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СОВЕРШЕНСТВОВАНИЕ СИСТЕМЫ УПРАВЛЕНИЯ ОРГАНИЗАЦИЕЙ ВЫСШЕГО ОБРАЗОВАНИЯ В КОНТЕКСТЕ ОБЕСПЕЧЕНИЯ ЕЁ КОНКУРЕНТОСПОСОБНОСТИ / Ю. А. Мишина ; ГОУ ВПО "ДОНАУИГС" //Сборник научных работ серии «Государственное управление». Вып. 25 : Экономика и управление народным хозяйством. – Донецк : ГОУ ВПО «ДОНАУИГС», 2022. - С. 178-190. В статье раскрыто содержание понятия «обеспечение конкурентоспособности образовательной организации высшего образования». Систематизированы факторы внешней и внутренней среды образовательной организации высшего образования. Представлена структура системы управления образовательной организацией высшего образования. Обоснована целесообразность совершенствования системы управления образовательной организацией в контексте обеспечения еѐ конкурентоспособности. Разработан механизм обеспечения конкурентоспособности образовательной организации высшего образования. Ключевые слова: образовательная организация, высшее образование, обеспечение, конкурентоспособность, факторы, система управления, механизм обеспечения конкурентоспособности. IMPROVING THE MANAGEMENT SYSTEM OF AN EDUCATIONAL ORGANIZATION OF HIGHER EDUCATION IN THE CONTEXT OF ENSURING ITS COMPETITIVENESS /Y. A.MISHINA ;SEE HPE "DAMPA" //Collection of scientific works of the series “Public administration». Issue 25 : ECONOMICS AND MANAGEMENTFOLK ECONOMY. – Donetsk : SEE HPE "DAMPA", 2022. - Р. 178-190. The content of the concept of «ensuring the competitiveness of an educational organization of higher education» is disclosed in the article. The factors of the external and internal environment of the educational organization of higher education are systematized. The structure of the management system of an educational organization of higher education is presented. The expediency of improving the management system of an educational organization in the context of ensuring its competitiveness is substantiated. The mechanism of ensuring the competitiveness of the educational organization of higher education has been developed. Keywords: educational organization, higher education, ensuring, competitiveness, factors, management system, mechanism of ensuring competitiveness. &nbsp

МЕХАНИЗМ РЕАЛИЗАЦИИ ВНЕШНЕЭКОНОМИЧЕСКОЙ ПОЛИТИКИ ТЕРРИТОРИИ В СИСТЕМЕ УПРАВЛЕНИЯ ВНЕШНЕЭКОНОМИЧЕСКОЙ ДЕЯТЕЛЬНОСТЬЮ / М. В. Гончарова, Ю. А. Мишина, А. В. Брилева ;ГОУ ВПО «ДОНАУИГС» // Менеджер. – 2022.–№ 1(99).–С. 3-12. В статье раскрыто содержание понятия «внешнеэкономическая политика», систематизированы цели и направления внешнеэкономической политики государства, представлена структура системы управления внешнеэкономической деятельностью. Обоснована целесообразность выделения в структуре механизма управления внешнеэкономической деятельностью специальных механизмов, направленных на формирование и реализацию внешнеэкономической политики территории, а также управление еёэкспортным потенциалом. Предложен механизм реализации внешнеэкономической политики территории. THE MECHANISM OF IMPLEMENTATION OF FOREIGN ECONOMIC POLICY OF THE TERRITORY IN THE SYSTEM OF MANAGEMENT OF FOREIGN ECONOMIC ACTIVITIES / M. V. Goncharova, Y. A. Mishina, A. V. Brileva ; SEE HPE «DAMPA»// Manager. - 2022. - No. 1 (99). – P. 3-12. The article reveals the content of the concept of "foreign economic policy", systematizes the goals and directions of the state's foreign economic policy, presents the structure of the foreign economic activity management system. The expediency of allocating special mechanisms in the structure of the mechanism for managing foreign economic activity aimed at the formation and implementation of the foreign economic policy of the territory, as well as the management of its export potential, is substantiated. A mechanism for the implementation of the foreign economic policy of the territory is proposed.

