities and knowledge systems. In the first part of the paper, we critically review debates and discussions on the significance of English language education in institutes of higher education in India. Specifically, we focus on discourses on the rationale behind continuing and contesting English education. The second part examines how in the postmodern context, English is being taught differently to different groups and highlights how these contexts of teaching have been defining knowledge systems, patterns of dominance and also, articulating resistance.

Supercapacitors (SCs) based on hierarchical nanoporous framework composite materials and aqueous electrolytes are recent interests for the researchers. The structure of UiO-66 exhibits extraordinary stability and high specific surface area, but the specific capacitance of UiO-66 (139.4 F g–1 at 2 A g–1) is limited due to its moderately conducting nature. Therefore, we report a method to modify UiO-66 with pineapple peel derived activated carbon (PA-AC) to form a facile composite. Owing to the high specific surface area and good conductivity of the UiO-66/PA-AC composite, a high specific capacitance of 295.9 F g–1 at 2 A g–1 has been achieved and is well suited for supercapacitor applications. At the maximum charging voltage range of 0–1.8 V, the UiO-66/PA-AC//UiO-66/PA-AC symmetrical SC delivered a maximum energy density of 29.6 Wh kg–1 at a power density of 170 W kg–1. After 5000 repeated charge–discharge cycles at 30 A g–1, the specific capacitance of the device increased from 100% to 120% of its initial specific capacitance. This study emphasized the potential importance of incorporating MOFs into pores of biowaste derived carbon as a strategy for enhancing the charge storage kinetics of moderately conducting MOFs. [ABSTRACT FROM AUTHOR]

Background & aim Paravertebral block (PVB) is a commonly used technique, for postoperative analgesia after modified radical mastectomy(MRM).Though many adjuvants to bupivacaine in PVB have been tried for postoperative analgesia, none has been found ideal. We have compared the duration of analgesia in PVB using adjuvant like dexmedetomidine and nalbuphine with bupivacaine after MRM. Methods Sixtyfive female patients posted for MRM were divided into two groups. Group BN received ultrasound guided PVB with 20 ml bupivacaine 0.25% with nalbuphine 10mg and Group BD received 20 ml bupivacaine 0.25% with dexmedetomidine 1 μg/kg. After confirming PVB, surgery was done under general anesthesia in all patients. Time for 1st rescue analgesic request was the primary aim of our study. Secondary aim of our study was numerical rating scores (NRS) for pain at rest and on movement and total analgesic consumption. Side effects like nausea and vomiting,hemodynamics and sedation in post operative 24 hrs were also assessed. Results The time of the first rescue analgesic requirement was prolonged in the group BD (7.32 ± 1.75 hours) in contrary to group BN (4.94 ± 2.12 hours). The mean total paracetamol consumption as rescue analgesia in the in the first 24 hours postoperatively was significantly reduced in group BD (2.7 ±0.94 gm) in contrary to group BN (3.6 ± 0.98 gm). (p<0.001) Decrease in hear rate and mean arterial pressure was more in BD group compared to BN group intraoperatively. (p<0.001) Conclusion Dexmedetomidine provides prolonged analgesia when used as additive to bupivacaine in PVB for modified radical mastectomy compared to nalbuphine. [ABSTRACT FROM AUTHOR]