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359 results on '"Mirsadraee, Saeed"'

1. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study

Author

Thomas, Sheena, Denton, Jon, Farral, Robyn, Taylor, Carolyn, Qin, Wendy, Kasongo, Mary, Anthony, Susan, Banning, Adrian, Xie, Cheng, Kharbanda, Rajesh K, Pritchard, Amy, Halborg, Thomas, Syed, Nigar, Fry, Sam, Mathers, Chris, Rose, Anne, Hudson, George, Bajaj, Amrita, Das, Intrajeet, Deshpande, Aparna, Rao, Praveen, Lawday, Dan, Mirsadraee, Saeed, Hudson, Benjamin, Berry, Colin, Marwan, Mohamed, Maurovich-Horvat, Pál, He, Guo-Wei, Lin, Wen-Hua, Fan, Li-Juan, Takahashi, Naohiko, Kondo, Hidekazu, Dai, Neng, Ge, Junbo, Koo, Bon-Kwon, Guglielmo, Marco, Pontone, Gianluca, Huck, Daniel, Benedek, Theodora, Rajani, Ronak, Vilic, Dijana, Aljazzaf, Haleema, Mun, Mak S, Benedetti, Giulia, Preston, Rebecca L, Raisi-Estabragh, Zahra, Connolly, Derek L, Sharma, Vinoda, Grenfell, Rebecca, Bradlow, William, Schmitt, Matthias, Serfaty, Fabiano, Gottlieb, Ilan, Neves, Mario FT, Newby, David E, Dweck, Marc R, Hatem, Stéphane, Redheuil, Alban, Benetos, Georgios, Beer, Meinrad, Granillo, Gastón AR, Selvanayagam, Joseph, Lopez-Jimenez, Francisco, De Bosscher, Ruben, Tavildari, Alain, Figtree, Gemma, Danad, Ibrahim, Shantouf, Ronney, Kietselaer, Bas, Tousoulis, Dimitris, Dangas, George, Mehta, Nehal N, Kontanidis, Christos, Kunadian, Vijay, Fairbairn, Timothy A, Chan, Kenneth, Wahome, Elizabeth, Tsiachristas, Apostolos, Antonopoulos, Alexios S, Patel, Parijat, Lyasheva, Maria, Kingham, Lucy, West, Henry, Oikonomou, Evangelos K, Volpe, Lucrezia, Mavrogiannis, Michail C, Nicol, Edward, Mittal, Tarun K, Kotronias, Rafail A, Adlam, David, Modi, Bhavik, Rodrigues, Jonathan, Screaton, Nicholas, Kardos, Attila, Greenwood, John P, Sabharwal, Nikant, De Maria, Giovanni Luigi, Munir, Shahzad, McAlindon, Elisa, Sohan, Yogesh, Tomlins, Pete, Siddique, Muhammad, Kelion, Andrew, Shirodaria, Cheerag, Pugliese, Francesca, Petersen, Steffen E, Blankstein, Ron, Desai, Milind, Gersh, Bernard J, Achenbach, Stephan, Libby, Peter, Neubauer, Stefan, Channon, Keith M, Deanfield, John, and Antoniades, Charalambos

Published
2024
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2. The Use and Efficacy of FFR-CT: Real-World Multicenter Audit of Clinical Data With Cost Analysis

Author

Mittal, Tarun K., Hothi, Sandeep S., Venugopal, Vinod, Taleyratne, John, O’Brien, David, Adnan, Kazi, Sehmi, Joban, Daskalopoulos, Georgios, Deshpande, Aparna, Elfawal, Sara, Sharma, Vinoda, Shahin, Rajai A., Yuan, Mengshi, Schlosshan, Dominik, Walker, Andrew, Abdel Rahman, Saif-El-Dean, Sunderji, Imran, Wagh, Sidhesh, Chow, Jocelyn, Masood, Mohammed, Sharma, Sumeet, Agrawal, Sharad, Duraikannu, Chary, McAlindon, Elisa, Mirsadraee, Saeed, Nicol, Edward D., and Kelion, Andrew D.

Published
2023
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5. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Author

