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2. Hospitalizations for Acute Otitis and Sinusitis in Patients Living with HIV: A Retrospective Analysis of a Tertiary Center in Romania

Author

Pleșca, Vlad Ștefan, primary, Miron, Victor Daniel, additional, Marinescu, Adrian Gabriel, additional, Drăgănescu, Anca Cristina, additional, Pleșca, Anca Doina, additional, Săndulescu, Oana, additional, Voiosu, Cătălina, additional, Hainăroșie, Răzvan, additional, and Streinu-Cercel, Anca, additional

Published
2024
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3. The Incidence and Characteristics of Oral Candidiasis in Patients Hospitalized for SARS-CoV-2 Infection During the Circulation of Alpha, Beta, and Delta Variants.

Author

Kouris, Elena Camelia, Mirea, Sînziana Irina, Luminos, Monica Luminița, and Miron, Victor Daniel

Subjects
COVID-19, SARS-CoV-2 Delta variant, THRUSH (Mouth disease), RESPIRATORY insufficiency, COMMUNICABLE diseases
Abstract

Background: Oral candidiasis has been documented in patients with SARS-CoV-2 infection, with varying prevalence rates across geographic regions and patient demographics. This study aimed to ascertain the incidence, characteristics, and risk factors associated with the development of oral candidiasis in patients hospitalized for SARS-CoV-2 infection in a tertiary infectious diseases hospital in Romania. Methods: A retrospective analysis was conducted on adult patients hospitalized between March 2020 and December 2022 with moderate or severe forms of SARS-CoV-2 infection, for whom a culture of lingual scrapings for Candida spp. was performed. Results: A total of 294 patients were deemed eligible for inclusion in the analysis, with an incidence rate of oral candidiasis of 17.0%. The incidence of oral candidiasis was 4.2 times higher in patients with severe forms of SARS-CoV-2 infection compared to those with moderate forms. Patients with a diagnosis of COVID-19 and oral candidiasis were more likely to receive antibiotics (98.0% vs. 86.1%, p = 0.017) and corticosteroids (100% vs. 83.6%, p = 0.003) than those without oral candidiasis. These findings were associated with a 19% higher relative risk of developing oral candidiasis for patients who received corticosteroid therapy compared to those who did not, and a 13% higher relative risk for those who were administered antibiotics compared to those who were not. The presence of respiratory insufficiency increased the odds of oral candidiasis association 4.7-fold (88.0% vs. 61.1%, p < 0.001). Conclusions: Although the data have been analyzed retrospectively, we have shown that individuals with severe forms of COVID-19 exhibited an elevated risk of developing oral candidiasis. The administration of antibiotics and corticosteroids was identified as a positive predictor for the development of oral candidiasis. The data presented here suggest that a key aspect of the therapeutic management of patients with SARS-CoV-2 infection should include the implementation of preventive measures to minimize the risk of secondary fungal infections. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Impact of Obesity on the Host–Pathogen Interaction with Influenza Viruses – Novel Insights: Narrative Review

Author

Miron,Victor Daniel, Drăgănescu,Anca Cristina, Pițigoi,Daniela, Aramă,Victoria, Streinu-Cercel,Adrian, Săndulescu,Oana, Miron,Victor Daniel, Drăgănescu,Anca Cristina, Pițigoi,Daniela, Aramă,Victoria, Streinu-Cercel,Adrian, and Săndulescu,Oana

Abstract

Victor Daniel Miron,1,2 Anca Cristina Dr&abreve;g&abreve;nescu,1,2 Daniela Pițigoi,1,2 Victoria Aram&abreve;,1,2 Adrian Streinu-Cercel,1,2,&ast; Oana S&abreve;ndulescu1,2,&ast; 1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania&ast;These authors contributed equally to this workCorrespondence: Anca Cristina Dr&abreve;g&abreve;nescu, Department of Pediatrics, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, No. 1 Dr. Calistrat Grozovici Street, Bucharest, 021105, Romania, Email anca.draganescu@umfcd.roAbstract: After exposure to a viral pathogen, the host–pathogen interaction is essential to determine whether or not infection will ensue, and what the clinical outline of the infection will be. Recent research has shown that the patient with obesity presents a set of particular pathophysiological changes that lead to higher severity of viral infections, and this is particularly true for infection with influenza viruses. Herein, we describe the main metabolic, endocrine, and immune dysregulations that occur in the presence of obesity and their impact on driving intra-host viral diversity, leading to heightened severity and virulence of influenza. We show that obesity is linked to modified responses of both the innate and adaptive immune systems during viral infections, including influenza. Due to chronic inflammation and metabolic, endocrine, and signaling pathway disruptions, individuals with obesity have a suboptimal immune response. This results in longer illness duration, increased virus shedding, higher risk of hospitalization and complications, and greater mortality rates. Additionally, they may have a blunted response to vaccination and a higher likelihood of genetic mutation selection. Unde

