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2. Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease

Author

Strnad, Luke, Varley, Cara, Lapidus, Jodi, Philley, Julie, McShane, Pamela, Devine, Megan, Griffith, David E., Kasperbauer, Shannon H., Huitt, Gwen, Eddy, Jared J., Marras, Theodore K., Brode, Sarah K., Addrizzo-Harris, Dorreen, Springer, Amy, Flume, Patrick, Mingora, Christina, Alkabab, Yursa, Dorman, Susan, Naureckas, Ted, Aksamit, Timothy R., Ruoss, Stephen, Hornick, Douglas B., Mirsaeidi, Mehdi, Salathe, Matthias, Waller, Stephen, Schmid, Andreas, ElMaraachli, Wael, Cowell, Anne, Thakur, Neeta, Nahid, Payam, Zha, Shoshana, Ignatius, Elisa H., Zenilman, Jonathan, Cohen, Keira, Belz, Daniel C., Ali, Juzar, Lapinel, Nicole, Swenson, Colin, Kapolka, Rebecca, Horne, David, Salerno, Daniel, DiMango, Angela, Moretta, Dafne, Tan, Laren, Furukawa, Brian, Wysham, Nicholas, Noone, Peader, Daniels, Leigh Anne, Chris Saddler, Misch, Elizabeth Ann, Hayes, Lisa, Epstein, Marcia, Kim, Angela, Myers, Janet N., Henkle, Emily, Quittner, Alexandra L., Dieckmann, Nathan F., Franklin, Heather, Brunton, Amanda E., Daley, Charles L., and Winthrop, Kevin L.

Published
2023
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3. Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience

Author

Cheng, Yao-Wen, Phelps, Emmalee, Ganapini, Vincent, Khan, Noor, Ouyang, Fangqian, Xu, Huiping, Khanna, Sahil, Tariq, Raseen, Friedman-Moraco, Rachel J, Woodworth, Michael H, Dhere, Tanvi, Kraft, Colleen S, Kao, Dina, Smith, Justin, Le, Lien, El-Nachef, Najwa, Kaur, Nirmal, Kowsika, Sree, Ehrlich, Adam, Smith, Michael, Safdar, Nasia, Misch, Elizabeth Ann, Allegretti, Jessica R, Flynn, Ann, Kassam, Zain, Sharfuddin, Asif, Vuppalanchi, Raj, and Fischer, Monika

Subjects
Clinical Research, Transplantation, Vaccine Related, Biodefense, Prevention, Emerging Infectious Diseases, Infectious Diseases, Organ Transplantation, Patient Safety, Digestive Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Clostridioides difficile, Clostridium Infections, Fecal Microbiota Transplantation, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Recurrence, Retrospective Studies, Transplant Recipients, Treatment Outcome, United States, clinical research, practice, complication: infectious, immunosuppression, immune modulation, infection and infectious agents - bacterial: Clostridium difficile, infectious disease, intestinal disease: infectious, organ transplantation in general, patient safety, clinical research/practice, immunosuppression/immune modulation, Medical and Health Sciences, Surgery
Abstract

Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors for failure in SOT patients. Primary cure and overall cure were defined as resolution of diarrhea or negative C difficile stool test after a single FMT or after subsequent FMT(s) ± anti-CDI antibiotics, respectively. Ninety-four SOT patients underwent FMT, 78% for recurrent CDI and 22% for severe or fulminant CDI. FMT-related adverse events (AE) occurred in 22.3% of cases, mainly comprising self-limiting conditions including nausea, abdominal pain, and FMT-related diarrhea. Severe AEs occurred in 3.2% of cases, with no FMT-related bacteremia. After FMT, 25% of patients with underlying inflammatory bowel disease had worsening disease activity, while 14% of cytomegalovirus-seropositive patients had reactivation. At 3 months, primary cure was 58.7%, while overall cure was 91.3%. Predictors of failing a single FMT included inpatient status, severe and fulminant CDI, presence of pseudomembranous colitis, and use of non-CDI antibiotics at the time of FMT. These data suggest FMT is safe in SOT patients. However, repeated FMT(s) or additional antibiotics may be needed to optimize rates of cure with FMT.

