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6 results on '"Mirzaev BS"'

1. Comparative study of transport of exogenous radioactive histone administered by various routes

Author

T. I. Stukolova, Gil'miiarova Fn, Mirzaev Bs, N. V. Shamina, Golenishchev VIu, O. B. Anikeeva, and Radomskaia Vm

Subjects
Radioactive Label, medicine.medical_treatment, Intraperitoneal injection, General Medicine, Pharmacology, Biology, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Histone, chemistry, In vivo, Metabolic effects, Lactate dehydrogenase, Immunology, medicine, biology.protein, Nasal administration
Abstract

Accumulation of radioactive label in olfactory bulbs is found to outstrip the label content in the blood of animals to which histone is administered intranasally. The concentration of the label in the blood is highest after intraperitoneal injection, but shortly afterwards radioactive histone is detected in the brain as well.

Published
1994

2. Assessment of theIn Vivo metabolic effect of exogenous lactate dehydrogenase

Author

F. N. Gil'miyarova, Mirzaev Bs, V. M. Radomskaya, N. V. Shamina, O. B. Anikeeva, V. Yu. Golenishchev, and T. I. Stukolova

Subjects
chemistry.chemical_classification, medicine.medical_specialty, biology, Transamination, General Medicine, Malate dehydrogenase, General Biochemistry, Genetics and Molecular Biology, Citric acid cycle, chemistry.chemical_compound, Endocrinology, Biochemistry, chemistry, Lactate dehydrogenase, Internal medicine, medicine, biology.protein, Urea, Citrate synthase, Glycolysis, Branched-chain alpha-keto acid dehydrogenase complex
Abstract

Active realization of 2-oxoglutarate, malate, and oxaloacetate is observed after administration of lactate dehydrogenase. The levels of transamination and urea formation are within the normal range. By its targeting of oxidative metabolism, lactate dehydrogenase may be regarded as a biogenic factor correcting the glycolytic processes.

Published
1994

4. [The modelling of hyperfermentemia--a method for studying the mechanisms of the formation of metabolic disorders].

Author

Gil'miiarova FN, Radomskaia VM, Golenishchev VIu, Mirzaev BS, Romanova IuV, and Fesenko VA

Subjects
Animals, Cytosol drug effects, Cytosol enzymology, Glycolysis drug effects, L-Lactate Dehydrogenase pharmacology, Microsomes, Liver drug effects, Microsomes, Liver enzymology, Mitochondria, Liver drug effects, Mitochondria, Liver enzymology, Oxidation-Reduction drug effects, Rabbits, Disease Models, Animal, Metabolic Diseases chemically induced, Metabolic Diseases enzymology
Abstract

The model of hyperenzymia caused by injection of lactate dehydrogenase (5000 U/kg body weight) causes an increase of NADP.H-dependent oxidation in liver microsomes, without changing oxidative intensity in mitochondria, by such NAD.H-depended dehydrogenases as glutamate dehydrogenase and beta-hydroxybutyrate dehydrogenase. The aim of the interaction with exogenous lactate dehydrogenase in the glycolytic metabolone system, where increased carbohydrate disintegration in vivo is induced. There is a high detoxification processes associated with ammonia detoxification and urea production. The stability of membrane permeability is characterized by the absence of glutamate dehydrogenase and glucoso-6-phosphate dehydrogenase activity in blood plasma. It has been shown that the introduction of exogenic lactate dehydrogenase into the metabolism of experimental animals gives the possibility of using this enzyme as an enzymotherapeutic remedy.

Published
1993

5. [Rate of gluconeogenesis in the liver of rats with myocardial infarction].

Author

Blinov VA and Mirzaev BS

Subjects
Animals, Male, Rats, Time Factors, Gluconeogenesis, Liver metabolism, Myocardial Infarction metabolism
Abstract

It has been shown for the first time that the rate of glucose synthesis from endogenous non-carbohydrate compounds in the perfused liver of rats with occlusion of the descending branch of the left coronary artery increased. Gluconeogenesis appeared to be the most intense by the third day after occlusion. The rate of gluconeogenesis was identical both in control and experimental animals by the 10th and 20th days after occlusion.

Published
1983

6. [Streptokinase and streptodecase--new inhibitors of gluconeogenesis].

Author

Blinov VA, Mirzaev BS, Torchilin VP, and Smirnov VN

Subjects
Animals, Liver drug effects, Liver metabolism, Male, Myocardial Infarction metabolism, Rats, Gluconeogenesis drug effects, Streptokinase pharmacology
Abstract

The influence of immobilized streptokinase-streptodecase preparation on the rate of gluconeogenesis in perfused liver of normal and infarcted rats was studied. The preparations were administered in a single dose on the basis of estimated appropriate clinical dosage. It was shown that perfused liver of normal rats can produce glucose from endogenous non-carbohydrate compounds. Polysaccharide dextran carrier, a streptodecase component, leads to the growth of glucose quantity in the perfusate. At the same time, streptokinase and streptodecase suppress sufficiently the rate of gluconeogenesis in normal and infarcted rats. The streptodecase effect is particularly marked and may be connected with the inhibition of endogenous substrate induction of glucogenesis as well as the inhibition of key enzymes. Catabolic activity of streptodecase appears to be weaker than that of streptokinase. It is supposed that streptodecase may be used for the treatment of various other pathologic states apart from myocardial infarction.

Published
1985

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