Published
2024

6. Clinical Differences between SARS-CoV-2 and RSV Infections in Infants: Findings from a Case–Control Study.

Author

Miron, Victor Daniel, Raianu, Raluca-Oana, Filimon, Claudiu, and Craiu, Mihai

Subjects
*RESPIRATORY syncytial virus infections, *INFANTS, *SARS-CoV-2, *RESPIRATORY syncytial virus, *CASE-control method
Abstract

Infants are a unique pediatric group due to their high hospitalization rates and unfavorable outcomes from acute infectious diseases. Understanding the clinical differences and aftereffects of SARS-CoV-2 in comparison to other prevalent viruses in this age group, like RSV, is crucial for effective management. We conducted a retrospective case–control study of infants hospitalized with SARS-CoV-2 or respiratory syncytial virus (RSV) infection in one year, in a tertiary pediatric hospital in Bucharest, Romania. A total of 188 infants were included in the analysis in a 1:1 ratio (94 with SARS-CoV-2 infection and 94 with RSV infection). Infants with COVID-19 were 10.2 times more likely to have fever (p < 0.001) and 2.4 times more likely to have diarrhea (p = 0.016). Conversely, infants with RSV were 2.5 times more likely to have a cough (p < 0.001), 3.0 times more likely to have nasal congestion (p < 0.001), and 14.7 times more likely to present with dyspnea (p < 0.001). Increased lymphocyte count was more common in infants with RSV (p = 0.008), while lymphopenia was more frequent in infants with SARS-CoV-2 (p = 0.011). The median length of hospital stay was one day longer in infants with RSV infection (5 days vs. 4 days). Overall, infants with RSV infection had a 27.3-fold increased risk of developing respiratory failure (p < 0.001), while infants with COVID-19 had a 5.8-fold increased risk of laryngitis (p = 0.003). Our findings suggest that infants with SARS-CoV-2 infection may present with polymorphic symptoms, mostly dominated by fever, whereas infants with RSV often present with respiratory symptoms. Laboratory differentiation between the two infections is challenging; therefore, the use of rapid antigen or molecular diagnostic tests is crucial for accurate diagnosis, epidemiologically appropriate measures, and effective management. Continued surveillance of both viruses in infants, and beyond, and the implementation of specific control measures are needed to mitigate their impact on this vulnerable pediatric group. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Comment on: “Prevalence, Antibiotic Susceptibility Profile and Associated Factors of Group A Streptococcal Pharyngitis Among Pediatric Patients with Acute Pharyngitis in Gondar, Northwest Ethiopia” [Letter]

Author

Miron,Victor Daniel, Săndulescu,Oana, Craiu,Mihai, Miron,Victor Daniel, Săndulescu,Oana, and Craiu,Mihai

Abstract

Victor Daniel Miron,1 Oana S&abreve;ndulescu,1,2 Mihai Craiu1,3 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania; 3National Institute for Mother and Child Health “Alessandrescu-Rusescu”, Bucharest, RomaniaCorrespondence: Victor Daniel Miron, Carol Davila University of Medicine and Pharmacy, 127, Lacul Tei Street, Second District, Bucharest, 020382, Romania, Email victor.miron@drd.umfcd.ro

Published
2023

11. Omicron in Infants—Respiratory or Digestive Disease?

Author

Drăgănescu, Anca Cristina, primary, Miron, Victor Daniel, additional, Săndulescu, Oana, additional, Bilaşco, Anuţa, additional, Streinu-Cercel, Anca, additional, Sandu, Roxana Gabriela, additional, Marinescu, Adrian, additional, Gunșahin, Deniz, additional, Hoffmann, Karina Ioana, additional, Horobeț, Daria Ștefana, additional, Pițigoi, Daniela, additional, Streinu-Cercel, Adrian, additional, and Pleșca, Doina Anca, additional

