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Otitis media (OM) is a common infection or inflammation of the middle ear causing conductive hearing loss that primarily affects children and may delay speech, language, and cognitive development. OM can manifest itself in different forms, and can be diagnosed using (video) otoscopy (visualizing the tympanic membrane) or (video) pneumatic otoscopy and tympanometry. Accurate diagnosis of OM is challenging due to subtle differences in otoscopic features. This research aims to develop an automated computer-aided design (CAD) system to assist clinicians in diagnosing OM using otoscopy images. The ground truths, generated manually and validated by otolaryngologists, are utilized to train the proposed nested U-Net++ model. Ten clinically relevant gray level co-occurrence matrix (GLCM) and morphological features were extracted from the segmented Region of Interest (ROI) and validated for OM classification based on a statistical significance test. These features serve as input for a Graph Neural Network (GNN) model, the base model in our research. An optimized GNN model is proposed after ablation study of the base model. Three datasets, one private dataset, and two public ones have been used, where the private dataset is utilized for both training and testing, and the public datasets are used to test the robustness of the proposed GNN model only. The proposed GNN model obtained the highest accuracy in diagnosing OM: 99.38 %, 93.51 %, and 91.38 % for the private dataset, public dataset1, and public dataset2, respectively. The proposed methodology and results of this research might enhance clinicians' effectiveness in diagnosing OM.

Bronchiectasis is a chronic respiratory disorder characterized by the dilation and damage of bronchial walls due to recurrent and prolonged episodes of inflammation and infection. The diagnosis of bronchiectasis requires objective measurement of abnormal bronchial dilation. It is confirmed radiologically using a chest tomography (C.T.). scan where the pathognomonic feature is increased broncho-arterial ratio (BAR) (>0.8 in children) and, often accompanied by other features such as bronchial wall thickening (W.T.). Developing image processing-based methods facilitates quicker interpretation of the scans and enable detailed evaluations according to the lobes and segments. However, challenges, such as inclined and oblique orientations of structures, and partial volume effect, can complicate accurate measurements in the upper and middle lobes using the same algorithms. Therefore, the accurate detection and measurement of airway and artery regions for BAR and wall thickness in each lobe require specialized image processing/machine learning methods and approaches. Here, we adopt a step-by-step approach and propose methods for three steps: 1. Separating right lower lobe (RLL) region from full-length C.T. scans using tracheal bifurcation (Carina) point as a central marker; 2. Updated technique to locate inner diameter of airways and outer diameter of arteries for BAR measurement; and 3. Measuring airway wall thickness (W.T.) by identifying the outer and inner diameter of airway boundaries (perimeter). Our analysis of 13 high resolution C.T. scans (HRCT) with varying thicknesses (0.67mm, 1mm, 2mm) demonstrates that the frame containing the tracheal bifurcation can be detected accurately in most cases, with a deviation of ±2 frames in some cases. Similarly, a Windows app is developed for measuring inner airway diameter, artery diameter, BAR, and wall thickness, allowing users to draw bounding around visible discrete B.A. pairs in the RLL region. Measurements of 10 B.A. pairs revealed accurate results comparable to those of a human reader, with deviations of ±0.10-0.15mm observed across all measurements. Additional studies and validation are necessary to consolidate inter- and intra-rater variability and enhance the proposed methods.

Otitis Media (OM), predominantly affecting children, is a significant global health issue, with an estimated 360 million pediatric cases yearly worldwide. OM causes mild and moderate conductive hearing loss which can be disabling for young children, particularly during the first three years of life when brain growth is rapid, resulting in poor speech and language development, poor communication skills, and increased vulnerability on entering school. OM therefore contributes to the global burden of all-cause hearing loss. This systematic review seeks to provide a comprehensive evaluation of pre-trained Artificial Intelligence (AI) models, including both classical Machine Learning (ML) and Deep Learning (DL), in the context of OM. This review proposes six research questions, and it summarizes the body of research across multiple domains, including the diversity and quantity of source material for training and testing models, including otoscopy images, videos, and tympanometry, and the methods used to assess quality and effectiveness in real-time settings. In addition, the review aims to provide insight into the impact and potential of AI in improving OM diagnosis and cast light on the existing challenges, such as model interpretability, limited medical expert involvement, and the need for knowledge discovery and unanswered questions, including the evolving landscape of OM diagnosis within this domain. The findings of this systematic review emphasize the importance of developing more interpretable AI models that incorporate both still images of the tympanic membrane and video recordings (with multiple frames) to maximize sensitivity and specificity of the model. In addition, collaboration with consumers and medical professionals in multiple specialties (general practice, pediatricians, audiologists and ear, nose, throat (ENT) surgeons) is needed to ensure applicability and confidence of these diagnostic digital support systems in real-world healthcare settings.

Bronchiectasis, one of the most neglected chronic lung conditions, has a high individual disease burden and economic cost and causes poor quality of life in children/adolescents and adults. Advances in image quality and a dramatic reduction in acquisition times, multiple high-resolution chest tomography (HRCT) acquisitions, and reconstructions of the lung have resulted in accurate categorization and determination of the extent of lung parenchyma and airway abnormality. For bronchiectasis, the diagnosis is confirmed using the key feature of abnormally increased broncho-arterial (B.A.) ratio (BAR), with or without other abnormalities, e.g., bronchial wall thickening, lack of bronchial tapering, and mucus plugging. Most of these features require shape analysis of the airway and artery regions to perform various assessments that can have inter-rater variability and are time-consuming. This challenge is amplified in pediatric patients due to age-related anatomical variations. The anatomical differences and variations in airway structures between Infants, Early Childhood, and middle Childhood can impact how the images can be processed and analyzed. To address this, we proposed two novel image-processing methods to detect and measure the B.A. pairs. The first method uses an optimized connected component labelling (CCL) algorithm to construct bounding boxes around the objects (airway, artery) and extract the regions of interest (ROIs) for potential B.A. pairs. The second method allows us to calculate 4 or 6 diameters for each object in the ROIs and use their mean value as the final diameter, demonstrating agreement with manual readings. Evaluating against a diverse set of HRCT scans from various categories validates the significance and practical utility of our proposed methods in detecting and measuring the disjointed B.A. pairs to assess increased BAR.