Ahern, David J, Ai, Zhichao, Ainsworth, Mark, Allan, Chris, Allcock, Alice, Angus, Brian, Ansari, M Azim, Arancibia-Cárcamo, Carolina, Aschenbrenner, Dominik, Attar, Moustafa, Baillie, J Kenneth, Barnes, Eleanor, Bashford-Rogers, Rachael, Bashyal, Archana, Beer, Sally, Berridge, Georgina, Beveridge, Amy, Bibi, Sagida, Bicanic, Tihana, Blackwell, Luke, Bowness, Paul, Brent, Andrew, Brown, Andrew, Broxholme, John, Buck, David, Burnham, Katie, Byrne, Helen, Camara, Susana, Ferreira, Ivan Candido, Charles, Philip, Chen, Wentao, Chen, Yi-Ling, Chong, Amanda, Clutterbuck, Elizabeth, Coles, Mark, Conlon, Christopher, Cornall, Richard, Cribbs, Adam, Curion, Fabiola, Davenport, Emma, Davidson, Neil, Davis, Simon, Dendrou, Calliope, Dequaire, Julie, Dib, Lea, Docker, James, Dold, Christina, Dong, Tao, Downes, Damien, Drakesmith, Hal, Dunachie, Susanna, Duncan, David, Eijsbouts, Chris, Esnouf, Robert, Espinosa, Alexis, Etherington, Rachel, Fairfax, Benjamin, Fairhead, Rory, Fang, Hai, Fassih, Shayan, Felle, Sally, Fernandez Mendoza, Maria, Ferreira, Ricardo, Fischer, Roman, Foord, Thomas, Forrow, Aden, Frater, John, Fries, Anastasia, Gallardo Sanchez, Veronica, Garner, Lucy, Geeves, Clementine, Georgiou, Dominique, Godfrey, Leila, Golubchik, Tanya, Gomez Vazquez, Maria, Green, Angie, Harper, Hong, Harrington, Heather, Heilig, Raphael, Hester, Svenja, Hill, Jennifer, Hinds, Charles, Hird, Clare, Ho, Ling-Pei, Hoekzema, Renee, Hollis, Benjamin, Hughes, Jim, Hutton, Paula, Jackson-Wood, Matthew, Jainarayanan, Ashwin, James-Bott, Anna, Jansen, Kathrin, Jeffery, Katie, Jones, Elizabeth, Jostins, Luke, Kerr, Georgina, Kim, David, Klenerman, Paul, Knight, Julian, Kumar, Vinod, Kumar Sharma, Piyush, Kurupati, Prathiba, Kwok, Andrew, Lee, Angela, Linder, Aline, Lockett, Teresa, Lonie, Lorne, Lopopolo, Maria, Lukoseviciute, Martyna, Luo, Jian, Marinou, Spyridoula, Marsden, Brian, Martinez, Jose, Matthews, Philippa, Mazurczyk, Michalina, McGowan, Simon, McKechnie, Stuart, Mead, Adam, Mentzer, Alexander, Mi, Yuxin, Monaco, Claudia, Montadon, Ruddy, Napolitani, Giorgio, Nassiri, Isar, Novak, Alex, O'Brien, Darragh, O'Connor, Daniel, O'Donnell, Denise, Ogg, Graham, Overend, Lauren, Park, Inhye, Pavord, Ian, Peng, Yanchun, Penkava, Frank, Pereira Pinho, Mariana, Perez, Elena, Pollard, Andrew, Powrie, Fiona, Psaila, Bethan, Quan, T Phuong, Repapi, Emmanouela, Revale, Santiago, Silva-Reyes, Laura, Richard, Jean-Baptiste, Rich-Griffin, Charlotte, Ritter, Thomas, Rollier, Christine, Rowland, Matthew, Ruehle, Fabian, Salio, Mariolina, Sansom, Stephen Nicholas, Sanches Peres, Raphael, Santos Delgado, Alberto, Sauka-Spengler, Tatjana, Schwessinger, Ron, Scozzafava, Giuseppe, Screaton, Gavin, Seigal, Anna, Semple, Malcolm, Sergeant, Martin, Simoglou Karali, Christina, Sims, David, Skelly, Donal, Slawinski, Hubert, Sobrinodiaz, Alberto, Sousos, Nikolaos, Stafford, Lizzie, Stockdale, Lisa, Strickland, Marie, Sumray, Otto, Sun, Bo, Taylor, Chelsea, Taylor, Stephen, Taylor, Adan, Thongjuea, Supat, Thraves, Hannah, Todd, John, Tomic, Adriana, Tong, Orion, Trebes, Amy, Trzupek, Dominik, Tucci, Felicia Anna, Turtle, Lance, Udalova, Irina, Uhlig, Holm, van Grinsven, Erinke, Vendrell, Iolanda, Verheul, Marije, Voda, Alexandru, Wang, Guanlin, Wang, Lihui, Wang, Dapeng, Watkinson, Peter, Watson, Robert, Weinberger, Michael, Whalley, Justin, Witty, Lorna, Wray, Katherine, Xue, Luzheng, Yuen Yeung, Hing, Yin, Zixi, Young, Rebecca, Youngs, Jonathan, Zhang, Ping, Zurke, Yasemin-Xiomara, Banning, Adrian, Antonopoulos, Alexios, Bajaj, Amrita, Kelion, Andrew, Deshpande, Aparna, Kardos, Attila, Hudson, Benjamin, Koo, Bon-Kwon, Shirodaria, Cheerag, Xie, Cheng, Kotanidis, Christos, Mahon, Ciara, Berry, Colin, Adlam, David, Newby, David, Connolly, Derek, Scaletta, Diane, Alexander, Donna, Nicol, Ed, McAlindon, Elisa, Oikonomou, Evangelos, Pugliese, Francesca, Pontone, Gianluca, Benedetti, Giulia, He, Guo-Wei, West, Henry, Kondo, Hidekazu, Benedek, Imre, Das, Intrajeet, Deanfield, John, Graby, John, Greenwood, John, Rodrigues, Jonathan, Ge, Junbo, Channon, Keith, Fabritz, Larissa, Fan, Li-Juan, Kingham, Lucy, Guglielmo, Marco, Lyasheva, Maria, Schmitt, Matthias, Beer, Meinrad, Anderson, Michelle, Desai, Milind, Marwan, Mohamed, Takahashi, Naohiko, Mehta, Nehal, Dai, Neng, Screaton, Nicholas, Sabharwal, Nikant, Maurovich-Horvat, Pál, Rao, Praveen, Kotronias, Rafail, Kharbanda, Rajesh, Preston, Rebecca, Wood, Richard, Blankstein, Ron, Rajani, Ronak, Mirsadraee, Saeed, Munir, Shahzad, Thomas, Sheena, Neubauer, Stefan, Klömpken, Steffen, Petersen, Steffen, Achenbach, Stephan, Anthony, Susan, Mak, Sze, Mittal, Tarun, Benedek, Theodora, Sharma, Vinoda, Lin, Wen-Hua, Kotanidis, Christos P, Rodrigues, Jonathan C L, O’Connor, Daniel, Siddique, Muhammad, Lockstone, Helen, Oikonomou, Evangelos K, Badi, Ileana, Lumley, Sheila F, Constantinides, Bede, Sanderson, Nicholas, Rodger, Gillian, Chau, Kevin K, Lodge, Archie, Tsakok, Maria, Gleeson, Fergus, Indrajeet, Das, Hudson, Benjamin J, Srivastava, Vivek, Farid, Shakil, Krasopoulos, George, Sayeed, Rana, Newby, David E, Channon, Keith M, and Antoniades, Charalambos