Published
2023
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13. Real-World Use of Molnupiravir in the Treatment of Outpatients with SARS-CoV-2 Infection—A Patient Profile Based on the Experience of a Tertiary Infectious Disease Center

Author

Streinu-Cercel, Anca, primary, Miron, Victor Daniel, additional, Oană, Alina Alexandra, additional, Irimia, Mădălina, additional, Popescu, Ramona Ștefania, additional, Dărămuș, Ioana Andreea, additional, Moțoi, Maria Magdalena, additional, Ceapraga, Gabriela Jana, additional, and Săndulescu, Oana, additional

Published
2022
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17. Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain?

Author

Matthews, Philippa C, Campbell, Cori, Săndulescu, Oana, Matičič, Mojca, Ruta, Simona Maria, Rivero-Juárez, Antonio, van Welzen, Berend Joost, Tan, Boun Kim, Garcia, Federico, Gherlan, George Sebastian, Çınar, Güle, Hasanoğlu, İmran, Gmizić, Ivana, Nicolini, Laura Ambra, Santos, Lurdes, Sargsyants, Narina, Velikov, Petar, Habibović, Selma, Fourati, Slim, Židovec-Lepej, Snježana, Herder, Vanessa, Dudman, Susanne, Miron, Victor Daniel, Irving, William, Şahin, Gülşen Özkaya, and Hepatitis, ESCMID Study Group for Viral

Subjects
FOS: Clinical medicine, Immunology, Infectious Disease, Genetics & Genomics
Abstract

During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster of cases was first observed in previously well children aged

Published
2022
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18. Comparative Analysis of Clinical and Epidemiological Characteristics in Patients with SARI Confirmed as Influenza or COVID-19 Admitted in a Tertiary Care Hospital in Bucharest, Romania

Author

Enciu (Milcu), Bianca Georgiana, primary, Drăgănescu, Anca Cristina, additional, Pițigoi, Daniela, additional, Săndulescu, Oana, additional, Crăciun, Maria Dorina, additional, Bilașco, Anuța, additional, Streinu-Cercel, Anca, additional, Streinu-Cercel, Adrian, additional, Florea, Dragoș, additional, Miron, Victor Daniel, additional, and Aramă, Victoria, additional

Published
2022
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22. Circulation of influenza A viruses among patients hospitalized for severe acute respiratory infection in a tertiary care hospital in Romania in the 2018/19 season

Author

Drăgănescu, Anca Cristina, primary, Miron, Victor Daniel, additional, Streinu-Cercel, Anca, additional, Florea, Dragoş, additional, Vlaicu, Ovidiu, additional, Bilaşco, Anuţa, additional, Oţelea, Dan, additional, Luminos, Monica Luminiţa, additional, Piţigoi, Daniela, additional, Streinu-Cercel, Adrian, additional, and Săndulescu, Oana, additional

Published
2021
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24. Treatment initiation or switch to BIC/FTC/TAF – real-world safety and efficacy data from two HIV centers in Romania

Author

Săndulescu, Oana, primary, Irimia, Mădălina, additional, Benea, Otilia Elisabeta, additional, Mărdărescu, Mariana, additional, Preoțescu, Liliana Lucia, additional, Dorobăț, Carmen Mihaela, additional, Loghin, Isabela Ioana, additional, Nicolau, Irina Cristina, additional, Jipa, Raluca Elena, additional, Popescu, Ramona Ștefania, additional, Benea, Cristina Loredana, additional, Cozma, Alina, additional, Dărămuș, Ioana Andreea, additional, Miron, Victor Daniel, additional, Prisăcariu, Liviu Jany, additional, Bahnă, Adriana Florina, additional, Nistor, Irina, additional, Secrieru, Oana Manuela, additional, George, Silvas, additional, Bîrcă, Andreea, additional, Dobrea, Loredana, additional, Șogorescu, Alexandra-Ștefana, additional, Viziteu, Ioana, additional, and Streinu-Cercel, Anca, additional

Published
2021
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26. Clinical and molecular epidemiology of influenza viruses from Romanian patients hospitalized during the 2019/20 season