Objective Early diagnosis of breast cancer can lead to effective treatment, possibly increase long-term survival rates, and improve quality of life. The objective of this study is to present an automated analysis and classification system for breast cancer using clinical markers such as tumor shape, orientation, margin, and surrounding tissue. The novelty and uniqueness of the study lie in the approach of considering medical features based on the diagnosis of radiologists. Methods Using clinical markers, a graph is generated where each feature is represented by a node, and the connection between them is represented by an edge which is derived through Pearson's correlation method. A graph convolutional network (GCN) model is proposed to classify breast tumors into benign and malignant, using the graph data. Several statistical tests are performed to assess the importance of the proposed features. The performance of the proposed GCN model is improved by experimenting with different layer configurations and hyper-parameter settings. Results Results show that the proposed model has a 98.73% test accuracy. The performance of the model is compared with a graph attention network, a one-dimensional convolutional neural network, and five transfer learning models, ten machine learning models, and three ensemble learning models. The performance of the model was further assessed with three supplementary breast cancer ultrasound image datasets, where the accuracies are 91.03%, 94.37%, and 89.62% for Dataset A, Dataset B, and Dataset C (combining Dataset A and Dataset B) respectively. Overfitting issues are assessed through k-fold cross-validation. Conclusion Several variants are utilized to present a more rigorous and fair evaluation of our work, especially the importance of extracting clinically relevant features. Moreover, a GCN model using graph data can be a promising solution for an automated feature-based breast image classification system.

The binaural masking level difference (BMLD) is a psychoacoustic method to determine binaural interaction and central auditory processes. The BMLD is the difference in hearing thresholds in homophasic and antiphasic conditions. The duration, phase and frequency of the stimuli can affect the BMLD. The main aim of the study is to evaluate the BMLD for stimuli of different durations and frequencies which could also be used in future electrophysiological studies. To this end we developed a GUI to present different frequency signals of variable duration and determine the BMLD. Three different durations and five different frequencies are explored. The results of the study confirm that the hearing threshold for the antiphasic condition is lower than the hearing threshold for the homophasic condition and that differences are significant for signals of 18ms and 48ms duration. Future objective binaural processing studies will be based on 18ms and 48ms stimuli with the same frequencies as used in the current study.

Knee Osteoarthritis (KOA) is a leading cause of disability and physical inactivity. It is a degenerative joint disease that affects the cartilage, cushions the bones, and protects them from rubbing against each other during motion. If not treated early, it may lead to knee replacement. In this regard, early diagnosis of KOA is necessary for better treatment. Nevertheless, manual KOA detection is time-consuming and error-prone for large data hubs. In contrast, an automated detection system aids the specialist in diagnosing KOA grades accurately and quickly. So, the main objective of this study is to create an automated decision system that can analyze KOA and classify the severity grades, utilizing the extracted features from segmented X-ray images. In this study, two different datasets were collected from the Mendeley and Kaggle database and combined to generate a large data hub containing five classes: Grade 0 (Healthy), Grade 1 (Doubtful), Grade 2 (Minimal), Grade 3 (Moderate), and Grade 4 (Severe). Several image processing techniques were employed to segment the region of interest (ROI). These included Gradient-weighted Class Activation Mapping (Grad-Cam) to detect the ROI, cropping the ROI portion, applying histogram equalization (HE) to improve contrast, brightness, and image quality, and noise reduction (using Otsu thresholding, inverting the image, and morphological closing). Besides, the focus filtering method was utilized to eliminate unwanted images. Then, six feature sets (morphological, GLCM, statistical, texture, LBP, and proposed features) were generated from segmented ROIs. After evaluating the statistical significance of the features and selection methods, the optimal feature set (prominent six distance features) was selected, and five machine learning (ML) models were employed. Additionally, a decision-making strategy based on the six optimal features is proposed. The XGB model outperformed other models with a 99.46 % accuracy, using six distance features, and the proposed decision-making strategy was validated by testing 30 images.

Introduction: Breast cancer stands as the second most deadly form of cancer among women worldwide. Early diagnosis and treatment can significantly mitigate mortality rates. Purpose: The study aims to classify breast ultrasound images into benign and malignant tumors. This approach involves segmenting the breast's region of interest (ROI) employing an optimized UNet architecture and classifying the ROIs through an optimized shallow CNN model utilizing an ablation study. Method: Several image processing techniques are utilized to improve image quality by removing text, artifacts, and speckle noise, and statistical analysis is done to check the enhanced image quality is satisfactory. With the processed dataset, the segmentation of breast tumor ROI is carried out, optimizing the UNet model through an ablation study where the architectural configuration and hyperparameters are altered. After obtaining the tumor ROIs from the fine-tuned UNet model (RKO-UNet), an optimized CNN model is employed to classify the tumor into benign and malignant classes. To enhance the CNN model's performance, an ablation study is conducted, coupled with the integration of an attention unit. The model's performance is further assessed by classifying breast cancer with mammogram images. Result: The proposed classification model (RKONet-13) results in an accuracy of 98.41 %. The performance of the proposed model is further compared with five transfer learning models for both pre-segmented and post-segmented datasets. K-fold cross-validation is done to assess the proposed RKONet-13 model's performance stability. Furthermore, the performance of the proposed model is compared with previous literature, where the proposed model outperforms existing methods, demonstrating its effectiveness in breast cancer diagnosis. Lastly, the model demonstrates its robustness for breast cancer classification, delivering an exceptional performance of 96.21 % on a mammogram dataset. Conclusion: The efficacy of this study relies on image pre-processing, segmentation with hybrid attention UNet, and classification with fine-tuned robust CNN model. This comprehensive approach aims to determine an effective technique for detecting breast cancer within ultrasound images.