Published
2022
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7. Fluid–structure interaction analysis of a healthy aortic valve and its surrounding haemodynamics.

Author

Yin, Zhongjie, Armour, Chlöe, Kandail, Harkamaljot, O'Regan, Declan P., Bahrami, Toufan, Mirsadraee, Saeed, Pirola, Selene, and Xu, Xiao Yun

Subjects
HEART beat, AORTIC valve, HEMODYNAMICS, TRICUSPID valve, SHEARING force, FLUID-structure interaction
Abstract

The opening and closing dynamics of the aortic valve (AV) has a strong influence on haemodynamics in the aortic root, and both play a pivotal role in maintaining normal physiological functions of the valve. The aim of this study was to establish a subject‐specific fluid–structure interaction (FSI) workflow capable of simulating the motion of a tricuspid healthy valve and the surrounding haemodynamics under physiologically realistic conditions. A subject‐specific aortic root was reconstructed from magnetic resonance (MR) images acquired from a healthy volunteer, whilst the valve leaflets were built using a parametric model fitted to the subject‐specific aortic root geometry. The material behaviour of the leaflets was described using the isotropic hyperelastic Ogden model, and subject‐specific boundary conditions were derived from 4D‐flow MR imaging (4D‐MRI). Strongly coupled FSI simulations were performed using a finite volume‐based boundary conforming method implemented in FlowVision. Our FSI model was able to simulate the opening and closing of the AV throughout the entire cardiac cycle. Comparisons of simulation results with 4D‐MRI showed a good agreement in key haemodynamic parameters, with stroke volume differing by 7.5% and the maximum jet velocity differing by less than 1%. Detailed analysis of wall shear stress (WSS) on the leaflets revealed much higher WSS on the ventricular side than the aortic side and different spatial patterns amongst the three leaflets. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study