Author

Miron, Victor Daniel, primary, Bănică, Leontina, additional, Săndulescu, Oana, additional, Paraschiv, Simona, additional, Surleac, Marius, additional, Florea, Dragoș, additional, Vlaicu, Ovidiu, additional, Milu, Petre, additional, Streinu-Cercel, Anca, additional, Bilașco, Anuta, additional, Oțelea, Dan, additional, Pițigoi, Daniela, additional, Streinu-Cercel, Adrian, additional, and Drăgănescu, Anca Cristina, additional

Published
2021
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34. Pneumococcal Colonization and Pneumococcal Disease in Children with Influenza Clinical, laboratory and epidemiological features

Author

Miron, Victor Daniel, primary, Draganescu, Anca Cristina, additional, Sandulescu, Oana, additional, Visan, Constanta Angelica, additional, Merisescu, Maria Madalina, additional, Cercel, Anca Streinu, additional, Pitigoi, Daniela, additional, Rafila, Alexandru, additional, Dorobat, Olga Mihaela, additional, Jugulete, Gheorghita, additional, Cercel, Adrian Streinu, additional, Stoicescu, Silvia, additional, and Luminos, Monica Luminita, additional

Published
2018
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37. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

Author

Niculae, Cristian-Mihail, primary, Manea, Eliza, additional, Jipa, Raluca, additional, Merisor, Simona, additional, Moroti, Ruxandra, additional, Benea, Serban, additional, Hristea, Adriana, additional, Neguț, Alina Cristina, additional, Săndulescu, Oana, additional, Streinu-Cercel, Anca, additional, Mărculescu, Dana, additional, Andrei, Magdalena Lorena, additional, Ilie, Veronica, additional, Popa, Marcela, additional, Bleotu, Coralia, additional, Chifiriuc, Carmen, additional, Popa, Mircea Ioan, additional, Streinu-Cercel, Adrian, additional, Orfanu, Alina, additional, Popescu, Cristina, additional, Leuștean, Anca, additional, Catană, Remulus, additional, Negru, Anca, additional, Badea, Alexandra, additional, Orfanu, Radu, additional, Tilișcan, Cătălin, additional, Aramă, Victoria, additional, Aramă, Ştefan Sorin, additional, Vișan, Constanța-Angelica, additional, Drăgănescu, Anca-Cristina, additional, Bilașco, Anuța, additional, Kouris, Camelia, additional, Merișescu, Mădălina, additional, Vasile, Magdalena, additional, Slavu, Diana-Maria, additional, Vintilă, Sabina, additional, Osman, Endis, additional, Oprea, Alina, additional, Sandu, Sabina, additional, Luminos, Monica, additional, Leuştean, Anca, additional, Popescu, Gabriel Adrian, additional, Stanculete, Ramona Georgiana, additional, Enoiu, Ana Vaduva, additional, Marinescu, Adelina Raluca, additional, Lazureanu, Voichita, additional, Marinescu, Adelina-Raluca, additional, Crișan, Alexandru, additional, Lăzureanu, Voichița, additional, Musta, Virgil, additional, Nicolescu, Narcisa, additional, Laza, Ruxandra, additional, Negru, Anca-Ruxandra, additional, Munteanu, Daniela-Ioana, additional, Mihăilescu, Raluca, additional, Dorobăț, Olga, additional, Rafila, Alexandru, additional, Căpraru, Emilia, additional, Niculescu, Marius, additional, Marinescu, Rodica, additional, Lupescu, Olivera, additional, Predescu, Vlad, additional, Tălăpan, Daniela, additional, Popescu, Ramona Ștefania, additional, Bradu, Luminița, additional, Florea, Dragoș, additional, Leca, Daniela Anicuta, additional, Bunea, Elena, additional, Teodor, Andra, additional, Miftode, Egidia, additional, Jugulete, Gheorghiță, additional, Dobrotă, Anamaria, additional, Ilie, Adina, additional, Preoțescu, Liliana Lucia, additional, Irimescu, Nicoleta, additional, Panait, Irina, additional, Niculae, Cristian, additional, Gavriliu, Liana Cătălina, additional, Benea, Otilia