© 2016, Econjournals. All rights reserved.Modernization of education implies substantial changes in the management of educational systems and processes for the transition of educational systems to a qualitatively new state and to a higher level of functioning. The aim of the article is to describe the phenomenon of manageability of education systems, which consists in the real possibility to influence on the course of processes in order to improve their performance in a high dynamism and activity of the managed elements of the system. The basis of the research is the stakeholder approach, which establishes an increasing degree of responsibility of all agents of education for their actions within the system. The authors identified the specifics of educational systems’ manageability based on the characteristics of educational agents and the balance of their requirements and expectations. The principles of the stakeholder approach’s implementation in education are proposed, which allowed offer a way to increase the controllability of educational systems. The paper submissions can be useful for experts of education authorities, teachers of pedagogical and management profile, managers and staff of educational organizations, researchers who are involved in the manageability of educational systems and processes.

Sertoli cells provide nutritional and physical support to germ cells during spermatogenesis. Sox8 encodes a high mobility group transcription factor closely related to Sox9 and Sox10. Sertoli cells produceSOX8 protein, and its elimination results in an age-dependent deregulation of spermatogenesis resulting in male infertility. This suggests that Sox8 is a critical regulator of Sertoli cell function for the maintenance of male fertility beyond the first wave of spermatogenesis. To better understand the roles of Sox8 in testicular development and maintenance of male fertility, we have performed a detailed analysis to explore its downstream genes. We have used mRNA expression profiling to identify affected genes in Sertoli cells in the mutant testes of 2-month-old mice. Expression profiling of the heterozygous and homozygous Sox8 mutant testes indicates alterations in several important spermatogenesis and blood-testis barrier genes, providing insight into the molecular basis of the defects in Sox8(-/-) testes beyond the first wave of spermatogenesis.

Amniotes, regardless of genetic sex, develop two sets of genital ducts: the Wolffian and Mulerian ducts. For normal sexual development to occur, one duct must differentiate into its corresponding organs, and the other must regress. In mammals, the Wolffian duct differentiates into the male reproductive tract, mainly the vasa deferentia, epididymides, and seminal vesicles, whereas the Mullerian duct develops into the four components of the female reproductive tract, the oviducts, uterus, cervix, and upper third of the vagina. In males, the fetal Leydig cells produce testosterone, which stimulates the differentiation of the Wolffian duct, whereas the Sertoli cells of the fetal testes express anti-Mullerian hormone, which activates the regression of the Mullerian duct. Anti-Mullerian hormone is a member of the transforming growth factor-beta (TGF-beta) family of secreted signaling molecules and has been shown to signal through the BMP pathway. It binds to its type II receptor, anti-Mullerian hormone receptor 2 (AMHR2), in the Mullerian duct mesenchyme and through an unknown mechanism(s); the mesenchyme induces the regression of the Mullerian duct mesoepithelium. Using tissue-specific gene inactivation with an Amhr2-Cre allele, we have determined that two TGF-beta type 1 receptors (Acvr1 and Bmpr1a) and all three BMP receptor-Smads (Smad1, Smad5, and Smad8) function redundantly in transducing the anti-Mullerian hormone signal required for Mullerian duct regression. Loss of these genes in the Mullerian duct mesenchyme results in male infertility due to retention of Mullerian duct derivatives in an otherwise virilized male. ispartof: Biology of Reproduction vol:78 issue:6 pages:994-1001 ispartof: location:United States status: published

Endocardial cushions are precursors of mature atrioventricular (AV) valves. Their formation is induced by signaling molecules originating from the AV myocardium, including bone morphogenetic proteins (BMPs). Here, we hypothesized that BMP signaling plays an important role in the AV myocardium during the maturation of AV valves from the cushions. To test our hypothesis, we used a unique Cre/lox system to target the deletion of a floxed Alk3 allele, the type IA receptor for BMPs, to cardiac myocytes of the AV canal (AVC). Lineage analysis indicated that cardiac myocytes of the AVC contributed to the tricuspid mural and posterior leaflets, the mitral septal leaflet, and the atrial border of the annulus fibrosus. When Alk3 was deleted in these cells, defects were seen in the same leaflets, ie, the tricuspid mural leaflet and mitral septal leaflet were longer, the tricuspid posterior leaflet was displaced and adherent to the ventricular wall, and the annulus fibrosus was disrupted resulting in ventricular preexcitation. The defects seen in mice with AVC-targeted deletion of Alk3 provide strong support for a role of Alk3 in human congenital heart diseases, such as Ebstein’s anomaly. In conclusion, our mouse model demonstrated critical roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus. ispartof: Circulation vol:110 issue:117 pages:59- ispartof: location:New Orleans status: published