Author

Chan, Kenneth, primary, Wahome, Elizabeth, additional, Tsiachristas, Apostolos, additional, Antonopoulos, Alexios S, additional, Patel, Parijat, additional, Lyasheva, Maria, additional, Kingham, Lucy, additional, West, Henry, additional, Oikonomou, Evangelos K, additional, Volpe, Lucrezia, additional, Mavrogiannis, Michail C, additional, Nicol, Edward, additional, Mittal, Tarun K, additional, Halborg, Thomas, additional, Kotronias, Rafail A, additional, Adlam, David, additional, Modi, Bhavik, additional, Rodrigues, Jonathan, additional, Screaton, Nicholas, additional, Kardos, Attila, additional, Greenwood, John P, additional, Sabharwal, Nikant, additional, De Maria, Giovanni Luigi, additional, Munir, Shahzad, additional, McAlindon, Elisa, additional, Sohan, Yogesh, additional, Tomlins, Pete, additional, Siddique, Muhammad, additional, Kelion, Andrew, additional, Shirodaria, Cheerag, additional, Pugliese, Francesca, additional, Petersen, Steffen E, additional, Blankstein, Ron, additional, Desai, Milind, additional, Gersh, Bernard J, additional, Achenbach, Stephan, additional, Libby, Peter, additional, Neubauer, Stefan, additional, Channon, Keith M, additional, Deanfield, John, additional, Antoniades, Charalambos, additional, Thomas, Sheena, additional, Denton, Jon, additional, Farral, Robyn, additional, Taylor, Carolyn, additional, Qin, Wendy, additional, Kasongo, Mary, additional, Anthony, Susan, additional, Banning, Adrian, additional, Xie, Cheng, additional, Kharbanda, Rajesh K, additional, Pritchard, Amy, additional, Syed, Nigar, additional, Fry, Sam, additional, Mathers, Chris, additional, Rose, Anne, additional, Hudson, George, additional, Bajaj, Amrita, additional, Das, Intrajeet, additional, Deshpande, Aparna, additional, Rao, Praveen, additional, Lawday, Dan, additional, Mirsadraee, Saeed, additional, Hudson, Benjamin, additional, Berry, Colin, additional, Marwan, Mohamed, additional, Maurovich-Horvat, Pál, additional, He, Guo-Wei, additional, Lin, Wen-Hua, additional, Fan, Li-Juan, additional, Takahashi, Naohiko, additional, Kondo, Hidekazu, additional, Dai, Neng, additional, Ge, Junbo, additional, Koo, Bon-Kwon, additional, Guglielmo, Marco, additional, Pontone, Gianluca, additional, Huck, Daniel, additional, Benedek, Theodora, additional, Rajani, Ronak, additional, Vilic, Dijana, additional, Aljazzaf, Haleema, additional, Mun, Mak S, additional, Benedetti, Giulia, additional, Preston, Rebecca L, additional, Raisi-Estabragh, Zahra, additional, Connolly, Derek L, additional, Sharma, Vinoda, additional, Grenfell, Rebecca, additional, Bradlow, William, additional, Schmitt, Matthias, additional, Serfaty, Fabiano, additional, Gottlieb, Ilan, additional, Neves, Mario FT, additional, Newby, David E, additional, Dweck, Marc R, additional, Hatem, Stéphane, additional, Redheuil, Alban, additional, Benetos, Georgios, additional, Beer, Meinrad, additional, Granillo, Gastón AR, additional, Selvanayagam, Joseph, additional, Lopez-Jimenez, Francisco, additional, De Bosscher, Ruben, additional, Tavildari, Alain, additional, Figtree, Gemma, additional, Danad, Ibrahim, additional, Shantouf, Ronney, additional, Kietselaer, Bas, additional, Tousoulis, Dimitris, additional, Dangas, George, additional, Mehta, Nehal N, additional, Kontanidis, Christos, additional, Kunadian, Vijay, additional, and Fairbairn, Timothy A, additional

Published
2024
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9. Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?

Author

Marin Aleksander, Murchison John T., Skwarski Kristopher M., Tavares Adriana A.S., Fletcher Alison, Wallace William A., Salapura Vladka, van Beek Edwin J.R., and Mirsadraee Saeed

Subjects
pulmonary nodule, perfusion, ct, dynamic, pet/ct, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The aim of the study was to derive and compare metabolic parameters relating to benign and malignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET/CT, and nodule perfusion parameters derived through perfusion computed tomography (CT).

Published
2021
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17. The authors reply

Author

Singh, Suveer, Gorog, Diana A., Mahon, Ciara F., Rawal, Bhavin, Semple, Thomas R., Nicol, Edward D., Arachchillage, Deepa R. J., Price, Susanna, Desai, Sujal, Ridge, Carole A., Padley, Simon P. G., and Mirsadraee, Saeed

Published
2021
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18. Time to TAVI: streamlining the pathway to treatment

Author

Hewitson, Lynsey Jane, primary, Cadiz, Suzane, additional, Al-Sayed, Sameeha, additional, Fellows, Sarah, additional, Amin, Alaaeldin, additional, Asimakopoulos, George, additional, Barnes, Edward, additional, Beale, Andrew, additional, Browne, Suzy, additional, Chandrasekaran, Badrinathan, additional, Dalby, Miles, additional, Foley, Paul, additional, Hawkins, Mark, additional, Haynes, Douglas, additional, Heng, Ee Ling, additional, Hyde, Tom, additional, Kabir, Tito, additional, Khavandi, Ali, additional, Mirsadraee, Saeed, additional, McCrea, William, additional, Petrou, Mario, additional, Senior, Roxy, additional, Smith, David, additional, Smith, Robert, additional, Spartera, Marco, additional, Wamil, Malgorzata, additional, Panoulas, Vasileios, additional, and Rahbi, Hazim, additional