Elisabeta, additional, Benea, Șerban, additional, Popoiu, Mona, additional, Dragonu, Livia, additional, Cupşa, Augustin, additional, Diaconescu, Iulian, additional, Niculescu, Irina, additional, Giubelan, Lucian, additional, Dumitrescu, Florentina, additional, Stoian, Andreea Cristina, additional, Guţă, Camelia, additional, Puiu, Simona, additional, Irina, Bunescu, additional, Vallée, Marilyse, additional, Huletsky, Ann, additional, Boudreau, Dominique K., additional, Bérubé, Ève, additional, Giroux, Richard, additional, Longtin, Jean, additional, Longtin, Yves, additional, Bergeron, Michel G., additional, Roșculeț, Cleo Nicoleta, additional, Toma, Dalila-Ana, additional, Ciuca, Catrinel, additional, Apostolescu, Cătălin, additional, Rogoz, Andrei, additional, Stangaciu, Andrei, additional, Mitescu, Viorica, additional, Vladoiu, Tudor, additional, Iovănescu, Doina, additional, Oana, Michaela, additional, Costin, Simona, additional, Moțoi, Maria Magdalena, additional, Dorobăț, Olga Mihaela, additional, Mihai, Alexandru, additional, Roşculeț, Cleo, additional, Popescu, Gabriel-Adrian, additional, Abagiu, Adrian, additional, Moroti-Constantinescu, Ruxandra, additional, Benea, Otilia, additional, Simoiu, Mădălina, additional, Bacruban, Rodica, additional, Bădicuț, Ioana, additional, Borcan, Alina, additional, Hurmuzache, Mihnea, additional, Enache, Georgiana, additional, Ciocan, Alexandra, additional, Bararu, Mircea, additional, Popazu, Madalina, additional, Iovănescu, Doina Viorica, additional, Apostolescu, Cătălin Gabriel, additional, Toma, Dalila, additional, Iliescu, Laura, additional, Minzala, Georgiana, additional, Toma, Letitia, additional, Baciu, Mihaela, additional, Tanase, Alina, additional, Orban, Carmen, additional, Pantea, Victor, additional, Placinta, Gheorghe, additional, Cebotarescu, Valentin, additional, Cojuhari, Lilia, additional, Jimbei, Paulina, additional, Dragomirescu, Cristina, additional, Murariu, Cristina, additional, Stratan, Laurențiu, additional, Munteanu, Daniela, additional, Năstase, Raluca, additional, Molagic, Violeta, additional, Rădulescu, Mihaela, additional, Diaconu, Ioan, additional, Bodosca, Iulia, additional, Niță, Violeta, additional, Năstase, Raluca Mihaela, additional, Bodoșca, Iulia, additional, Diaconu, Ioan Alexandru, additional, Erturk, Yagmur, additional, Șchiopu, Claudiu Mihai, additional, Tenita, Angelica, additional, Aramă, Ștefan Sorin, additional, Iacob, Simona Alexandra, additional, Iacob, Diana Gabriela, additional, Predescu, Mioara, additional, Mărdărescu, Alexandra, additional, Săndulescu, Mihai, additional, Ciuca, Catrinel Olimpia, additional, Toma, Dalila Ana, additional, Mitu, Cristina Elena, additional, Mitescu, Viorica Daniela, additional, Vladoiu, Tudor Gheorghe, additional, Stoica, Monica Andreea, additional, Manolache, Daniela, additional, Ceapraga, Gabriela Jana, additional, Mircea, Gabriela, additional, Durbală, Ionel, additional, Russu, Irina, additional, Holban, Tiberiu, additional, Pantilimonov, Tatiana, additional, Chiriacov, Galina, additional, Macvovei, Arcadie, additional, Scorohodico, Elena, additional, Dmitriev, Oleg, additional, Costache, Diana Alexandra, additional, Benea, Anca, additional, Benea, Elisabeta, additional, Mitran, Mihai, additional, Georgescu, Carmen, additional, Mitran, Loredana, additional, Vladareanu, Simona, additional, Magirescu, Andreea Ioana, additional, Andreev, Viorica, additional, Nicolau, Cristina, additional, Largu, Alexandra, additional, Dorobat, Carmen, additional, Manciuc, Carmen, additional, Isac, Ina, additional, Șerban, Iulia