Published
2019

9. Hypoalbuminemia is a risk factor for invasive fungal infections and poor outcomes in infected kidney transplant recipients.

Author

Santos, Angelie, Jorgenson, Margaret R., Osman, Fauzia, Srivastava, Aniruddha, Misch, Elizabeth Ann, Garg, Neetika, Aziz, Fahad, Swanson, Kurtis J., Mohamed, Maha, Djamali, Arjang, Mandelbrot, Didier, and Parajuli, Sandesh

Subjects
MYCOSES, KIDNEY transplantation, SERUM albumin, BLASTOMYCOSIS, HISTOPLASMOSIS, IMMUNOSUPPRESSION
Abstract

Introduction: Invasive fungal infections (IFI), are estimated to occur in 2%–14% of kidney transplant recipients (KTRs) in the current era of immune suppression and are associated with high mortality rates. We hypothesized that hypoalbuminemia in KTRs is a risk factor for IFI and would be associated with poor outcomes. Methods: In this study, using data from a prospective cohort registry, we describe the frequency of IFI due to Blastomycosis, Coccidioidomycosis, Histoplasmosis, Aspergillosis, and Cryptococcus in KTRs with serum albumin levels measured 3–6 months before diagnosis. Controls were selected based on incidence density sampling. KTRs were divided into three groups based on the pre‐IFI serum albumin level: normal (≥4 g/dL), mild (3–4 g/dL), or severe (<3 g/dL) hypoalbuminemia. Outcomes of interest were uncensored graft failure after IFI and overall mortality. Results: A total of 113 KTRs with IFI were compared with 348 controls. The incidence rate of IFI among individuals with normal, mild, and severe hypoalbuminemia was 3.6, 8.7, and 29.3 per 100 person‐years, respectively. After adjustment for multiple variables, the trend for risk of uncensored graft failure following IFI was greater in KTRS with mild (HR = 2.1; 95% CI,.75–6.1) and severe (HR = 4.47; 95% CI, 1.56–12.8) hypoalbuminemia (P‐trend <.001) compared to those with normal serum albumin. Similarly, mortality was higher in severe hypoalbuminemia (HR = 1.9; 95% CI,.67–5.6) compared to normal serum albumin (P‐trend <.001). Conclusion: Hypoalbuminemia precedes the diagnosis of IFI in KTRs, and is associated with poor outcomes following IFI. Hypoalbuminemia may be a useful predictor of IFI in KTRs and could be incorporated into screening algorithms. [ABSTRACT FROM AUTHOR]

Published
2023
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12. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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16. Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium aviumComplex Pulmonary Disease

Author

Henkle, Emily, Quittner, Alexandra L., Dieckmann, Nathan F., Franklin, Heather, Brunton, Amanda E., Daley, Charles L., Winthrop, Kevin L., Strnad, Luke, Varley, Cara, Lapidus, Jodi, Philley, Julie, McShane, Pamela, Devine, Megan, Griffith, David E., Kasperbauer, Shannon H., Huitt, Gwen, Eddy, Jared J., Marras, Theodore K., Brode, Sarah K., Addrizzo-Harris, Dorreen, Springer, Amy, Flume, Patrick, Mingora, Christina, Alkabab, Yursa, Dorman, Susan, Naureckas, Ted, Aksamit, Timothy R., Ruoss, Stephen, Hornick, Douglas B., Mirsaeidi, Mehdi, Salathe, Matthias, Waller, Stephen, Schmid, Andreas, ElMaraachli, Wael, Cowell, Anne, Thakur, Neeta, Nahid, Payam, Zha, Shoshana, Ignatius, Elisa H., Zenilman, Jonathan, Cohen, Keira, Belz, Daniel C., Ali, Juzar, Lapinel, Nicole, Swenson, Colin, Kapolka, Rebecca, Horne, David, Salerno, Daniel, DiMango, Angela, Moretta, Dafne, Tan, Laren, Furukawa, Brian, Wysham, Nicholas, Noone, Peader, Daniels, Leigh Anne, Saddler, Chris, Misch, Elizabeth Ann, Hayes, Lisa, Epstein, Marcia, Kim, Angela, and Myers, Janet N.

