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This article discusses the importance of hair-cell regeneration in mammals and explores the regenerative abilities of non-mammalian vertebrates, specifically zebrafish. The researchers highlight the advantages of studying hair-cell regeneration in zebrafish and present recent findings on the mechanisms involved. The article emphasizes the need for further research in this field and the potential for future breakthroughs in treating hearing loss in humans. The document is a list of references for various scientific articles related to auditory hair cell regeneration in avian and zebrafish models, providing valuable information for researchers in this area. [Extracted from the article]

Mutations in eya1 cause branchio-oto-renal syndrome (BOR) in humans and the equivalent condition in animal models. BOR is characterized by multi-organ malformations. To better understand the role of Eya1 in organogenesis we used the zebrafish posterior lateral-line primordium. This multicellular tissue moves from head-to-tail at a constant velocity via the simultaneous action of two chemokine receptors, Cxcr4b and Ackr3b (formerly cxcr7b). We found that loss of eya1 strongly reduces the expression of ackr3b , disrupting the coherent motion of the primordium and leading to lateral-line truncations. These findings point to abnormal collective cell chemotaxis as the origin of organ dysmorphia in BOR., Competing Interests: The authors declare that there are no conflicts of interest present., (Copyright: © 2024 by the authors.)