Gabriela, additional, Resul, Ghiulendan, additional, Marcaș, Consuela, additional, Marincu, Iosif, additional, Poptelecan, Patricia, additional, Trincă, Bogdan, additional, Mitrescu, Sorina, additional, Tudor, Anca, additional, Vlad, Daliborca, additional, Tirnea, Livius, additional, Baydaroglu, Nurcan, additional, Ceapraga, Gabriela, additional, Pagute, Mariana, additional, Dorobăț, Carmen, additional, Diaconu, Ioan-Alexandru, additional, Ion, Daniela, additional, Nichita, Luciana, additional, Diaconu, Alexandra, additional, Duport-Dodot, Irina, additional, Mărdărescu, Mariana, additional, Petre, Cristina, additional, Iancu, Marieta, additional, Ungurianu, Rodica, additional, Cibea, Alina, additional, Drăghicenoiu, Ruxandra, additional, Tudor, Ana Maria, additional, Vlad, Delia, additional, Petrea, Sorin, additional, Matei, Carina, additional, Oțelea, Dan, additional, Crăciun, Carmen, additional, Anghelina, Cristian, additional, Dumea, Elena, additional, Rugină, Sorin, additional, Petcu, Lucian Cristian, additional, Halichidis, Stela, additional, Cambrea, Simona Claudia, additional, Chiriac, Carmen, additional, Bodnar, Nina-Ioana, additional, Zaharia-Kezdi, Iringo-Erzsebet, additional, Gîrbovan, Cristina, additional, Incze, Andrea, additional, Georgescu, Anca Meda, additional, Panaitescu, Eugenia, additional, Cojocaru, Manole, additional, Laurențiu, Vochita, additional, Andreia, Vochita, additional, Radu, Opreanu, additional, Bogdan, Trinca, additional, Ovidiu, Rosca, additional, Iosif, Marincu, additional, Zamfir, Ramona, additional, Angelescu, Alina, additional, Popa, Alena Andreea, additional, Gavriliu, Liana, additional, Popa, Alena-Andreea, additional, Ducu, Georgeta, additional, Camburu, Daniela, additional, Cozma, Alina, additional, Podani, Manuela, additional, Dumitriu, Roxana, additional, Cupșa, Augustin, additional, Ionescu, Loredana, additional, Abagiu, Adrian Octavian, additional, Stoica, Loredana Nicoleta, additional, Blaga, Catrinel, additional, Koulosousas, Archontis, additional, Ștefănescu, Roxana, additional, Atomoaie, Alice, additional, Paraschiv, Florentina, additional, Duna, Florin Matache, additional, Olteanu, Rodica, additional, Ion, Roxana, additional, Zota, Alexandra, additional, Jaballah, Isra Ennour, additional, Mahfoud, Lara, additional, Preda, Georgeta, additional, Constantin, Magda, additional, Nicolae, Ilinca, additional, Ene, Corina Daniela, additional, Mitran, Mădălina Irina, additional, Benea, Vasile, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Bodoșca, Iulia Cristina, additional, Aramă, Sorin, additional, Caramăngiu, Iuliana, additional, Rosca, Ovidiu, additional, Cialma, Monica, additional, Opreanu, Radu, additional, Vochita, Laurențiu, additional, Murărescu, Vlad, additional, Palaghiță, Marilena, additional, Camburu, Cornel, additional, Duşan, Irina, additional, Bîrlad, Andreea, additional, Miron, Victor Daniel, additional, Drăgănescu, Anca Cristina, additional, Pițigoi, Daniela, additional, Luminos, Monica Luminița, additional, Șchiopu, Sabina, additional, Vasile, Magda, additional, Ionică, Mihaela, additional, Stăncescu, Adina, additional, Popescu, Cristina Elena, additional, Marin, Luminița, additional, Zaharia, Diana, additional, Dumitrescu, Cristina, additional, Tudor, Lucia, additional, Negulescu, Cristina, additional, Caliman-Sturdza, Olga Adriana, additional, Roșculeț, Cleo, additional, Manu, Bogdana, additional, Vaduva-Enoiu, Ana, additional, Lazureanu, Voichita Elena, additional, Niță, Elena-Violeta, additional, Dumitru, Sînziana, additional, Negru, Anca Ruxandra, additional, Ionescu, Ligia, additional, Ion, Liliana, additional, Neacșu, Marioara, additional, Mitran, Cristina Iulia, additional, Pribac, George