Bronchiectasis in children is a major health issue which can be life-threatening if not diagnosed and effectively treated. In the diagnosis of bronchiectasis, an increased broncho-arterial (BA) ratio is considered a significant marker. The BA ratio is measured by evaluating BA pairs, using high-resolution computed tomography (HRCT) scans. Detecting BA pairs automatically is challenging due to the complex characteristics of BA pairs and the ambiguous appearance of the bronchi. This study proposes an effective computerized approach to detect BA pairs and assess BA ratio using HRCT scans of children and employing computer-aided techniques and novel custom-build algorithms. Attention is given to reconstructing broken bronchial walls and identifying discrete BA pairs using custom-built kernel based and patch-based algorithms for pixel-level image analysis. To detect BA pairs, the lung region is segmented in the HRCT slices and image preprocessing techniques, including noise reduction, binarizing, largest contour detection and a hole-filling algorithm, are applied. A histogram analysis method is introduced to clean the images. A kernel-based algorithm is proposed to reconstruct the pixel distribution if the bronchial wall is so that the bronchi can be detected precisely. Potential arteries are detected using balanced histogram thresholding, morphological opening and an approach based on four conditions related to the object area circularity, rectangular boundary box ratio and enclosing circle area ratio. Potential bronchi are detected through matching of object coordinates with potential arteries, hole-filling and four condition based approaches. The potential BA pairs are detected by matching the coordinates of potential bronchi with those of potential arteries as the artery and bronchus are adjacent to each other in BA pairs. Finally, from the potential BA pairs, actual BA pairs are identified using a custom-built patch algorithm. The study is conducted using 2471 HRCT slices of seven children, obtained from the Royal Darwin Hospital, Australia. The BA ratio is derived based on the ratio of diameters, major axis lengths, minor axis lengths, area, convex hull and equivalent diameter where the BA ratios are respectively 0.51–0.65, 0.49–0.59, 0.59–0.77, 0.25–0.42, 0.29–0.47, 1.5–2 and 0.50–0.65.

the recognition of Hand gestures has become a critical point as it is widely used in everyday applications. the challenge in this is to improve the recognition effect and develop a fast recognition method. Glove and led-based methods involve external devices in detecting and interpreting hand gestures, making human-computer interaction less natural. So, different approaches have been used previously that use purely hand gestures in many systems based on human-computer interaction. This system provides a more natural human-computer interaction; it must be made efficient processing speed of classifying the test data (images) from among the training data (database stored for gestures recognition). This speed makes gesture recognition more effective and reliable to use as compared to previously proposed methods. In this research paper, a proposed system based on a camera-based interactive wall display using bare hand gestures with efficient processing speed for controlling the speed of the mouse and other functions. This system has three modules: one uses Genetic Algorithm and Otsu thresholding to identify the query images as the right or wrong gesture and perform the correct action in case of the proper motion, another module controls functions outside of PowerPoint files or Word documents, e.g., to open folders and go through drives, and the third module uses the convexity hull method for finding the number of fingers open in the user's gesture and operates accordingly.

Searching, retrieving, and arranging text in ever-larger document collections necessitate more efficient information processing algorithms. Document categorization is a crucial component of various information processing systems for supervised learning. As the quantity of documents grows, the performance of classic supervised classifiers has deteriorated because of the number of document categories. Assigning documents to a predetermined set of classes is called text classification. It is utilized extensively in a wide range of data-intensive applications. However, the fact that real-world implementations of these models are plagued with shortcomings begs for more investigation. Imbalanced datasets hinder the most prevalent high-performance algorithms. In this paper, we propose an approach name multi-class Convolutional Neural Network (MCNN)-Long Short-Time Memory (LSTM), which combines two deep learning techniques, Convolutional Neural Network (CNN) and Long Short-Time Memory, for text classification in news data. CNN’s are used as feature extractors for the LSTMs on text input data and have the spatial structure of words in a sentence, paragraph, or document. The dataset is also imbalanced, and we use the Tomek-Link algorithm to balance the dataset and then apply our model, which shows better performance in terms of F1-score (98%) and Accuracy (99.71%) than the existing works. The combination of deep learning techniques used in our approach is ideal for the classification of imbalanced datasets with underrepresented categories. Hence, our method outperformed other machine learning algorithms in text classification by a large margin. We also compare our results with traditional machine learning algorithms in terms of imbalanced and balanced datasets.

Diabetic retinopathy (DR) is a common complication of diabetes mellitus, and retinal blood vessel damage can lead to vision loss and blindness if not recognized at an early stage. Manual DR detection using large fundus image data is time-consuming and error-prone. An effective automatic DR detection system can be significantly faster and potentially more accurate. This study aims to classify fundus images into five DR classes, using deep learning methods, with the highest possible accuracy and the lowest possible computational time. Three distinct DR datasets, APTOS, Messidor2, and IDRiD, are merged, resulting in 5,819 raw images. Before training the model, various image preprocessing techniques are applied to remove artifacts and noise from the images and improve their quality. Three augmentation techniques: geometric, photometric, and elastic deformation, are used to create a balanced dataset. A shallow convolutional neural network (CNN) is developed using three blocks of convolutional layers and maxpool layers with a categorical cross-entropy loss function, Adam optimizer, 0.0001 learning rate, and 64 batch size as a base model, and this is also employed to determine the best data augmentation method for further processing. A study to optimize the performance is then conducted by changing different components and hyperparameters of the base model, resulting in our proposed RetNet-10 model. Six cutting-edge models are employed for comparison. Our proposed RetNet-10 model performed the best, with a testing accuracy of 98.65%. MobileNetV2, VGG16, Xception, VGG19, InceptionV3 and ResNet50 achieved testing accuracies of 91.42%, 90.16%,89.57%, 88.21%, 87.68% and 87.23%, respectively. The model is also trained with several k values to assess its robustness. After image processing and data augmentation, using the combined dataset, and fine-tuning the base model, our proposed RetNet-10 model outperformed other automated methods for DR diagnosis.