Abstract

Nontuberculous mycobacteria (NTM), predominately Mycobacterium aviumcomplex (MAC), cause chronic pulmonary disease. Improvements in symptoms and health-related quality of life (HRQoL) are important treatment outcomes, but no validated patient-reported outcome (PRO) measure exists.

Published
2023
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20. Powassan Virus Infection Likely Acquired Through Blood Transfusion Presenting as Encephalitis in a Kidney Transplant Recipient

Author

Taylor, Lindsay, primary, Condon, Taryn, additional, Destrampe, Eric M, additional, Brown, Jennifer A, additional, McGavic, Jeanette, additional, Gould, Carolyn V, additional, Chambers, Trudy V, additional, Kosoy, Olga I, additional, Burkhalter, Kristen L, additional, Annambhotla, Pallavi, additional, Basavaraju, Sridhar V, additional, Groves, Jamel, additional, Osborn, Rebecca A, additional, Weiss, John, additional, Stramer, Susan L, additional, and Misch, Elizabeth A, additional

Published
2020
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21. Powassan Virus Infection Likely Acquired Through Blood Transfusion Presenting as Encephalitis in a Kidney Transplant Recipient.

Author

Taylor, Lindsay, Condon, Taryn, Destrampe, Eric M, Brown, Jennifer A, McGavic, Jeanette, Gould, Carolyn V, Chambers, Trudy V, Kosoy, Olga I, Burkhalter, Kristen L, Annambhotla, Pallavi, Basavaraju, Sridhar V, Groves, Jamel, Osborn, Rebecca A, Weiss, John, Stramer, Susan L, and Misch, Elizabeth A

Subjects
ENCEPHALITIS, BLOOD transfusion, KIDNEY transplantation, FLAVIVIRAL diseases, TRANSPLANTATION of organs, tissues, etc., DISEASE risk factors
Abstract

A kidney transplant patient without known tick exposure developed encephalitis 3 weeks after transplantation. During the transplant hospitalization, the patient had received a blood transfusion from an asymptomatic donor later discovered to have been infected with Powassan virus. Here, we describe a probable instance of transfusion-transmitted Powassan virus infection. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria

Author

Graustein, Andrew D., primary, Misch, Elizabeth A., additional, Musvosvi, Munyaradzi, additional, Shey, Muki, additional, Shah, Javeed A., additional, Seshadri, Chetan, additional, Aguoju, Augustine, additional, Bowman, Kathryn, additional, Mulenga, Humphrey, additional, Veldsman, Ashley, additional, Hanekom, Willem A., additional, Hatherill, Mark, additional, Scriba, Thomas J., additional, and Hawn, Thomas R., additional

Published
2018
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25. Tu1875 - Fecal Microbiota Transplantation for the Treatment of Clostridium Difficile Infection is Efficacious and Safe in Solid Organ Transplant Recipients

Author

Cheng, Yao-Wen, primary, Phelps, Emmalee L., additional, Ganipini, Vincent, additional, Khan, Noor, additional, Ouyang, Fangqian, additional, Khanna, Sahil, additional, Tariq, Raseen, additional, Friedman-Moraco, Rachel, additional, Woodworth, Michael H., additional, Kraft, Colleen, additional, Kao, Dina H., additional, Smith, Justin D., additional, Le, Lien, additional, El-Nachef, Najwa, additional, Kaur, Nirmal, additional, Kowsika, Sree, additional, Ehrlich, Adam C., additional, Smith, Michael S., additional, Safdar, Nasia, additional, Misch, Elizabeth A., additional, Allegretti, Jessica R., additional, Flynn, Ann D., additional, Kassam, Zain, additional, Xu, Huiping, additional, and Fischer, Monika, additional

Published
2018
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26. Leprosy and the human genome

Author

Misch, Elizabeth A., Berrington, William R., Vary, James C., and Hawn, Thomas R.