Ciprian, additional, Prisca, Mirandolina, additional, Ursoiu, Fulvia, additional, Neamtu, Carmen, additional, Totolici, Bogdan, additional, Cotoraci, Coralia, additional, Ardelean, Aurel, additional, Albu, Simona Elena, additional, Carsote, Mara, additional, Miclăuș, Beatrice, additional, Mihai, Diana, additional, Vasiliu, Cristina, additional, Gorgoi, Corina, additional, Blescun, Amelia, additional, Breaza, Gelu, additional, Vintila, Sabina, additional, Mihai, Felicia, additional, Omer, Meilin, additional, Dragan, Cornel, additional, Pitigoi, Daniela, additional, Ciucu, Mirela, additional, Ionescu, Marius-Dan, additional, Roskanovic, Cristina, additional, Barbu, Valentina, additional, Zamfir, Ramona-Alexandra, additional, Dumitru, Alexandra-Sînziana, additional, Ispas, Viorica, additional, Leahu, Diana Oana, additional, Safta, Cristina Maria, additional, Benea, Mihaela Anca, additional, Munteanu, Octavian, additional, Bohâlțea, Roxana, additional, Trașcă, Livia, additional, Cîrstoiu, Monica, additional, Georgescu, Mădălina, additional, Ivanciuc, Alina Elena, additional, Lazar, Mihaela, additional, Ionescu, Teodora, additional, Cherciu, Carmen Maria, additional, Țecu, Cristina, additional, Mihai, Maria Elena, additional, Nițescu, Maria, additional, Azamfire, Delia, additional, Dumitrescu, Aura, additional, Ianosik, Elena, additional, Leca, Daniela, additional, Duca, Elena, additional, Bejan, Codrina, additional, Ceaușu, Emanoil, additional, Florescu, Simin-Aysel, additional, Popescu, Corneliu, additional, Târdei, Grațiela, additional, Juganariu, Codrina, additional, Lupulescu, Emilia, additional, Rodina, Ligia, additional, Cocuz, Maria Elena, additional, Stoian, Andreea, additional, Ionica, Mihaela, additional, Benea, Otilia-Elisabeta, additional, Sîrbu, Maria-Cristina, additional, Dobrotă, AnaMaria, additional, Duda, Roxana, additional, Dragomirescu, Cristiana Cerasella, additional, Fendrihan, Sergiu, additional, Scortan, Ecaterina, additional, Popescu, Corneliu P., additional, Benea, Șerban N., additional, Petcu, Andra E., additional, Podea, Iuliana A., additional, Jipa, Raluca E., additional, Hrișcă, Raluca M., additional, Nica, Manuela, additional, Merișor, Simona, additional, Nicolae, Cristian M., additional, Florescu, Simin A., additional, Dumitru, Irina M., additional, Moroti, Ruxandra V., additional, Nițescu, Bogdan, additional, Mustaţă, Iulia Monica, additional, Boldeanu, Sorina Claudia, additional, Furtunescu, Florentina, additional, Gheorghe, Mihaela, additional, Slavcovici, Adriana, additional, Tripon, Raluca, additional, Iubu, Roxana, additional, Marcu, Cristian, additional, Sabou, Mihaela, additional, Muntean, Monica, additional, Chiriac, Ion, additional, Tazlavanu, Liviu, additional, Cernat, Roxana, additional, Iringo, Kezdi, additional, Vâță, Andrei, additional, Arbune, Manuela, additional, Moisil, Teodora, additional, Ene, Corina-Daniela, additional, Georgescu, Roxana Simona, additional, Ene, Cosmin-Victor, additional, Ciortea, Marilena, additional, Dulgheru, Lucreția, additional, Luca, Mihaela Cătălina, additional, Harja-Alexa, Ioana-Alina, additional, Nemescu, Roxana, additional, Popazu, Mădălina, additional, Luca, Andrei Ștefan, additional, Bancescu, Gabriela, additional, Dabu, Bogdan, additional, Bancescu, Adrian, additional, Ilie, Adina Elena, additional, Pohrib, Săftica-Mariana, additional, Tache, Maria-Sabina, additional, Iliescu, Ion Aurel, additional, Tecu, Cristina, additional, Mihai, Maria-Elena, additional, Lazăr, Mihaela, additional, Cherciu, Carmen, additional, Ivanciuc, Alina, additional, Paliu, Mirela, additional, Curescu, Manuela, additional, Cerbu, Bianca, additional, Bunescu, Irina, additional, Pasnin, Ana, additional, Semeniuc, Stela, additional, and Popovici, Raisa, additional