Convolutional neural networks (CNNs) have been established for a comprehensive range of computer vision problems across several benchmarks. Visualization and analysis of feature maps generated by convolutional layers can be an effective approach to explore the hidden and complex characteristic of a CNN model. Convolutional layers provide diverse feature maps however, the extent of this diversity needs to be explored. This research attempts to provide five insights of the ‘Black box’ mechanism of CNNs, using skin cancer dermoscopy and lung scan computed tomography (CT) Scan datasets by statistically analyzing layer by layer (three convolutional layers) feature maps using 17 geometrical and 6 intensity-based features to determine the characteristics and level of diversity. Significance and difference of the feature maps layer by layer, black feature maps analysis, difference of the feature maps to each other and to the original image, variations among the feature maps when running the model multiple times and inter-class variation among the feature maps for different iteration are explored. Various statistical methods including T-test, analysis of variance (ANOVA), mean, median, mean squared error (MSE), peak signal to noise ratio (PSNR), structural similarity index (SSIM), root mean squared error (RMSE), dice similarity score (DSC), universal image quality index (UQI) and Spectral angle mapper (SAM) are employed. Experimental results show that for the skin cancer dermoscopy dataset, a large number of black feature maps are produced (20–60%) while the proportion of black feature maps for the CT Scan dataset is comparatively low (2–20%). This demonstrates that for different datasets, feature maps with diverse characteristics can be produced. The layer by layer differences between the feature maps is evaluated using T-tests and ANOVA for seventeen geometrical features and six intensity-based features. For both datasets across most of the geometrical features and across most of the intensity-based features a significant diversity can be observed. The difference of the feature maps to each other and to the original image is quite high, with MSE values for the dermoscopy and CT Scan datasets in the range of 1860–31,399 and 171–6089, respectively, PSNR 3–15 and 10–25, SSIM values of 0.01–0.84 and 0.3–0.81, RMSE values of 0.81–1 and 0.21–1, DSC values of 0.37–0.53 and 0.47–0.75, UQI values of 0.02–0.86 and 0.01–0.88 and SAM values of 0.12–1.53 and 0.19–1.55 for the dermoscopy and CT Scan datasets respectively. When running the model multiple times (three iterations), a notable iteration by iteration diversity is found in terms of mean, median, maximum and minimum values for most of the geometrical features. The inter-class variation among the feature maps for different iterations and layers are evaluated based on the F-value of the ANOVA test. For the dermoscopy dataset, the highest mean F-value is found for layer 1 and iteration 3 while for the CT scan dataset the highest mean F-value is found for layer 3 and iteration 3 indicating that for these feature maps the highest inter-class dissimilarity is generated. The findings of this study may aid in exploring the complex mechanism of convolutional layers, kernels and feature maps.

Named Entity Recognition (NER) plays a significant role in enhancing the performance of all types of domain specific applications in Natural Language Processing (NLP). According to the type of application, the goal of NER is to identify target entities based on the context of other existing entities in a sentence. Numerous architectures have demonstrated good performance for high-resource languages such as English and Chinese NER. However, currently existing NER models for Bengali could not achieve reliable accuracy due to morphological richness of Bengali and limited availability of resources. This work integrates both Data and Model Centric AI concepts to achieve a state-of-the-art performance. A unique dataset was created for this study demonstrating the impact of a good quality dataset on accuracy. We proposed a method for developing a high quality NER dataset for any language. We have used our dataset to evaluate the performance of various Deep Learning models. A hybrid model performed with the exact match F1 score of 87.50%, partial match F1 score of 92.31%, and micro F1 score of 98.32%. Our proposed model reduces the need for feature engineering and utilizes minimal resources.

Early identification and adequate treatment can help prevent lung disorders from becoming chronic, severe, and life-threatening. X-ray images are commonly used and an automated and effective method involving deep learning techniques can potentially contribute to quick and accurate diagnosis of lung disorders. However, in the study of medical imaging using deep learning, two obstacles limit interpretability. One is an insufficient and imbalanced number of training samples in most medical datasets. The other is excessive training time. Although training time can be reduced by decreasing the number of pixels in the images, training with low resolution images tends to result in poor performance. This study represents a solution to overcome these impediments by balancing the number of images and reducing overall processing time while preserving accuracy. The dataset used in this research contains an unequal number of images in the different classes. The quantity of data in the classes is balanced by creating synthetic images based on the patterns and characteristics of the original images, using a Deep Convolutional Generative Adversarial Network (DCGAN). Unwanted regions are removed from the X-ray images, the brightness and contrast of the images are enhanced, and the abnormalities are highlighted by using different artifact removal, noise reduction, and enhancement techniques. We propose a Modified Compact Convolutional Transformer (MCCT) model using 32 × 32 sized images for the categorization of lung disorders into four classes. An ablation study of eleven cases is employed to adjust several hyper parameters and layer topologies. This reduces training time while preserving accuracy. Six transfer learning models, VGG19, VGG16, ResNet152, ResNet50, ResNet50V2, and MobileNet are applied with the same image size the performance is compared with the proposed MCCT model. Our MCCT model records the greatest test accuracy of 95.37%, requiring a short training time, 10-12 s/epoch, whereas the other models only reach near-moderate performance with accuracies ranging from 43% to 79% and training times of 80-90 s/epoch. The robustness of the model with regards to the number of training samples is validated by training the model multiple times reducing the number of training images gradually from 49621 images to 6204 images. Results suggest that even with a smaller dataset, the performance is sustained. Our proposed approach may contribute to an effective CAD based diagnostic system by addressing the issues of insufficient and imbalanced numbers of medical images, excessive training times and low-resolution images.

With the development of computer vision and deep learning technologies, rapidly expanding approaches have been introduced that allow anyone to create videos and pictures that are both phony and incredibly lifelike. The term deepfake methodology is used to describe such technologies. Face alteration can be performed both in videos and pictures with extreme realism using deepfake innovation. Deepfake recordings, the majority of them targeting politicians or celebrity personalities, have been widely disseminated online. On the other hand, different strategies have been outlined in the research to combat the issues brought up by deepfake. In this paper, we carry out a review by analyzing and comparing (1) the notable research contributions in the field of deepfake models and (2) widely used deepfake tools. We have also built two separate taxonomies for deepfake models and tools. These models and tools are also compared in terms of underlying algorithms, datasets they have used and their accuracy. A number of challenges and open issues have also been identified.