Published
2023
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19. Medical Imaging

Author

Hoskins, Peter R., Keevil, Stephen F., Mirsadraee, Saeed, Hoskins, Peter R., editor, Lawford, Patricia V., editor, and Doyle, Barry J., editor

Published
2017
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21. CT Imaging of the Heart-Lung Axis

Author

van Beek, Edwin J. R., Mirsadraee, Saeed, Kauczor, Hans-Ulrich, Series editor, Hricak, Hedvig, Series editor, Essig, Marco, Series editor, Brady, Luther W., Series editor, Combs, Stephanie E., Series editor, Lu, Jiade J., Series editor, Schoepf, U. Joseph, editor, and Meinel, Felix G., editor

Published
2016
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23. A computational study of the effects of size, location, and number of tears on haemodynamics in surgically repaired type A aortic dissection

Author

Motoki, Kyosuke, Zhu, Yu, Mirsadraee, Saeed, Rosendahl, Ulrich, Pepper, John, and Xu, Xiao Yun

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Objective: This study aimed to comprehensively examine the roles of size, location, and number of tears in the progression of surgically repaired type A aortic dissection (TAAD) by assessing haemodynamic changes through patient-specific computational fluid dynamic (CFD) simulations. Methods: Two patient-specific TAAD geometries with replaced ascending aorta were reconstructed based upon computed 15 tomography (CT) scans, after which 10 hypothetical models (5 per patient) with different tear configurations were artificially created. CFD simulations were performed on all the models under physiologically realistic boundary conditions. Results: Our simulation results showed that increasing either the size or number of the re-entry tears reduced the luminal pressure difference (LPD) and maximum time-averaged wall shear stress (TAWSS), as well as areas exposed to abnormally high or low TAWSS values. Models with a large re-entry tear outperformed the others by reducing the maximum LPD by 1.88 mmHg and 7.39 mmHg, for patients 1 and 2, respectively. Moreover, proximally located re-entry tears in the descending aorta were more effective at reducing LPD than distal re-entry tears. Discussion: These computational results indicate that the presence of a relatively large re-entry tear in the proximal descending aorta might help stabilize post-surgery aortic growth. This finding has important implications for the management and risk stratification of surgically repaired TAAD patients. Nevertheless, further validation in a large patient cohort is needed.