Published
2016
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38. Clinical Differences between SARS-CoV-2 and RSV Infections in Infants: Findings from a Case-Control Study.

Author

Miron VD, Raianu RO, Filimon C, and Craiu M

Subjects
Infant, Humans, Child, SARS-CoV-2, Case-Control Studies, Retrospective Studies, Fever epidemiology, COVID-19 epidemiology, Respiratory Syncytial Virus Infections epidemiology
Abstract

Infants are a unique pediatric group due to their high hospitalization rates and unfavorable outcomes from acute infectious diseases. Understanding the clinical differences and aftereffects of SARS-CoV-2 in comparison to other prevalent viruses in this age group, like RSV, is crucial for effective management. We conducted a retrospective case-control study of infants hospitalized with SARS-CoV-2 or respiratory syncytial virus (RSV) infection in one year, in a tertiary pediatric hospital in Bucharest, Romania. A total of 188 infants were included in the analysis in a 1:1 ratio (94 with SARS-CoV-2 infection and 94 with RSV infection). Infants with COVID-19 were 10.2 times more likely to have fever ( p < 0.001) and 2.4 times more likely to have diarrhea ( p = 0.016). Conversely, infants with RSV were 2.5 times more likely to have a cough ( p < 0.001), 3.0 times more likely to have nasal congestion ( p < 0.001), and 14.7 times more likely to present with dyspnea ( p < 0.001). Increased lymphocyte count was more common in infants with RSV ( p = 0.008), while lymphopenia was more frequent in infants with SARS-CoV-2 ( p = 0.011). The median length of hospital stay was one day longer in infants with RSV infection (5 days vs. 4 days). Overall, infants with RSV infection had a 27.3-fold increased risk of developing respiratory failure ( p < 0.001), while infants with COVID-19 had a 5.8-fold increased risk of laryngitis ( p = 0.003). Our findings suggest that infants with SARS-CoV-2 infection may present with polymorphic symptoms, mostly dominated by fever, whereas infants with RSV often present with respiratory symptoms. Laboratory differentiation between the two infections is challenging; therefore, the use of rapid antigen or molecular diagnostic tests is crucial for accurate diagnosis, epidemiologically appropriate measures, and effective management. Continued surveillance of both viruses in infants, and beyond, and the implementation of specific control measures are needed to mitigate their impact on this vulnerable pediatric group.

Published
2023
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39. Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain?

Author

Matthews PC, Campbell C, Săndulescu O, Matičič M, Ruta SM, Rivero-Juárez A, van Welzen BJ, Tan BK, Garcia F, Gherlan GS, Çınar G, Hasanoğlu İ, Gmizić I, Nicolini LA, Santos L, Sargsyants N, Velikov P, Habibović S, Fourati S, Židovec-Lepej S, Herder V, Dudman S, Miron VD, Irving W, and Şahin GÖ

Abstract

During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster of cases was first observed in previously well children aged <6 years. Sporadic cases were then reported across Europe and worldwide, although in most countries incidence did not increase above the expected baseline. There were no consistent epidemiological links between cases, and microbiological investigations ruled out known infectious causes of hepatitis. In this review, we explore the evidence for the role of viral infection, superimposed on a specific host genetic background, as a trigger for liver pathology. This hypothesis is based on a high prevalence of Human Adenovirus (HAdV) 41F in affected children, together with metagenomic evidence of adeno-associated virus (Adeno-associated viruses)-2, which is a putative trigger for an immune-mediated liver injury. Roles for superantigen-mediated pathology have also been explored, with a focus on the potential contribution of SARS-CoV-2 infection. Affected children also had a high frequency of the MHC allele HLA-DRB1*04:01, supporting an immunological predisposition, and may have been vulnerable to viral coinfections due to disruption in normal patterns of exposure and immunity as a result of population lockdowns during the COVID-19 pandemic. We discuss areas of ongoing uncertainty, and highlight the need for ongoing scrutiny to inform clinical and public health interventions for this outbreak and for others that may evolve in future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Matthews, Campbell, Săndulescu, Matičič, Ruta, Rivero-Juárez, van Welzen, Tan, Garcia, Gherlan, Çınar, Hasanoğlu, Gmizić, Nicolini, Santos, Sargsyants, Velikov, Habibović, Fourati, Židovec-Lepej, Herder, Dudman, Miron, Irving and Şahin.)

Published
2022
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