Bronchiectasis in children can progress to a severe lung condition if not diagnosed and treated early. The radiological diagnostic criteria for the diagnosis of bronchiectasis is an increased broncho-arterial (BA) ratio. From high-resolution computed tomography (HRCT) scans, the BA pairs must be detected first to derive the BA ratio. This study aims to identify potential BA pairs from HRCT scans of children undertaken to evaluate suppurative lung disease through an automated approach. After segmenting the lung regions, the HRCT scans are cleaned using a histogram analysis-based approach followed by a potential arteries identification process comprising four conditions based on imaging features. Potential arteries and their connected components are extracted, and potential bronchi are identified. Finally, the coordinates of potential arteries and potential bronchi are matched as the last step of BA pairs extraction. A total of 8–50 BA pairs are detected for each patient. Additionally, the area and several diameters of the bronchi and arteries are measured, and BA ratios based on these are calculated. Through this approach, the BA pairs of a CT scan datasets are detected and utilizing a deep learning model, a high classification test accuracy of 98.53% is achieved, validating the robustness of the proposed BA detection approach. The results show that visible BA pairs can be identified and segmented automatically, and the BA ratio calculated may help diagnose bronchiectasis with less effort and time.

Skin cancer these days have become quite a common occurrence especially in certain geographic areas such as Oceania. Early detection of such cancer with high accuracy is of utmost importance, and studies have shown that deep learning- based intelligent approaches to address this concern have been fruitful. In this research, we present a novel deep learning- based classifier that has shown promise in classifying this type of cancer on a relevant preprocessed dataset having important features pre-identified through an effective feature extraction method.Skin cancer in modern times has become one of the most ubiquitous types of cancer. Accurate identification of cancerous skin lesions is of vital importance in treating this malady. In this research, we employed a deep learning approach to identify benign and malignant skin lesions. The initial dataset was obtained from Kaggle before several preprocessing steps for hair and background removal, image enhancement, selection of the region of interest (ROI), region-based segmentation, morphological gradient, and feature extraction were performed, resulting in histopathological images data with 20 input features based on geometrical and textural features. A principle component analysis (PCA)-based feature extraction technique was put into action to reduce the dimensionality to 10 input features. Subsequently, we applied our deep learning classifier, SkinNet-16, to detect the cancerous lesion accurately at a very early stage. The highest accuracy was obtained with the Adamax optimizer with a learning rate of 0.006 from the neural network-based model developed in this study. The model also delivered an impressive accuracy of approximately 99.19%.

Interpretation of medical images with a computer-aided diagnosis (CAD) system is arduous because of the complex structure of cancerous lesions in different imaging modalities, high degree of resemblance between inter-classes, presence of dissimilar characteristics in intra-classes, scarcity of medical data, and presence of artifacts and noises. In this study, these challenges are addressed by developing a shallow convolutional neural network (CNN) model with optimal configuration performing ablation study by altering layer structure and hyper-parameters and utilizing a suitable augmentation technique. Eight medical datasets with different modalities are investigated where the proposed model, named MNet-10, with low computational complexity is able to yield optimal performance across all datasets. The impact of photometric and geometric augmentation techniques on different datasets is also evaluated. We selected the mammogram dataset to proceed with the ablation study for being one of the most challenging imaging modalities. Before generating the model, the dataset is augmented using the two approaches. A base CNN model is constructed first and applied to both the augmented and non-augmented mammogram datasets where the highest accuracy is obtained with the photometric dataset. Therefore, the architecture and hyper-parameters of the model are determined by performing an ablation study on the base model using the mammogram photometric dataset. Afterward, the robustness of the network and the impact of different augmentation techniques are assessed by training the model with the rest of the seven datasets. We obtain a test accuracy of 97.34% on the mammogram, 98.43% on the skin cancer, 99.54% on the brain tumor magnetic resonance imaging (MRI), 97.29% on the COVID chest X-ray, 96.31% on the tympanic membrane, 99.82% on the chest computed tomography (CT) scan, and 98.75% on the breast cancer ultrasound datasets by photometric augmentation and 96.76% on the breast cancer microscopic biopsy dataset by geometric augmentation. Moreover, some elastic deformation augmentation methods are explored with the proposed model using all the datasets to evaluate their effectiveness. Finally, VGG16, InceptionV3, and ResNet50 were trained on the best-performing augmented datasets, and their performance consistency was compared with that of the MNet-10 model. The findings may aid future researchers in medical data analysis involving ablation studies and augmentation techniques.

Diabetic retinopathy (DR) is the foremost cause of blindness in people with diabetes worldwide, and early diagnosis is essential for effective treatment. Unfortunately, the present DR screening method requires the skill of ophthalmologists and is time-consuming. In this study, we present an automated system for DR severity classification employing the fine-tuned Compact Convolutional Transformer (CCT) model to overcome these issues. We assembled five datasets to generate a more extensive dataset containing 53,185 raw images. Various image pre-processing techniques and 12 types of augmentation procedures were applied to improve image quality and create a massive dataset. A new DR-CCTNet model is proposed. It is a modification of the original CCT model to address training time concerns and work with a large amount of data. Our proposed model delivers excellent accuracy even with low-pixel images and still has strong performance with fewer images, indicating that the model is robust. We compare our model’s performance with transfer learning models such as VGG19, VGG16, MobileNetV2, and ResNet50. The test accuracy of the VGG19, ResNet50, VGG16, and MobileNetV2 were, respectively, 72.88%, 76.67%, 73.22%, and 71.98%. Our proposed DR-CCTNet model to classify DR outperformed all of these with a 90.17% test accuracy. This approach provides a novel and efficient method for the detection of DR, which may lower the burden on ophthalmologists and expedite treatment for patients.