Published
2023

29. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Author

Kotanidis, Christos P, primary, Xie, Cheng, additional, Alexander, Donna, additional, Rodrigues, Jonathan C L, additional, Burnham, Katie, additional, Mentzer, Alexander, additional, O’Connor, Daniel, additional, Knight, Julian, additional, Siddique, Muhammad, additional, Lockstone, Helen, additional, Thomas, Sheena, additional, Kotronias, Rafail, additional, Oikonomou, Evangelos K, additional, Badi, Ileana, additional, Lyasheva, Maria, additional, Shirodaria, Cheerag, additional, Lumley, Sheila F, additional, Constantinides, Bede, additional, Sanderson, Nicholas, additional, Rodger, Gillian, additional, Chau, Kevin K, additional, Lodge, Archie, additional, Tsakok, Maria, additional, Gleeson, Fergus, additional, Adlam, David, additional, Rao, Praveen, additional, Indrajeet, Das, additional, Deshpande, Aparna, additional, Bajaj, Amrita, additional, Hudson, Benjamin J, additional, Srivastava, Vivek, additional, Farid, Shakil, additional, Krasopoulos, George, additional, Sayeed, Rana, additional, Ho, Ling-Pei, additional, Neubauer, Stefan, additional, Newby, David E, additional, Channon, Keith M, additional, Deanfield, John, additional, Antoniades, Charalambos, additional, Ahern, David J, additional, Ai, Zhichao, additional, Ainsworth, Mark, additional, Allan, Chris, additional, Allcock, Alice, additional, Angus, Brian, additional, Ansari, M Azim, additional, Arancibia-Cárcamo, Carolina, additional, Aschenbrenner, Dominik, additional, Attar, Moustafa, additional, Baillie, J Kenneth, additional, Barnes, Eleanor, additional, Bashford-Rogers, Rachael, additional, Bashyal, Archana, additional, Beer, Sally, additional, Berridge, Georgina, additional, Beveridge, Amy, additional, Bibi, Sagida, additional, Bicanic, Tihana, additional, Blackwell, Luke, additional, Bowness, Paul, additional, Brent, Andrew, additional, Brown, Andrew, additional, Broxholme, John, additional, Buck, David, additional, Byrne, Helen, additional, Camara, Susana, additional, Ferreira, Ivan Candido, additional, Charles, Philip, additional, Chen, Wentao, additional, Chen, Yi-Ling, additional, Chong, Amanda, additional, Clutterbuck, Elizabeth, additional, Coles, Mark, additional, Conlon, Christopher, additional, Cornall, Richard, additional, Cribbs, Adam, additional, Curion, Fabiola, additional, Davenport, Emma, additional, Davidson, Neil, additional, Davis, Simon, additional, Dendrou, Calliope, additional, Dequaire, Julie, additional, Dib, Lea, additional, Docker, James, additional, Dold, Christina, additional, Dong, Tao, additional, Downes, Damien, additional, Drakesmith, Hal, additional, Dunachie, Susanna, additional, Duncan, David, additional, Eijsbouts, Chris, additional, Esnouf, Robert, additional, Espinosa, Alexis, additional, Etherington, Rachel, additional, Fairfax, Benjamin, additional, Fairhead, Rory, additional, Fang, Hai, additional, Fassih, Shayan, additional, Felle, Sally, additional, Fernandez Mendoza, Maria, additional, Ferreira, Ricardo, additional, Fischer, Roman, additional, Foord, Thomas, additional, Forrow, Aden, additional, Frater, John, additional, Fries, Anastasia, additional, Gallardo Sanchez, Veronica, additional, Garner, Lucy, additional, Geeves, Clementine, additional, Georgiou, Dominique, additional, Godfrey, Leila, additional, Golubchik, Tanya, additional, Gomez Vazquez, Maria, additional, Green, Angie, additional, Harper, Hong, additional, Harrington, Heather, additional, Heilig, Raphael, additional, Hester, Svenja, additional, Hill, Jennifer, additional, Hinds, Charles, additional, Hird, Clare, additional, Hoekzema, Renee, additional, Hollis, Benjamin, additional, Hughes, Jim, additional, Hutton, Paula, additional, Jackson-Wood, Matthew, additional, Jainarayanan, Ashwin, additional, James-Bott, Anna, additional, Jansen, Kathrin, additional, Jeffery, Katie, additional, Jones, Elizabeth, additional, Jostins, Luke, additional, Kerr, Georgina, additional, Kim, David, additional, Klenerman, Paul, additional, Kumar, Vinod, additional, Kumar Sharma, Piyush, additional, Kurupati, Prathiba, additional, Kwok, Andrew, additional, Lee, Angela, additional, Linder, Aline, additional, Lockett, Teresa, additional, Lonie, Lorne, additional, Lopopolo, Maria, additional, Lukoseviciute, Martyna, additional, Luo, Jian, additional, Marinou, Spyridoula, additional, Marsden, Brian, additional, Martinez, Jose, additional, Matthews, Philippa, additional, Mazurczyk, Michalina, additional, McGowan, Simon, additional, McKechnie, Stuart, additional, Mead, Adam, additional, Mi, Yuxin, additional, Monaco, Claudia, additional, Montadon, Ruddy, additional, Napolitani, Giorgio, additional, Nassiri, Isar, additional, Novak, Alex, additional, O'Brien, Darragh, additional, O'Connor, Daniel, additional, O'Donnell, Denise, additional, Ogg, Graham, additional, Overend, Lauren, additional, Park, Inhye, additional, Pavord, Ian, additional, Peng, Yanchun, additional, Penkava, Frank, additional, Pereira Pinho, Mariana, additional, Perez, Elena, additional, Pollard, Andrew, additional, Powrie, Fiona, additional, Psaila, Bethan, additional, Quan, T Phuong, additional, Repapi, Emmanouela, additional, Revale, Santiago, additional, Silva-Reyes, Laura, additional, Richard, Jean-Baptiste, additional, Rich-Griffin, Charlotte, additional, Ritter, Thomas, additional, Rollier, Christine, additional, Rowland, Matthew, additional, Ruehle, Fabian, additional, Salio, Mariolina, additional, Sansom, Stephen Nicholas, additional, Sanches Peres, Raphael, additional, Santos Delgado, Alberto, additional, Sauka-Spengler, Tatjana, additional, Schwessinger, Ron, additional, Scozzafava, Giuseppe, additional, Screaton, Gavin, additional, Seigal, Anna, additional, Semple, Malcolm, additional, Sergeant, Martin, additional, Simoglou Karali, Christina, additional, Sims, David, additional, Skelly, Donal, additional, Slawinski, Hubert, additional, Sobrinodiaz, Alberto, additional, Sousos, Nikolaos, additional, Stafford, Lizzie, additional, Stockdale, Lisa, additional, Strickland, Marie, additional, Sumray, Otto, additional, Sun, Bo, additional, Taylor, Chelsea, additional, Taylor, Stephen, additional, Taylor, Adan, additional, Thongjuea, Supat, additional, Thraves, Hannah, additional, Todd, John, additional, Tomic, Adriana, additional, Tong, Orion, additional, Trebes, Amy, additional, Trzupek, Dominik, additional, Tucci, Felicia Anna, additional, Turtle, Lance, additional, Udalova, Irina, additional, Uhlig, Holm, additional, van Grinsven, Erinke, additional, Vendrell, Iolanda, additional, Verheul, Marije, additional, Voda, Alexandru, additional, Wang, Guanlin, additional, Wang, Lihui, additional, Wang, Dapeng, additional, Watkinson, Peter, additional, Watson, Robert, additional, Weinberger, Michael, additional, Whalley, Justin, additional, Witty, Lorna, additional, Wray, Katherine, additional, Xue, Luzheng, additional, Yuen Yeung, Hing, additional, Yin, Zixi, additional, Young, Rebecca, additional, Youngs, Jonathan, additional, Zhang, Ping, additional, Zurke, Yasemin-Xiomara, additional, Banning, Adrian, additional, Antonopoulos, Alexios, additional, Kelion, Andrew, additional, Kardos, Attila, additional, Hudson, Benjamin, additional, Koo, Bon-Kwon, additional, Kotanidis, Christos, additional, Mahon, Ciara, additional, Berry, Colin, additional, Newby, David, additional, Connolly, Derek, additional, Scaletta, Diane, additional, Nicol, Ed, additional, McAlindon, Elisa, additional, Oikonomou, Evangelos, additional, Pugliese, Francesca, additional, Pontone, Gianluca, additional, Benedetti, Giulia, additional, He, Guo-Wei, additional, West, Henry, additional, Kondo, Hidekazu, additional, Benedek, Imre, additional, Das, Intrajeet, additional, Graby, John, additional, Greenwood, John, additional, Rodrigues, Jonathan, additional, Ge, Junbo, additional, Channon, Keith, additional, Fabritz, Larissa, additional, Fan, Li-Juan, additional, Kingham, Lucy, additional, Guglielmo, Marco, additional, Schmitt, Matthias, additional, Beer, Meinrad, additional, Anderson, Michelle, additional, Desai, Milind, additional, Marwan, Mohamed, additional, Takahashi, Naohiko, additional, Mehta, Nehal, additional, Dai, Neng, additional, Screaton, Nicholas, additional, Sabharwal, Nikant, additional, Maurovich-Horvat, Pál, additional, Kharbanda, Rajesh, additional, Preston, Rebecca, additional, Wood, Richard, additional, Blankstein, Ron, additional, Rajani, Ronak, additional, Mirsadraee, Saeed, additional, Munir, Shahzad, additional, Klömpken, Steffen, additional, Petersen, Steffen, additional, Achenbach, Stephan, additional, Anthony, Susan, additional, Mak, Sze, additional, Mittal, Tarun, additional, Benedek, Theodora, additional, Sharma, Vinoda, additional, and Lin, Wen-Hua, additional