Subjects
Immune response -- Research, Leprosy -- Genetic aspects, Leprosy -- Risk factors, Leprosy -- Research, Mycobacterium leprae -- Genetic aspects, Mycobacterium leprae -- Research, Human genome -- Research, Biological sciences
Published
2010

27. Fecal Microbiota Transplantation is Safe and Effective for the Treatment of Clostridium Difficile Infection in Solid Organ Transplant Recipients

Author

Fischer, Monika, primary, Khan, Mahnoor, additional, Phelps, Emmalee L., additional, Safdar, Nasia, additional, Misch, Elizabeth A., additional, Kaur, Nirmal, additional, Kowsika, Sree S., additional, Smith, Justin D., additional, Kassam, Zain, additional, Allegretti, Jessica R., additional, Xu, Huiping, additional, and Kao, Dina H., additional

Published
2017
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30. HSP90B1 Regulates TLR-dependent Monocyte Signaling and its Common Variants are Associated with BCG-specific T-cell Responses and Protection from Pediatric TB Disease

Author

Graustein, Andrew, primary, Misch, Elizabeth A, additional, Musvosvi, Munyaradzi, additional, Shey, Muki, additional, Shah, Javeed, additional, Wells, Rick, additional, Hanekom, Willem, additional, Hatherill, Mark, additional, Scriba, Thomas, additional, and Hawn, Thomas, additional

Published
2016
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31. Clostridioides difficileInfection in the Stem Cell Transplant and Hematologic Malignancy Population

Author

Misch, Elizabeth Ann and Safdar, Nasia

Abstract

Clostridioides difficile infection (CDI) is common in the stem cell transplant (SCT) and hematologic malignancy (HM) population and mostly occurs in the early posttransplant period. Treatment of CDI in SCT/HM is the same as for the general population, with the exception that fecal microbiota transplant (FMT) has not been widely adopted because of safety concerns. Several case reports, small series, and retrospective studies have shown that FMT is effective and safe. A randomized controlled trial of FMT for prophylaxis of CDI in SCT patients is underway. In addition, an abundance of novel therapeutics for CDI is currently in development.

Published
2019
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35. Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficileinfection in solid organ transplant recipients: A multicenter experience

Author

Cheng, Yao‐Wen, Phelps, Emmalee, Ganapini, Vincent, Khan, Noor, Ouyang, Fangqian, Xu, Huiping, Khanna, Sahil, Tariq, Raseen, Friedman‐Moraco, Rachel J., Woodworth, Michael H., Dhere, Tanvi, Kraft, Colleen S., Kao, Dina, Smith, Justin, Le, Lien, El‐Nachef, Najwa, Kaur, Nirmal, Kowsika, Sree, Ehrlich, Adam, Smith, Michael, Safdar, Nasia, Misch, Elizabeth Ann, Allegretti, Jessica R., Flynn, Ann, Kassam, Zain, Sharfuddin, Asif, Vuppalanchi, Raj, and Fischer, Monika

Abstract

Fecal microbiota transplant (FMT) is recommended for Clostridium difficileinfection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors for failure in SOT patients. Primary cure and overall cure were defined as resolution of diarrhea or negative C difficilestool test after a single FMT or after subsequent FMT(s) ± anti‐CDI antibiotics, respectively. Ninety‐four SOT patients underwent FMT, 78% for recurrent CDI and 22% for severe or fulminant CDI. FMT‐related adverse events (AE) occurred in 22.3% of cases, mainly comprising self‐limiting conditions including nausea, abdominal pain, and FMT‐related diarrhea. Severe AEs occurred in 3.2% of cases, with no FMT‐related bacteremia. After FMT, 25% of patients with underlying inflammatory bowel disease had worsening disease activity, while 14% of cytomegalovirus‐seropositive patients had reactivation. At 3 months, primary cure was 58.7%, while overall cure was 91.3%. Predictors of failing a single FMT included inpatient status, severe and fulminant CDI, presence of pseudomembranous colitis, and use of non‐CDI antibiotics at the time of FMT. These data suggest FMT is safe in SOT patients. However, repeated FMT(s) or additional antibiotics may be needed to optimize rates of cure with FMT. Fecal microbiota transplantation (FMT) for the treatment of Clostridium difficileinfection in patients with a history of solid organ transplantation is associated with low adverse event rates and high rates of cure, especially with repeat FMT(s) and/or additional antibiotics.

Published
2019
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