The privacy and security of patients’ health records have been an ongoing issue, and researchers are in a race against technology to design a system that can help stop the compromising of patient data. Many researchers have proposed solutions; however, most solutions have not incorporated potential parameters that can ensure private and secure personal health records management, which is the focus of this study. To design and develop a solution, this research thoroughly investigated existing solutions and identified potential key contexts. These include IOTA Tangle, Distributed Ledger Technology (DLT), IPFS protocols, Application Programming Interface (API), Proxy Re-encryption (PRE), and access control, which are analysed and integrated to secure patient medical records, and Internet of Things (IoT) medical devices, to develop a patient-based access management system that gives patients full control of their health records. This research developed four prototype applications to demonstrate the proposed solution: the web appointment application, the patient application, the doctor application, and the remote medical IoT device application. The results indicate that the proposed framework can improve healthcare services by providing immutable, secure, scalable, trusted, self-managed, and traceable patient health records while giving patients full control of their own medical records.

Breast cancer is the most diagnosed cancer in Australia with crude incidence rates increasing drastically from 62.8 at ages 35–39 to 271.4 at ages 50–54 (cases per 100,000 women). Various researchers have proposed methods and tools based on Machine Learning and Convolutional Neural Networks for assessing mammographic images, but these methods have produced detection and interpretation errors resulting in false-positive and false-negative cases when used in the real world. We believe that this problem can potentially be resolved by implementing effective image pre-processing techniques to create training data for Deep-CNN. Therefore, the main aim of this research is to propose effective image pre-processing methods to create datasets that can save computational time for the neural network and improve accuracy and classification rates. To do so, this research proposes methods for background removal, pectoral muscle removal, adding noise to the images, and image enhancements. Adding noise without affecting the quality of details in the images makes the input images for the neural network more representative, which may improve the performance of the neural network model when used in the real world. The proposed method for background removal is the “Rolling Ball Algorithm” and “Huang’s Fuzzy Thresholding”, which succeed in removing background from 100% of the images. For pectoral muscle removal “Canny Edge Detection” and “Hough’s Line Transform” are used, which removed muscle from 99.06% of the images. “Invert”, “CTI_RAS” and “ISOCONTOUR” lookup tables (LUTs) were used for image enhancements to outline the ROIs and regions within the ROIs.

Binaural hearing is the ability of the human auditory system to integrate information received from both ears simultaneously. Binaural hearing is fundamental in understanding speech in noisy backgrounds. Any disfunction in one or both ears could cause a disruption in the processing mechanism. Auditory evoked potentials (AEPs) are electrical potentials evoked by externally presented auditory stimuli from any part of the auditory system. A non-invasive technology, electroencephalography (EEG) is used for the monitoring of AEPs. The research aims to identify the best suited electrode positions through correlation analysis and analyse the AEP signals from the selected electrodes in order to detect binaural sensitivity of the human brain. The study evaluates the time-averaged EEG responses of normal hearing subjects to auditory stimuli. The stimuli used for the study are 500 Hz Blackman windowed pure tones, presented in either homophasic (the same phase in both ears) or antiphasic (180-degree phase difference between the two ears) conditions. The study focuses on understanding the effect of phase reversal of auditory stimuli, an under interaural time difference (ITD) cue, on the middle latency response (MLR) region of the AEPs. A correlation analysis was carried out between the eight different locations and as a result, Cz and Pz electrode positions were selected as the best suited positions for further analysis. The selected electrode signals were further processed in the time domain and frequency domain analysis. In the time domain analysis, it was found that Cz electrode for eight subjects out of nine and Pz electrode for seven subjects out of nine, had the larger area under signal curve obtained in the antiphasic condition than in the homophasic signals. Frequency domain analysis showed that the frequency bands 20 to 25Hz and 25 to 30Hz had the most energy when elicited by antiphasic stimuli than by homophasic stimuli. The findings of this study can be further utilised for the detection of binaural processing in a human brain.

Cardiovascular diseases (CVD) are among the most common serious illnesses affecting human health. CVDs may be prevented or mitigated by early diagnosis, and this may reduce mortality rates. Identifying risk factors using machine learning models is a promising approach. We would like to propose a model that incorporates different methods to achieve effective prediction of heart disease. For our proposed model to be successful, we have used efficient Data Collection, Data Pre-processing and Data Transformation methods to create accurate information for the training model. We have used a combined dataset (Cleveland, Long Beach VA, Switzerland, Hungarian and Stat log). Suitable features are selected by using the Relief, and Least Absolute Shrinkage and Selection Operator (LASSO) techniques. New hybrid classifiers like Decision Tree Bagging Method (DTBM), Random Forest Bagging Method (RFBM), K-Nearest Neighbors Bagging Method (KNNBM), AdaBoost Boosting Method (ABBM), and Gradient Boosting Boosting Method (GBBM) are developed by integrating the traditional classifiers with bagging and boosting methods, which are used in the training process. We have also instrumented some machine learning algorithms to calculate the Accuracy (ACC), Sensitivity (SEN), Error Rate, Precision (PRE) and F1 Score (F1) of our model, along with the Negative Predictive Value (NPR), False Positive Rate (FPR), and False Negative Rate (FNR). The results are shown separately to provide comparisons. Based on the result analysis, we can conclude that our proposed model produced the highest accuracy while using RFBM and Relief feature selection methods (99.05%).

The incidence, prevalence, and progression of chronic kidney disease (CKD) conditions have evolved over time, especially in countries that have varied social determinants of health. In most countries, diabetics and hypertension are the main causes of CKDs. The global guidelines classify CKD as a condition that results in decreased kidney function over time, as indicated by glomerular filtration rate (GFR) and markers of kidney damage. People with CKDs are likely to die at an early age. It is crucial for doctors to diagnose various conditions associated with CKD in an early stage because early detection may prevent or even reverse kidney damage. Early detection can provide better treatment and proper care to the patients. In many regional hospital/clinics, there is a shortage of nephrologists or general medical persons who diagnose the symptoms. This has resulted in patients waiting longer to get a diagnosis. Therefore, this research believes developing an intelligent system to classify a patient into classes of ‘CKD’ or ‘Non-CKD’ can help the doctors to deal with multiple patients and provide diagnosis faster. In time, organizations can implement the proposed machine learning framework in regional clinics that have lower medical expert retention, this can provide early diagnosis to patients in regional areas. Although, several researchers have tried to address the situation by developing intelligent systems using supervised machine learning methods, till date limited studies have used unsupervised machine learning algorithms. The primary aim of this research is to implement and compare the performance of various unsupervised algorithms and identify best possible combinations that can provide better accuracy and detection rate. This research has implemented five unsupervised algorithms, K-Means Clustering, DB-Scan, I-Forest, and Autoencoder. And integrating them with various feature selection methods. Integrating feature reduction methods with K-Means Clustering algorithm has achieved an overall accuracy of 99% in classifying the clinical data of CKD and Non-CKD.