Published
2022
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32. 136 The use and efficacy of ffr-ct – a real-world multi-centre audit of clinical data and cost-analysis

Author

Hothi, Sandeep, primary, Mittal, Tarun, additional, Duarte, Ana, additional, Venugopal, Vinod, additional, Taleyratne, Dinal, additional, O’Brien, David, additional, Adnan, Kazi, additional, Sehmi, Joban, additional, Daskalopoulos, Georgios, additional, Deshpande, Aparna, additional, Elfawal, Sara, additional, Sharma, Vinoda, additional, Shahin, Rajai, additional, Yuan, Mengshi, additional, Schlosshan, Dominik, additional, Walker, Andrew, additional, Rahman, Saif-el-Dean, additional, Sunderji, Imran, additional, Wagh, Sidhesh, additional, Beattie, Anna, additional, Chow, Jocelyn, additional, Masood, Mohammed, additional, Sharma, Sumeet, additional, Agrawal, Sharad, additional, Duraikannu, Chary, additional, McAlindon, Elisa, additional, Mirsadraee, Saeed, additional, Nicol, Ed, additional, and Kelion, Andrew, additional

Published
2022
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41. Association of individual aortic leaflet calcification on paravalvular regurgitation and conduction abnormalities with self-expanding trans-catheter aortic valve insertion

Author

Mahon, Ciara, primary, Davies, Allan, additional, Gambaro, Alessia, additional, Musella, Francesca, additional, Costa, Ana Luisa, additional, Panoulas, Vasileios, additional, Nicol, Edward, additional, Duncan, Alison, additional, Davies, Simon, additional, and Mirsadraee, Saeed, additional

Published
2021
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42. Cardiac Energetics Before, During, and After Anthracycline-Based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study

Author

Macnaught, Gillian, primary, Oikonomidou, Olga, additional, Rodgers, Christopher T., additional, Clarke, William, additional, Cooper, Annette, additional, McVicars, Heather, additional, Hayward, Larry, additional, Mirsadraee, Saeed, additional, Semple, Scott, additional, and Denvir, Martin A., additional

Published
2021
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44. Percutaneous devices for the treatment of complex native valve mitral leaflet and aortomitral continuity defects: Review and case series

