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Polydactyly is a typical abnormality, happening both as a segregated deformity or as component of a syndrome. The presence of mirror polydactyly, however, is rare. One such feature is seen in Laurin-Sandrow syndrome (LSS). Laurin-Sandrow syndrome (LSS) is characterized by complete polysyndactyly of hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella), often associated with ulnar or fibular duplication (and sometimes tibial agenesis). This image describes a case of 2-year-old boy, who came to the clinic with complaints of cough and cold for 1 week duration. The Child was alert, active and feeding well. The child was born at term by normal delivery to a healthy parent. Antenatal period was normal. No systematic illness occurred in the neonatal period. On Examination, there was cup shaped hands with syndactyly on the fingers extending upto the tip. Polysyndactyly was present in the feet, with nine digits on the right foot and ten on the left. Conspicuous nose with short columella, depressed nasal bridge, underdeveloped nasal alae. There are not many cases of LSS revealed in the literature. Hence there are no clear insights regarding the etiopathogenesis. Laurin-Sandrow syndrome is supposed to be an autosomal dominant disorder and the gene associated is said to be limb development membrane Protein 1 (LMBR1). The child was treated for cold and referred to an orthopedician and pediatrician for further management with respect to LSS.

Mirror foot anomalies are extremely rare forms of duplications of toes. They can be associated with several other anomalies such as mirror hands, fibular dimelia, tibial hypoplasia/aplasia or facial deformities. A case of a mirror foot anomaly in association with an extremely rare variant of tibial hemimelia is presented. Other similar cases in the literature and modern theories regarding the aetiology are also presented.

We report a girl with mirror hands and feet and associated groove of the nasal columella. She represents only the sixth reported case of this spectrum of congenital anomalies,first reported by Laurin and Sandrow.

We report on a father and daughter with mirror hands and feet and a distinct nasa defect and compare their condition to a similar one reported previously in one other family. © 1993 Wiley-Liss, Inc.