The complex feature characteristics and low contrast of cancer lesions, a high degree of inter-class resemblance between malignant and benign lesions, and the presence of various artifacts including hairs make automated melanoma recognition in dermoscopy images quite challenging. To date, various computer-aided solutions have been proposed to identify and classify skin cancer. In this paper, a deep learning model with a shallow architecture is proposed to classify the lesions into benign and malignant. To achieve effective training while limiting overfitting problems due to limited training data, image preprocessing and data augmentation processes are introduced. After this, the ‘box blur’ down-scaling method is employed, which adds efficiency to our study by reducing the overall training time and space complexity significantly. Our proposed shallow convolutional neural network (SCNN_12) model is trained and evaluated on the Kaggle skin cancer data ISIC archive which was augmented to 16485 images by implementing different augmentation techniques. The model was able to achieve an accuracy of 98.87% with optimizer Adam and a learning rate of 0.001. In this regard, parameter and hyper-parameters of the model are determined by performing ablation studies. To assert no occurrence of overfitting, experiments are carried out exploring k-fold cross-validation and different dataset split ratios. Furthermore, to affirm the robustness the model is evaluated on noisy data to examine the performance when the image quality gets corrupted.This research corroborates that effective training for medical image analysis, addressing training time and space complexity, is possible even with a lightweighted network using a limited amount of training data.

Current research indicates that for the identification of lung disorders, comprising pneumonia and COVID-19, structural distortions of bronchi and arteries (BA) should be taken into account. CT scans are an effective modality to detect lung anomalies. However, anomalies in bronchi and arteries can be difficult to detect. Therefore, in this study, alterations of bronchi and arteries are considered in the classification of lung diseases. Four approaches to highlight these are introduced: (a) a Hessian-based approach, (b) a region-growing algorithm, (c) a clustering-based approach, and (d) a color-coding-based approach. Prior to this, the lungs are segmented, employing several image preprocessing algorithms. The utilized COVID-19 Lung CT scan dataset contains three classes named Non-COVID, COVID, and community-acquired pneumonia, having 6983, 7593, and 2618 samples, respectively. To classify the CT scans into three classes, two deep learning architectures, (a) a convolutional neural network (CNN) and (b) a CNN with long short-term memory (LSTM) and an attention mechanism, are considered. Both these models are trained with the four datasets achieved from the four approaches. Results show that the CNN model achieved test accuracies of 88.52%, 87.14%, 92.36%, and 95.84% for the Hessian, the region-growing, the color-coding, and the clustering-based approaches, respectively. The CNN with LSTM and an attention mechanism model results in an increase in overall accuracy for all approaches with an 89.61%, 88.28%, 94.61%, and 97.12% test accuracy for the Hessian, region-growing, color-coding, and clustering-based approaches, respectively. To assess overfitting, the accuracy and loss curves and k-fold cross-validation technique are employed. The Hessian-based and region-growing algorithm-based approaches produced nearly equivalent outcomes. Our proposed method outperforms state-of-the-art studies, indicating that it may be worthwhile to pay more attention to BA features in lung disease classification based on CT images.

Heart disease can be life-threatening if not detected and treated at an early stage. The electrocardiogram (ECG) plays a vital role in classifying cardiovascular diseases, and often physicians and medical researchers examine paper-based ECG images for cardiac diagnosis. An automated heart disease prediction system might help to classify heart diseases accurately at an early stage. This study aims to classify cardiac diseases into five classes with paper-based ECG images using a deep learning approach with the highest possible accuracy and the lowest possible time complexity. This research consists of two approaches. In the first approach, five deep learning models, InceptionV3, ResNet50, MobileNetV2, VGG19, and DenseNet201, are employed. In the second approach, an integrated deep learning model (InRes-106) is introduced, combining InceptionV3 and ResNet50. This model is developed as a deep convolutional neural network capable of extracting hidden and high-level features from images. An ablation study is conducted on the proposed model altering several components and hyperparameters, improving the performance even further. Before training the model, several image pre-processing techniques are employed to remove artifacts and enhance the image quality. Our proposed hybrid InRes-106 model performed best with a testing accuracy of 98.34%. The InceptionV3 model acquired a testing accuracy of 90.56%, the ResNet50 89.63%, the DenseNet201 88.94%, the VGG19 87.87%, and the MobileNetV2 achieved 80.56% testing accuracy. The model is trained with a k-fold cross-validation technique with different k values to evaluate the robustness further. Although the dataset contains a limited number of complex ECG images, our proposed approach, based on various image pre-processing techniques, model fine-tuning, and ablation studies, can effectively diagnose cardiac diseases.

Young academics have been facing a problem of high turnover rate due to missing links between the institutions’ policies and the performance. This study explores the effect of job embeddedness and community embeddedness on creative work performance and intentions to leave of young teaching staff in academic institutions in Pakistan. In this study, 300 qualified young academics from public and private universities were selected as subjects and asked to complete a questionnaire. Data were collected via mail-survey. A variance-based structural equation model is employed to measure the path model. The results show that the fit-dimension of organizational- and community-embeddedness, along with the moderating effect of organization size and the availability of nearby alternative jobs have a significant impact on improving perceived creative performance and reducing staff turnover intentions. This study suggests that organizations should focus on organizational-fit and community-fit constructs in their nurturing strategies to embed young teachers in their academic institutions. This study also suggests that monetary rewards only are relatively ineffective to improve retention. Hence, public and private sector universities should facilitate meaningful contributions from young teachers in creative work and provide opportunities for social interactions and personal development.