Author

Jabbour, Richard J., primary, Rana, Bushra, additional, Sutaria, Nilesh, additional, Frame, Angela, additional, Seligman, Henry, additional, Gopalan, Deepa, additional, Ariff, Ben, additional, Mirsadraee, Saeed, additional, Barden, Edward, additional, Ruparelia, Neil, additional, and Malik, Iqbal S., additional

Published
2021
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45. In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis

Author

Jenkins, William S, Vesey, Alex T, Vickers, Anna, Neale, Anoushka, Moles, Catriona, Connell, Martin, Joshi, Nikhil Vilas, Lucatelli, Christophe, Fletcher, Alison M, Spratt, James C, Mirsadraee, Saeed, Van Beek, Edwin, Rudd, James Hf, Newby, David E, Dweck, Marc R, Jenkins, William S [0000-0001-8872-0413], Rudd, James Hf [0000-0003-2243-3117], and Apollo - University of Cambridge Repository

Subjects
Male, Cardiac & Cardiovascular Systems, positron emission tomography, PET/CT, integrin, Aortic Diseases, Carboxylic Acids, Myocardial Infarction, Aorta, Thoracic, 18F-SODIUM FLUORIDE UPTAKE, Polyethylene Glycols, POSITRON-EMISSION-TOMOGRAPHY, Positron Emission Tomography Computed Tomography, Image Interpretation, Computer-Assisted, Humans, Carotid Stenosis, Vascular Calcification, 1102 Cardiorespiratory Medicine and Haematology, ALPHA(V)BETA(3), Aged, F-18-AH111585, Inflammation, Science & Technology, 1103 Clinical Sciences, computed tomography, Aortic and Vascular Disease, Integrin alphaV, Middle Aged, Atherosclerosis, Integrin alphaVbeta3, CALCIFICATION, MYOCARDIAL-INFARCTION, Cardiovascular System & Hematology, MARKER, Positron-Emission Tomography, Cardiovascular System & Cardiology, Female, Radiopharmaceuticals, Peptides, Life Sciences & Biomedicine, Cyclobutanes
Abstract

Objectives Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the applicability of the αvβ3-integrin receptor-selective positron emission tomography (PET) radiotracer 18F-fluciclatide in assessing human aortic atherosclerosis.Methods Vascular 18F-fluciclatide binding was evaluated using ex vivo analysis of carotid endarterectomy samples with autoradiography and immunohistochemistry, and in vivo kinetic modelling following radiotracer administration. Forty-six subjects with a spectrum of atherosclerotic disease categorised as stable (n=27) or unstable (n=19; recent myocardial infarction) underwent PET and CT imaging of the thorax after administration of 229 (IQR 217–237) MBq 18F-fluciclatide. Thoracic aortic 18F-fluciclatide uptake was quantified on fused PET-CT images and corrected for blood-pool activity using the maximum tissue-to-background ratio (TBRmax). Aortic atherosclerotic burden was quantified by CT wall thickness, plaque volume and calcium scoring.Results 18F-Fluciclatide uptake co-localised with regions of increased αvβ3 integrin expression, and markers of inflammation and angiogenesis. 18F-Fluciclatide vascular uptake was confirmed in vivo using kinetic modelling, and on static imaging correlated with measures of aortic atherosclerotic burden: wall thickness (r=0.57, p=0.001), total plaque volume (r=0.56, p=0.001) and aortic CT calcium score (r=0.37, p=0.01). Patients with recent myocardial infarction had greater aortic 18F-fluciclatide uptake than those with stable disease (TBRmax 1.29 vs 1.21, p=0.02).Conclusions In vivo expression of αvβ3 integrin in human aortic atheroma is associated with plaque burden and is increased in patients with recent myocardial infarction. Quantification of αvβ3 integrin expression with 18F-fluciclatide PET has potential to assess plaque vulnerability and disease activity in atherosclerosis.This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made.

Published
2019

47. Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning

Author

Mirsadraee, Saeed, primary, Gorog, Diana A., additional, Mahon, Ciara F., additional, Rawal, Bhavin, additional, Semple, Thomas R., additional, Nicol, Edward D., additional, Arachchillage, Deepa R. J., additional, Devaraj, Anand, additional, Price, Susanna, additional, Desai, Sujal R., additional, Ridge, Carole A., additional, Singh, Suveer, additional, and Padley, Simon P. G., additional

Published
2021
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48. Cardiac Energetics Before, During and After Anthracycline-based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study

Author

Macnaught, Gillian, primary, Oikonomidou, Olga, additional, Rodgers, Christopher T., additional, Clarke, William, additional, Cooper, Annette, additional, McVicars, Heather, additional, Hayward, Larry, additional, Mirsadraee, Saeed, additional, Semple, Scott, additional, and Denvir, Martin A, additional

Published
2020
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