Electronic Health Records (EHR) are the healthcare sector’s core digital strategy meant to improve the quality of care provided to patients. Despite the benefits afforded by this digital transformation initiative, adoption among healthcare organizations has been slower than desired. The sheer volume and sensitive nature of patient records compel these organizations to exercise a healthy amount of caution in implementing EHR. Cyberattacks have also increased the risks associated with non-optimal EHR implementations. An influx of high-profile data breaches has plagued the sector during the COVID-19 pandemic, which put the spotlight on EHR cybersecurity. One objective of this research project is to aid the acceleration of EHR adoption. Another objective is to ensure the robustness of the system to resist malicious attacks. For the former, a systematic review was used to unearth all the possible causes why the adoption of EHR has been anemic. In this paper, sixty-five existing proposed EHR solutions were analyzed and it was found that there are fourteen major challenges that need to be addressed to reduce friction and risk for health organizations. These were privacy, security, confidentiality, interoperability, access control, scalability, authentication, accessibility, availability, data storage, data ownership, data validity, data integrity, and ease of use. We propose EHRChain, a new framework that tackles all the listed challenges simultaneously to address the first objective while also being designed to achieve the second objective. It is enabled by dual-blockchains based on Hyperledger Sawtooth to allow patient data decentralization via a consortium blockchain and IPFS for distributed data storage.

While previous studies have examined the impact of informal institutions to determine entrepreneurial activities, this paper explores the different configurational paths of informal institutions to promote men’s and women’s entrepreneurial activities across factor-driven and efficiency-driven economies. We collected data from the Global Entrepreneurship Monitor for 56 countries for the years 2008–2013 and employed fuzzy-set qualitative comparative analysis to conduct the empirical analysis. The results confirm that a single antecedent condition is unable to produce an outcome while combination of different conditions can produce an outcome. We find that cultural-cognitive institutional antecedents in combination with social-normative antecedents create configurations of conditions that lead to the higher levels of men’s and women’s entrepreneurial activities in factor-driven and efficiency-driven economies. Moreover, this study shows that these causal conditions configure differently to promote men’s and women’s entrepreneurial activities in factor-driven and efficiency-driven nations. This paper may create awareness in potential entrepreneurs regarding specific sets of institutional antecedents that can increase the emergence of entrepreneurship in different economic clusters. We show that institutional antecedents which are essential to promote entrepreneurship combine distinctly for men’s and women’s entrepreneurship and this combination varies in different stages of economic development.

Background: Identification and treatment of breast cancer at an early stage can reduce mortality. Currently, mammography is the most widely used effective imaging technique in breast cancer detection. However, an erroneous mammogram based interpretation may result in false diagnosis rate, as distinguishing cancerous masses from adjacent tissue is often complex and error-prone. Methods: Six pre-trained and fine-tuned deep CNN architectures: VGG16, VGG19, MobileNetV2, ResNet50, DenseNet201, and InceptionV3 are evaluated to determine which model yields the best performance. We propose a BreastNet18 model using VGG16 as foundational base, since VGG16 performs with the highest accuracy. An ablation study is performed on BreastNet18, to evaluate its robustness and achieve the highest possible accuracy. Various image processing techniques with suitable parameter values are employed to remove artefacts and increase the image quality. A total dataset of 1442 preprocessed mammograms was augmented using seven augmentation techniques, resulting in a dataset of 11,536 images. To investigate possible overfitting issues, a k-fold cross validation is carried out. The model was then tested on noisy mammograms to evaluate its robustness. Results were compared with previous studies. Results: Proposed BreastNet18 model performed best with a training accuracy of 96.72%, a validating accuracy of 97.91%, and a test accuracy of 98.02%. In contrast to this, VGGNet19 yielded test accuracy of 96.24%, MobileNetV2 77.84%, ResNet50 79.98%, DenseNet201 86.92%, and InceptionV3 76.87%. Conclusions: Our proposed approach based on image processing, transfer learning, fine-tuning, and ablation study has demonstrated a high correct breast cancer classification while dealing with a limited number of complex medical images.

As the world grapples with the COVID-19 pandemic, there has been a sudden and abrupt change in global energy landscape. Traditional fossil fuels that serve as the linchpin of modern civilization have found their consumption has rapidly fallen across most categories due to strict lockdown and stringent measures that have been adopted to suppress the disease. These changes consequently steered various environmental benefits across the world in recent time. The present article is an attempt to investigate these environmental benefits and reversals that have been materialized in this unfolding situation due to reduced consumption of fossil fuels. The life cycle assessment tool was used hereby to evaluate nine environmental impacts and one energy based impact. These impacts include ozone formation (terrestrial ecosystems), terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial ecotoxicity, freshwater ecotoxicity, marine ecotoxicity, land use, mineral resources scarcity, and cumulative exergy demand. Outcomes from the study demonstrate that COVID-19 has delivered impressive changes in global environment and life cycle exergy demand, with about 11–25% curtailment in all the above-mentioned impacts in 2020 in comparison to their corresponding readings in 2019.

Spam emails, also known as non-self, are unsolicited commercial or malicious emails, sent to affect either a single individual or a corporation or a group of people. Besides advertising, these may contain links to phishing or malware hosting websites set up to steal confidential information. In this paper, a study of the effectiveness of using a Negative Selection Algorithm (NSA) for anomaly detection applied to spam filtering is presented. NSA has a high performance and a low false detection rate. The designed framework intelligently works through three detection phases to finally determine an email’s legitimacy based on the knowledge gathered in the training phase. The system operates by elimination through Negative Selection similar to the functionality of T-cells’ in biological systems. It has been observed that with the inclusion of more datasets, the performance continues to improve, resulting in a 6% increase of True Positive and True Negative detection rate while achieving an actual detection rate of spam and ham of 98.5%. The model has been further compared against similar studies, and the result shows that the proposed system results in an increase of 2 to 15% in the correct detection rate of spam and ham.